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PubMed code 25088191

Compile data set for download or QSAR
Found 77 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50055992
PNG
(CHEMBL3325842)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H26FN5O5S/c1-12(2)30-20(27)26-9-7-14(8-10-26)31-19-17(21)18(22-11-23-19)25-15-5-6-16(24-13(15)3)32(4,28)29/h5-6,11-12,14H,7-10H2,1-4H3,(H,22,23,25)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9 (unknown origin)


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50364559
PNG
(CHEMBL1951032)
Show SMILES COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9 (unknown origin)


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (human))
BDBM50056004
PNG
(CHEMBL3326667)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2(C)CC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O6S/c1-13-15(4-5-16(25-13)33(3,28)29)31-19-17(22)18(23-12-24-19)30-14-6-10-26(11-7-14)20(27)32-21(2)8-9-21/h4-5,12,14H,6-11H2,1-3H3
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n/an/a 2.34E+4n/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19 (unknown origin)


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50056004
PNG
(CHEMBL3326667)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2(C)CC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O6S/c1-13-15(4-5-16(25-13)33(3,28)29)31-19-17(22)18(23-12-24-19)30-14-6-10-26(11-7-14)20(27)32-21(2)8-9-21/h4-5,12,14H,6-11H2,1-3H3
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n/an/a 2.57E+4n/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9 (unknown origin)


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50055993
PNG
(CHEMBL3325843)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H25FN4O6S/c1-12(2)29-20(26)25-9-7-14(8-10-25)30-18-17(21)19(23-11-22-18)31-15-5-6-16(24-13(15)3)32(4,27)28/h5-6,11-12,14H,7-10H2,1-4H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9 (unknown origin)


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364559
PNG
(CHEMBL1951032)
Show SMILES COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
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n/an/an/an/a 46n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056000
PNG
(CHEMBL3325850)
Show SMILES C[C@H](CF)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H24F2N4O6S/c1-12(10-21)30-20(27)26-8-6-14(7-9-26)31-18-17(22)19(24-11-23-18)32-15-4-5-16(25-13(15)2)33(3,28)29/h4-5,11-12,14H,6-10H2,1-3H3/t12-/m1/s1
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n/an/an/an/a 196n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056003
PNG
(CHEMBL3326666)
Show SMILES C[C@H](OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F)C(F)(F)F
Show InChI InChI=1S/C20H22F4N4O6S/c1-11-14(4-5-15(27-11)35(3,30)31)34-18-16(21)17(25-10-26-18)33-13-6-8-28(9-7-13)19(29)32-12(2)20(22,23)24/h4-5,10,12-13H,6-9H2,1-3H3/t12-/m0/s1
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n/an/an/an/a 9.90n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056033
PNG
(CHEMBL3326686)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)c2noc(n2)C(C)(C)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C22H24F2N6O6S/c1-12-14(5-6-15(27-12)37(4,32)33)35-19-16(23)18(25-11-26-19)34-13-7-9-30(10-8-13)20(31)17-28-21(36-29-17)22(2,3)24/h5-6,11,13H,7-10H2,1-4H3
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n/an/an/an/a 14n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056000
PNG
(CHEMBL3325850)
Show SMILES C[C@H](CF)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H24F2N4O6S/c1-12(10-21)30-20(27)26-8-6-14(7-9-26)31-18-17(22)19(24-11-23-18)32-15-4-5-16(25-13(15)2)33(3,28)29/h4-5,11-12,14H,6-10H2,1-3H3/t12-/m1/s1
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n/an/an/an/a 1.52E+3n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056009
PNG
(CHEMBL3326672)
Show SMILES CC(C)SC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H25FN4O5S2/c1-12(2)31-20(26)25-9-7-14(8-10-25)29-18-17(21)19(23-11-22-18)30-15-5-6-16(24-13(15)3)32(4,27)28/h5-6,11-12,14H,7-10H2,1-4H3
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n/an/an/an/a 41n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056010
PNG
(CHEMBL3326673)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)SC(C)(C)C)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H27FN4O5S2/c1-13-15(6-7-16(25-13)33(5,28)29)31-19-17(22)18(23-12-24-19)30-14-8-10-26(11-9-14)20(27)32-21(2,3)4/h6-7,12,14H,8-11H2,1-5H3
