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PubMed code 24737316

Compile data set for download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
beta-Galactosidase (β-Gal)(R201C)


(Homo sapiens (Human))
BDBM228800
PNG
(NOEV | Sapienic acid (SpA))
Show SMILES CCCCCCCCN[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C15H29NO4/c1-2-3-4-5-6-7-8-16-12-9-11(10-17)13(18)15(20)14(12)19/h9,12-20H,2-8,10H2,1H3/t12-,13+,14-,15-/m0/s1
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UniChem
Article
PubMed
940 -35.8n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)


(Homo sapiens (Human))
BDBM228800
PNG
(NOEV | Sapienic acid (SpA))
Show SMILES CCCCCCCCN[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C15H29NO4/c1-2-3-4-5-6-7-8-16-12-9-11(10-17)13(18)15(20)14(12)19/h9,12-20H,2-8,10H2,1H3/t12-,13+,14-,15-/m0/s1
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UniChem
Article
PubMed
1.10E+3 -35.4n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)(I51T)


(Homo sapiens (Human))
BDBM228800
PNG
(NOEV | Sapienic acid (SpA))
Show SMILES CCCCCCCCN[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C15H29NO4/c1-2-3-4-5-6-7-8-16-12-9-11(10-17)13(18)15(20)14(12)19/h9,12-20H,2-8,10H2,1H3/t12-,13+,14-,15-/m0/s1
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UniChem
Article
PubMed
1.20E+3 -35.2n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)(I51T)


(Homo sapiens (Human))
BDBM50163440
PNG
((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6-/m1/s1
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PubMed
4.47E+4 -25.8n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)(R201C)


(Homo sapiens (Human))
BDBM50163440
PNG
((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6-/m1/s1
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PubMed
4.90E+4 -25.6n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)(R201C)


(Homo sapiens (Human))
BDBM228802
PNG
(5N,6S-(N'-butyliminomethylidene)-6-thio-1-deox...)
Show SMILES CCCC\N=C1/SC[C@@H]2[C@H](O)[C@H](O)[C@@H](O)CN12
Show InChI InChI=1S/C11H20N2O3S/c1-2-3-4-12-11-13-5-8(14)10(16)9(15)7(13)6-17-11/h7-10,14-16H,2-6H2,1H3/b12-11-/t7-,8+,9+,10-/m1/s1
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5.33E+4 -25.4n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)


(Homo sapiens (Human))
BDBM50163440
PNG
((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6-/m1/s1
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PubMed
6.18E+4 -25.0n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)


(Homo sapiens (Human))
BDBM228802
PNG
(5N,6S-(N'-butyliminomethylidene)-6-thio-1-deox...)
Show SMILES CCCC\N=C1/SC[C@@H]2[C@H](O)[C@H](O)[C@@H](O)CN12
Show InChI InChI=1S/C11H20N2O3S/c1-2-3-4-12-11-13-5-8(14)10(16)9(15)7(13)6-17-11/h7-10,14-16H,2-6H2,1H3/b12-11-/t7-,8+,9+,10-/m1/s1
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6.83E+4 -24.7n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)(I51T)


(Homo sapiens (Human))
BDBM228802
PNG
(5N,6S-(N'-butyliminomethylidene)-6-thio-1-deox...)
Show SMILES CCCC\N=C1/SC[C@@H]2[C@H](O)[C@H](O)[C@@H](O)CN12
Show InChI InChI=1S/C11H20N2O3S/c1-2-3-4-12-11-13-5-8(14)10(16)9(15)7(13)6-17-11/h7-10,14-16H,2-6H2,1H3/b12-11-/t7-,8+,9+,10-/m1/s1
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6.88E+4 -24.7n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)


(Homo sapiens (Human))
BDBM228803
PNG
(5N,6S-(N'-butyliminomethylidene)-6-thiogalacto...)
Show SMILES CCCC\N=C1\SCC2[C@H](O)[C@H](O)C(O)[C@@H](O)N12
Show InChI InChI=1S/C11H20N2O4S/c1-2-3-4-12-11-13-6(5-18-11)7(14)8(15)9(16)10(13)17/h6-10,14-17H,2-5H2,1H3/b12-11+/t6?,7-,8-,9?,10+/m0/s1
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2.53E+5 -21.4n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)(I51T)


