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PubMed code 24634223

Compile data set for download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PR domain-containing protein 9 (PRDM9)


(Homo sapiens (Human))
BDBM228652
PNG
(H3 (21-44) K36me2 | LATKAARKSAPSTGGVKKPHRYRP)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCC[NH+](C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C115H197N39O30/c1-60(2)51-71(119)94(165)134-64(7)93(164)149-90(67(10)158)108(179)141-72(27-13-17-41-116)95(166)135-62(5)91(162)133-63(6)92(163)137-75(31-21-44-127-113(120)121)96(167)138-73(28-14-18-42-117)99(170)146-81(57-155)102(173)136-65(8)109(180)152-48-24-34-83(152)105(176)147-82(58-156)103(174)150-89(66(9)157)106(177)131-55-86(160)130-56-87(161)148-88(61(3)4)107(178)140-74(29-16-20-47-151(11)12)97(168)142-77(30-15-19-43-118)110(181)153-49-25-35-84(153)104(175)145-80(53-69-54-126-59-132-69)101(172)139-76(32-22-45-128-114(122)123)98(169)144-79(52-68-37-39-70(159)40-38-68)100(171)143-78(33-23-46-129-115(124)125)111(182)154-50-26-36-85(154)112(183)184/h37-40,54,59-67,71-85,88-90,155-159H,13-36,41-53,55-58,116-119H2,1-12H3,(H,126,132)(H,130,160)(H,131,177)(H,133,162)(H,134,165)(H,135,166)(H,136,173)(H,137,163)(H,138,167)(H,139,172)(H,140,178)(H,141,179)(H,142,168)(H,143,171)(H,144,169)(H,145,175)(H,146,170)(H,147,176)(H,148,161)(H,149,164)(H,150,174)(H,183,184)(H4,120,121,127)(H4,122,123,128)(H4,124,125,129)/p+1/t62-,63-,64-,65-,66+,67+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,88-,89-,90-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 4.20E+3n/an/an/a8.523



University of Toronto



Assay Description
In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...


J Biol Chem 289: 12177-88 (2014)


Article DOI: 10.1074/jbc.M113.523183
BindingDB Entry DOI: 10.7270/Q2SQ8Z86
More data for this
Ligand-Target Pair
PR domain-containing protein 9 (PRDM9)


(Homo sapiens (Human))
BDBM228647
PNG
(H3 (1-25) K4me1 | MARTKQTARKSTGGKAPRKQLATKA)
Show SMILES C[NH2+]CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCSC)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C113H207N41O33S/c1-56(2)52-77(102(178)134-59(5)90(166)150-86(64(10)158)107(183)146-68(29-15-20-43-115)93(169)137-61(7)110(186)187)148-99(175)75(37-39-80(119)160)143-94(170)69(30-16-21-44-116)141-97(173)73(34-25-48-129-112(123)124)145-104(180)79-36-27-50-154(79)109(185)60(6)136-92(168)67(28-14-19-42-114)138-83(163)54-131-82(162)53-132-105(181)84(62(8)156)151-103(179)78(55-155)149-98(174)70(31-17-22-45-117)142-96(172)72(33-24-47-128-111(121)122)139-89(165)58(4)135-106(182)85(63(9)157)152-101(177)76(38-40-81(120)161)144-95(171)71(32-18-23-46-127-12)147-108(184)87(65(11)159)153-100(176)74(35-26-49-130-113(125)126)140-88(164)57(3)133-91(167)66(118)41-51-188-13/h56-79,84-87,127,155-159H,14-55,114-118H2,1-13H3,(H2,119,160)(H2,120,161)(H,131,162)(H,132,181)(H,133,167)(H,134,178)(H,135,182)(H,136,168)(H,137,169)(H,138,163)(H,139,165)(H,140,164)(H,141,173)(H,142,172)(H,143,170)(H,144,171)(H,145,180)(H,146,183)(H,147,184)(H,148,175)(H,149,174)(H,150,166)(H,151,179)(H,152,177)(H,153,176)(H,186,187)(H4,121,122,128)(H4,123,124,129)(H4,125,126,130)/p+1/t57-,58-,59-,60-,61-,62+,63+,64+,65+,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,84-,85-,86-,87-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 4.70E+3n/an/an/a8.523



University of Toronto



Assay Description
In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...


