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PubMed code 24785465

Compile data set for download or QSAR
Found 80 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044463
PNG
(CHEMBL3357458)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(CC3)C(=O)\C=C\CN(C)C)c2)ncc1Cl
Show InChI InChI=1S/C31H39ClN8O4S/c1-22(2)45(43,44)27-12-6-5-11-26(27)36-30-25(32)20-33-31(37-30)35-24-10-7-9-23(19-24)34-28(41)21-39-15-17-40(18-16-39)29(42)13-8-14-38(3)4/h5-13,19-20,22H,14-18,21H2,1-4H3,(H,34,41)(H2,33,35,36,37)/b13-8+
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n/an/a 0.700n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044428
PNG
(CHEMBL3357452)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)C3CN(C3)C(=O)CCCN(C)C)c2)ncc1Cl
Show InChI InChI=1S/C29H36ClN7O4S/c1-19(2)42(40,41)25-12-6-5-11-24(25)34-27-23(30)16-31-29(35-27)33-22-10-7-9-21(15-22)32-28(39)20-17-37(18-20)26(38)13-8-14-36(3)4/h5-7,9-12,15-16,19-20H,8,13-14,17-18H2,1-4H3,(H,32,39)(H2,31,33,34,35)
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n/an/a 0.800n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044461
PNG
(CHEMBL3357456)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(C)CC3)c2)ncc1Cl
Show InChI InChI=1S/C26H32ClN7O3S/c1-18(2)38(36,37)23-10-5-4-9-22(23)31-25-21(27)16-28-26(32-25)30-20-8-6-7-19(15-20)29-24(35)17-34-13-11-33(3)12-14-34/h4-10,15-16,18H,11-14,17H2,1-3H3,(H,29,35)(H2,28,30,31,32)
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n/an/a 1.70n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044325
PNG
(CHEMBL3357444)
Show SMILES C[C@H](N)C(=O)Nc1cccc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c1
Show InChI InChI=1S/C22H25ClN6O3S/c1-13(2)33(31,32)19-10-5-4-9-18(19)28-20-17(23)12-25-22(29-20)27-16-8-6-7-15(11-16)26-21(30)14(3)24/h4-14H,24H2,1-3H3,(H,26,30)(H2,25,27,28,29)/t14-/m0/s1
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n/an/a 1.80n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306682
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044465
PNG
(CHEMBL3357460)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CC3CN4)c2)ncc1Cl
Show InChI InChI=1S/C26H30ClN7O3S/c1-16(2)38(36,37)23-9-4-3-8-22(23)32-25-21(27)13-29-26(33-25)31-18-7-5-6-17(10-18)30-24(35)15-34-14-19-11-20(34)12-28-19/h3-10,13,16,19-20,28H,11-12,14-15H2,1-2H3,(H,30,35)(H2,29,31,32,33)
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n/an/a 2.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044468
PNG
(CHEMBL3357463)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCC4CNCC34)c2)ncc1Cl
Show InChI InChI=1S/C27H32ClN7O3S/c1-17(2)39(37,38)24-9-4-3-8-22(24)33-26-21(28)14-30-27(34-26)32-20-7-5-6-19(12-20)31-25(36)16-35-11-10-18-13-29-15-23(18)35/h3-9,12,14,17-18,23,29H,10-11,13,15-16H2,1-2H3,(H,31,36)(H2,30,32,33,34)
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n/an/a 2.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044460
PNG
(CHEMBL3357455)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCNCC3)c2)ncc1Cl
Show InChI InChI=1S/C25H30ClN7O3S/c1-17(2)37(35,36)22-9-4-3-8-21(22)31-24-20(26)15-28-25(32-24)30-19-7-5-6-18(14-19)29-23(34)16-33-12-10-27-11-13-33/h3-9,14-15,17,27H,10-13,16H2,1-2H3,(H,29,34)(H2,28,30,31,32)
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n/an/a 2.5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044303
PNG
(CHEMBL3357439)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O3S/c1-13(2)32(30,31)18-9-4-3-8-17(18)27-20-16(22)12-24-21(28-20)26-15-7-5-6-14(10-15)25-19(29)11-23/h3-10,12-13H,11,23H2,1-2H3,(H,25,29)(H2,24,26,27,28)
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n/an/a 2.70n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044467
PNG
(CHEMBL3357462)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CC3CC4O)c2)ncc1Cl
Show InChI InChI=1S/C27H31ClN6O4S/c1-16(2)39(37,38)24-9-4-3-8-22(24)32-26-21(28)13-29-27(33-26)31-19-7-5-6-18(11-19)30-25(36)15-34-14-17-10-20(34)12-23(17)35/h3-9,11,13,16-17,20,23,35H,10,12,14-15H2,1-2H3,(H,30,36)(H2,29,31,32,33)
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n/an/a 3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044374