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n/an/an/an/a 31n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056016
PNG
(CHEMBL3326680)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)C(C)(F)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C19H21F3N4O5S/c1-11-13(4-5-14(25-11)32(3,28)29)31-17-15(20)16(23-10-24-17)30-12-6-8-26(9-7-12)18(27)19(2,21)22/h4-5,10,12H,6-9H2,1-3H3
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n/an/an/an/a 239n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056033
PNG
(CHEMBL3326686)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)c2noc(n2)C(C)(C)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C22H24F2N6O6S/c1-12-14(5-6-15(27-12)37(4,32)33)35-19-16(23)18(25-11-26-19)34-13-7-9-30(10-8-13)20(31)17-28-21(36-29-17)22(2,3)24/h5-6,11,13H,7-10H2,1-4H3
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n/an/an/an/a 103n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50055993
PNG
(CHEMBL3325843)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H25FN4O6S/c1-12(2)29-20(26)25-9-7-14(8-10-25)30-18-17(21)19(23-11-22-18)31-15-5-6-16(24-13(15)3)32(4,27)28/h5-6,11-12,14H,7-10H2,1-4H3
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n/an/an/an/a 21n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056005
PNG
(CHEMBL3326668)
Show SMILES CCC1(CC1)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C22H27FN4O6S/c1-4-22(9-10-22)33-21(28)27-11-7-15(8-12-27)31-19-18(23)20(25-13-24-19)32-16-5-6-17(26-14(16)2)34(3,29)30/h5-6,13,15H,4,7-12H2,1-3H3
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n/an/an/an/a 22n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056015
PNG
(CHEMBL3326679)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)C(F)(F)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C18H18F4N4O5S/c1-10-12(3-4-13(25-10)32(2,28)29)31-16-14(19)15(23-9-24-16)30-11-5-7-26(8-6-11)17(27)18(20,21)22/h3-4,9,11H,5-8H2,1-2H3
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n/an/an/an/a 151n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056005
PNG
(CHEMBL3326668)
Show SMILES CCC1(CC1)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C22H27FN4O6S/c1-4-22(9-10-22)33-21(28)27-11-7-15(8-12-27)31-19-18(23)20(25-13-24-19)32-16-5-6-17(26-14(16)2)34(3,29)30/h5-6,13,15H,4,7-12H2,1-3H3
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n/an/an/an/a 333n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50055995
PNG
(CHEMBL3325845)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2CCC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O6S/c1-13-16(6-7-17(25-13)33(2,28)29)32-20-18(22)19(23-12-24-20)30-15-8-10-26(11-9-15)21(27)31-14-4-3-5-14/h6-7,12,14-15H,3-5,8-11H2,1-2H3
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n/an/an/an/a 14n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056022
PNG
(CHEMBL3326685)
Show SMILES CC(C)c1nc(no1)C(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C22H25FN6O6S/c1-12(2)19-27-18(28-35-19)22(30)29-9-7-14(8-10-29)33-20-17(23)21(25-11-24-20)34-15-5-6-16(26-13(15)3)36(4,31)32/h5-6,11-12,14H,7-10H2,1-4H3
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n/an/an/an/a 21n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364559
PNG
(CHEMBL1951032)
Show SMILES COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
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n/an/an/an/a 421n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50055994
PNG
(CHEMBL3325844)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC(C)(C)C)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H27FN4O6S/c1-13-15(6-7-16(25-13)33(5,28)29)31-19-17(22)18(23-12-24-19)30-14-8-10-26(11-9-14)20(27)32-21(2,3)4/h6-7,12,14H,8-11H2,1-5H3
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n/an/an/an/a 50n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50055996
PNG
(CHEMBL3325846)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC(C)(C)C(F)(F)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H24F4N4O6S/c1-12-14(5-6-15(28-12)36(4,31)32)34-18-16(22)17(26-11-27-18)33-13-7-9-29(10-8-13)19(30)35-20(2,3)21(23,24)25/h5-6,11,13H,7-10H2,1-4H3
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n/an/an/an/a 47n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056004
