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PubMed code 24900416

Compile data set for download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400772
PNG
(CHEMBL2204985)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)n1ncc(COc2ccc(cc2F)C#N)c1C#N
Show InChI InChI=1S/C23H22FN7O/c1-2-16-12-27-23(28-13-16)30-7-5-19(6-8-30)31-21(11-26)18(14-29-31)15-32-22-4-3-17(10-25)9-20(22)24/h3-4,9,12-14,19H,2,5-8,15H2,1H3
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9.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400773
PNG
(CHEMBL2204984)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)n1ncc(COc2ccc(cc2)-n2cnnn2)c1C#N
Show InChI InChI=1S/C23H24N10O/c1-2-17-12-25-23(26-13-17)31-9-7-20(8-10-31)33-22(11-24)18(14-28-33)15-34-21-5-3-19(4-6-21)32-16-27-29-30-32/h3-6,12-14,16,20H,2,7-10,15H2,1H3
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15n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400774
PNG
(CHEMBL2204983)
Show SMILES CC1(CC1)OC(=O)N1CCC(CC1)n1ncc(COc2ccc(cc2)-n2cnnn2)c1C#N
Show InChI InChI=1S/C22H24N8O3/c1-22(8-9-22)33-21(31)28-10-6-18(7-11-28)30-20(12-23)16(13-25-30)14-32-19-4-2-17(3-5-19)29-15-24-26-27-29/h2-5,13,15,18H,6-11,14H2,1H3
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30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400776
PNG
(CHEMBL2204986)
Show SMILES CC1(CC1)OC(=O)N1CCC(CC1)n1ncc(COc2ccc(cc2F)C#N)c1C#N
Show InChI InChI=1S/C22H22FN5O3/c1-22(6-7-22)31-21(29)27-8-4-17(5-9-27)28-19(12-25)16(13-26-28)14-30-20-3-2-15(11-24)10-18(20)23/h2-3,10,13,17H,4-9,14H2,1H3
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37n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400775
PNG
(CHEMBL2204982)
Show SMILES Cn1nnnc1-c1ccc(OCc2cnn(C3CCN(CC3)C(=O)OC3(C)CC3)c2C#N)c(F)c1
Show InChI InChI=1S/C23H25FN8O3/c1-23(7-8-23)35-22(33)31-9-5-17(6-10-31)32-19(12-25)16(13-26-32)14-34-20-4-3-15(11-18(20)24)21-27-28-29-30(21)2/h3-4,11,13,17H,5-10,14H2,1-2H3
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99n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400772
PNG
(CHEMBL2204985)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)n1ncc(COc2ccc(cc2F)C#N)c1C#N
Show InChI InChI=1S/C23H22FN7O/c1-2-16-12-27-23(28-13-16)30-7-5-19(6-8-30)31-21(11-26)18(14-29-31)15-32-22-4-3-17(10-25)9-20(22)24/h3-4,9,12-14,19H,2,5-8,15H2,1H3
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n/an/an/an/a 5.40n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in human U20S cells assessed as binding to beta-arrestin by chemilumiscence analysis


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400776
PNG
(CHEMBL2204986)
Show SMILES CC1(CC1)OC(=O)N1CCC(CC1)n1ncc(COc2ccc(cc2F)C#N)c1C#N
Show InChI InChI=1S/C22H22FN5O3/c1-22(6-7-22)31-21(29)27-8-4-17(5-9-27)28-19(12-25)16(13-26-28)14-30-20-3-2-15(11-24)10-18(20)23/h2-3,10,13,17H,4-9,14H2,1H3
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n/an/an/an/a 30n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in human U20S cells assessed as binding to beta-arrestin by chemilumiscence analysis


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400768
PNG
(CHEMBL2204978)
Show SMILES C[C@]1(Cc2cc(ncc2O1)C1=CCN(CC1)S(C)(=O)=O)C1CCN(CC1)c1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O3S/c1-23(18-5-7-31(8-6-18)22-29-13-19(14-30-22)24(25,26)27)12-17-11-20(28-15-21(17)35-23)16-3-9-32(10-4-16)36(2,33)34/h3,11,13-15,18H,4-10,12H2,1-2H3/t23-/m0/s1
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n/an/an/an/a 3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in MIN6 cells assessed as intracellular cAMP concentration after 45 mins by Alphascreen analysis


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400774
PNG
(CHEMBL2204983)
Show SMILES CC1(CC1)OC(=O)N1CCC(CC1)n1ncc(COc2ccc(cc2)-n2cnnn2)c1C#N
Show InChI InChI=1S/C22H24N8O3/c1-22(8-9-22)33-21(31)28-10-6-18(7-11-28)30-20(12-23)16(13-25-30)14-32-19-4-2-17(3-5-19)29-15-24-26-27-29/h2-5,13,15,18H,6-11,14H2,1H3
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n/an/an/an/a 22n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in human HEK293 cells assessed as cAMP level by beta-lactamase reporter gene assay