PNG
(CHEMBL3357449)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CCN)c2)ncc1Cl
Show InChI InChI=1S/C22H25ClN6O3S/c1-14(2)33(31,32)19-9-4-3-8-18(19)28-21-17(23)13-25-22(29-21)27-16-7-5-6-15(12-16)26-20(30)10-11-24/h3-9,12-14H,10-11,24H2,1-2H3,(H,26,30)(H2,25,27,28,29)
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n/an/a 3.10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044462
PNG
(CHEMBL3357457)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(CC3)C3COC3)c2)ncc1Cl
Show InChI InChI=1S/C28H34ClN7O4S/c1-19(2)41(38,39)25-9-4-3-8-24(25)33-27-23(29)15-30-28(34-27)32-21-7-5-6-20(14-21)31-26(37)16-35-10-12-36(13-11-35)22-17-40-18-22/h3-9,14-15,19,22H,10-13,16-18H2,1-2H3,(H,31,37)(H2,30,32,33,34)
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n/an/a 4.90n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044328
PNG
(CHEMBL3357447)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)C(C)(C)N)c2)ncc1Cl
Show InChI InChI=1S/C23H27ClN6O3S/c1-14(2)34(32,33)19-11-6-5-10-18(19)29-20-17(24)13-26-22(30-20)28-16-9-7-8-15(12-16)27-21(31)23(3,4)25/h5-14H,25H2,1-4H3,(H,27,31)(H2,26,28,29,30)
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n/an/a 5.5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044469
PNG
(CHEMBL3357464)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CNCC4C3)c2)ncc1Cl
Show InChI InChI=1S/C27H32ClN7O3S/c1-17(2)39(37,38)24-9-4-3-8-23(24)33-26-22(28)13-30-27(34-26)32-21-7-5-6-20(10-21)31-25(36)16-35-14-18-11-29-12-19(18)15-35/h3-10,13,17-19,29H,11-12,14-16H2,1-2H3,(H,31,36)(H2,30,32,33,34)
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n/an/a 5.5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044298
PNG
(CHEMBL3356906)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C20H20ClN7O2/c1-23-19(30)14-7-2-3-8-16(14)27-18-15(21)11-24-20(28-18)26-13-6-4-5-12(9-13)25-17(29)10-22/h2-9,11H,10,22H2,1H3,(H,23,30)(H,25,29)(H2,24,26,27,28)
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n/an/a 6.5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044325
PNG
(CHEMBL3357444)
Show SMILES C[C@H](N)C(=O)Nc1cccc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c1
Show InChI InChI=1S/C22H25ClN6O3S/c1-13(2)33(31,32)19-10-5-4-9-18(19)28-20-17(23)12-25-22(29-20)27-16-8-6-7-15(11-16)26-21(30)14(3)24/h4-14H,24H2,1-3H3,(H,26,30)(H2,25,27,28,29)/t14-/m0/s1
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n/an/a 6.90n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044299
PNG
(CHEMBL3356907)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2cccc(NC(=O)CNC(=O)OC(C)(C)C)c2)ncc1Cl
Show InChI InChI=1S/C25H27ClFN7O4/c1-25(2,3)38-24(37)30-13-19(35)31-14-7-5-8-15(11-14)32-23-29-12-17(26)21(34-23)33-20-16(22(36)28-4)9-6-10-18(20)27/h5-12H,13H2,1-4H3,(H,28,36)(H,30,37)(H,31,35)(H2,29,32,33,34)
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n/an/a 7.10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044302
PNG
(CHEMBL3357438)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2cccc(NC(=O)CNC(=O)NC(C)(C)C)c2)ncc1Cl
Show InChI InChI=1S/C25H28ClFN8O3/c1-25(2,3)35-24(38)30-13-19(36)31-14-7-5-8-15(11-14)32-23-29-12-17(26)21(34-23)33-20-16(22(37)28-4)9-6-10-18(20)27/h5-12H,13H2,1-4H3,(H,28,37)(H,31,36)(H2,30,35,38)(H2,29,32,33,34)
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n/an/a 7.5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044306
PNG
(CHEMBL3357442)
Show SMILES CN(c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl)S(C)(=O)=O
Show InChI InChI=1S/C20H22ClN7O3S/c1-28(32(2,30)31)17-9-4-3-8-16(17)26-19-15(21)12-23-20(27-19)25-14-7-5-6-13(10-14)24-18(29)11-22/h3-10,12H,11,22H2,1-2H3,(H,24,29)(H2,23,25,26,27)
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n/an/a 7.70n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044464
PNG
(CHEMBL3357459)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(CC3)C(=O)CO)c2)ncc1Cl
Show InChI InChI=1S/C27H32ClN7O5S/c1-18(2)41(39,40)23-9-4-3-8-22(23)32-26-21(28)15-29-27(33-26)31-20-7-5-6-19(14-20)30-24(37)16-34-10-12-35(13-11-34)25(38)17-36/h3-9,14-15,18,36H,10-13,16-17H2,1-2H3,(H,30,37)(H2,29,31,32,33)
