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PubMed code 24900831

Compile data set for download or QSAR
Found 62 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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<10n/an/an/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Antagonist activity at dopamine D5 receptor (unknown origin)


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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<10n/an/an/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Antagonist activity at dopamine D1 receptor (unknown origin)


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50004822
PNG
((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...)
Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
Show InChI InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2/t14-/m1/s1
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73n/an/an/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Agonist activity at dopamine D1 receptor (unknown origin)


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010460
PNG
(CHEMBL3263992)
Show SMILES CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C23H27ClN6O2S/c1-15-14-30(3)11-10-16-8-9-17(12-18(15)16)27-23-26-13-19(24)22(29-23)28-20-6-4-5-7-21(20)33(31,32)25-2/h4-9,12-13,15,25H,10-11,14H2,1-3H3,(H2,26,27,28,29)
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n/an/a 1.30n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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n/an/a 1.60n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010418
PNG
(CHEMBL3263982)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CC(C)c3c2)C(C)=O)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O2/c1-15-14-32(16(2)33)11-10-17-8-9-18(12-20(15)17)29-25-28-13-21(26)23(31-25)30-22-7-5-4-6-19(22)24(34)27-3/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,27,34)(H2,28,29,30,31)
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n/an/a 1.90n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306682
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010414
PNG
(CHEMBL3263981)
Show SMILES CCC(=O)N1CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc2C(C)C1
Show InChI InChI=1S/C26H29ClN6O2/c1-4-23(34)33-12-11-17-9-10-18(13-20(17)16(2)15-33)30-26-29-14-21(27)24(32-26)31-22-8-6-5-7-19(22)25(35)28-3/h5-10,13-14,16H,4,11-12,15H2,1-3H3,(H,28,35)(H2,29,30,31,32)
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n/an/a 2.40n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010396
PNG
(CHEMBL3263972)
Show SMILES CCCCC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc12
Show InChI InChI=1S/C27H33ClN6O/c1-4-5-8-19-17-34(3)14-13-18-11-12-20(15-22(18)19)31-27-30-16-23(28)25(33-27)32-24-10-7-6-9-21(24)26(35)29-2/h6-7,9-12,15-16,19H,4-5,8,13-14,17H2,1-3H3,(H,29,35)(H2,30,31,32,33)
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n/an/a 2.80n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010458
PNG
(CHEMBL3263990)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H30ClN5O2S/c1-16(2)34(32,33)23-8-6-5-7-22(23)29-24-21(26)14-27-25(30-24)28-19-10-9-18-11-12-31(4)15-17(3)20(18)13-19/h5-10,13-14,16-17H,11-12,15H2,1-4H3,(H2,27,28,29,30)
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n/an/a 3.5n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010400
PNG
(CHEMBL3263976)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)C\C(=C\C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O/c1-4-16-15-32(3)12-11-17-9-10-18(13-20(16)17)29-25-28-14-21(26)23(31-25)30-22-8-6-5-7-19(22)24(33)27-2/h4-10,13-14H,11-12,15H2,1-3H3,(H,27,33)(H2,28,29,30,31)/b16-4-
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n/an/a 5.20n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010395
PNG
(CHEMBL3263971)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H27ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 6n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010397
