BindingDB logo
myBDB logout

PubMed code 24847082

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelin-converting enzyme 2 (ECE-2)


(Homo sapiens (Human))
BDBM231638
PNG
(SM19712)
Show SMILES Cc1[nH]nc(NC(=O)[N-]S(=O)(=O)c2ccc(Cl)cc2)c1C#N
Show InChI InChI=1S/C12H10ClN5O3S/c1-7-10(6-14)11(17-16-7)15-12(19)18-22(20,21)9-4-2-8(13)3-5-9/h2-5H,1H3,(H3,15,16,17,18,19)/p-1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5n/an/an/an/a5.5n/a



Icahn School of Medicine at Mount Sinai



Assay Description
Recombinant ECE2 (32.5 ng) with a specific activity of 12 pmol/min/μg protein was generated as described previously. Secreted soluble recombinan...


J Biol Chem 289: 19613-26 (2014)


Article DOI: 10.1074/jbc.M113.537704
BindingDB Entry DOI: 10.7270/Q2VD6XBF
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1 (ECE1)


(Homo sapiens (Human))
BDBM231638
PNG
(SM19712)
Show SMILES Cc1[nH]nc(NC(=O)[N-]S(=O)(=O)c2ccc(Cl)cc2)c1C#N
Show InChI InChI=1S/C12H10ClN5O3S/c1-7-10(6-14)11(17-16-7)15-12(19)18-22(20,21)9-4-2-8(13)3-5-9/h2-5H,1H3,(H3,15,16,17,18,19)/p-1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10E+3n/an/an/an/a7.4n/a



Icahn School of Medicine at Mount Sinai



Assay Description
Recombinant ECE2 (32.5 ng) with a specific activity of 12 pmol/min/μg protein was generated as described previously. Secreted soluble recombinan...


J Biol Chem 289: 19613-26 (2014)


Article DOI: 10.1074/jbc.M113.537704
BindingDB Entry DOI: 10.7270/Q2VD6XBF
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 2 (ECE-2)


(Homo sapiens (Human))
BDBM50271179
PNG
(2-(2-(quinolin-2-yl)vinyl)phenol | CHEMBL487942 | ...)
Show SMILES Oc1ccccc1\C=C/c1ccc2ccccc2n1
Show InChI InChI=1S/C17H13NO/c19-17-8-4-2-6-14(17)10-12-15-11-9-13-5-1-3-7-16(13)18-15/h1-12,19H/b12-10-
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.60E+3n/an/an/an/a5.5n/a



Icahn School of Medicine at Mount Sinai



Assay Description
Recombinant ECE2 (32.5 ng) with a specific activity of 12 pmol/min/μg protein was generated as described previously. Secreted soluble recombinan...


J Biol Chem 289: 19613-26 (2014)


Article DOI: 10.1074/jbc.M113.537704
BindingDB Entry DOI: 10.7270/Q2VD6XBF
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1 (ECE1)


(Homo sapiens (Human))
BDBM50271179
PNG
(2-(2-(quinolin-2-yl)vinyl)phenol | CHEMBL487942 | ...)
Show SMILES Oc1ccccc1\C=C/c1ccc2ccccc2n1
Show InChI InChI=1S/C17H13NO/c19-17-8-4-2-6-14(17)10-12-15-11-9-13-5-1-3-7-16(13)18-15/h1-12,19H/b12-10-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.4n/a



Icahn School of Medicine at Mount Sinai



Assay Description
Recombinant ECE2 (32.5 ng) with a specific activity of 12 pmol/min/μg protein was generated as described previously. Secreted soluble recombinan...


J Biol Chem 289: 19613-26 (2014)


Article DOI: 10.1074/jbc.M113.537704
BindingDB Entry DOI: 10.7270/Q2VD6XBF
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1 (ECE1)


(Homo sapiens (Human))
BDBM231638
PNG
(SM19712)
Show SMILES Cc1[nH]nc(NC(=O)[N-]S(=O)(=O)c2ccc(Cl)cc2)c1C#N
Show InChI InChI=1S/C12H10ClN5O3S/c1-7-10(6-14)11(17-16-7)15-12(19)18-22(20,21)9-4-2-8(13)3-5-9/h2-5H,1H3,(H3,15,16,17,18,19)/p-1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/a5.5n/a



Icahn School of Medicine at Mount Sinai



Assay Description
Recombinant ECE2 (32.5 ng) with a specific activity of 12 pmol/min/μg protein was generated as described previously. Secreted soluble recombinan...


J Biol Chem 289: 19613-26 (2014)


Article DOI: 10.1074/jbc.M113.537704
BindingDB Entry DOI: 10.7270/Q2VD6XBF
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1 (ECE1)


(Homo sapiens (Human))
BDBM50271179
PNG
(2-(2-(quinolin-2-yl)vinyl)phenol | CHEMBL487942 | ...)
Show SMILES Oc1ccccc1\C=C/c1ccc2ccccc2n1
Show InChI InChI=1S/C17H13NO/c19-17-8-4-2-6-14(17)10-12-15-11-9-13-5-1-3-7-16(13)18-15/h1-12,19H/b12-10-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a5.5n/a



Icahn School of Medicine at Mount Sinai



Assay Description
Recombinant ECE2 (32.5 ng) with a specific activity of 12 pmol/min/μg protein was generated as described previously. Secreted soluble recombinan...


J Biol Chem 289: 19613-26 (2014)


Article DOI: 10.1074/jbc.M113.537704
BindingDB Entry DOI: 10.7270/Q2VD6XBF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%