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PubMed code 24900773

Compile data set for download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50446188
PNG
(CHEMBL3109017)
Show SMILES CCc1ccc(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3cccc(C)c23)cc1
Show InChI InChI=1/C24H29NO5/c1-3-15-7-9-16(10-8-15)11-17-12-25(18-6-4-5-14(2)20(17)18)24-23(29)22(28)21(27)19(13-26)30-24/h4-10,12,19,21-24,26-29H,3,11,13H2,1-2H3/t19-,21-,22+,23-,24-/s2
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n/an/a 1.10n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50346265
PNG
((2R,3R,4S,5S,6R)-2-(3-(4-cyclopropylbenzyl)-4-fluo...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(F)cccc12
Show InChI InChI=1/C24H26FNO5/c25-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-26(18)24-23(30)22(29)21(28)19(12-27)31-24/h1-7,11,15,19,21-24,27-30H,8-10,12H2/t19-,21-,22+,23-,24-/s2
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n/an/a 1.40n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50446186
PNG
(CHEMBL3109016)
Show SMILES Cc1cccc2n(cc(Cc3ccc(cc3)C3CC3)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C25H29NO5/c1-14-3-2-4-19-21(14)18(11-15-5-7-16(8-6-15)17-9-10-17)12-26(19)25-24(30)23(29)22(28)20(13-27)31-25/h2-8,12,17,20,22-25,27-30H,9-11,13H2,1H3/t20-,22-,23+,24-,25-/s2
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n/an/a 1.60n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50446185
PNG
(CHEMBL3109015)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2ccccc12
Show InChI InChI=1/C24H27NO5/c26-13-20-21(27)22(28)23(29)24(30-20)25-12-17(18-3-1-2-4-19(18)25)11-14-5-7-15(8-6-14)16-9-10-16/h1-8,12,16,20-24,26-29H,9-11,13H2/t20-,21-,22+,23-,24-/s2
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n/an/a 2.20n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50446190
PNG
(CHEMBL3109019)
Show SMILES CCOc1ccc(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3cccc(F)c23)cc1
Show InChI InChI=1/C23H26FNO6/c1-2-30-15-8-6-13(7-9-15)10-14-11-25(17-5-3-4-16(24)19(14)17)23-22(29)21(28)20(27)18(12-26)31-23/h3-9,11,18,20-23,26-29H,2,10,12H2,1H3/t18-,20-,21+,22-,23-/s2
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n/an/a 4.80n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50446187
PNG
(CHEMBL3109020)
Show SMILES CCc1ccc(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3cccc(F)c23)cc1
Show InChI InChI=1/C23H26FNO5/c1-2-13-6-8-14(9-7-13)10-15-11-25(17-5-3-4-16(24)19(15)17)23-22(29)21(28)20(27)18(12-26)30-23/h3-9,11,18,20-23,26-29H,2,10,12H2,1H3/t18-,20-,21+,22-,23-/s2
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n/an/a 5.20n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50441082
PNG
(CHEMBL2430319)
Show SMILES CCc1ccc(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3ccccc23)cc1
Show InChI InChI=1/C23H27NO5/c1-2-14-7-9-15(10-8-14)11-16-12-24(18-6-4-3-5-17(16)18)23-22(28)21(27)20(26)19(13-25)29-23/h3-10,12,19-23,25-28H,2,11,13H2,1H3/t19-,20-,21+,22-,23-/s2
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n/an/a 7.10n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50446184
PNG
(CHEMBL3109014)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CCC2)c2ccccc12
Show InChI InChI=1/C25H29NO5/c27-14-21-22(28)23(29)24(30)25(31-21)26-13-18(19-6-1-2-7-20(19)26)12-15-8-10-17(11-9-15)16-4-3-5-16/h1-2,6-11,13,16,21-25,27-30H,3-5,12,14H2/t21-,22-,23+,24-,25-/s2
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n/an/a 11n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50446189
PNG
(CHEMBL3109018)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(Cl)cc2)c2c(F)cccc12
Show InChI InChI=1/C21H21ClFNO5/c22-13-6-4-11(5-7-13)8-12-9-24(15-3-1-2-14(23)17(12)15)21-20(28)19(27)18(26)16(10-25)29-21/h1-7,9,16,18-21,25-28H,8,10H2/t16-,18-,19+,20-,21-/s2
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n/an/a 18n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50446186
PNG
(CHEMBL3109016)
Show SMILES Cc1cccc2n(cc(Cc3ccc(cc3)C3CC3)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C25H29NO5/c1-14-3-2-4-19-21(14)18(11-15-5-7-16(8-6-15)17-9-10-17)12-26(19)25-24(30)23(29)22(28)20(13-27)31-25/h2-8,12,17,20,22-25,27-30H,9-11,13H2,1H3/t20-,22-,23+,24-,25-/s2
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n/an/a 22n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50446182
PNG
(CHEMBL3109012)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CCCC2)c2c(F)cccc12
Show InChI InChI=1/C26H30FNO5/c27-19-6-3-7-20-22(19)18(12-15-8-10-17(11-9-15)16-4-1-2-5-16)13-28(20)26-25(32)24(31)23(30)21(14-29)33-26/h3,6-11,13,16,21,23-26,29-32H,1-2,4-5,12,14H2/t21-,23-,24+,25-,26-/s2
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n/an/a 24n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50446183
PNG
(CHEMBL3109013)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CCCC2)c2ccccc12
Show InChI InChI=1/C26H31NO5/c28-15-22-23(29)24(30)25(31)26(32-22)27-14-19(20-7-3-4-8-21(20)27)13-16-9-11-18(12-10-16)17-5-1-2-6-17/h3-4,7-12,14,17,22-26,28-31H,1-2,5-6,13,15H2/t22-,23-,24+,25-,26-/s2
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n/an/a 93n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50446187
PNG
(CHEMBL3109020)
Show SMILES CCc1ccc(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3cccc(F)c23)cc1
Show InChI InChI=1/C23H26FNO5/c1-2-13-6-8-14(9-7-13)10-15-11-25(17-5-3-4-16(24)19(15)17)23-22(29)21(28)20(27)18(12-26)30-23/h3-9,11,18,20-23,26-29H,2,10,12H2,1H3/t18-,20-,21+,22-,23-/s2
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n/an/a 210n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50346265
PNG
((2R,3R,4S,5S,6R)-2-(3-(4-cyclopropylbenzyl)-4-fluo...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(F)cccc12
Show InChI InChI=1/C24H26FNO5/c25-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-26(18)24-23(30)22(29)21(28)19(12-27)31-24/h1-7,11,15,19,21-24,27-30H,8-10,12H2/t19-,21-,22+,23-,24-/s2
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n/an/a 230n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1-mediated [14C]-AMG uptake expressed in CHOK cells preincubated for 10 mins followed by [14C]-AMG addition measured after 12...


ACS Med Chem Lett 5: 51-5 (2014)


Article DOI: 10.1021/ml400339b
BindingDB Entry DOI: 10.7270/Q24J0GM7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%