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PubMed code 24900220

Compile data set for download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50338992
PNG
(CHEMBL1687978 | N-[5-(2-Furyl)-1,3,4-oxadiazol-2-y...)
Show SMILES O=C(Nc1nnc(o1)-c1ccco1)c1cc(nc2ccccc12)-c1cccc2ccccc12
Show InChI InChI=1S/C26H16N4O3/c31-24(28-26-30-29-25(33-26)23-13-6-14-32-23)20-15-22(27-21-12-4-3-10-19(20)21)18-11-5-8-16-7-1-2-9-17(16)18/h1-15H,(H,28,30,31)
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n/an/a 5.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of STAT3 transcriptional activity in human HeLa cells by luciferase reporter gene assay


ACS Med Chem Lett 1: 371-375 (2010)


Article DOI: 10.1021/ml1000273
BindingDB Entry DOI: 10.7270/Q2FJ2H21
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50338996
PNG
(2-(4-Chlorophenyl)-N-(5-phenyl-1,3,4-oxadiazol-2-y...)
Show SMILES Clc1ccc(cc1)-c1nnc(NC(=O)c2cc(nc3ccccc23)-c2ccccc2)o1
Show InChI InChI=1S/C24H15ClN4O2/c25-17-12-10-16(11-13-17)23-28-29-24(31-23)27-22(30)19-14-21(15-6-2-1-3-7-15)26-20-9-5-4-8-18(19)20/h1-14H,(H,27,29,30)
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n/an/a 6.10E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of STAT3 transcriptional activity in human HeLa cells by luciferase reporter gene assay


ACS Med Chem Lett 1: 371-375 (2010)


Article DOI: 10.1021/ml1000273
BindingDB Entry DOI: 10.7270/Q2FJ2H21
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50338994
PNG
(CHEMBL1687976 | N-[5-(2-Furyl)-1,3,4-oxadiazol-2-y...)
Show SMILES O=C(Nc1nnc(o1)-c1ccco1)c1cc(nc2ccccc12)-c1cccs1
Show InChI InChI=1S/C20H12N4O3S/c25-18(22-20-24-23-19(27-20)16-7-3-9-26-16)13-11-15(17-8-4-10-28-17)21-14-6-2-1-5-12(13)14/h1-11H,(H,22,24,25)
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n/an/a 6.30E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of STAT3 transcriptional activity in human HeLa cells by luciferase reporter gene assay


ACS Med Chem Lett 1: 371-375 (2010)


Article DOI: 10.1021/ml1000273
BindingDB Entry DOI: 10.7270/Q2FJ2H21
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50338995
PNG
(2-Phenyl-N-(5-phenyl-1,3,4-oxadiazol-2-yl)-4-quino...)
Show SMILES O=C(Nc1nnc(o1)-c1ccccc1)c1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C24H16N4O2/c29-22(26-24-28-27-23(30-24)17-11-5-2-6-12-17)19-15-21(16-9-3-1-4-10-16)25-20-14-8-7-13-18(19)20/h1-15H,(H,26,28,29)
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n/an/a 6.60E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of STAT3 transcriptional activity in human HeLa cells by luciferase reporter gene assay


ACS Med Chem Lett 1: 371-375 (2010)


Article DOI: 10.1021/ml1000273
BindingDB Entry DOI: 10.7270/Q2FJ2H21
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50338993
PNG
(2-(2-Furyl)-N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-4...)
Show SMILES O=C(Nc1nnc(o1)-c1ccco1)c1cc(nc2ccccc12)-c1ccco1
Show InChI InChI=1S/C20H12N4O4/c25-18(22-20-24-23-19(28-20)17-8-4-10-27-17)13-11-15(16-7-3-9-26-16)21-14-6-2-1-5-12(13)14/h1-11H,(H,22,24,25)
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n/an/a 6.60E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of STAT3 transcriptional activity in human HeLa cells by luciferase reporter gene assay


ACS Med Chem Lett 1: 371-375 (2010)


Article DOI: 10.1021/ml1000273
BindingDB Entry DOI: 10.7270/Q2FJ2H21
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50338998
PNG
(CHEMBL1687965 | N-[5-(3-Furyl)-1,3,4-oxadiazol-2-y...)
Show SMILES O=C(Nc1nnc(o1)-c1ccoc1)c1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C22H14N4O3/c27-20(24-22-26-25-21(29-22)15-10-11-28-13-15)17-12-19(14-6-2-1-3-7-14)23-18-9-5-4-8-16(17)18/h1-13H,(H,24,26,27)
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n/an/a 7.20E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of STAT3 transcriptional activity in human HeLa cells by luciferase reporter gene assay


ACS Med Chem Lett 1: 371-375 (2010)


Article DOI: 10.1021/ml1000273
BindingDB Entry DOI: 10.7270/Q2FJ2H21
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50338991
PNG
(CHEMBL1687979 | N-[5-(2-Furyl)-1,3,4-oxadiazol-2-y...)
Show SMILES O=C(Nc1nnc(o1)-c1ccco1)c1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C22H14N4O3/c27-20(24-22-26-25-21(29-22)19-11-6-12-28-19)16-13-18(14-7-2-1-3-8-14)23-17-10-5-4-9-15(16)17/h1-13H,(H,24,26,27)
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n/an/a 7.40E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of STAT3 transcriptional activity in human HeLa cells by luciferase reporter gene assay


ACS Med Chem Lett 1: 371-375 (2010)


Article DOI: 10.1021/ml1000273
BindingDB Entry DOI: 10.7270/Q2FJ2H21
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50338997
PNG
(CHEMBL1687966 | N-(5-Benzyl-1,3,4-oxadiazol-2-yl)-...)
Show SMILES O=C(Nc1nnc(Cc2ccccc2)o1)c1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C25H18N4O2/c30-24(27-25-29-28-23(31-25)15-17-9-3-1-4-10-17)20-16-22(18-11-5-2-6-12-18)26-21-14-8-7-13-19(20)21/h1-14,16H,15H2,(H,27,29,30)
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n/an/a 7.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of STAT3 transcriptional activity in human HeLa cells by luciferase reporter gene assay


ACS Med Chem Lett 1: 371-375 (2010)


Article DOI: 10.1021/ml1000273
BindingDB Entry DOI: 10.7270/Q2FJ2H21
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))
BDBM50338999
PNG
(2-Phenyl-N-[5-(2-thienyl)-1,3,4-oxadiazol-2-yl)-4-...)
Show SMILES O=C(Nc1nnc(o1)-c1cccs1)c1cc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C22H14N4O2S/c27-20(24-22-26-25-21(28-22)19-11-6-12-29-19)16-13-18(14-7-2-1-3-8-14)23-17-10-5-4-9-15(16)17/h1-13H,(H,24,26,27)
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n/an/a 7.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of STAT3 transcriptional activity in human HeLa cells by luciferase reporter gene assay


ACS Med Chem Lett 1: 371-375 (2010)


Article DOI: 10.1021/ml1000273
BindingDB Entry DOI: 10.7270/Q2FJ2H21
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%