PNG
(CHEMBL3263973)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCNCC(=C)c3c2)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O/c1-14-12-26-10-9-15-7-8-16(11-18(14)15)28-23-27-13-19(24)21(30-23)29-20-6-4-3-5-17(20)22(31)25-2/h3-8,11,13,26H,1,9-10,12H2,2H3,(H,25,31)(H2,27,28,29,30)
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n/an/a 6.10n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010403
PNG
(CHEMBL3263979)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCNCC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O/c1-14-12-26-10-9-15-7-8-16(11-18(14)15)28-23-27-13-19(24)21(30-23)29-20-6-4-3-5-17(20)22(31)25-2/h3-8,11,13-14,26H,9-10,12H2,1-2H3,(H,25,31)(H2,27,28,29,30)
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n/an/a 6.40n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010395
PNG
(CHEMBL3263971)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H27ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 6.40n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010398
PNG
(CHEMBL3263974)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(=C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H25ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13H,1,10-11,14H2,2-3H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 6.40n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010399
PNG
(CHEMBL3263975)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)C\C(=C/C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O/c1-4-16-15-32(3)12-11-17-9-10-18(13-20(16)17)29-25-28-14-21(26)23(31-25)30-22-8-6-5-7-19(22)24(33)27-2/h4-10,13-14H,11-12,15H2,1-3H3,(H,27,33)(H2,28,29,30,31)/b16-4+
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n/an/a 6.5n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010459
PNG
(CHEMBL3263991)
Show SMILES CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C4CC4)n3)cc12
Show InChI InChI=1S/C25H28ClN5O2S/c1-16-15-31(2)12-11-17-7-8-18(13-20(16)17)28-25-27-14-21(26)24(30-25)29-22-5-3-4-6-23(22)34(32,33)19-9-10-19/h3-8,13-14,16,19H,9-12,15H2,1-2H3,(H2,27,28,29,30)
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n/an/a 7.10n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010404
PNG
(CHEMBL3263980)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CC(=O)N(C)C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C27H32ClN7O2/c1-17-15-35(16-24(36)34(3)4)12-11-18-9-10-19(13-21(17)18)31-27-30-14-22(28)25(33-27)32-23-8-6-5-7-20(23)26(37)29-2/h5-10,13-14,17H,11-12,15-16H2,1-4H3,(H,29,37)(H2,30,31,32,33)
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n/an/a 7.20n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010396
PNG
(CHEMBL3263972)
Show SMILES CCCCC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc12
Show InChI InChI=1S/C27H33ClN6O/c1-4-5-8-19-17-34(3)14-13-18-11-12-20(15-22(18)19)31-27-30-16-23(28)25(33-27)32-24-10-7-6-9-21(24)26(35)29-2/h6-7,9-12,15-16,19H,4-5,8,13-14,17H2,1-3H3,(H,29,35)(H2,30,31,32,33)
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n/an/a 7.70n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010403
PNG
(CHEMBL3263979)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCNCC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O/c1-14-12-26-10-9-15-7-8-16(11-18(14)15)28-23-27-13-19(24)21(30-23)29-20-6-4-3-5-17(20)22(31)25-2/h3-8,11,13-14,26H,9-10,12H2,1-2H3,(H,25,31)(H2,27,28,29,30)
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n/an/a 7.90n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010395
PNG
(CHEMBL3263971)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H27ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 9n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010395
PNG
(CHEMBL3263971)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H27ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 11n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010400
