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PubMed code 25084145

Compile data set for download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dynamin-2


(Rattus norvegicus)
BDBM50055861
PNG
(CHEMBL3329968)
Show SMILES OC(=O)c1ccc(NC2=CC(=O)C(Nc3ccc(cc3)C(O)=O)=CC2=O)cc1
Show InChI InChI=1S/C20H14N2O6/c23-17-10-16(22-14-7-3-12(4-8-14)20(27)28)18(24)9-15(17)21-13-5-1-11(2-6-13)19(25)26/h1-10,21-22H,(H,25,26)(H,27,28)
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Article
PubMed
n/an/a 9.10E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of phosphatidylserine-stimulated GTPase activity of recombinant rat Dynamin 2 expressed in Sf21 cells assessed as inhibition of orthophosp...


Eur J Med Chem 85: 191-206 (2014)


Article DOI: 10.1016/j.ejmech.2014.06.070
BindingDB Entry DOI: 10.7270/Q28G8NCR
More data for this
Ligand-Target Pair
Dynamin-2


(Rattus norvegicus)
BDBM50055860
PNG
(CHEMBL3329967)
Show SMILES OC(=O)c1cccc(NC2=CC(=O)C(Nc3cccc(c3)C(O)=O)=CC2=O)c1
Show InChI InChI=1S/C20H14N2O6/c23-17-10-16(22-14-6-2-4-12(8-14)20(27)28)18(24)9-15(17)21-13-5-1-3-11(7-13)19(25)26/h1-10,21-22H,(H,25,26)(H,27,28)
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PubMed
n/an/a 1.47E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of phosphatidylserine-stimulated GTPase activity of recombinant rat Dynamin 2 expressed in Sf21 cells assessed as inhibition of orthophosp...


Eur J Med Chem 85: 191-206 (2014)


Article DOI: 10.1016/j.ejmech.2014.06.070
BindingDB Entry DOI: 10.7270/Q28G8NCR
More data for this
Ligand-Target Pair
Dynamin-2


(Rattus norvegicus)
BDBM50055859
PNG
(CHEMBL3329966)
Show SMILES Oc1ccc(NC2=CC(=O)C(Nc3ccc(O)cc3)=CC2=O)cc1
Show InChI InChI=1S/C18H14N2O4/c21-13-5-1-11(2-6-13)19-15-9-18(24)16(10-17(15)23)20-12-3-7-14(22)8-4-12/h1-10,19-22H
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PubMed
n/an/a 2.36E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of phosphatidylserine-stimulated GTPase activity of recombinant rat Dynamin 2 expressed in Sf21 cells assessed as inhibition of orthophosp...


Eur J Med Chem 85: 191-206 (2014)


Article DOI: 10.1016/j.ejmech.2014.06.070
BindingDB Entry DOI: 10.7270/Q28G8NCR
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50055859
PNG
(CHEMBL3329966)
Show SMILES Oc1ccc(NC2=CC(=O)C(Nc3ccc(O)cc3)=CC2=O)cc1
Show InChI InChI=1S/C18H14N2O4/c21-13-5-1-11(2-6-13)19-15-9-18(24)16(10-17(15)23)20-12-3-7-14(22)8-4-12/h1-10,19-22H
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n/an/a 3.60E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of Dynamin 1 in serum-starved human U2OS cells assessed as inhibition of clathrin-mediated Alexa-495-cojugated transferrin uptake pretreat...


Eur J Med Chem 85: 191-206 (2014)


Article DOI: 10.1016/j.ejmech.2014.06.070
BindingDB Entry DOI: 10.7270/Q28G8NCR
More data for this
Ligand-Target Pair
Dynamin-2


(Rattus norvegicus)
BDBM50055862
PNG
(CHEMBL3329969)
Show SMILES Oc1cccc(NC2=CC(=O)C(Nc3cccc(O)c3)=CC2=O)c1
Show InChI InChI=1S/C18H14N2O4/c21-13-5-1-3-11(7-13)19-15-9-18(24)16(10-17(15)23)20-12-4-2-6-14(22)8-12/h1-10,19-22H
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Article
PubMed
n/an/a 4.37E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of phosphatidylserine-stimulated GTPase activity of recombinant rat Dynamin 2 expressed in Sf21 cells assessed as inhibition of orthophosp...


