BindingDB logo
myBDB logout

PubMed code 24900831

Compile data set for download or QSAR
Found 62 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
<10n/an/an/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Antagonist activity at dopamine D5 receptor (unknown origin)


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
<10n/an/an/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Antagonist activity at dopamine D1 receptor (unknown origin)


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50004822
PNG
((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...)
Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
Show InChI InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2/t14-/m1/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
73n/an/an/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Agonist activity at dopamine D1 receptor (unknown origin)


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010460
PNG
(CHEMBL3263992)
Show SMILES CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1/C23H27ClN6O2S/c1-15-14-30(3)11-10-16-8-9-17(12-18(15)16)27-23-26-13-19(24)22(29-23)28-20-6-4-5-7-21(20)33(31,32)25-2/h4-9,12-13,15,25H,10-11,14H2,1-3H3,(H2,26,27,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 1.60n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010418
PNG
(CHEMBL3263982)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CC(C)c3c2)C(C)=O)ncc1Cl
Show InChI InChI=1/C25H27ClN6O2/c1-15-14-32(16(2)33)11-10-17-8-9-18(12-20(15)17)29-25-28-13-21(26)23(31-25)30-22-7-5-4-6-19(22)24(34)27-3/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,27,34)(H2,28,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.90n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306682
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010414
PNG
(CHEMBL3263981)
Show SMILES CCC(=O)N1CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc2C(C)C1
Show InChI InChI=1/C26H29ClN6O2/c1-4-23(34)33-12-11-17-9-10-18(13-20(17)16(2)15-33)30-26-29-14-21(27)24(32-26)31-22-8-6-5-7-19(22)25(35)28-3/h5-10,13-14,16H,4,11-12,15H2,1-3H3,(H,28,35)(H2,29,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010396
PNG
(CHEMBL3263972)
Show SMILES CCCCC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc12
Show InChI InChI=1/C27H33ClN6O/c1-4-5-8-19-17-34(3)14-13-18-11-12-20(15-22(18)19)31-27-30-16-23(28)25(33-27)32-24-10-7-6-9-21(24)26(35)29-2/h6-7,9-12,15-16,19H,4-5,8,13-14,17H2,1-3H3,(H,29,35)(H2,30,31,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.80n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010458
PNG
(CHEMBL3263990)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1/C25H30ClN5O2S/c1-16(2)34(32,33)23-8-6-5-7-22(23)29-24-21(26)14-27-25(30-24)28-19-10-9-18-11-12-31(4)15-17(3)20(18)13-19/h5-10,13-14,16-17H,11-12,15H2,1-4H3,(H2,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.5n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010400
PNG
(CHEMBL3263976)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)C\C(=C\C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O/c1-4-16-15-32(3)12-11-17-9-10-18(13-20(16)17)29-25-28-14-21(26)23(31-25)30-22-8-6-5-7-19(22)24(33)27-2/h4-10,13-14H,11-12,15H2,1-3H3,(H,27,33)(H2,28,29,30,31)/b16-4-
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.20n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010395
PNG
(CHEMBL3263971)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1/C24H27ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,26,32)(H2,27,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010397
PNG