PNG
(CHEMBL3263976)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)C\C(=C\C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O/c1-4-16-15-32(3)12-11-17-9-10-18(13-20(16)17)29-25-28-14-21(26)23(31-25)30-22-8-6-5-7-19(22)24(33)27-2/h4-10,13-14H,11-12,15H2,1-3H3,(H,27,33)(H2,28,29,30,31)/b16-4-
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n/an/a 13n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010394
PNG
(CHEMBL3263970)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(c4ccccc4)c3c2)ncc1Cl
Show InChI InChI=1S/C29H29ClN6O/c1-31-28(37)22-10-6-7-11-26(22)34-27-25(30)17-32-29(35-27)33-21-13-12-20-14-15-36(2)18-24(23(20)16-21)19-8-4-3-5-9-19/h3-13,16-17,24H,14-15,18H2,1-2H3,(H,31,37)(H2,32,33,34,35)
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n/an/a 13n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010394
PNG
(CHEMBL3263970)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(c4ccccc4)c3c2)ncc1Cl
Show InChI InChI=1S/C29H29ClN6O/c1-31-28(37)22-10-6-7-11-26(22)34-27-25(30)17-32-29(35-27)33-21-13-12-20-14-15-36(2)18-24(23(20)16-21)19-8-4-3-5-9-19/h3-13,16-17,24H,14-15,18H2,1-2H3,(H,31,37)(H2,32,33,34,35)
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n/an/a 14n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010394
PNG
(CHEMBL3263970)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(c4ccccc4)c3c2)ncc1Cl
Show InChI InChI=1S/C29H29ClN6O/c1-31-28(37)22-10-6-7-11-26(22)34-27-25(30)17-32-29(35-27)33-21-13-12-20-14-15-36(2)18-24(23(20)16-21)19-8-4-3-5-9-19/h3-13,16-17,24H,14-15,18H2,1-2H3,(H,31,37)(H2,32,33,34,35)
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n/an/a 14n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010395
PNG
(CHEMBL3263971)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H27ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 15n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010399
PNG
(CHEMBL3263975)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)C\C(=C/C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O/c1-4-16-15-32(3)12-11-17-9-10-18(13-20(16)17)29-25-28-14-21(26)23(31-25)30-22-8-6-5-7-19(22)24(33)27-2/h4-10,13-14H,11-12,15H2,1-3H3,(H,27,33)(H2,28,29,30,31)/b16-4+
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n/an/a 17n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010401
PNG
(CHEMBL3263977)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cc3CCCCCN(C)CCc3cc2OC)ncc1Cl
Show InChI InChI=1S/C27H33ClN6O2/c1-29-26(35)20-10-6-7-11-22(20)31-25-21(28)17-30-27(33-25)32-23-15-18-9-5-4-8-13-34(2)14-12-19(18)16-24(23)36-3/h6-7,10-11,15-17H,4-5,8-9,12-14H2,1-3H3,(H,29,35)(H2,30,31,32,33)
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n/an/a 17n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010397
PNG
(CHEMBL3263973)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCNCC(=C)c3c2)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O/c1-14-12-26-10-9-15-7-8-16(11-18(14)15)28-23-27-13-19(24)21(30-23)29-20-6-4-3-5-17(20)22(31)25-2/h3-8,11,13,26H,1,9-10,12H2,2H3,(H,25,31)(H2,27,28,29,30)
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n/an/a 19n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010394
PNG
(CHEMBL3263970)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(c4ccccc4)c3c2)ncc1Cl
Show InChI InChI=1S/C29H29ClN6O/c1-31-28(37)22-10-6-7-11-26(22)34-27-25(30)17-32-29(35-27)33-21-13-12-20-14-15-36(2)18-24(23(20)16-21)19-8-4-3-5-9-19/h3-13,16-17,24H,14-15,18H2,1-2H3,(H,31,37)(H2,32,33,34,35)
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n/an/a 21n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010395
PNG
(CHEMBL3263971)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H27ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 24n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50306682
