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PubMed code 25516785

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041564
PNG
(CHEMBL3358889)
Show SMILES CCn1nccc1Oc1cc(C[C@H]2C[C@](C)(O)C2)cnc1NC(=O)NC
Show InChI InChI=1S/C18H25N5O3/c1-4-23-15(5-6-21-23)26-14-8-12(7-13-9-18(2,25)10-13)11-20-16(14)22-17(24)19-3/h5-6,8,11,13,25H,4,7,9-10H2,1-3H3,(H2,19,20,22,24)/t13-,18-
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n/an/an/an/a 280n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose and 4% HSA


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041667
PNG
(CHEMBL3358888)
Show SMILES CCn1nccc1Oc1cc(C[C@H]2C[C@@](C)(O)C2)cnc1NC(=O)NC
Show InChI InChI=1S/C18H25N5O3/c1-4-23-15(5-6-21-23)26-14-8-12(7-13-9-18(2,25)10-13)11-20-16(14)22-17(24)19-3/h5-6,8,11,13,25H,4,7,9-10H2,1-3H3,(H2,19,20,22,24)/t13-,18+
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n/an/an/an/a 710n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041571
PNG
(CHEMBL3358428)
Show SMILES CCc1ncccc1Oc1cc(CCCCOC)cnc1NC(=O)NC
Show InChI InChI=1S/C19H26N4O3/c1-4-15-16(9-7-10-21-15)26-17-12-14(8-5-6-11-25-3)13-22-18(17)23-19(24)20-2/h7,9-10,12-13H,4-6,8,11H2,1-3H3,(H2,20,22,23,24)
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n/an/an/an/a 110n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041655
PNG
(CHEMBL3352877)
Show SMILES CCn1nc(COC)cc1Oc1cc(CC2CCOCC2)cnc1NC(=O)NC
Show InChI InChI=1S/C20H29N5O4/c1-4-25-18(11-16(24-25)13-27-3)29-17-10-15(9-14-5-7-28-8-6-14)12-22-19(17)23-20(26)21-2/h10-12,14H,4-9,13H2,1-3H3,(H2,21,22,23,26)
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n/an/an/an/a 820n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041661
PNG
(CHEMBL3358886)
Show SMILES CCn1nccc1Oc1cc(C[C@@H]2C[C@H](O)C2)cnc1NC(=O)NC
Show InChI InChI=1S/C17H23N5O3/c1-3-22-15(4-5-20-22)25-14-9-12(6-11-7-13(23)8-11)10-19-16(14)21-17(24)18-2/h4-5,9-11,13,23H,3,6-8H2,1-2H3,(H2,18,19,21,24)/t11-,13+
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n/an/an/an/a 530n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041607
PNG
(CHEMBL3358433)
Show SMILES CCc1ncccc1Oc1cc(CC2CCOCC2)cnc1NC(=O)NC
Show InChI InChI=1S/C20H26N4O3/c1-3-16-17(5-4-8-22-16)27-18-12-15(11-14-6-9-26-10-7-14)13-23-19(18)24-20(25)21-2/h4-5,8,12-14H,3,6-7,9-11H2,1-2H3,(H2,21,23,24,25)
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n/an/an/an/a 290n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041610
PNG
(CHEMBL3358436)
Show SMILES CCn1nccc1Oc1cc(CC2CCOCC2)cnc1NC(=O)NC
Show InChI InChI=1S/C18H25N5O3/c1-3-23-16(4-7-21-23)26-15-11-14(10-13-5-8-25-9-6-13)12-20-17(15)22-18(24)19-2/h4,7,11-13H,3,5-6,8-10H2,1-2H3,(H2,19,20,22,24)
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n/an/an/an/a 350n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041656
PNG
(CHEMBL3358442)
Show SMILES CCn1nccc1Oc1cc(C[C@H]2CC[C@H](O)CC2)cnc1NC(=O)NC
Show InChI InChI=1S/C19H27N5O3/c1-3-24-17(8-9-22-24)27-16-11-14(10-13-4-6-15(25)7-5-13)12-21-18(16)23-19(26)20-2/h8-9,11-13,15,25H,3-7,10H2,1-2H3,(H2,20,21,23,26)/t13-,15-
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n/an/an/an/a 68n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041658
PNG
(CHEMBL3358444)
Show SMILES CCn1nccc1Oc1cc(C[C@H]2CC[C@](C)(O)CC2)cnc1NC(=O)NC
Show InChI InChI=1S/C20H29N5O3/c1-4-25-17(7-10-23-25)28-16-12-15(13-22-18(16)24-19(26)21-3)11-14-5-8-20(2,27)9-6-14/h7,10,12-14,27H,4-6,8-9,11H2,1-3H3,(H2,21,22,24,26)/t14-,20-
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n/an/an/an/a 110n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041575
PNG
(CHEMBL3358430)
Show SMILES CCc1ncccc1Oc1cc(CCCCO)cnc1NC(=O)NC
Show InChI InChI=1S/C18H24N4O3/c1-3-14-15(8-6-9-20-14)25-16-11-13(7-4-5-10-23)12-21-17(16)22-18(24)19-2/h6,8-9,11-12,23H,3-5,7,10H2,1-2H3,(H2,19,21,22,24)
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n/an/an/an/a 350n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041612