(CHEMBL3263973)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCNCC(=C)c3c2)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O/c1-14-12-26-10-9-15-7-8-16(11-18(14)15)28-23-27-13-19(24)21(30-23)29-20-6-4-3-5-17(20)22(31)25-2/h3-8,11,13,26H,1,9-10,12H2,2H3,(H,25,31)(H2,27,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.10n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010403
PNG
(CHEMBL3263979)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCNCC(C)c3c2)ncc1Cl
Show InChI InChI=1/C23H25ClN6O/c1-14-12-26-10-9-15-7-8-16(11-18(14)15)28-23-27-13-19(24)21(30-23)29-20-6-4-3-5-17(20)22(31)25-2/h3-8,11,13-14,26H,9-10,12H2,1-2H3,(H,25,31)(H2,27,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.40n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010395
PNG
(CHEMBL3263971)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1/C24H27ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,26,32)(H2,27,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.40n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010398
PNG
(CHEMBL3263974)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(=C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H25ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13H,1,10-11,14H2,2-3H3,(H,26,32)(H2,27,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.40n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010399
PNG
(CHEMBL3263975)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)C\C(=C/C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O/c1-4-16-15-32(3)12-11-17-9-10-18(13-20(16)17)29-25-28-14-21(26)23(31-25)30-22-8-6-5-7-19(22)24(33)27-2/h4-10,13-14H,11-12,15H2,1-3H3,(H,27,33)(H2,28,29,30,31)/b16-4+
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.5n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010459
PNG
(CHEMBL3263991)
Show SMILES CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C4CC4)n3)cc12
Show InChI InChI=1/C25H28ClN5O2S/c1-16-15-31(2)12-11-17-7-8-18(13-20(16)17)28-25-27-14-21(26)24(30-25)29-22-5-3-4-6-23(22)34(32,33)19-9-10-19/h3-8,13-14,16,19H,9-12,15H2,1-2H3,(H2,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.10n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010404
PNG
(CHEMBL3263980)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CC(=O)N(C)C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1/C27H32ClN7O2/c1-17-15-35(16-24(36)34(3)4)12-11-18-9-10-19(13-21(17)18)31-27-30-14-22(28)25(33-27)32-23-8-6-5-7-20(23)26(37)29-2/h5-10,13-14,17H,11-12,15-16H2,1-4H3,(H,29,37)(H2,30,31,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.20n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010396
PNG
(CHEMBL3263972)
Show SMILES CCCCC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc12
Show InChI InChI=1/C27H33ClN6O/c1-4-5-8-19-17-34(3)14-13-18-11-12-20(15-22(18)19)31-27-30-16-23(28)25(33-27)32-24-10-7-6-9-21(24)26(35)29-2/h6-7,9-12,15-16,19H,4-5,8,13-14,17H2,1-3H3,(H,29,35)(H2,30,31,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.70n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010403
PNG
(CHEMBL3263979)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCNCC(C)c3c2)ncc1Cl
Show InChI InChI=1/C23H25ClN6O/c1-14-12-26-10-9-15-7-8-16(11-18(14)15)28-23-27-13-19(24)21(30-23)29-20-6-4-3-5-17(20)22(31)25-2/h3-8,11,13-14,26H,9-10,12H2,1-2H3,(H,25,31)(H2,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.90n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010395
PNG
(CHEMBL3263971)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1/C24H27ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,26,32)(H2,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010395
PNG