PNG
(CHEMBL3326667)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2(C)CC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O6S/c1-13-15(4-5-16(25-13)33(3,28)29)31-19-17(22)18(23-12-24-19)30-14-6-10-26(11-7-14)20(27)32-21(2)8-9-21/h4-5,12,14H,6-11H2,1-3H3
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n/an/an/an/a 169n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056014
PNG
(CHEMBL3326677)
Show SMILES CC(C)OC(=S)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H25FN4O5S2/c1-12(2)28-20(31)25-9-7-14(8-10-25)29-18-17(21)19(23-11-22-18)30-15-5-6-16(24-13(15)3)32(4,26)27/h5-6,11-12,14H,7-10H2,1-4H3
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n/an/an/an/a 1.05E+3n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056018
PNG
(CHEMBL3326681)
Show SMILES CCC(F)(F)C(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H23F3N4O5S/c1-4-20(22,23)19(28)27-9-7-13(8-10-27)31-17-16(21)18(25-11-24-17)32-14-5-6-15(26-12(14)2)33(3,29)30/h5-6,11,13H,4,7-10H2,1-3H3
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n/an/an/an/a 69n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056019
PNG
(CHEMBL3326682)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)C2(F)CCC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H24F2N4O5S/c1-13-15(4-5-16(26-13)33(2,29)30)32-19-17(22)18(24-12-25-19)31-14-6-10-27(11-7-14)20(28)21(23)8-3-9-21/h4-5,12,14H,3,6-11H2,1-2H3
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n/an/an/an/a 123n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056022
PNG
(CHEMBL3326685)
Show SMILES CC(C)c1nc(no1)C(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C22H25FN6O6S/c1-12(2)19-27-18(28-35-19)22(30)29-9-7-14(8-10-29)33-20-17(23)21(25-11-24-20)34-15-5-6-16(26-13(15)3)36(4,31)32/h5-6,11-12,14H,7-10H2,1-4H3
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n/an/an/an/a 176n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056010
PNG
(CHEMBL3326673)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)SC(C)(C)C)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H27FN4O5S2/c1-13-15(6-7-16(25-13)33(5,28)29)31-19-17(22)18(23-12-24-19)30-14-8-10-26(11-9-14)20(27)32-21(2,3)4/h6-7,12,14H,8-11H2,1-5H3
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n/an/an/an/a 4.80n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056011
PNG
(CHEMBL3326674)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)SC2CC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C20H23FN4O5S2/c1-12-15(5-6-16(24-12)32(2,27)28)30-19-17(21)18(22-11-23-19)29-13-7-9-25(10-8-13)20(26)31-14-3-4-14/h5-6,11,13-14H,3-4,7-10H2,1-2H3
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n/an/an/an/a 25n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056016
PNG
(CHEMBL3326680)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)C(C)(F)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C19H21F3N4O5S/c1-11-13(4-5-14(25-11)32(3,28)29)31-17-15(20)16(23-10-24-17)30-12-6-8-26(9-7-12)18(27)19(2,21)22/h4-5,10,12H,6-9H2,1-3H3
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n/an/an/an/a 37n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056019
PNG
(CHEMBL3326682)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)C2(F)CCC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H24F2N4O5S/c1-13-15(4-5-16(26-13)33(2,29)30)32-19-17(22)18(24-12-25-19)31-14-6-10-27(11-7-14)20(28)21(23)8-3-9-21/h4-5,12,14H,3,6-11H2,1-2H3
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n/an/an/an/a 25n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056104
PNG
(CHEMBL3326689)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)c2ncc(Cl)cn2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H20ClFN6O5S/c1-12-15(3-4-16(28-12)35(2,31)32)34-20-17(23)19(26-11-27-20)33-14-5-7-29(8-6-14)21(30)18-24-9-13(22)10-25-18/h3-4,9-11,14H,5-8H2,1-2H3
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n/an/an/an/a 6.10n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50055998
PNG
(CHEMBL3325848)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC(C)(C)CF)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H26F2N4O6S/c1-13-15(5-6-16(26-13)34(4,29)30)32-19-17(23)18(24-12-25-19)31-14-7-9-27(10-8-14)20(28)33-21(2,3)11-22/h5-6,12,14H,7-11H2,1-4H3
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n/an/an/an/a 138n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056011