J Biol Chem 289: 12177-88 (2014)


Article DOI: 10.1074/jbc.M113.523183
BindingDB Entry DOI: 10.7270/Q2SQ8Z86
More data for this
Ligand-Target Pair
PR domain-containing protein 9 (PRDM9)


(Homo sapiens (Human))
BDBM228653
PNG
(H3 (21-44) K36me3 | LATKAARKSAPSTGGVKKPHRYRP)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C116H199N39O30/c1-61(2)52-72(120)95(166)135-65(7)94(165)150-91(68(10)159)109(180)142-73(28-14-18-42-117)96(167)136-63(5)92(163)134-64(6)93(164)138-76(32-22-45-128-114(121)122)97(168)139-74(29-15-19-43-118)100(171)147-82(58-156)103(174)137-66(8)110(181)152-48-25-35-84(152)106(177)148-83(59-157)104(175)151-90(67(9)158)107(178)132-56-87(161)131-57-88(162)149-89(62(3)4)108(179)141-75(30-17-21-51-155(11,12)13)98(169)143-78(31-16-20-44-119)111(182)153-49-26-36-85(153)105(176)146-81(54-70-55-127-60-133-70)102(173)140-77(33-23-46-129-115(123)124)99(170)145-80(53-69-38-40-71(160)41-39-69)101(172)144-79(34-24-47-130-116(125)126)112(183)154-50-27-37-86(154)113(184)185/h38-41,55,60-68,72-86,89-91,156-159H,14-37,42-54,56-59,117-120H2,1-13H3,(H34-,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,184,185)/p+1/t63-,64-,65-,66-,67+,68+,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,89-,90-,91-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 9.60E+3n/an/an/a8.523



University of Toronto



Assay Description
In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...


J Biol Chem 289: 12177-88 (2014)


Article DOI: 10.1074/jbc.M113.523183
BindingDB Entry DOI: 10.7270/Q2SQ8Z86
More data for this
Ligand-Target Pair
PR domain-containing protein 9 (PRDM9)


(Homo sapiens (Human))
BDBM228646
PNG
(H3 (1-25) K4me0 | MARTKQTARKSTGGKAPRKQLATKA)
Show SMILES CSCC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C112H205N41O33S/c1-55(2)51-76(101(177)133-58(5)89(165)149-85(63(10)157)106(182)145-67(28-14-19-42-114)92(168)136-60(7)109(185)186)147-98(174)74(36-38-79(119)159)142-93(169)68(29-15-20-43-115)140-96(172)72(33-24-47-128-111(123)124)144-103(179)78-35-26-49-153(78)108(184)59(6)135-91(167)66(27-13-18-41-113)137-82(162)53-130-81(161)52-131-104(180)83(61(8)155)150-102(178)77(54-154)148-97(173)69(30-16-21-44-116)141-95(171)71(32-23-46-127-110(121)122)138-88(164)57(4)134-105(181)84(62(9)156)151-100(176)75(37-39-80(120)160)143-94(170)70(31-17-22-45-117)146-107(183)86(64(11)158)152-99(175)73(34-25-48-129-112(125)126)139-87(163)56(3)132-90(166)65(118)40-50-187-12/h55-78,83-86,154-158H,13-54,113-118H2,1-12H3,(H2,119,159)(H2,120,160)(H,130,161)(H,131,180)(H,132,166)(H,133,177)(H,134,181)(H,135,167)(H,136,168)(H,137,162)(H,138,164)(H,139,163)(H,140,172)(H,141,171)(H,142,169)(H,143,170)(H,144,179)(H,145,182)(H,146,183)(H,147,174)(H,148,173)(H,149,165)(H,150,178)(H,151,176)(H,152,175)(H,185,186)(H4,121,122,127)(H4,123,124,128)(H4,125,126,129)/t56-,57-,58-,59-,60-,61+,62+,63+,64+,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,83-,84-,85-,86-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 3.60E+3n/an/an/a8.523



University of Toronto



Assay Description
In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...