(Homo sapiens (Human))
BDBM228803
PNG
(5N,6S-(N'-butyliminomethylidene)-6-thiogalacto...)
Show SMILES CCCC\N=C1\SCC2[C@H](O)[C@H](O)C(O)[C@@H](O)N12
Show InChI InChI=1S/C11H20N2O4S/c1-2-3-4-12-11-13-6(5-18-11)7(14)8(15)9(16)10(13)17/h6-10,14-17H,2-5H2,1H3/b12-11+/t6?,7-,8-,9?,10+/m0/s1
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UniChem
Article
PubMed
3.20E+5 -20.8n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)(R201C)


(Homo sapiens (Human))
BDBM228803
PNG
(5N,6S-(N'-butyliminomethylidene)-6-thiogalacto...)
Show SMILES CCCC\N=C1\SCC2[C@H](O)[C@H](O)C(O)[C@@H](O)N12
Show InChI InChI=1S/C11H20N2O4S/c1-2-3-4-12-11-13-6(5-18-11)7(14)8(15)9(16)10(13)17/h6-10,14-17H,2-5H2,1H3/b12-11+/t6?,7-,8-,9?,10+/m0/s1
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3.20E+5 -20.7n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)(I51T)


(Homo sapiens (Human))
BDBM228804
PNG
(N-(N'-butylthiocarbamoyl)-1-deoxygalactonojiri...)
Show SMILES CCCCNC(=S)N1CC(O)[C@@H](O)[C@@H](O)C1CO
Show InChI InChI=1S/C11H22N2O4S/c1-2-3-4-12-11(18)13-5-8(15)10(17)9(16)7(13)6-14/h7-10,14-17H,2-6H2,1H3,(H,12,18)/t7?,8?,9-,10+/m0/s1
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3.29E+5 -20.7n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)


(Homo sapiens (Human))
BDBM228804
PNG
(N-(N'-butylthiocarbamoyl)-1-deoxygalactonojiri...)
Show SMILES CCCCNC(=S)N1CC(O)[C@@H](O)[C@@H](O)C1CO
Show InChI InChI=1S/C11H22N2O4S/c1-2-3-4-12-11(18)13-5-8(15)10(17)9(16)7(13)6-14/h7-10,14-17H,2-6H2,1H3,(H,12,18)/t7?,8?,9-,10+/m0/s1
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3.73E+5 -20.4n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)(R201C)


(Homo sapiens (Human))
BDBM228804
PNG
(N-(N'-butylthiocarbamoyl)-1-deoxygalactonojiri...)
Show SMILES CCCCNC(=S)N1CC(O)[C@@H](O)[C@@H](O)C1CO
Show InChI InChI=1S/C11H22N2O4S/c1-2-3-4-12-11(18)13-5-8(15)10(17)9(16)7(13)6-14/h7-10,14-17H,2-6H2,1H3,(H,12,18)/t7?,8?,9-,10+/m0/s1
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3.88E+5 -20.3n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)


(Homo sapiens (Human))
BDBM228805
PNG
(Galactose)
Show SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6?/m1/s1
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4.14E+6 -14.1n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)(I51T)


(Homo sapiens (Human))
BDBM228805
PNG
(Galactose)
Show SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6?/m1/s1
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4.91E+6 -13.7n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
beta-Galactosidase (β-Gal)(R201C)


(Homo sapiens (Human))
BDBM228805
PNG
(Galactose)
Show SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6?/m1/s1
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5.61E+6 -13.4n/an/an/an/an/a4.537



The University of Tokyo



Assay Description
β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl...


J Biol Chem 289: 14560-8 (2014)


Article DOI: 10.1074/jbc.M113.529529
BindingDB Entry DOI: 10.7270/Q2WH2NW4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%