PNG
(CHEMBL3326674)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)SC2CC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C20H23FN4O5S2/c1-12-15(5-6-16(24-12)32(2,27)28)30-19-17(21)18(22-11-23-19)29-13-7-9-25(10-8-13)20(26)31-14-3-4-14/h5-6,11,13-14H,3-4,7-10H2,1-2H3
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n/an/an/an/a 126n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056053
PNG
(CHEMBL3326687)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)c2nc(no2)C(C)(C)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C22H24F2N6O6S/c1-12-14(5-6-15(27-12)37(4,32)33)35-18-16(23)17(25-11-26-18)34-13-7-9-30(10-8-13)20(31)19-28-21(29-36-19)22(2,3)24/h5-6,11,13H,7-10H2,1-4H3
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n/an/an/an/a 606n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50055997
PNG
(CHEMBL3325847)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC(C)(C)C#N)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H24FN5O6S/c1-13-15(5-6-16(26-13)34(4,29)30)32-19-17(22)18(24-12-25-19)31-14-7-9-27(10-8-14)20(28)33-21(2,3)11-23/h5-6,12,14H,7-10H2,1-4H3
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n/an/an/an/a 93n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50055999
PNG
(CHEMBL3325849)
Show SMILES CC(F)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C19H22F2N4O6S/c1-11-14(4-5-15(24-11)32(3,27)28)31-18-16(21)17(22-10-23-18)30-13-6-8-25(9-7-13)19(26)29-12(2)20/h4-5,10,12-13H,6-9H2,1-3H3
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n/an/an/an/a 66n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056006
PNG
(CHEMBL3326669)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2COC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C20H23FN4O7S/c1-12-15(3-4-16(24-12)33(2,27)28)32-19-17(21)18(22-11-23-19)30-13-5-7-25(8-6-13)20(26)31-14-9-29-10-14/h3-4,11,13-14H,5-10H2,1-2H3
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n/an/an/an/a 326n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056009
PNG
(CHEMBL3326672)
Show SMILES CC(C)SC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H25FN4O5S2/c1-12(2)31-20(26)25-9-7-14(8-10-25)29-18-17(21)19(23-11-22-18)30-15-5-6-16(24-13(15)3)32(4,27)28/h5-6,11-12,14H,7-10H2,1-4H3
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n/an/an/an/a 6.80n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056053
PNG
(CHEMBL3326687)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)c2nc(no2)C(C)(C)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C22H24F2N6O6S/c1-12-14(5-6-15(27-12)37(4,32)33)35-18-16(23)17(25-11-26-18)34-13-7-9-30(10-8-13)20(31)19-28-21(29-36-19)22(2,3)24/h5-6,11,13H,7-10H2,1-4H3
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n/an/an/an/a 43n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50055992
PNG
(CHEMBL3325842)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H26FN5O5S/c1-12(2)30-20(27)26-9-7-14(8-10-26)31-19-17(21)18(22-11-23-19)25-15-5-6-16(24-13(15)3)32(4,28)29/h5-6,11-12,14H,7-10H2,1-4H3,(H,22,23,25)
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n/an/an/an/a 265n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50055999
PNG
(CHEMBL3325849)
Show SMILES CC(F)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C19H22F2N4O6S/c1-11-14(4-5-15(24-11)32(3,27)28)31-18-16(21)17(22-10-23-18)30-13-6-8-25(9-7-13)19(26)29-12(2)20/h4-5,10,12-13H,6-9H2,1-3H3
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n/an/an/an/a 315n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056008
PNG
(CHEMBL3326671)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2(COC2)C(F)(F)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H22F4N4O7S/c1-12-14(3-4-15(28-12)37(2,31)32)35-18-16(22)17(26-11-27-18)34-13-5-7-29(8-6-13)19(30)36-20(9-33-10-20)21(23,24)25/h3-4,11,13H,5-10H2,1-2H3
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n/an/an/an/a 342n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056020
PNG
(CHEMBL3326683)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)C2CCCC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27FN4O5S/c1-14-17(7-8-18(26-14)33(2,29)30)32-21-19(23)20(24-13-25-21)31-16-9-11-27(12-10-16)22(28)15-5-3-4-6-15/h7-8,13,15-16H,3-6,9-12H2,1-2H3
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n/an/an/an/a 407n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056055
