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PubMed code 24934571

Compile data set for download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020725
PNG
(CHEMBL3291439)
Show SMILES COc1ccc(-c2nc(c(-c3ccc(Cl)cc3)n2C(=O)N2CCN(CCO)CC2)-c2ccc(Cl)cc2)c(OC(C)C)c1
Show InChI InChI=1S/C32H34Cl2N4O4/c1-21(2)42-28-20-26(41-3)12-13-27(28)31-35-29(22-4-8-24(33)9-5-22)30(23-6-10-25(34)11-7-23)38(31)32(40)37-16-14-36(15-17-37)18-19-39/h4-13,20-21,39H,14-19H2,1-3H3
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PubMed
n/an/a 260n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020716
PNG
(CHEMBL3286447)
Show SMILES Cc1[nH]c(c(c1-c1ccnc2nc3ccccc3n12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C27H20N4/c1-18-24(23-16-17-28-27-30-21-14-8-9-15-22(21)31(23)27)25(19-10-4-2-5-11-19)26(29-18)20-12-6-3-7-13-20/h2-17,29H,1H3
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n/an/a 360n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020717
PNG
(CHEMBL3291433)
Show SMILES Cc1[nH]c(c(c1-c1ccnc2[nH]c(=S)[nH]c(=O)c12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H18N4OS/c1-14-18(17-12-13-25-22-20(17)23(29)28-24(30)27-22)19(15-8-4-2-5-9-15)21(26-14)16-10-6-3-7-11-16/h2-13,26H,1H3,(H2,25,27,28,29,30)
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n/an/a 440n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020724
PNG
(CHEMBL3291438)
Show SMILES CCOC(=O)c1ccc([nH]c1=O)-c1c(C)[nH]c(c1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C25H22N2O3/c1-3-30-25(29)19-14-15-20(27-24(19)28)21-16(2)26-23(18-12-8-5-9-13-18)22(21)17-10-6-4-7-11-17/h4-15,26H,3H2,1-2H3,(H,27,28)
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n/an/a 550n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020723
PNG
(CHEMBL3291437)
Show SMILES Cc1[nH]c(c(c1-c1ccc(C#N)c(=O)[nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H17N3O/c1-15-20(19-13-12-18(14-24)23(27)26-19)21(16-8-4-2-5-9-16)22(25-15)17-10-6-3-7-11-17/h2-13,25H,1H3,(H,26,27)
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n/an/a 570n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020722
PNG
(CHEMBL3291436)
Show SMILES CCOC(=O)c1ccc(nc1-c1ccccc1)-c1c(C)[nH]c(c1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C31H26N2O2/c1-3-35-31(34)25-19-20-26(33-29(25)23-15-9-5-10-16-23)27-21(2)32-30(24-17-11-6-12-18-24)28(27)22-13-7-4-8-14-22/h4-20,32H,3H2,1-2H3
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n/an/a 610n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020721
PNG
(CHEMBL3291435)
Show SMILES CCOC(=O)c1ccc(nc1C)-c1c(C)[nH]c(c1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C26H24N2O2/c1-4-30-26(29)21-15-16-22(27-17(21)2)23-18(3)28-25(20-13-9-6-10-14-20)24(23)19-11-7-5-8-12-19/h5-16,28H,4H2,1-3H3
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n/an/a 780n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020720
PNG
(CHEMBL3291434)
Show SMILES CC(=O)c1ccc(nc1C)-c1c(C)[nH]c(c1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C25H22N2O/c1-16-21(18(3)28)14-15-22(26-16)23-17(2)27-25(20-12-8-5-9-13-20)24(23)19-10-6-4-7-11-19/h4-15,27H,1-3H3
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n/an/a 810n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020715
PNG
(CHEMBL3291222)
Show SMILES Cc1[nH]c(c(c1-c1ccnc2nnnn12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H16N6/c1-14-18(17-12-13-22-21-24-25-26-27(17)21)19(15-8-4-2-5-9-15)20(23-14)16-10-6-3-7-11-16/h2-13,23H,1H3
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n/an/a 840n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020726
PNG
(CHEMBL3291221)
Show SMILES Cc1[nH]c(c(c1-c1ccnc2ncnn12)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H17N5/c1-15-19(18-12-13-23-22-24-14-25-27(18)22)20(16-8-4-2-5-9-16)21(26-15)17-10-6-3-7-11-17/h2-14,26H,1H3
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n/an/a 890n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020727
PNG
(CHEMBL3291220)
Show SMILES Cc1[nH]c(c(c1-c1ccnc2c(cnn12)C#N)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H17N5/c1-16-21(20-12-13-26-24-19(14-25)15-27-29(20)24)22(17-8-4-2-5-9-17)23(28-16)18-10-6-3-7-11-18/h2-13,15,28H,1H3
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n/an/a 910n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020728
PNG
(CHEMBL3291219)
Show SMILES Cc1[nH]c(c(c1-c1ccon1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C20H16N2O/c1-14-18(17-12-13-23-22-17)19(15-8-4-2-5-9-15)20(21-14)16-10-6-3-7-11-16/h2-13,21H,1H3
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n/an/a 940n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020729
PNG
(CHEMBL3291218)
Show SMILES Cc1[nH]c(c(c1-c1ccnn1-c1ccccc1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C26H21N3/c1-19-24(23-17-18-27-29(23)22-15-9-4-10-16-22)25(20-11-5-2-6-12-20)26(28-19)21-13-7-3-8-14-21/h2-18,28H,1H3
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n/an/a 970n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM50020714
PNG
(CHEMBL3291217)
Show SMILES Cc1[nH]c(c(c1-c1ccn[nH]1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C20H15N3/c1-14-18(17-12-13-21-23-17)19(15-8-4-2-5-9-15)20(22-14)16-10-6-3-7-11-16/h2-13H,1H3/b18-17+
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n/an/a 990n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53...


Eur J Med Chem 82: 472-9 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%