(CHEMBL3263971)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1/C24H27ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,26,32)(H2,27,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010400
PNG
(CHEMBL3263976)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)C\C(=C\C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O/c1-4-16-15-32(3)12-11-17-9-10-18(13-20(16)17)29-25-28-14-21(26)23(31-25)30-22-8-6-5-7-19(22)24(33)27-2/h4-10,13-14H,11-12,15H2,1-3H3,(H,27,33)(H2,28,29,30,31)/b16-4-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010394
PNG
(CHEMBL3263970)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(c4ccccc4)c3c2)ncc1Cl
Show InChI InChI=1/C29H29ClN6O/c1-31-28(37)22-10-6-7-11-26(22)34-27-25(30)17-32-29(35-27)33-21-13-12-20-14-15-36(2)18-24(23(20)16-21)19-8-4-3-5-9-19/h3-13,16-17,24H,14-15,18H2,1-2H3,(H,31,37)(H2,32,33,34,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010394
PNG
(CHEMBL3263970)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(c4ccccc4)c3c2)ncc1Cl
Show InChI InChI=1/C29H29ClN6O/c1-31-28(37)22-10-6-7-11-26(22)34-27-25(30)17-32-29(35-27)33-21-13-12-20-14-15-36(2)18-24(23(20)16-21)19-8-4-3-5-9-19/h3-13,16-17,24H,14-15,18H2,1-2H3,(H,31,37)(H2,32,33,34,35)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010394
PNG
(CHEMBL3263970)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(c4ccccc4)c3c2)ncc1Cl
Show InChI InChI=1/C29H29ClN6O/c1-31-28(37)22-10-6-7-11-26(22)34-27-25(30)17-32-29(35-27)33-21-13-12-20-14-15-36(2)18-24(23(20)16-21)19-8-4-3-5-9-19/h3-13,16-17,24H,14-15,18H2,1-2H3,(H,31,37)(H2,32,33,34,35)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010395
PNG
(CHEMBL3263971)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1/C24H27ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,26,32)(H2,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 15n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010399
PNG
(CHEMBL3263975)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)C\C(=C/C)c3c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O/c1-4-16-15-32(3)12-11-17-9-10-18(13-20(16)17)29-25-28-14-21(26)23(31-25)30-22-8-6-5-7-19(22)24(33)27-2/h4-10,13-14H,11-12,15H2,1-3H3,(H,27,33)(H2,28,29,30,31)/b16-4+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010401
PNG
(CHEMBL3263977)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cc3CCCCCN(C)CCc3cc2OC)ncc1Cl
Show InChI InChI=1S/C27H33ClN6O2/c1-29-26(35)20-10-6-7-11-22(20)31-25-21(28)17-30-27(33-25)32-23-15-18-9-5-4-8-13-34(2)14-12-19(18)16-24(23)36-3/h6-7,10-11,15-17H,4-5,8-9,12-14H2,1-3H3,(H,29,35)(H2,30,31,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010397
PNG
(CHEMBL3263973)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCNCC(=C)c3c2)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O/c1-14-12-26-10-9-15-7-8-16(11-18(14)15)28-23-27-13-19(24)21(30-23)29-20-6-4-3-5-17(20)22(31)25-2/h3-8,11,13,26H,1,9-10,12H2,2H3,(H,25,31)(H2,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010394
PNG
(CHEMBL3263970)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(c4ccccc4)c3c2)ncc1Cl
Show InChI InChI=1/C29H29ClN6O/c1-31-28(37)22-10-6-7-11-26(22)34-27-25(30)17-32-29(35-27)33-21-13-12-20-14-15-36(2)18-24(23(20)16-21)19-8-4-3-5-9-19/h3-13,16-17,24H,14-15,18H2,1-2H3,(H,31,37)(H2,32,33,34,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 21n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010395
PNG
(CHEMBL3263971)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1/C24H27ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,26,32)(H2,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 24n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50306682