PNG
(CHEMBL3326688)
Show SMILES CCc1cnc(nc1)C(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C23H25FN6O5S/c1-4-15-11-25-20(26-12-15)23(31)30-9-7-16(8-10-30)34-21-19(24)22(28-13-27-21)35-17-5-6-18(29-14(17)2)36(3,32)33/h5-6,11-13,16H,4,7-10H2,1-3H3
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n/an/an/an/a 41n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50055992
PNG
(CHEMBL3325842)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H26FN5O5S/c1-12(2)30-20(27)26-9-7-14(8-10-26)31-19-17(21)18(22-11-23-19)25-15-5-6-16(24-13(15)3)32(4,28)29/h5-6,11-12,14H,7-10H2,1-4H3,(H,22,23,25)
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n/an/an/an/a 132n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50055996
PNG
(CHEMBL3325846)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC(C)(C)C(F)(F)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H24F4N4O6S/c1-12-14(5-6-15(28-12)36(4,31)32)34-18-16(22)17(26-11-27-18)33-13-7-9-29(10-8-13)19(30)35-20(2,3)21(23,24)25/h5-6,11,13H,7-10H2,1-4H3
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n/an/an/an/a 6.5n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056012
PNG
(CHEMBL3326675)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)SC2(C)CC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O5S2/c1-13-15(4-5-16(25-13)33(3,28)29)31-19-17(22)18(23-12-24-19)30-14-6-10-26(11-7-14)20(27)32-21(2)8-9-21/h4-5,12,14H,6-11H2,1-3H3
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n/an/an/an/a 13n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056013
PNG
(CHEMBL3326676)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)SC2CCC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O5S2/c1-13-16(6-7-17(25-13)33(2,28)29)31-20-18(22)19(23-12-24-20)30-14-8-10-26(11-9-14)21(27)32-15-4-3-5-15/h6-7,12,14-15H,3-5,8-11H2,1-2H3
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n/an/an/an/a 8.5n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056018
PNG
(CHEMBL3326681)
Show SMILES CCC(F)(F)C(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H23F3N4O5S/c1-4-20(22,23)19(28)27-9-7-13(8-10-27)31-17-16(21)18(25-11-24-17)32-14-5-6-15(26-12(14)2)33(3,29)30/h5-6,11,13H,4,7-10H2,1-3H3
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n/an/an/an/a 17n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056021
PNG
(CHEMBL3326684)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)C2(C)CC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O5S/c1-13-15(4-5-16(25-13)32(3,28)29)31-19-17(22)18(23-12-24-19)30-14-6-10-26(11-7-14)20(27)21(2)8-9-21/h4-5,12,14H,6-11H2,1-3H3
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n/an/an/an/a 761n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056055
PNG
(CHEMBL3326688)
Show SMILES CCc1cnc(nc1)C(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C23H25FN6O5S/c1-4-15-11-25-20(26-12-15)23(31)30-9-7-16(8-10-30)34-21-19(24)22(28-13-27-21)35-17-5-6-18(29-14(17)2)36(3,32)33/h5-6,11-13,16H,4,7-10H2,1-3H3
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n/an/an/an/a 4.70n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50055995
PNG
(CHEMBL3325845)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2CCC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O6S/c1-13-16(6-7-17(25-13)33(2,28)29)32-20-18(22)19(23-12-24-20)30-15-8-10-26(11-9-15)21(27)31-14-4-3-5-14/h6-7,12,14-15H,3-5,8-11H2,1-2H3
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n/an/an/an/a 167n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056002
PNG
(CHEMBL3325852)
Show SMILES C[C@@H](OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F)C(F)(F)F
Show InChI InChI=1S/C20H22F4N4O6S/c1-11-14(4-5-15(27-11)35(3,30)31)34-18-16(21)17(25-10-26-18)33-13-6-8-28(9-7-13)19(29)32-12(2)20(22,23)24/h4-5,10,12-13H,6-9H2,1-3H3/t12-/m1/s1
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n/an/an/an/a 110n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056012
PNG
(CHEMBL3326675)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)SC2(C)CC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O5S2/c1-13-15(4-5-16(25-13)33(3,28)29)31-19-17(22)18(23-12-24-19)30-14-6-10-26(11-7-14)20(27)32-21(2)8-9-21/h4-5,12,14H,6-11H2,1-3H3
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n/an/an/an/a 166n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056015