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n/an/a 9n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50306682
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
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Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044326
PNG
(CHEMBL3357445)
Show SMILES CC(C)[C@H](N)C(=O)Nc1cccc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c1
Show InChI InChI=1S/C24H29ClN6O3S/c1-14(2)21(26)23(32)28-16-8-7-9-17(12-16)29-24-27-13-18(25)22(31-24)30-19-10-5-6-11-20(19)35(33,34)15(3)4/h5-15,21H,26H2,1-4H3,(H,28,32)(H2,27,29,30,31)/t21-/m0/s1
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PubMed
n/an/a 15n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044301
PNG
(CHEMBL3357437)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CNC(=O)C3CCCN3)c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN8O3/c1-27-23(36)17-8-2-3-9-19(17)33-22-18(26)13-30-25(34-22)32-16-7-4-6-15(12-16)31-21(35)14-29-24(37)20-10-5-11-28-20/h2-4,6-9,12-13,20,28H,5,10-11,14H2,1H3,(H,27,36)(H,29,37)(H,31,35)(H2,30,32,33,34)
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n/an/a 16n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044434
PNG
(CHEMBL3357453)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCOCC3)c2)ncc1Cl
Show InChI InChI=1S/C25H29ClN6O4S/c1-17(2)37(34,35)22-9-4-3-8-21(22)30-24-20(26)15-27-25(31-24)29-19-7-5-6-18(14-19)28-23(33)16-32-10-12-36-13-11-32/h3-9,14-15,17H,10-13,16H2,1-2H3,(H,28,33)(H2,27,29,30,31)
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n/an/a 18n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044416
PNG
(CHEMBL3357450)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CCCN)c2)ncc1Cl
Show InChI InChI=1S/C23H27ClN6O3S/c1-15(2)34(32,33)20-10-4-3-9-19(20)29-22-18(24)14-26-23(30-22)28-17-8-5-7-16(13-17)27-21(31)11-6-12-25/h3-5,7-10,13-15H,6,11-12,25H2,1-2H3,(H,27,31)(H2,26,28,29,30)
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n/an/a 19n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044423
PNG
(CHEMBL3352867)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)C3CNC3)c2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O3S/c1-14(2)34(32,33)20-9-4-3-8-19(20)29-21-18(24)13-26-23(30-21)28-17-7-5-6-16(10-17)27-22(31)15-11-25-12-15/h3-10,13-15,25H,11-12H2,1-2H3,(H,27,31)(H2,26,28,29,30)
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n/an/a 21n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044459
PNG
(CHEMBL3357454)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3C[C@H](C)O[C@H](C)C3)c2)ncc1Cl
Show InChI InChI=1S/C27H33ClN6O4S/c1-17(2)39(36,37)24-11-6-5-10-23(24)32-26-22(28)13-29-27(33-26)31-21-9-7-8-20(12-21)30-25(35)16-34-14-18(3)38-19(4)15-34/h5-13,17-19H,14-16H2,1-4H3,(H,30,35)(H2,29,31,32,33)/t18-,19+
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n/an/a 26n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044328
PNG
(CHEMBL3357447)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)C(C)(C)N)c2)ncc1Cl
Show InChI InChI=1S/C23H27ClN6O3S/c1-14(2)34(32,33)19-11-6-5-10-18(19)29-20-17(24)13-26-22(30-20)28-16-9-7-8-15(12-16)27-21(31)23(3,4)25/h5-14H,25H2,1-4H3,(H,27,31)(H2,26,28,29,30)
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n/an/a 27n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044329
PNG
(CHEMBL3357448)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)[C@@H](N)Cc3c[nH]cn3)c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN8O3S/c1-15(2)38(36,37)22-9-4-3-8-21(22)33-23-19(26)13-29-25(34-23)32-17-7-5-6-16(10-17)31-24(35)20(27)11-18-12-28-14-30-18/h3-10,12-15,20H,11,27H2,1-2H3,(H,28,30)(H,31,35)(H2,29,32,33,34)/t20-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044460
PNG
(CHEMBL3357455)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCNCC3)c2)ncc1Cl
Show InChI InChI=1S/C25H30ClN7O3S/c1-17(2)37(35,36)22-9-4-3-8-21(22)31-24-20(26)15-28-25(32-24)30-19-7-5-6-18(14-19)29-23(34)16-33-12-10-27-11-13-33/h3-9,14-15,17,27H,10-13,16H2,1-2H3,(H,29,34)(H2,28,30,31,32)