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010459
PNG
(CHEMBL3263991)
Show SMILES CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C4CC4)n3)cc12
Show InChI InChI=1S/C25H28ClN5O2S/c1-16-15-31(2)12-11-17-7-8-18(13-20(16)17)28-25-27-14-21(26)24(30-25)29-22-5-3-4-6-23(22)34(32,33)19-9-10-19/h3-8,13-14,16,19H,9-12,15H2,1-2H3,(H2,27,28,29,30)
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n/an/a 31n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010460
PNG
(CHEMBL3263992)
Show SMILES CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C23H27ClN6O2S/c1-15-14-30(3)11-10-16-8-9-17(12-18(15)16)27-23-26-13-19(24)22(29-23)28-20-6-4-5-7-21(20)33(31,32)25-2/h4-9,12-13,15,25H,10-11,14H2,1-3H3,(H2,26,27,28,29)
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n/an/a 31n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010402
PNG
(CHEMBL3263978)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cc3CCCCN(C)CCc3cc2OC)ncc1Cl
Show InChI InChI=1S/C26H31ClN6O2/c1-28-25(34)19-9-4-5-10-21(19)30-24-20(27)16-29-26(32-24)31-22-14-17-8-6-7-12-33(2)13-11-18(17)15-23(22)35-3/h4-5,9-10,14-16H,6-8,11-13H2,1-3H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 33n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010402
PNG
(CHEMBL3263978)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cc3CCCCN(C)CCc3cc2OC)ncc1Cl
Show InChI InChI=1S/C26H31ClN6O2/c1-28-25(34)19-9-4-5-10-21(19)30-24-20(27)16-29-26(32-24)31-22-14-17-8-6-7-12-33(2)13-11-18(17)15-23(22)35-3/h4-5,9-10,14-16H,6-8,11-13H2,1-3H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 36n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010404
PNG
(CHEMBL3263980)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CC(=O)N(C)C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C27H32ClN7O2/c1-17-15-35(16-24(36)34(3)4)12-11-18-9-10-19(13-21(17)18)31-27-30-14-22(28)25(33-27)32-23-8-6-5-7-20(23)26(37)29-2/h5-10,13-14,17H,11-12,15-16H2,1-4H3,(H,29,37)(H2,30,31,32,33)
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n/an/a 38n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010394
PNG
(CHEMBL3263970)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(c4ccccc4)c3c2)ncc1Cl
Show InChI InChI=1S/C29H29ClN6O/c1-31-28(37)22-10-6-7-11-26(22)34-27-25(30)17-32-29(35-27)33-21-13-12-20-14-15-36(2)18-24(23(20)16-21)19-8-4-3-5-9-19/h3-13,16-17,24H,14-15,18H2,1-2H3,(H,31,37)(H2,32,33,34,35)
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n/an/a 39n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010394
PNG
(CHEMBL3263970)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(c4ccccc4)c3c2)ncc1Cl
Show InChI InChI=1S/C29H29ClN6O/c1-31-28(37)22-10-6-7-11-26(22)34-27-25(30)17-32-29(35-27)33-21-13-12-20-14-15-36(2)18-24(23(20)16-21)19-8-4-3-5-9-19/h3-13,16-17,24H,14-15,18H2,1-2H3,(H,31,37)(H2,32,33,34,35)
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n/an/a 42n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010461
PNG
(CHEMBL3263993)
Show SMILES CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(N[C@@H]4[C@@H]5C[C@@H](C=C5)[C@@H]4C(N)=O)n3)cc12
Show InChI InChI=1S/C24H29ClN6O/c1-13-12-31(2)8-7-14-5-6-17(10-18(13)14)28-24-27-11-19(25)23(30-24)29-21-16-4-3-15(9-16)20(21)22(26)32/h3-6,10-11,13,15-16,20-21H,7-9,12H2,1-2H3,(H2,26,32)(H2,27,28,29,30)/t13?,15-,16+,20+,21-/m1/s1
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n/an/a 49n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010414
PNG
(CHEMBL3263981)
Show SMILES CCC(=O)N1CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc2C(C)C1
Show InChI InChI=1S/C26H29ClN6O2/c1-4-23(34)33-12-11-17-9-10-18(13-20(17)16(2)15-33)30-26-29-14-21(27)24(32-26)31-22-8-6-5-7-19(22)25(35)28-3/h5-10,13-14,16H,4,11-12,15H2,1-3H3,(H,28,35)(H2,29,30,31,32)
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n/an/a 50n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010418
PNG