PNG
(CHEMBL3326679)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)C(F)(F)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C18H18F4N4O5S/c1-10-12(3-4-13(25-10)32(2,28)29)31-16-14(19)15(23-9-24-16)30-11-5-7-26(8-6-11)17(27)18(20,21)22/h3-4,9,11H,5-8H2,1-2H3
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n/an/an/an/a 880n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056002
PNG
(CHEMBL3325852)
Show SMILES C[C@@H](OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F)C(F)(F)F
Show InChI InChI=1S/C20H22F4N4O6S/c1-11-14(4-5-15(27-11)35(3,30)31)34-18-16(21)17(25-10-26-18)33-13-6-8-28(9-7-13)19(29)32-12(2)20(22,23)24/h4-5,10,12-13H,6-9H2,1-3H3/t12-/m1/s1
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n/an/an/an/a 9.20n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056004
PNG
(CHEMBL3326667)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2(C)CC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O6S/c1-13-15(4-5-16(25-13)33(3,28)29)31-19-17(22)18(23-12-24-19)30-14-6-10-26(11-7-14)20(27)32-21(2)8-9-21/h4-5,12,14H,6-11H2,1-3H3
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n/an/an/an/a 14n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056008
PNG
(CHEMBL3326671)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2(COC2)C(F)(F)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H22F4N4O7S/c1-12-14(3-4-15(28-12)37(2,31)32)35-18-16(22)17(26-11-27-18)34-13-5-7-29(8-6-13)19(30)36-20(9-33-10-20)21(23,24)25/h3-4,11,13H,5-10H2,1-2H3
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n/an/an/an/a 29n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50055997
PNG
(CHEMBL3325847)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC(C)(C)C#N)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H24FN5O6S/c1-13-15(5-6-16(26-13)34(4,29)30)32-19-17(22)18(24-12-25-19)31-14-7-9-27(10-8-14)20(28)33-21(2,3)11-23/h5-6,12,14H,7-10H2,1-4H3
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n/an/an/an/a 1.32E+3n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056007
PNG
(CHEMBL3326670)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2(CCC2)C(F)(F)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C22H24F4N4O6S/c1-13-15(4-5-16(29-13)37(2,32)33)35-19-17(23)18(27-12-28-19)34-14-6-10-30(11-7-14)20(31)36-21(8-3-9-21)22(24,25)26/h4-5,12,14H,3,6-11H2,1-2H3
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n/an/an/an/a 63n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056013
PNG
(CHEMBL3326676)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)SC2CCC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O5S2/c1-13-16(6-7-17(25-13)33(2,28)29)31-20-18(22)19(23-12-24-20)30-14-8-10-26(11-9-14)21(27)32-15-4-3-5-15/h6-7,12,14-15H,3-5,8-11H2,1-2H3
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n/an/an/an/a 77n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056105
PNG
(CHEMBL3326678)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=S)OC2(C)CC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O5S2/c1-13-15(4-5-16(25-13)33(3,27)28)30-19-17(22)18(23-12-24-19)29-14-6-10-26(11-7-14)20(32)31-21(2)8-9-21/h4-5,12,14H,6-11H2,1-3H3
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n/an/an/an/a 49n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056104
PNG
(CHEMBL3326689)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)c2ncc(Cl)cn2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H20ClFN6O5S/c1-12-15(3-4-16(28-12)35(2,31)32)34-20-17(23)19(26-11-27-20)33-14-5-7-29(8-6-14)21(30)18-24-9-13(22)10-25-18/h3-4,9-11,14H,5-8H2,1-2H3
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n/an/an/an/a 31n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50055994
PNG
(CHEMBL3325844)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC(C)(C)C)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H27FN4O6S/c1-13-15(6-7-16(25-13)33(5,28)29)31-19-17(22)18(23-12-24-19)30-14-8-10-26(11-9-14)20(27)32-21(2,3)4/h6-7,12,14H,8-11H2,1-5H3
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n/an/an/an/a 7.90n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50055998
PNG
(CHEMBL3325848)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC(C)(C)CF)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H26F2N4O6S/c1-13-15(5-6-16(26-13)34(4,29)30)32-19-17(23)18(24-12-25-19)31-14-7-9-27(10-8-14)20(28)33-21(2,3)11-22/h5-6,12,14H,7-11H2,1-4H3