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n/an/a 32n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044470
PNG
(CHEMBL3357465)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)Cc3ccco3)c2)ncc1Cl
Show InChI InChI=1S/C25H24ClN5O4S/c1-16(2)36(33,34)22-11-4-3-10-21(22)30-24-20(26)15-27-25(31-24)29-18-8-5-7-17(13-18)28-23(32)14-19-9-6-12-35-19/h3-13,15-16H,14H2,1-2H3,(H,28,32)(H2,27,29,30,31)
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n/an/a 32n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044298
PNG
(CHEMBL3356906)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C20H20ClN7O2/c1-23-19(30)14-7-2-3-8-16(14)27-18-15(21)11-24-20(28-18)26-13-6-4-5-12(9-13)25-17(29)10-22/h2-9,11H,10,22H2,1H3,(H,23,30)(H,25,29)(H2,24,26,27,28)
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n/an/a 33n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044304
PNG
(CHEMBL3357440)
Show SMILES CNC(=O)[C@H]1[C@H]2C[C@H](C=C2)[C@H]1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H24ClN7O2/c1-24-20(31)17-11-5-6-12(7-11)18(17)28-19-15(22)10-25-21(29-19)27-14-4-2-3-13(8-14)26-16(30)9-23/h2-6,8,10-12,17-18H,7,9,23H2,1H3,(H,24,31)(H,26,30)(H2,25,27,28,29)/t11-,12+,17+,18-/m1/s1
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n/an/a 34n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044422
PNG
(CHEMBL3357451)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)C3CCN3)c2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O3S/c1-14(2)34(32,33)20-9-4-3-8-18(20)29-21-17(24)13-26-23(30-21)28-16-7-5-6-15(12-16)27-22(31)19-10-11-25-19/h3-9,12-14,19,25H,10-11H2,1-2H3,(H,27,31)(H2,26,28,29,30)
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n/an/a 35n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044374
PNG
(CHEMBL3357449)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CCN)c2)ncc1Cl
Show InChI InChI=1S/C22H25ClN6O3S/c1-14(2)33(31,32)19-9-4-3-8-18(19)28-21-17(23)13-25-22(29-21)27-16-7-5-6-15(12-16)26-20(30)10-11-24/h3-9,12-14H,10-11,24H2,1-2H3,(H,26,30)(H2,25,27,28,29)
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n/an/a 43n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044422
PNG
(CHEMBL3357451)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)C3CCN3)c2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O3S/c1-14(2)34(32,33)20-9-4-3-8-18(20)29-21-17(24)13-26-23(30-21)28-16-7-5-6-15(12-16)27-22(31)19-10-11-25-19/h3-9,12-14,19,25H,10-11H2,1-2H3,(H,27,31)(H2,26,28,29,30)
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n/an/a 44n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044466
PNG
(CHEMBL3357461)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CCC(C3)O4)c2)ncc1Cl
Show InChI InChI=1S/C27H31ClN6O4S/c1-17(2)39(36,37)24-9-4-3-8-23(24)32-26-22(28)13-29-27(33-26)31-19-7-5-6-18(12-19)30-25(35)16-34-14-20-10-11-21(15-34)38-20/h3-9,12-13,17,20-21H,10-11,14-16H2,1-2H3,(H,30,35)(H2,29,31,32,33)
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n/an/a 51n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044327
PNG
(CHEMBL3357446)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)C3(N)CC3)c2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O3S/c1-14(2)34(32,33)19-9-4-3-8-18(19)29-20-17(24)13-26-22(30-20)28-16-7-5-6-15(12-16)27-21(31)23(25)10-11-23/h3-9,12-14H,10-11,25H2,1-2H3,(H,27,31)(H2,26,28,29,30)
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n/an/a 51n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044306
PNG
(CHEMBL3357442)
Show SMILES CN(c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl)S(C)(=O)=O
Show InChI InChI=1S/C20H22ClN7O3S/c1-28(32(2,30)31)17-9-4-3-8-16(17)26-19-15(21)12-23-20(27-19)25-14-7-5-6-13(10-14)24-18(29)11-22/h3-10,12H,11,22H2,1-2H3,(H,24,29)(H2,23,25,26,27)
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n/an/a 51n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044300
PNG
(CHEMBL3356908)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CNC(=O)N3CCCC3)c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN8O3/c1-27-23(36)18-9-2-3-10-20(18)32-22-19(26)14-28-24(33-22)31-17-8-6-7-16(13-17)30-21(35)15-29-25(37)34-11-4-5-12-34/h2-3,6-10,13-14H,4-5,11-12,15H2,1H3,(H,27,36)(H,29,37)(H,30,35)(H2,28,31,32,33)