Eur J Med Chem 85: 191-206 (2014)


Article DOI: 10.1016/j.ejmech.2014.06.070
BindingDB Entry DOI: 10.7270/Q28G8NCR
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50055863
PNG
(CHEMBL2252571)
Show SMILES O=C1C=C(NCc2ccccc2)C(=O)C=C1NCc1ccccc1
Show InChI InChI=1S/C20H18N2O2/c23-19-12-18(22-14-16-9-5-2-6-10-16)20(24)11-17(19)21-13-15-7-3-1-4-8-15/h1-12,21-22H,13-14H2
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PubMed
n/an/a 1.20E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of Dynamin 1 in serum-starved human U2OS cells assessed as inhibition of clathrin-mediated Alexa-495-cojugated transferrin uptake pretreat...


Eur J Med Chem 85: 191-206 (2014)


Article DOI: 10.1016/j.ejmech.2014.06.070
BindingDB Entry DOI: 10.7270/Q28G8NCR
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50266767
PNG
(2,2'-(3,6-dioxocyclohexa-1,4-diene-1,4-diyl)bis(az...)
Show SMILES OC(=O)c1ccccc1NC1=CC(=O)C(Nc2ccccc2C(O)=O)=CC1=O
Show InChI InChI=1S/C20H14N2O6/c23-17-10-16(22-14-8-4-2-6-12(14)20(27)28)18(24)9-15(17)21-13-7-3-1-5-11(13)19(25)26/h1-10,21-22H,(H,25,26)(H,27,28)
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Article
PubMed
n/an/a 1.62E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of Dynamin 1 in serum-starved human U2OS cells assessed as inhibition of clathrin-mediated Alexa-495-cojugated transferrin uptake pretreat...


Eur J Med Chem 85: 191-206 (2014)


Article DOI: 10.1016/j.ejmech.2014.06.070
BindingDB Entry DOI: 10.7270/Q28G8NCR
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50055861
PNG
(CHEMBL3329968)
Show SMILES OC(=O)c1ccc(NC2=CC(=O)C(Nc3ccc(cc3)C(O)=O)=CC2=O)cc1
Show InChI InChI=1S/C20H14N2O6/c23-17-10-16(22-14-7-3-12(4-8-14)20(27)28)18(24)9-15(17)21-13-5-1-11(2-6-13)19(25)26/h1-10,21-22H,(H,25,26)(H,27,28)
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PubMed
n/an/a 2.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of Dynamin 1 in serum-starved human U2OS cells assessed as inhibition of clathrin-mediated Alexa-495-cojugated transferrin uptake pretreat...


Eur J Med Chem 85: 191-206 (2014)


Article DOI: 10.1016/j.ejmech.2014.06.070
BindingDB Entry DOI: 10.7270/Q28G8NCR
More data for this
Ligand-Target Pair
Dynamin-1


(Homo sapiens)
BDBM50055860
PNG
(CHEMBL3329967)
Show SMILES OC(=O)c1cccc(NC2=CC(=O)C(Nc3cccc(c3)C(O)=O)=CC2=O)c1
Show InChI InChI=1S/C20H14N2O6/c23-17-10-16(22-14-6-2-4-12(8-14)20(27)28)18(24)9-15(17)21-13-5-1-3-11(7-13)19(25)26/h1-10,21-22H,(H,25,26)(H,27,28)
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n/an/a>3.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of Dynamin 1 in serum-starved human U2OS cells assessed as inhibition of clathrin-mediated Alexa-495-cojugated transferrin uptake pretreat...


Eur J Med Chem 85: 191-206 (2014)


Article DOI: 10.1016/j.ejmech.2014.06.070
BindingDB Entry DOI: 10.7270/Q28G8NCR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%