(CHEMBL3263982)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CC(C)c3c2)C(C)=O)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O2/c1-15-14-32(16(2)33)11-10-17-8-9-18(12-20(15)17)29-25-28-13-21(26)23(31-25)30-22-7-5-4-6-19(22)24(34)27-3/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,27,34)(H2,28,29,30,31)
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n/an/a 53n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010461
PNG
(CHEMBL3263993)
Show SMILES CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(N[C@@H]4[C@@H]5C[C@@H](C=C5)[C@@H]4C(N)=O)n3)cc12
Show InChI InChI=1S/C24H29ClN6O/c1-13-12-31(2)8-7-14-5-6-17(10-18(13)14)28-24-27-11-19(25)23(30-24)29-21-16-4-3-15(9-16)20(21)22(26)32/h3-6,10-11,13,15-16,20-21H,7-9,12H2,1-2H3,(H2,26,32)(H2,27,28,29,30)/t13?,15-,16+,20+,21-/m1/s1
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n/an/a 58n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010398
PNG
(CHEMBL3263974)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(=C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H25ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13H,1,10-11,14H2,2-3H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 60n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010458
PNG
(CHEMBL3263990)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H30ClN5O2S/c1-16(2)34(32,33)23-8-6-5-7-22(23)29-24-21(26)14-27-25(30-24)28-19-10-9-18-11-12-31(4)15-17(3)20(18)13-19/h5-10,13-14,16-17H,11-12,15H2,1-4H3,(H2,27,28,29,30)
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n/an/a 63n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010401
PNG
(CHEMBL3263977)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cc3CCCCCN(C)CCc3cc2OC)ncc1Cl
Show InChI InChI=1S/C27H33ClN6O2/c1-29-26(35)20-10-6-7-11-22(20)31-25-21(28)17-30-27(33-25)32-23-15-18-9-5-4-8-13-34(2)14-12-19(18)16-24(23)36-3/h6-7,10-11,15-17H,4-5,8-9,12-14H2,1-3H3,(H,29,35)(H2,30,31,32,33)
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n/an/a 710n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010457
PNG
(CHEMBL3263989)
Show SMILES CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)N4CCOCC4)n3)cc12
Show InChI InChI=1S/C27H31ClN6O2/c1-18-17-33(2)10-9-19-7-8-20(15-22(18)19)30-27-29-16-23(28)25(32-27)31-24-6-4-3-5-21(24)26(35)34-11-13-36-14-12-34/h3-8,15-16,18H,9-14,17H2,1-2H3,(H2,29,30,31,32)
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n/an/a>1.00E+3n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010457
PNG
(CHEMBL3263989)
Show SMILES CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)N4CCOCC4)n3)cc12
Show InChI InChI=1S/C27H31ClN6O2/c1-18-17-33(2)10-9-19-7-8-20(15-22(18)19)30-27-29-16-23(28)25(32-27)31-24-6-4-3-5-21(24)26(35)34-11-13-36-14-12-34/h3-8,15-16,18H,9-14,17H2,1-2H3,(H2,29,30,31,32)
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CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010456
PNG
(CHEMBL3263988)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc2ccccc12
Show InChI InChI=1S/C28H30N6O/c1-18-17-34(3)15-14-19-12-13-20(16-23(18)19)30-28-32-24-10-6-4-8-21(24)26(33-28)31-25-11-7-5-9-22(25)27(35)29-2/h4-13,16,18H,14-15,17H2,1-3H3,(H,29,35)(H2,30,31,32,33)
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CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010456
PNG
(CHEMBL3263988)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc2ccccc12
Show InChI InChI=1S/C28H30N6O/c1-18-17-34(3)15-14-19-12-13-20(16-23(18)19)30-28-32-24-10-6-4-8-21(24)26(33-28)31-25-11-7-5-9-22(25)27(35)29-2/h4-13,16,18H,14-15,17H2,1-3H3,(H,29,35)(H2,30,31,32,33)
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CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010454
PNG
(CHEMBL3263986)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc2sccc12
Show InChI InChI=1S/C26H28N6OS/c1-16-15-32(3)12-10-17-8-9-18(14-21(16)17)28-26-30-23(20-11-13-34-25(20)31-26)29-22-7-5-4-6-19(22)24(33)27-2/h4-9,11,13-14,16H,10,12,15H2,1-3H3,(H,27,33)(H2,28,29,30,31)