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n/an/a 53n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044301
PNG
(CHEMBL3357437)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CNC(=O)C3CCCN3)c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN8O3/c1-27-23(36)17-8-2-3-9-19(17)33-22-18(26)13-30-25(34-22)32-16-7-4-6-15(12-16)31-21(35)14-29-24(37)20-10-5-11-28-20/h2-4,6-9,12-13,20,28H,5,10-11,14H2,1H3,(H,27,36)(H,29,37)(H,31,35)(H2,30,32,33,34)
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n/an/a 80n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044471
PNG
(CHEMBL3357466)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)Cc3cc4ccccc4[nH]3)c2)ncc1Cl
Show InChI InChI=1S/C29H27ClN6O3S/c1-18(2)40(38,39)26-13-6-5-12-25(26)35-28-23(30)17-31-29(36-28)34-21-10-7-9-20(15-21)33-27(37)16-22-14-19-8-3-4-11-24(19)32-22/h3-15,17-18,32H,16H2,1-2H3,(H,33,37)(H2,31,34,35,36)
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n/an/a 95n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044305
PNG
(CHEMBL3357441)
Show SMILES CS(=O)(=O)Nc1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C19H20ClN7O3S/c1-31(29,30)27-16-8-3-2-7-15(16)25-18-14(20)11-22-19(26-18)24-13-6-4-5-12(9-13)23-17(28)10-21/h2-9,11,27H,10,21H2,1H3,(H,23,28)(H2,22,24,25,26)
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n/an/a 95n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044463
PNG
(CHEMBL3357458)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(CC3)C(=O)\C=C\CN(C)C)c2)ncc1Cl
Show InChI InChI=1S/C31H39ClN8O4S/c1-22(2)45(43,44)27-12-6-5-11-26(27)36-30-25(32)20-33-31(37-30)35-24-10-7-9-23(19-24)34-28(41)21-39-15-17-40(18-16-39)29(42)13-8-14-38(3)4/h5-13,19-20,22H,14-18,21H2,1-4H3,(H,34,41)(H2,33,35,36,37)/b13-8+
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n/an/a 102n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044304
PNG
(CHEMBL3357440)
Show SMILES CNC(=O)[C@H]1[C@H]2C[C@H](C=C2)[C@H]1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H24ClN7O2/c1-24-20(31)17-11-5-6-12(7-11)18(17)28-19-15(22)10-25-21(29-19)27-14-4-2-3-13(8-14)26-16(30)9-23/h2-6,8,10-12,17-18H,7,9,23H2,1H3,(H,24,31)(H,26,30)(H2,25,27,28,29)/t11-,12+,17+,18-/m1/s1
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n/an/a 111n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044467
PNG
(CHEMBL3357462)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CC3CC4O)c2)ncc1Cl
Show InChI InChI=1S/C27H31ClN6O4S/c1-16(2)39(37,38)24-9-4-3-8-22(24)32-26-21(28)13-29-27(33-26)31-19-7-5-6-18(11-19)30-25(36)15-34-14-17-10-20(34)12-23(17)35/h3-9,11,13,16-17,20,23,35H,10,12,14-15H2,1-2H3,(H,30,36)(H2,29,31,32,33)
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n/an/a 112n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044305
PNG
(CHEMBL3357441)
Show SMILES CS(=O)(=O)Nc1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C19H20ClN7O3S/c1-31(29,30)27-16-8-3-2-7-15(16)25-18-14(20)11-22-19(26-18)24-13-6-4-5-12(9-13)23-17(28)10-21/h2-9,11,27H,10,21H2,1H3,(H,23,28)(H2,22,24,25,26)
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n/an/a 120n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044462
PNG
(CHEMBL3357457)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(CC3)C3COC3)c2)ncc1Cl
Show InChI InChI=1S/C28H34ClN7O4S/c1-19(2)41(38,39)25-9-4-3-8-24(25)33-27-23(29)15-30-28(34-27)32-21-7-5-6-20(14-21)31-26(37)16-35-10-12-36(13-11-35)22-17-40-18-22/h3-9,14-15,19,22H,10-13,16-18H2,1-2H3,(H,31,37)(H2,30,32,33,34)
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n/an/a 130n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044326
PNG
(CHEMBL3357445)
Show SMILES CC(C)[C@H](N)C(=O)Nc1cccc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c1
Show InChI InChI=1S/C24H29ClN6O3S/c1-14(2)21(26)23(32)28-16-8-7-9-17(12-16)29-24-27-13-18(25)22(31-24)30-19-10-5-6-11-20(19)35(33,34)15(3)4/h5-15,21H,26H2,1-4H3,(H,28,32)(H2,27,29,30,31)/t21-/m0/s1
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n/an/a 137n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044329
