BindingDB logo
myBDB logout

PubMed code 24922538

Compile data set for download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM113824
PNG
(1-(2-((4-Methoxyphenyl)amino)-3-oxo-3,4 dihydroqui...)
Show SMILES COc1ccc(Nc2nc3ccc(NC(=O)Nc4ccccc4)cc3[nH]c2=O)cc1
Show InChI InChI=1S/C22H19N5O3/c1-30-17-10-7-15(8-11-17)23-20-21(28)27-19-13-16(9-12-18(19)26-20)25-22(29)24-14-5-3-2-4-6-14/h2-13H,1H3,(H,23,26)(H,27,28)(H2,24,25,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.03E+4n/an/an/an/an/an/a



Ain Shams University, Abassia, Cairo 11566, Egypt.



Assay Description
Assays are performed for 15 min at 30 °C, with 50 µM of P33-ATP in a final volume of 25 µL. The assays are terminated by spotting 20 &...


Bioorg Chem 16-26 (2014)


Article DOI: 10.1016/j.bioorg.2014.05.010
BindingDB Entry DOI: 10.7270/Q2JM289W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM113825
PNG
(2-((2-((4-Methoxyphenyl)amino)-3-oxo-3,4- dihydroq...)
Show SMILES COc1ccc(Nc2nc3ccc(NC(=O)c4ccccc4C(O)=O)cc3[nH]c2=O)cc1
Show InChI InChI=1S/C23H18N4O5/c1-32-15-9-6-13(7-10-15)24-20-22(29)27-19-12-14(8-11-18(19)26-20)25-21(28)16-4-2-3-5-17(16)23(30)31/h2-12H,1H3,(H,24,26)(H,25,28)(H,27,29)(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.18E+4n/an/an/an/an/an/a



Ain Shams University, Abassia, Cairo 11566, Egypt.



Assay Description
Assays are performed for 15 min at 30 °C, with 50 µM of P33-ATP in a final volume of 25 µL. The assays are terminated by spotting 20 &...


Bioorg Chem 16-26 (2014)


Article DOI: 10.1016/j.bioorg.2014.05.010
BindingDB Entry DOI: 10.7270/Q2JM289W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM113828
PNG
(1-(3-Chlorophenyl)-3-(4-((6-nitroquinoxalin-2-yl)a...)
Show SMILES [O-][N+](=O)c1ccc2nc(Nc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)cnc2c1
Show InChI InChI=1S/C21H15ClN6O3/c22-13-2-1-3-16(10-13)26-21(29)25-15-6-4-14(5-7-15)24-20-12-23-19-11-17(28(30)31)8-9-18(19)27-20/h1-12H,(H,24,27)(H2,25,26,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.54E+4n/an/an/an/an/an/a



Ain Shams University, Abassia, Cairo 11566, Egypt.



Assay Description
Assays are performed for 15 min at 30 °C, with 50 µM of P33-ATP in a final volume of 25 µL. The assays are terminated by spotting 20 &...


Bioorg Chem 16-26 (2014)


Article DOI: 10.1016/j.bioorg.2014.05.010
BindingDB Entry DOI: 10.7270/Q2JM289W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM113826
PNG
(1-(2-((4-Methoxyphenyl)amino)quinoxalin-6-yl)-3-(m...)
Show SMILES COc1ccc(Nc2cnc3cc(NC(=O)Nc4cccc(C)c4)ccc3n2)cc1
Show InChI InChI=1S/C23H21N5O2/c1-15-4-3-5-17(12-15)26-23(29)27-18-8-11-20-21(13-18)24-14-22(28-20)25-16-6-9-19(30-2)10-7-16/h3-14H,1-2H3,(H,25,28)(H2,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.10E+5n/an/an/an/an/an/a



Ain Shams University, Abassia, Cairo 11566, Egypt.



Assay Description
Assays are performed for 15 min at 30 °C, with 50 µM of P33-ATP in a final volume of 25 µL. The assays are terminated by spotting 20 &...


Bioorg Chem 16-26 (2014)


Article DOI: 10.1016/j.bioorg.2014.05.010
BindingDB Entry DOI: 10.7270/Q2JM289W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM113827
PNG
(1-(4-((6-Nitroquinoxalin-2-yl)amino)phenyl)-3-phen...)
Show SMILES [O-][N+](=O)c1ccc2nc(Nc3ccc(NC(=O)Nc4ccccc4)cc3)cnc2c1
Show InChI InChI=1S/C21H16N6O3/c28-21(24-14-4-2-1-3-5-14)25-16-8-6-15(7-9-16)23-20-13-22-19-12-17(27(29)30)10-11-18(19)26-20/h1-13H,(H,23,26)(H2,24,25,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.68E+5n/an/an/an/an/an/a



Ain Shams University, Abassia, Cairo 11566, Egypt.



Assay Description
Assays are performed for 15 min at 30 °C, with 50 µM of P33-ATP in a final volume of 25 µL. The assays are terminated by spotting 20 &...


Bioorg Chem 16-26 (2014)


Article DOI: 10.1016/j.bioorg.2014.05.010
BindingDB Entry DOI: 10.7270/Q2JM289W
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%