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 28n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010459
PNG
(CHEMBL3263991)
Show SMILES CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C4CC4)n3)cc12
Show InChI InChI=1/C25H28ClN5O2S/c1-16-15-31(2)12-11-17-7-8-18(13-20(16)17)28-25-27-14-21(26)24(30-25)29-22-5-3-4-6-23(22)34(32,33)19-9-10-19/h3-8,13-14,16,19H,9-12,15H2,1-2H3,(H2,27,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 31n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010460
PNG
(CHEMBL3263992)
Show SMILES CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1/C23H27ClN6O2S/c1-15-14-30(3)11-10-16-8-9-17(12-18(15)16)27-23-26-13-19(24)22(29-23)28-20-6-4-5-7-21(20)33(31,32)25-2/h4-9,12-13,15,25H,10-11,14H2,1-3H3,(H2,26,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 31n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010402
PNG
(CHEMBL3263978)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cc3CCCCN(C)CCc3cc2OC)ncc1Cl
Show InChI InChI=1S/C26H31ClN6O2/c1-28-25(34)19-9-4-5-10-21(19)30-24-20(27)16-29-26(32-24)31-22-14-17-8-6-7-12-33(2)13-11-18(17)15-23(22)35-3/h4-5,9-10,14-16H,6-8,11-13H2,1-3H3,(H,28,34)(H2,29,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 33n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010402
PNG
(CHEMBL3263978)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cc3CCCCN(C)CCc3cc2OC)ncc1Cl
Show InChI InChI=1S/C26H31ClN6O2/c1-28-25(34)19-9-4-5-10-21(19)30-24-20(27)16-29-26(32-24)31-22-14-17-8-6-7-12-33(2)13-11-18(17)15-23(22)35-3/h4-5,9-10,14-16H,6-8,11-13H2,1-3H3,(H,28,34)(H2,29,30,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 36n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010404
PNG
(CHEMBL3263980)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CC(=O)N(C)C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1/C27H32ClN7O2/c1-17-15-35(16-24(36)34(3)4)12-11-18-9-10-19(13-21(17)18)31-27-30-14-22(28)25(33-27)32-23-8-6-5-7-20(23)26(37)29-2/h5-10,13-14,17H,11-12,15-16H2,1-4H3,(H,29,37)(H2,30,31,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 38n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010394
PNG
(CHEMBL3263970)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(c4ccccc4)c3c2)ncc1Cl
Show InChI InChI=1/C29H29ClN6O/c1-31-28(37)22-10-6-7-11-26(22)34-27-25(30)17-32-29(35-27)33-21-13-12-20-14-15-36(2)18-24(23(20)16-21)19-8-4-3-5-9-19/h3-13,16-17,24H,14-15,18H2,1-2H3,(H,31,37)(H2,32,33,34,35)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 39n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010394
PNG
(CHEMBL3263970)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(c4ccccc4)c3c2)ncc1Cl
Show InChI InChI=1/C29H29ClN6O/c1-31-28(37)22-10-6-7-11-26(22)34-27-25(30)17-32-29(35-27)33-21-13-12-20-14-15-36(2)18-24(23(20)16-21)19-8-4-3-5-9-19/h3-13,16-17,24H,14-15,18H2,1-2H3,(H,31,37)(H2,32,33,34,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 42n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010461
PNG
(CHEMBL3263993)
Show SMILES CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(N[C@@H]4[C@@H]5C[C@@H](C=C5)[C@@H]4C(N)=O)n3)cc12
Show InChI InChI=1/C24H29ClN6O/c1-13-12-31(2)8-7-14-5-6-17(10-18(13)14)28-24-27-11-19(25)23(30-24)29-21-16-4-3-15(9-16)20(21)22(26)32/h3-6,10-11,13,15-16,20-21H,7-9,12H2,1-2H3,(H2,26,32)(H2,27,28,29,30)/t13?,15-,16+,20+,21-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 49n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010414
PNG
(CHEMBL3263981)
Show SMILES CCC(=O)N1CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc2C(C)C1