PNG
(CHEMBL3357448)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)[C@@H](N)Cc3c[nH]cn3)c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN8O3S/c1-15(2)38(36,37)22-9-4-3-8-21(22)33-23-19(26)13-29-25(34-23)32-17-7-5-6-16(10-17)31-24(35)20(27)11-18-12-28-14-30-18/h3-10,12-15,20H,11,27H2,1-2H3,(H,28,30)(H,31,35)(H2,29,32,33,34)/t20-/m0/s1
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n/an/a 143n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044459
PNG
(CHEMBL3357454)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3C[C@H](C)O[C@H](C)C3)c2)ncc1Cl
Show InChI InChI=1S/C27H33ClN6O4S/c1-17(2)39(36,37)24-11-6-5-10-23(24)32-26-22(28)13-29-27(33-26)31-21-9-7-8-20(12-21)30-25(35)16-34-14-18(3)38-19(4)15-34/h5-13,17-19H,14-16H2,1-4H3,(H,30,35)(H2,29,31,32,33)/t18-,19+
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n/an/a 148n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044303
PNG
(CHEMBL3357439)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O3S/c1-13(2)32(30,31)18-9-4-3-8-17(18)27-20-16(22)12-24-21(28-20)26-15-7-5-6-14(10-15)25-19(29)11-23/h3-10,12-13H,11,23H2,1-2H3,(H,25,29)(H2,24,26,27,28)
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n/an/a 153n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044465
PNG
(CHEMBL3357460)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CC3CN4)c2)ncc1Cl
Show InChI InChI=1S/C26H30ClN7O3S/c1-16(2)38(36,37)23-9-4-3-8-22(23)32-25-21(27)13-29-26(33-25)31-18-7-5-6-17(10-18)30-24(35)15-34-14-19-11-20(34)12-28-19/h3-10,13,16,19-20,28H,11-12,14-15H2,1-2H3,(H,30,35)(H2,29,31,32,33)
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n/an/a 164n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044469
PNG
(CHEMBL3357464)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CNCC4C3)c2)ncc1Cl
Show InChI InChI=1S/C27H32ClN7O3S/c1-17(2)39(37,38)24-9-4-3-8-23(24)33-26-22(28)13-30-27(34-26)32-21-7-5-6-20(10-21)31-25(36)16-35-14-18-11-29-12-19(18)15-35/h3-10,13,17-19,29H,11-12,14-16H2,1-2H3,(H,31,36)(H2,30,32,33,34)
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n/an/a 244n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044300
PNG
(CHEMBL3356908)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CNC(=O)N3CCCC3)c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN8O3/c1-27-23(36)18-9-2-3-10-20(18)32-22-19(26)14-28-24(33-22)31-17-8-6-7-16(13-17)30-21(35)15-29-25(37)34-11-4-5-12-34/h2-3,6-10,13-14H,4-5,11-12,15H2,1H3,(H,27,36)(H,29,37)(H,30,35)(H2,28,31,32,33)
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n/an/a 280n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044416
PNG
(CHEMBL3357450)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CCCN)c2)ncc1Cl
Show InChI InChI=1S/C23H27ClN6O3S/c1-15(2)34(32,33)20-10-4-3-9-19(20)29-22-18(24)14-26-23(30-22)28-17-8-5-7-16(13-17)27-21(31)11-6-12-25/h3-5,7-10,13-15H,6,11-12,25H2,1-2H3,(H,27,31)(H2,26,28,29,30)
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n/an/a 292n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044464
PNG
(CHEMBL3357459)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(CC3)C(=O)CO)c2)ncc1Cl
Show InChI InChI=1S/C27H32ClN7O5S/c1-18(2)41(39,40)23-9-4-3-8-22(23)32-26-21(28)15-29-27(33-26)31-20-7-5-6-19(14-20)30-24(37)16-34-10-12-35(13-11-34)25(38)17-36/h3-9,14-15,18,36H,10-13,16-17H2,1-2H3,(H,30,37)(H2,29,31,32,33)
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n/an/a 338n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044434
PNG
(CHEMBL3357453)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCOCC3)c2)ncc1Cl
Show InChI InChI=1S/C25H29ClN6O4S/c1-17(2)37(34,35)22-9-4-3-8-21(22)30-24-20(26)15-27-25(31-24)29-19-7-5-6-18(14-19)28-23(33)16-32-10-12-36-13-11-32/h3-9,14-15,17H,10-13,16H2,1-2H3,(H,28,33)(H2,27,29,30,31)
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n/an/a 389n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044468
PNG
(CHEMBL3357463)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCC4CNCC34)c2)ncc1Cl