J Biol Chem 289: 12177-88 (2014)


Article DOI: 10.1074/jbc.M113.523183
BindingDB Entry DOI: 10.7270/Q2SQ8Z86
More data for this
Ligand-Target Pair
PR domain-containing protein 9 (PRDM9)


(Homo sapiens (Human))
BDBM228651
PNG
(H3 (21-44) K36me1 | LATKAARKSAPSTGGVKKPHRYRP)
Show SMILES C[NH2+]CCCC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C114H195N39O30/c1-59(2)50-70(118)93(164)134-63(7)92(163)149-89(66(10)157)107(178)141-71(26-12-16-40-115)94(165)135-61(5)90(161)133-62(6)91(162)137-74(30-20-44-127-112(119)120)95(166)138-72(27-13-17-41-116)98(169)146-80(56-154)101(172)136-64(8)108(179)151-47-23-33-82(151)104(175)147-81(57-155)102(173)150-88(65(9)156)105(176)131-54-85(159)130-55-86(160)148-87(60(3)4)106(177)140-73(28-15-19-43-125-11)96(167)142-76(29-14-18-42-117)109(180)152-48-24-34-83(152)103(174)145-79(52-68-53-126-58-132-68)100(171)139-75(31-21-45-128-113(121)122)97(168)144-78(51-67-36-38-69(158)39-37-67)99(170)143-77(32-22-46-129-114(123)124)110(181)153-49-25-35-84(153)111(182)183/h36-39,53,58-66,70-84,87-89,125,154-158H,12-35,40-52,54-57,115-118H2,1-11H3,(H,126,132)(H,130,159)(H,131,176)(H,133,161)(H,134,164)(H,135,165)(H,136,172)(H,137,162)(H,138,166)(H,139,171)(H,140,177)(H,141,178)(H,142,167)(H,143,170)(H,144,168)(H,145,174)(H,146,169)(H,147,175)(H,148,160)(H,149,163)(H,150,173)(H,182,183)(H4,119,120,127)(H4,121,122,128)(H4,123,124,129)/p+1/t61-,62-,63-,64-,65+,66+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,87-,88-,89-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 4.10E+3n/an/an/a8.523



University of Toronto



Assay Description
In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...


J Biol Chem 289: 12177-88 (2014)


Article DOI: 10.1074/jbc.M113.523183
BindingDB Entry DOI: 10.7270/Q2SQ8Z86
More data for this
Ligand-Target Pair
PR domain-containing protein 9 (PRDM9)


(Homo sapiens (Human))
BDBM228649
PNG
(H3 (1-25) K4me3 | MARTKQTARKSTGGKAPRKQLATKA)
Show SMILES CSCC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C115H211N41O33S/c1-58(2)54-79(104(180)135-61(5)92(168)151-88(66(10)160)109(185)147-70(31-17-22-45-117)95(171)138-63(7)112(188)189)149-101(177)77(39-41-82(121)162)144-96(172)71(32-18-23-46-118)142-99(175)75(36-27-49-130-114(125)126)146-106(182)81-38-29-51-155(81)111(187)62(6)137-94(170)69(30-16-21-44-116)139-85(165)56-132-84(164)55-133-107(183)86(64(8)158)152-105(181)80(57-157)150-100(176)72(33-19-24-47-119)143-98(174)74(35-26-48-129-113(123)124)140-91(167)60(4)136-108(184)87(65(9)159)153-103(179)78(40-42-83(122)163)145-97(173)73(34-20-25-52-156(12,13)14)148-110(186)89(67(11)161)154-102(178)76(37-28-50-131-115(127)128)141-90(166)59(3)134-93(169)68(120)43-53-190-15/h58-81,86-89,157-161H,16-57,116-120H2,1-15H3,(H39-,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186,188,189)/p+1/t59-,60-,61-,62-,63-,64+,65+,66+,67+,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,86-,87-,88-,89-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.20E+4n/an/an/a8.523



University of Toronto



Assay Description
In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...


