BindingDB logo
myBDB logout

PubMed code 24675136

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50044269
PNG
(CHEMBL3310347)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc(cs1)-c1ccc(O)cc1
Show InChI InChI=1S/C18H14N4O5S/c23-13-7-5-11(6-8-13)15-10-28-18(19-15)21-20-14(17(24)25)9-12-3-1-2-4-16(12)22(26)27/h1-8,10,23H,9H2,(H,19,21)(H,24,25)/b20-14-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 3.66E+7n/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenc...


Eur J Med Chem 77: 361-77 (2014)


Article DOI: 10.1016/j.ejmech.2014.03.034
BindingDB Entry DOI: 10.7270/Q2Z89F19
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50044268
PNG
(CHEMBL3310215)
Show SMILES Nc1ccc(C\C(=N\Nc2nc(cs2)-c2ccc(Cl)c(Cl)c2)C(O)=O)cc1[N+]([O-])=O
Show InChI InChI=1S/C18H13Cl2N5O4S/c19-11-3-2-10(7-12(11)20)15-8-30-18(22-15)24-23-14(17(26)27)5-9-1-4-13(21)16(6-9)25(28)29/h1-4,6-8H,5,21H2,(H,22,24)(H,26,27)/b23-14-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 5.01E+6n/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenc...


Eur J Med Chem 77: 361-77 (2014)


Article DOI: 10.1016/j.ejmech.2014.03.034
BindingDB Entry DOI: 10.7270/Q2Z89F19
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50018919
PNG
(CHEMBL254578)
Show SMILES OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 8.74E+6n/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenc...


Eur J Med Chem 77: 361-77 (2014)


Article DOI: 10.1016/j.ejmech.2014.03.034
BindingDB Entry DOI: 10.7270/Q2Z89F19
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%