Show InChI InChI=1S/C27H32ClN7O3S/c1-17(2)39(37,38)24-9-4-3-8-22(24)33-26-21(28)14-30-27(34-26)32-20-7-5-6-19(12-20)31-25(36)16-35-11-10-18-13-29-15-23(18)35/h3-9,12,14,17-18,23,29H,10-11,13,15-16H2,1-2H3,(H,31,36)(H2,30,32,33,34)
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n/an/a 448n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044461
PNG
(CHEMBL3357456)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(C)CC3)c2)ncc1Cl
Show InChI InChI=1S/C26H32ClN7O3S/c1-18(2)38(36,37)23-10-5-4-9-22(23)31-25-21(27)16-28-26(32-25)30-20-8-6-7-19(15-20)29-24(35)17-34-13-11-33(3)12-14-34/h4-10,15-16,18H,11-14,17H2,1-3H3,(H,29,35)(H2,28,30,31,32)
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n/an/a 549n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044470
PNG
(CHEMBL3357465)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)Cc3ccco3)c2)ncc1Cl
Show InChI InChI=1S/C25H24ClN5O4S/c1-16(2)36(33,34)22-11-4-3-10-21(22)30-24-20(26)15-27-25(31-24)29-18-8-5-7-17(13-18)28-23(32)14-19-9-6-12-35-19/h3-13,15-16H,14H2,1-2H3,(H,28,32)(H2,27,29,30,31)
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n/an/a 634n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044423
PNG
(CHEMBL3352867)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)C3CNC3)c2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O3S/c1-14(2)34(32,33)20-9-4-3-8-19(20)29-21-18(24)13-26-23(30-21)28-17-7-5-6-16(10-17)27-22(31)15-11-25-12-15/h3-10,13-15,25H,11-12H2,1-2H3,(H,27,31)(H2,26,28,29,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044307
PNG
(CHEMBL3357443)
Show SMILES CS(=O)(=O)N1CCN(c2ccccc12)c1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H22ClN7O3S/c1-33(31,32)29-10-9-28(17-7-2-3-8-18(17)29)20-16(22)13-24-21(27-20)26-15-6-4-5-14(11-15)25-19(30)12-23/h2-8,11,13H,9-10,12,23H2,1H3,(H,25,30)(H,24,26,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044327
PNG
(CHEMBL3357446)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)C3(N)CC3)c2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O3S/c1-14(2)34(32,33)19-9-4-3-8-18(19)29-20-17(24)13-26-22(30-20)28-16-7-5-6-15(12-16)27-21(31)23(25)10-11-23/h3-9,12-14H,10-11,25H2,1-2H3,(H,27,31)(H2,26,28,29,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044471
PNG
(CHEMBL3357466)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)Cc3cc4ccccc4[nH]3)c2)ncc1Cl
Show InChI InChI=1S/C29H27ClN6O3S/c1-18(2)40(38,39)26-13-6-5-12-25(26)35-28-23(30)17-31-29(36-28)34-21-10-7-9-20(15-21)33-27(37)16-22-14-19-8-3-4-11-24(19)32-22/h3-15,17-18,32H,16H2,1-2H3,(H,33,37)(H2,31,34,35,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50044303
PNG
(CHEMBL3357439)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O3S/c1-13(2)32(30,31)18-9-4-3-8-17(18)27-20-16(22)12-24-21(28-20)26-15-7-5-6-14(10-15)25-19(29)11-23/h3-10,12-13H,11,23H2,1-2H3,(H,25,29)(H2,24,26,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of EGFR (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044307
PNG
(CHEMBL3357443)
Show SMILES CS(=O)(=O)N1CCN(c2ccccc12)c1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H22ClN7O3S/c1-33(31,32)29-10-9-28(17-7-2-3-8-18(17)29)20-16(22)13-24-21(27-20)26-15-6-4-5-14(11-15)25-19(30)12-23/h2-8,11,13H,9-10,12,23H2,1H3,(H,25,30)(H,24,26,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044428
PNG
(CHEMBL3357452)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)C3CN(C3)C(=O)CCCN(C)C)c2)ncc1Cl
Show InChI InChI=1S/C29H36ClN7O4S/c1-19(2)42(40,41)25-12-6-5-11-24(25)34-27-23(30)16-31-29(35-27)33-22-10-7-9-21(15-22)32-28(39)20-17-37(18-20)26(38)13-8-14-36(3)4/h5-7,9-12,15-16,19-20H,8,13-14,17-18H2,1-4H3,(H,32,39)(H2,31,33,34,35)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50044466
PNG
(CHEMBL3357461)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CCC(C3)O4)c2)ncc1Cl
Show InChI InChI=1S/C27H31ClN6O4S/c1-17(2)39(36,37)24-9-4-3-8-23(24)32-26-22(28)13-29-27(33-26)31-19-7-5-6-18(12-19)30-25(35)16-34-14-20-10-11-21(15-34)38-20/h3-9,12-13,17,20-21H,10-11,14-16H2,1-2H3,(H,30,35)(H2,29,31,32,33)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50044303
PNG