Show InChI InChI=1/C26H29ClN6O2/c1-4-23(34)33-12-11-17-9-10-18(13-20(17)16(2)15-33)30-26-29-14-21(27)24(32-26)31-22-8-6-5-7-19(22)25(35)28-3/h5-10,13-14,16H,4,11-12,15H2,1-3H3,(H,28,35)(H2,29,30,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 50n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010418
PNG
(CHEMBL3263982)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CC(C)c3c2)C(C)=O)ncc1Cl
Show InChI InChI=1/C25H27ClN6O2/c1-15-14-32(16(2)33)11-10-17-8-9-18(12-20(15)17)29-25-28-13-21(26)23(31-25)30-22-7-5-4-6-19(22)24(34)27-3/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,27,34)(H2,28,29,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 53n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010461
PNG
(CHEMBL3263993)
Show SMILES CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(N[C@@H]4[C@@H]5C[C@@H](C=C5)[C@@H]4C(N)=O)n3)cc12
Show InChI InChI=1/C24H29ClN6O/c1-13-12-31(2)8-7-14-5-6-17(10-18(13)14)28-24-27-11-19(25)23(30-24)29-21-16-4-3-15(9-16)20(21)22(26)32/h3-6,10-11,13,15-16,20-21H,7-9,12H2,1-2H3,(H2,26,32)(H2,27,28,29,30)/t13?,15-,16+,20+,21-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 58n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010398
PNG
(CHEMBL3263974)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(=C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H25ClN6O/c1-15-14-31(3)11-10-16-8-9-17(12-19(15)16)28-24-27-13-20(25)22(30-24)29-21-7-5-4-6-18(21)23(32)26-2/h4-9,12-13H,1,10-11,14H2,2-3H3,(H,26,32)(H2,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 60n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010458
PNG
(CHEMBL3263990)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)ncc1Cl
Show InChI InChI=1/C25H30ClN5O2S/c1-16(2)34(32,33)23-8-6-5-7-22(23)29-24-21(26)14-27-25(30-24)28-19-10-9-18-11-12-31(4)15-17(3)20(18)13-19/h5-10,13-14,16-17H,11-12,15H2,1-4H3,(H2,27,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 63n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010401
PNG
(CHEMBL3263977)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2cc3CCCCCN(C)CCc3cc2OC)ncc1Cl
Show InChI InChI=1S/C27H33ClN6O2/c1-29-26(35)20-10-6-7-11-22(20)31-25-21(28)17-30-27(33-25)32-23-15-18-9-5-4-8-13-34(2)14-12-19(18)16-24(23)36-3/h6-7,10-11,15-17H,4-5,8-9,12-14H2,1-3H3,(H,29,35)(H2,30,31,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 710n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010457
PNG
(CHEMBL3263989)
Show SMILES CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)N4CCOCC4)n3)cc12
Show InChI InChI=1/C27H31ClN6O2/c1-18-17-33(2)10-9-19-7-8-20(15-22(18)19)30-27-29-16-23(28)25(32-27)31-24-6-4-3-5-21(24)26(35)34-11-13-36-14-12-34/h3-8,15-16,18H,9-14,17H2,1-2H3,(H2,29,30,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010457
PNG
(CHEMBL3263989)
Show SMILES CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)N4CCOCC4)n3)cc12
Show InChI InChI=1/C27H31ClN6O2/c1-18-17-33(2)10-9-19-7-8-20(15-22(18)19)30-27-29-16-23(28)25(32-27)31-24-6-4-3-5-21(24)26(35)34-11-13-36-14-12-34/h3-8,15-16,18H,9-14,17H2,1-2H3,(H2,29,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010456
PNG
(CHEMBL3263988)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc2ccccc12
Show InChI InChI=1/C28H30N6O/c1-18-17-34(3)15-14-19-12-13-20(16-23(18)19)30-28-32-24-10-6-4-8-21(24)26(33-28)31-25-11-7-5-9-22(25)27(35)29-2/h4-13,16,18H,14-15,17H2,1-3H3,(H,29,35)(H2,30,31,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010456
PNG
(CHEMBL3263988)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc2ccccc12