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CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010453
PNG
(CHEMBL3263985)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc(N2CCOCC2)c1Cl
Show InChI InChI=1S/C28H34ClN7O2/c1-18-17-35(3)11-10-19-8-9-20(16-22(18)19)31-28-33-25(24(29)26(34-28)36-12-14-38-15-13-36)32-23-7-5-4-6-21(23)27(37)30-2/h4-9,16,18H,10-15,17H2,1-3H3,(H,30,37)(H2,31,32,33,34)
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CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010453
PNG
(CHEMBL3263985)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc(N2CCOCC2)c1Cl
Show InChI InChI=1S/C28H34ClN7O2/c1-18-17-35(3)11-10-19-8-9-20(16-22(18)19)31-28-33-25(24(29)26(34-28)36-12-14-38-15-13-36)32-23-7-5-4-6-21(23)27(37)30-2/h4-9,16,18H,10-15,17H2,1-3H3,(H,30,37)(H2,31,32,33,34)
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CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010452
PNG
(CHEMBL3263984)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc(NC)c1Cl
Show InChI InChI=1S/C25H30ClN7O/c1-15-14-33(4)12-11-16-9-10-17(13-19(15)16)29-25-31-22(27-2)21(26)23(32-25)30-20-8-6-5-7-18(20)24(34)28-3/h5-10,13,15H,11-12,14H2,1-4H3,(H,28,34)(H3,27,29,30,31,32)
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CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010455
PNG
(CHEMBL3263987)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc2cccnc12
Show InChI InChI=1S/C27H29N7O/c1-17-16-34(3)14-12-18-10-11-19(15-21(17)18)30-27-32-23-9-6-13-29-24(23)25(33-27)31-22-8-5-4-7-20(22)26(35)28-2/h4-11,13,15,17H,12,14,16H2,1-3H3,(H,28,35)(H2,30,31,32,33)
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CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010455
PNG
(CHEMBL3263987)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc2cccnc12
Show InChI InChI=1S/C27H29N7O/c1-17-16-34(3)14-12-18-10-11-19(15-21(17)18)30-27-32-23-9-6-13-29-24(23)25(33-27)31-22-8-5-4-7-20(22)26(35)28-2/h4-11,13,15,17H,12,14,16H2,1-3H3,(H,28,35)(H2,30,31,32,33)
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CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010454
PNG
(CHEMBL3263986)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc2sccc12
Show InChI InChI=1S/C26H28N6OS/c1-16-15-32(3)12-10-17-8-9-18(14-21(16)17)28-26-30-23(20-11-13-34-25(20)31-26)29-22-7-5-4-6-19(22)24(33)27-2/h4-9,11,13-14,16H,10,12,15H2,1-3H3,(H,27,33)(H2,28,29,30,31)
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CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010434
PNG
(CHEMBL3263983)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc(F)c1Cl
Show InChI InChI=1S/C24H26ClFN6O/c1-14-13-32(3)11-10-15-8-9-16(12-18(14)15)28-24-30-21(26)20(25)22(31-24)29-19-7-5-4-6-17(19)23(33)27-2/h4-9,12,14H,10-11,13H2,1-3H3,(H,27,33)(H2,28,29,30,31)
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CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010434
PNG
(CHEMBL3263983)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc(F)c1Cl
Show InChI InChI=1S/C24H26ClFN6O/c1-14-13-32(3)11-10-15-8-9-16(12-18(14)15)28-24-30-21(26)20(25)22(31-24)29-19-7-5-4-6-17(19)23(33)27-2/h4-9,12,14H,10-11,13H2,1-3H3,(H,27,33)(H2,28,29,30,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010452
PNG
(CHEMBL3263984)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc(NC)c1Cl
Show InChI InChI=1S/C25H30ClN7O/c1-15-14-33(4)12-11-16-9-10-17(13-19(15)16)29-25-31-22(27-2)21(26)23(32-25)30-20-8-6-5-7-18(20)24(34)28-3/h5-10,13,15H,11-12,14H2,1-4H3,(H,28,34)(H3,27,29,30,31,32)
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n/an/a>1.00E+3n/an/an/an/an/an/a



CAS Key Laboratory of Receptor Research, and Synthetic Organic& Medicinal Chemistry Laboratory (SOMCL), Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institu

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%