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400765
PNG
(CHEMBL2203304)
Show SMILES CNC(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc(no3)C(C)(C)F)c2F)c(F)c1
Show InChI InChI=1S/C22H24F3N7O2/c1-22(2,25)21-30-20(34-31-21)12-6-8-32(9-7-12)18-16(24)17(27-11-28-18)29-15-5-4-13(10-14(15)23)19(33)26-3/h4-5,10-12H,6-9H2,1-3H3,(H,26,33)(H,27,28,29)
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n/an/an/an/a 27n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 expressed in CHO-K1 cells assessed as cAMP level after 1 hr by homogenous time-resolved fluorescence assay


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400769
PNG
(CHEMBL2204977)
Show SMILES CS(=O)(=O)N1CCC(=CC1)c1cc2C[C@@H](Oc2cn1)C1CCN(CC1)c1ncc(cn1)C1CC1
Show InChI InChI=1S/C25H31N5O3S/c1-34(31,32)30-10-6-18(7-11-30)22-12-20-13-23(33-24(20)16-26-22)19-4-8-29(9-5-19)25-27-14-21(15-28-25)17-2-3-17/h6,12,14-17,19,23H,2-5,7-11,13H2,1H3/t23-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in MIN6 cells assessed as intracellular cAMP concentration after 45 mins by Alphascreen analysis


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400775
PNG
(CHEMBL2204982)
Show SMILES Cn1nnnc1-c1ccc(OCc2cnn(C3CCN(CC3)C(=O)OC3(C)CC3)c2C#N)c(F)c1
Show InChI InChI=1S/C23H25FN8O3/c1-23(7-8-23)35-22(33)31-9-5-17(6-10-31)32-19(12-25)16(13-26-32)14-34-20-4-3-15(11-18(20)24)21-27-28-29-30(21)2/h3-4,11,13,17H,5-10,14H2,1-2H3
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n/an/an/an/a 63n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in human U20S cells assessed as binding to beta-arrestin by chemilumiscence analysis


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400776
PNG
(CHEMBL2204986)
Show SMILES CC1(CC1)OC(=O)N1CCC(CC1)n1ncc(COc2ccc(cc2F)C#N)c1C#N
Show InChI InChI=1S/C22H22FN5O3/c1-22(6-7-22)31-21(29)27-8-4-17(5-9-27)28-19(12-25)16(13-26-28)14-30-20-3-2-15(11-24)10-18(20)23/h2-3,10,13,17H,4-9,14H2,1H3
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n/an/an/an/a 19n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in human HEK293 cells assessed as cAMP level by beta-lactamase reporter gene assay


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400771
PNG
(CHEMBL2204975)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)C1Cc2cc(ncc2O1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C24H33N5O3S/c1-3-17-14-26-24(27-15-17)28-8-4-19(5-9-28)22-13-20-12-21(25-16-23(20)32-22)18-6-10-29(11-7-18)33(2,30)31/h12,14-16,18-19,22H,3-11,13H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in MIN6 cells assessed as intracellular cAMP concentration after 45 mins by Alphascreen analysis


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400774
PNG
(CHEMBL2204983)
Show SMILES CC1(CC1)OC(=O)N1CCC(CC1)n1ncc(COc2ccc(cc2)-n2cnnn2)c1C#N
Show InChI InChI=1S/C22H24N8O3/c1-22(8-9-22)33-21(31)28-10-6-18(7-11-28)30-20(12-23)16(13-25-30)14-32-19-4-2-17(3-5-19)29-15-24-26-27-29/h2-5,13,15,18H,6-11,14H2,1H3
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TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in human U20S cells assessed as binding to beta-arrestin by chemilumiscence analysis


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400772
PNG
(CHEMBL2204985)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)n1ncc(COc2ccc(cc2F)C#N)c1C#N
Show InChI InChI=1S/C23H22FN7O/c1-2-16-12-27-23(28-13-16)30-7-5-19(6-8-30)31-21(11-26)18(14-29-31)15-32-22-4-3-17(10-25)9-20(22)24/h3-4,9,12-14,19H,2,5-8,15H2,1H3
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n/an/an/an/a 2.80n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in human HEK293 cells assessed as cAMP level by beta-lactamase reporter gene assay


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400777
PNG
(CHEMBL2204974)
Show SMILES CC(C)(F)c1noc(n1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2F)C(O)=O)c1F
Show InChI InChI=1S/C21H21F3N6O3/c1-21(2,24)20-28-18(33-29-20)11-5-7-30(8-6-11)17-15(23)16(25-10-26-17)27-14-4-3-12(19(31)32)9-13(14)22/h3-4,9-11H,5-8H2,1-2H3,(H,31,32)(H,25,26,27)
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n/an/an/an/a 1.00E+8n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 expressed in CHO-K1 cells assessed as cAMP level after 1 hr by homogenous time-resolved fluorescence assay


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400773
PNG
(CHEMBL2204984)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)n1ncc(COc2ccc(cc2)-n2cnnn2)c1C#N
Show InChI InChI=1S/C23H24N10O/c1-2-17-12-25-23(26-13-17)31-9-7-20(8-10-31)33-22(11-24)18(14-28-33)15-34-21-5-3-19(4-6-21)32-16-27-29-30-32/h3-6,12-14,16,20H,2,7-10,15H2,1H3
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n/an/an/an/a 5.30n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in human U20S cells assessed as binding to beta-arrestin by chemilumiscence analysis