Show InChI InChI=1/C28H30N6O/c1-18-17-34(3)15-14-19-12-13-20(16-23(18)19)30-28-32-24-10-6-4-8-21(24)26(33-28)31-25-11-7-5-9-22(25)27(35)29-2/h4-13,16,18H,14-15,17H2,1-3H3,(H,29,35)(H2,30,31,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010454
PNG
(CHEMBL3263986)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc2sccc12
Show InChI InChI=1/C26H28N6OS/c1-16-15-32(3)12-10-17-8-9-18(14-21(16)17)28-26-30-23(20-11-13-34-25(20)31-26)29-22-7-5-4-6-19(22)24(33)27-2/h4-9,11,13-14,16H,10,12,15H2,1-3H3,(H,27,33)(H2,28,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010453
PNG
(CHEMBL3263985)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc(N2CCOCC2)c1Cl
Show InChI InChI=1/C28H34ClN7O2/c1-18-17-35(3)11-10-19-8-9-20(16-22(18)19)31-28-33-25(24(29)26(34-28)36-12-14-38-15-13-36)32-23-7-5-4-6-21(23)27(37)30-2/h4-9,16,18H,10-15,17H2,1-3H3,(H,30,37)(H2,31,32,33,34)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010453
PNG
(CHEMBL3263985)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc(N2CCOCC2)c1Cl
Show InChI InChI=1/C28H34ClN7O2/c1-18-17-35(3)11-10-19-8-9-20(16-22(18)19)31-28-33-25(24(29)26(34-28)36-12-14-38-15-13-36)32-23-7-5-4-6-21(23)27(37)30-2/h4-9,16,18H,10-15,17H2,1-3H3,(H,30,37)(H2,31,32,33,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010452
PNG
(CHEMBL3263984)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc(NC)c1Cl
Show InChI InChI=1/C25H30ClN7O/c1-15-14-33(4)12-11-16-9-10-17(13-19(15)16)29-25-31-22(27-2)21(26)23(32-25)30-20-8-6-5-7-18(20)24(34)28-3/h5-10,13,15H,11-12,14H2,1-4H3,(H,28,34)(H3,27,29,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010455
PNG
(CHEMBL3263987)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc2cccnc12
Show InChI InChI=1/C27H29N7O/c1-17-16-34(3)14-12-18-10-11-19(15-21(17)18)30-27-32-23-9-6-13-29-24(23)25(33-27)31-22-8-5-4-7-20(22)26(35)28-2/h4-11,13,15,17H,12,14,16H2,1-3H3,(H,28,35)(H2,30,31,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010455
PNG
(CHEMBL3263987)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc2cccnc12
Show InChI InChI=1/C27H29N7O/c1-17-16-34(3)14-12-18-10-11-19(15-21(17)18)30-27-32-23-9-6-13-29-24(23)25(33-27)31-22-8-5-4-7-20(22)26(35)28-2/h4-11,13,15,17H,12,14,16H2,1-3H3,(H,28,35)(H2,30,31,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010454
PNG
(CHEMBL3263986)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc2sccc12
Show InChI InChI=1/C26H28N6OS/c1-16-15-32(3)12-10-17-8-9-18(14-21(16)17)28-26-30-23(20-11-13-34-25(20)31-26)29-22-7-5-4-6-19(22)24(33)27-2/h4-9,11,13-14,16H,10,12,15H2,1-3H3,(H,27,33)(H2,28,29,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010434
PNG
(CHEMBL3263983)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc(F)c1Cl
Show InChI InChI=1/C24H26ClFN6O/c1-14-13-32(3)11-10-15-8-9-16(12-18(14)15)28-24-30-21(26)20(25)22(31-24)29-19-7-5-4-6-17(19)23(33)27-2/h4-9,12,14H,10-11,13H2,1-3H3,(H,27,33)(H2,28,29,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50010434
PNG
(CHEMBL3263983)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc(F)c1Cl
Show InChI InChI=1/C24H26ClFN6O/c1-14-13-32(3)11-10-15-8-9-16(12-18(14)15)28-24-30-21(26)20(25)22(31-24)29-19-7-5-4-6-17(19)23(33)27-2/h4-9,12,14H,10-11,13H2,1-3H3,(H,27,33)(H2,28,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50010452
PNG
(CHEMBL3263984)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(C)CC(C)c3c2)nc(NC)c1Cl
Show InChI InChI=1/C25H30ClN7O/c1-15-14-33(4)12-11-16-9-10-17(13-19(15)16)29-25-31-22(27-2)21(26)23(32-25)30-20-8-6-5-7-18(20)24(34)28-3/h5-10,13,15H,11-12,14H2,1-4H3,(H,28,34)(H3,27,29,30,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISA


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%