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n/an/an/an/a 20n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056001
PNG
(CHEMBL3325851)
Show SMILES C[C@@H](CF)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H24F2N4O6S/c1-12(10-21)30-20(27)26-8-6-14(7-9-26)31-18-17(22)19(24-11-23-18)32-15-4-5-16(25-13(15)2)33(3,28)29/h4-5,11-12,14H,6-10H2,1-3H3/t12-/m0/s1
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n/an/an/an/a 186n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056007
PNG
(CHEMBL3326670)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2(CCC2)C(F)(F)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C22H24F4N4O6S/c1-13-15(4-5-16(29-13)37(2,32)33)35-19-17(23)18(27-12-28-19)34-14-6-10-30(11-7-14)20(31)36-21(8-3-9-21)22(24,25)26/h4-5,12,14H,3,6-11H2,1-2H3
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n/an/an/an/a 14n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056014
PNG
(CHEMBL3326677)
Show SMILES CC(C)OC(=S)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H25FN4O5S2/c1-12(2)28-20(31)25-9-7-14(8-10-25)29-18-17(21)19(23-11-22-18)30-15-5-6-16(24-13(15)3)32(4,26)27/h5-6,11-12,14H,7-10H2,1-4H3
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n/an/an/an/a 70n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056017
PNG
(CHEMBL3325461)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)C(C)(C)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C20H24F2N4O5S/c1-12-14(5-6-15(25-12)32(4,28)29)31-18-16(21)17(23-11-24-18)30-13-7-9-26(10-8-13)19(27)20(2,3)22/h5-6,11,13H,7-10H2,1-4H3
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n/an/an/an/a 76n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056020
PNG
(CHEMBL3326683)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)C2CCCC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27FN4O5S/c1-14-17(7-8-18(26-14)33(2,29)30)32-21-19(23)20(24-13-25-21)31-16-9-11-27(12-10-16)22(28)15-5-3-4-6-15/h7-8,13,15-16H,3-6,9-12H2,1-2H3
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n/an/an/an/a 73n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50055993
PNG
(CHEMBL3325843)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H25FN4O6S/c1-12(2)29-20(26)25-9-7-14(8-10-25)30-18-17(21)19(23-11-22-18)31-15-5-6-16(24-13(15)3)32(4,27)28/h5-6,11-12,14H,7-10H2,1-4H3
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n/an/an/an/a 142n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056001
PNG
(CHEMBL3325851)
Show SMILES C[C@@H](CF)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F
Show InChI InChI=1S/C20H24F2N4O6S/c1-12(10-21)30-20(27)26-8-6-14(7-9-26)31-18-17(22)19(24-11-23-18)32-15-4-5-16(25-13(15)2)33(3,28)29/h4-5,11-12,14H,6-10H2,1-3H3/t12-/m0/s1
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n/an/an/an/a 1.68E+3n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056003
PNG
(CHEMBL3326666)
Show SMILES C[C@H](OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1F)C(F)(F)F
Show InChI InChI=1S/C20H22F4N4O6S/c1-11-14(4-5-15(27-11)35(3,30)31)34-18-16(21)17(25-10-26-18)33-13-6-8-28(9-7-13)19(29)32-12(2)20(22,23)24/h4-5,10,12-13H,6-9H2,1-3H3/t12-/m0/s1
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n/an/an/an/a 109n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056006
PNG
(CHEMBL3326669)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2COC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C20H23FN4O7S/c1-12-15(3-4-16(24-12)33(2,27)28)32-19-17(21)18(22-11-23-19)30-13-5-7-25(8-6-13)20(26)31-14-9-29-10-14/h3-4,11,13-14H,5-10H2,1-2H3
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n/an/an/an/a 2.50E+3n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056017
PNG
(CHEMBL3325461)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)C(C)(C)F)c1F)S(C)(=O)=O
Show InChI InChI=1S/C20H24F2N4O5S/c1-12-14(5-6-15(25-12)32(4,28)29)31-18-16(21)17(23-11-24-18)30-13-7-9-26(10-8-13)19(27)20(2,3)22/h5-6,11,13H,7-10H2,1-4H3
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n/an/an/an/a 296n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat GPR119 activity by homogeneous time resolved fluorescence cyclase (cAMP) assay


Bioorg Med Chem Lett 24: 4332-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.06.071
BindingDB Entry DOI: 10.7270/Q2C82BZ7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%