J Biol Chem 289: 12177-88 (2014)


Article DOI: 10.1074/jbc.M113.523183
BindingDB Entry DOI: 10.7270/Q2SQ8Z86
More data for this
Ligand-Target Pair
PR domain-containing protein 9 (PRDM9)


(Homo sapiens (Human))
BDBM228648
PNG
(H3 (1-25) K4me2 | MARTKQTARKSTGGKAPRKQLATKA)
Show SMILES CSCC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCC[NH+](C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C114H209N41O33S/c1-57(2)53-78(103(179)134-60(5)91(167)150-87(65(10)159)108(184)146-69(30-16-21-44-116)94(170)137-62(7)111(187)188)148-100(176)76(38-40-81(120)161)143-95(171)70(31-17-22-45-117)141-98(174)74(35-26-48-129-113(124)125)145-105(181)80-37-28-51-155(80)110(186)61(6)136-93(169)68(29-15-20-43-115)138-84(164)55-131-83(163)54-132-106(182)85(63(8)157)151-104(180)79(56-156)149-99(175)71(32-18-23-46-118)142-97(173)73(34-25-47-128-112(122)123)139-90(166)59(4)135-107(183)86(64(9)158)152-102(178)77(39-41-82(121)162)144-96(172)72(33-19-24-50-154(12)13)147-109(185)88(66(11)160)153-101(177)75(36-27-49-130-114(126)127)140-89(165)58(3)133-92(168)67(119)42-52-189-14/h57-80,85-88,156-160H,15-56,115-119H2,1-14H3,(H2,120,161)(H2,121,162)(H,131,163)(H,132,182)(H,133,168)(H,134,179)(H,135,183)(H,136,169)(H,137,170)(H,138,164)(H,139,166)(H,140,165)(H,141,174)(H,142,173)(H,143,171)(H,144,172)(H,145,181)(H,146,184)(H,147,185)(H,148,176)(H,149,175)(H,150,167)(H,151,180)(H,152,178)(H,153,177)(H,187,188)(H4,122,123,128)(H4,124,125,129)(H4,126,127,130)/p+1/t58-,59-,60-,61-,62-,63+,64+,65+,66+,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,85-,86-,87-,88-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 5.80E+3n/an/an/a8.523



University of Toronto



Assay Description
In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...


J Biol Chem 289: 12177-88 (2014)


Article DOI: 10.1074/jbc.M113.523183
BindingDB Entry DOI: 10.7270/Q2SQ8Z86
More data for this
Ligand-Target Pair
PR domain-containing protein 9 (PRDM9)


(Homo sapiens (Human))
BDBM228650
PNG
(H3 (21-44) K36me0 | LATKAARKSAPSTGGVKKPHRYRP)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C113H193N39O30/c1-58(2)49-69(118)92(163)133-62(7)91(162)148-88(65(10)156)106(177)140-70(25-11-15-39-114)93(164)134-60(5)89(160)132-61(6)90(161)136-73(29-19-43-126-111(119)120)94(165)137-71(26-12-16-40-115)97(168)145-79(55-153)100(171)135-63(8)107(178)150-46-22-32-81(150)103(174)146-80(56-154)101(172)149-87(64(9)155)104(175)130-53-84(158)129-54-85(159)147-86(59(3)4)105(176)139-72(27-13-17-41-116)95(166)141-75(28-14-18-42-117)108(179)151-47-23-33-82(151)102(173)144-78(51-67-52-125-57-131-67)99(170)138-74(30-20-44-127-112(121)122)96(167)143-77(50-66-35-37-68(157)38-36-66)98(169)142-76(31-21-45-128-113(123)124)109(180)152-48-24-34-83(152)110(181)182/h35-38,52,57-65,69-83,86-88,153-157H,11-34,39-51,53-56,114-118H2,1-10H3,(H,125,131)(H,129,158)(H,130,175)(H,132,160)(H,133,163)(H,134,164)(H,135,171)(H,136,161)(H,137,165)(H,138,170)(H,139,176)(H,140,177)(H,141,166)(H,142,169)(H,143,167)(H,144,173)(H,145,168)(H,146,174)(H,147,159)(H,148,162)(H,149,172)(H,181,182)(H4,119,120,126)(H4,121,122,127)(H4,123,124,128)/t60-,61-,62-,63-,64+,65+,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,86-,87-,88-/m0/s1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 4.60E+3n/an/an/a8.523



University of Toronto



Assay Description
In this assay [3H]AdoMet (PerkinElmer Life Sciences; catalog number NET155V250UC)was used as a methyl donor to methylate biotinylated histone peptide...


J Biol Chem 289: 12177-88 (2014)


Article DOI: 10.1074/jbc.M113.523183
BindingDB Entry DOI: 10.7270/Q2SQ8Z86
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%