(CHEMBL3357439)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O3S/c1-13(2)32(30,31)18-9-4-3-8-17(18)27-20-16(22)12-24-21(28-20)26-15-7-5-6-14(10-15)25-19(29)11-23/h3-10,12-13H,11,23H2,1-2H3,(H,25,29)(H2,24,26,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of AXL (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens)
BDBM50044303
PNG
(CHEMBL3357439)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O3S/c1-13(2)32(30,31)18-9-4-3-8-17(18)27-20-16(22)12-24-21(28-20)26-15-7-5-6-14(10-15)25-19(29)11-23/h3-10,12-13H,11,23H2,1-2H3,(H,25,29)(H2,24,26,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of Mer (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50044303
PNG
(CHEMBL3357439)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O3S/c1-13(2)32(30,31)18-9-4-3-8-17(18)27-20-16(22)12-24-21(28-20)26-15-7-5-6-14(10-15)25-19(29)11-23/h3-10,12-13H,11,23H2,1-2H3,(H,25,29)(H2,24,26,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-alpha (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50044303
PNG
(CHEMBL3357439)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O3S/c1-13(2)32(30,31)18-9-4-3-8-17(18)27-20-16(22)12-24-21(28-20)26-15-7-5-6-14(10-15)25-19(29)11-23/h3-10,12-13H,11,23H2,1-2H3,(H,25,29)(H2,24,26,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-beta (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50044303
PNG
(CHEMBL3357439)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O3S/c1-13(2)32(30,31)18-9-4-3-8-17(18)27-20-16(22)12-24-21(28-20)26-15-7-5-6-14(10-15)25-19(29)11-23/h3-10,12-13H,11,23H2,1-2H3,(H,25,29)(H2,24,26,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ABL (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50044303
PNG
(CHEMBL3357439)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O3S/c1-13(2)32(30,31)18-9-4-3-8-17(18)27-20-16(22)12-24-21(28-20)26-15-7-5-6-14(10-15)25-19(29)11-23/h3-10,12-13H,11,23H2,1-2H3,(H,25,29)(H2,24,26,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50044303
PNG
(CHEMBL3357439)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O3S/c1-13(2)32(30,31)18-9-4-3-8-17(18)27-20-16(22)12-24-21(28-20)26-15-7-5-6-14(10-15)25-19(29)11-23/h3-10,12-13H,11,23H2,1-2H3,(H,25,29)(H2,24,26,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044299
PNG
(CHEMBL3356907)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2cccc(NC(=O)CNC(=O)OC(C)(C)C)c2)ncc1Cl
Show InChI InChI=1S/C25H27ClFN7O4/c1-25(2,3)38-24(37)30-13-19(35)31-14-7-5-8-15(11-14)32-23-29-12-17(26)21(34-23)33-20-16(22(36)28-4)9-6-10-18(20)27/h5-12H,13H2,1-4H3,(H,28,36)(H,30,37)(H,31,35)(H2,29,32,33,34)
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PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50044303
PNG
(CHEMBL3357439)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O3S/c1-13(2)32(30,31)18-9-4-3-8-17(18)27-20-16(22)12-24-21(28-20)26-15-7-5-6-14(10-15)25-19(29)11-23/h3-10,12-13H,11,23H2,1-2H3,(H,25,29)(H2,24,26,27,28)
PDB
MMDB

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PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Src (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50044302
PNG
(CHEMBL3357438)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2cccc(NC(=O)CNC(=O)NC(C)(C)C)c2)ncc1Cl
Show InChI InChI=1S/C25H28ClFN8O3/c1-25(2,3)35-24(38)30-13-19(36)31-14-7-5-8-15(11-14)32-23-29-12-17(26)21(34-23)33-20-16(22(37)28-4)9-6-10-18(20)27/h5-12H,13H2,1-4H3,(H,28,37)(H,31,36)(H2,30,35,38)(H2,29,32,33,34)
PDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
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PC sid
UniChem

Patents


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Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50044303
PNG
(CHEMBL3357439)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl
Show InChI InChI=1S/C21H23ClN6O3S/c1-13(2)32(30,31)18-9-4-3-8-17(18)27-20-16(22)12-24-21(28-20)26-15-7-5-6-14(10-15)25-19(29)11-23/h3-10,12-13H,11,23H2,1-2H3,(H,25,29)(H2,24,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of Flt-1 (unknown origin) after 60 mins by ELISA


J Med Chem 58: 197-211 (2015)


Article DOI: 10.1021/jm5005144
BindingDB Entry DOI: 10.7270/Q2FB54MQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%