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400766
PNG
(CHEMBL2204980)
Show SMILES CN(C)C(=O)c1ccc(Nc2ncnc(N3CCC(CC3)c3nc(no3)C(C)(C)F)c2F)c(F)c1
Show InChI InChI=1S/C23H26F3N7O2/c1-23(2,26)22-30-20(35-31-22)13-7-9-33(10-8-13)19-17(25)18(27-12-28-19)29-16-6-5-14(11-15(16)24)21(34)32(3)4/h5-6,11-13H,7-10H2,1-4H3,(H,27,28,29)
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n/an/an/an/a 23n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 expressed in CHO-K1 cells assessed as cAMP level after 1 hr by homogenous time-resolved fluorescence assay


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400775
PNG
(CHEMBL2204982)
Show SMILES Cn1nnnc1-c1ccc(OCc2cnn(C3CCN(CC3)C(=O)OC3(C)CC3)c2C#N)c(F)c1
Show InChI InChI=1S/C23H25FN8O3/c1-23(7-8-23)35-22(33)31-9-5-17(6-10-31)32-19(12-25)16(13-26-32)14-34-20-4-3-15(11-18(20)24)21-27-28-29-30(21)2/h3-4,11,13,17H,5-10,14H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in human HEK293 cells assessed as cAMP level by beta-lactamase reporter gene assay


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400770
PNG
(CHEMBL2204976)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)C1Cc2cc(ccc2O1)-c1ccc(cc1)C(=O)N1CC(F)(F)C1
Show InChI InChI=1S/C29H30F2N4O2/c1-2-19-15-32-28(33-16-19)34-11-9-21(10-12-34)26-14-24-13-23(7-8-25(24)37-26)20-3-5-22(6-4-20)27(36)35-17-29(30,31)18-35/h3-8,13,15-16,21,26H,2,9-12,14,17-18H2,1H3
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n/an/an/an/a 228n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in MIN6 cells assessed as intracellular cAMP concentration after 45 mins by Alphascreen analysis


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400775
PNG
(CHEMBL2204982)
Show SMILES Cn1nnnc1-c1ccc(OCc2cnn(C3CCN(CC3)C(=O)OC3(C)CC3)c2C#N)c(F)c1
Show InChI InChI=1S/C23H25FN8O3/c1-23(7-8-23)35-22(33)31-9-5-17(6-10-31)32-19(12-25)16(13-26-32)14-34-20-4-3-15(11-18(20)24)21-27-28-29-30(21)2/h3-4,11,13,17H,5-10,14H2,1-2H3
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n/an/an/an/a 141n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in human HEK293 cells by beta-lactamase reporter gene assay


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400773
PNG
(CHEMBL2204984)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)n1ncc(COc2ccc(cc2)-n2cnnn2)c1C#N
Show InChI InChI=1S/C23H24N10O/c1-2-17-12-25-23(26-13-17)31-9-7-20(8-10-31)33-22(11-24)18(14-28-33)15-34-21-5-3-19(4-6-21)32-16-27-29-30-32/h3-6,12-14,16,20H,2,7-10,15H2,1H3
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n/an/an/an/a 11n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in human HEK293 cells assessed as cAMP level by beta-lactamase reporter gene assay


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400767
PNG
(CHEMBL2204979)
Show SMILES CS(=O)(=O)N1CCC(=CC1)c1cc2C[C@@H](Oc2cn1)C1CCN(CC1)c1ncc(cc1F)C(F)(F)F
Show InChI InChI=1S/C24H26F4N4O3S/c1-36(33,34)32-8-4-15(5-9-32)20-10-17-11-21(35-22(17)14-29-20)16-2-6-31(7-3-16)23-19(25)12-18(13-30-23)24(26,27)28/h4,10,12-14,16,21H,2-3,5-9,11H2,1H3/t21-/m1/s1
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n/an/an/an/a 2n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in MIN6 cells assessed as intracellular cAMP concentration after 45 mins by Alphascreen analysis


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50400764
PNG
(CHEMBL2204981)
Show SMILES CC(C)(F)c1noc(n1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2F)C(N)=O)c1F
Show InChI InChI=1S/C21H22F3N7O2/c1-21(2,24)20-29-19(33-30-20)11-5-7-31(8-6-11)18-15(23)17(26-10-27-18)28-14-4-3-12(16(25)32)9-13(14)22/h3-4,9-11H,5-8H2,1-2H3,(H2,25,32)(H,26,27,28)
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n/an/an/an/a 28n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 expressed in CHO-K1 cells assessed as cAMP level after 1 hr by homogenous time-resolved fluorescence assay


ACS Med Chem Lett 3: 955-958 (2012)


Article DOI: 10.1021/ml300296q
BindingDB Entry DOI: 10.7270/Q2SB46WV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%