PNG
(CHEMBL3358437)
Show SMILES CCn1nccc1Oc1cc(cnc1NC(=O)NC)C(O)C1CCOCC1
Show InChI InChI=1S/C18H25N5O4/c1-3-23-15(4-7-21-23)27-14-10-13(11-20-17(14)22-18(25)19-2)16(24)12-5-8-26-9-6-12/h4,7,10-12,16,24H,3,5-6,8-9H2,1-2H3,(H2,19,20,22,25)
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n/an/an/an/a 1.68E+4n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041653
PNG
(CHEMBL3358441)
Show SMILES CNC(=O)Nc1ncc(CC2CCOCC2)cc1Oc1ccnn1C(C)C
Show InChI InChI=1S/C19H27N5O3/c1-13(2)24-17(4-7-22-24)27-16-11-15(10-14-5-8-26-9-6-14)12-21-18(16)23-19(25)20-3/h4,7,11-14H,5-6,8-10H2,1-3H3,(H2,20,21,23,25)
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n/an/an/an/a 2.76E+3n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041657
PNG
(CHEMBL3358443)
Show SMILES CCn1nccc1Oc1cc(C[C@@H]2CC[C@H](O)CC2)cnc1NC(=O)NC
Show InChI InChI=1S/C19H27N5O3/c1-3-24-17(8-9-22-24)27-16-11-14(10-13-4-6-15(25)7-5-13)12-21-18(16)23-19(26)20-2/h8-9,11-13,15,25H,3-7,10H2,1-2H3,(H2,20,21,23,26)/t13-,15+
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n/an/an/an/a 120n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041605
PNG
(CHEMBL3358431)
Show SMILES CCc1ncccc1Oc1cc(CCCC(C)(C)O)cnc1NC(=O)NC
Show InChI InChI=1S/C20H28N4O3/c1-5-15-16(9-7-11-22-15)27-17-12-14(8-6-10-20(2,3)26)13-23-18(17)24-19(25)21-4/h7,9,11-13,26H,5-6,8,10H2,1-4H3,(H2,21,23,24,25)
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n/an/an/an/a 110n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041614
PNG
(CHEMBL3358439)
Show SMILES CCn1nccc1Oc1cc(C[C@H]2CCO[C@H](COC)C2)cnc1NC(=O)NC
Show InChI InChI=1S/C20H29N5O4/c1-4-25-18(5-7-23-25)29-17-11-15(12-22-19(17)24-20(26)21-2)9-14-6-8-28-16(10-14)13-27-3/h5,7,11-12,14,16H,4,6,8-10,13H2,1-3H3,(H2,21,22,24,26)/t14-,16+/m1/s1
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n/an/an/an/a 490n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041565
PNG
(CHEMBL3358425)
Show SMILES CCc1ncccc1Oc1cc(CC(C)C)cnc1NC(=O)NC
Show InChI InChI=1S/C18H24N4O2/c1-5-14-15(7-6-8-20-14)24-16-10-13(9-12(2)3)11-21-17(16)22-18(23)19-4/h6-8,10-12H,5,9H2,1-4H3,(H2,19,21,22,23)
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n/an/an/an/a 120n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041567
PNG
(CHEMBL3358427)
Show SMILES CCc1ncccc1Oc1cc(CCCOC)cnc1NC(=O)NC
Show InChI InChI=1S/C18H24N4O3/c1-4-14-15(8-5-9-20-14)25-16-11-13(7-6-10-24-3)12-21-17(16)22-18(23)19-2/h5,8-9,11-12H,4,6-7,10H2,1-3H3,(H2,19,21,22,23)
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n/an/an/an/a 440n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041566
PNG
(CHEMBL3358426)
Show SMILES CCOCCc1cnc(NC(=O)NC)c(Oc2cccnc2CC)c1
Show InChI InChI=1S/C18H24N4O3/c1-4-14-15(7-6-9-20-14)25-16-11-13(8-10-24-5-2)12-21-17(16)22-18(23)19-3/h6-7,9,11-12H,4-5,8,10H2,1-3H3,(H2,19,21,22,23)
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n/an/an/an/a 590n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041608
PNG
(CHEMBL3358434)
Show SMILES CCn1nccc1Oc1cc(CCCCOC)cnc1NC(=O)NC
Show InChI InChI=1S/C17H25N5O3/c1-4-22-15(8-9-20-22)25-14-11-13(7-5-6-10-24-3)12-19-16(14)21-17(23)18-2/h8-9,11-12H,4-7,10H2,1-3H3,(H2,18,19,21,23)
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n/an/an/an/a 460n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041613
PNG
(CHEMBL3358438)
Show SMILES CCn1nccc1Oc1cc(CN2CCOCC2)cnc1NC(=O)NC
Show InChI InChI=1S/C17H24N6O3/c1-3-23-15(4-5-20-23)26-14-10-13(12-22-6-8-25-9-7-22)11-19-16(14)21-17(24)18-2/h4-5,10-11H,3,6-9,12H2,1-2H3,(H2,18,19,21,24)
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n/an/an/an/a 7.98E+3n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041615
PNG
(CHEMBL3358440)
Show SMILES CCn1nccc1Oc1cc(C[C@@H]2CCO[C@@H](COC)C2)cnc1NC(=O)NC
Show InChI InChI=1S/C20H29N5O4/c1-4-25-18(5-7-23-25)29-17-11-15(12-22-19(17)24-20(26)21-2)9-14-6-8-28-16(10-14)13-27-3/h5,7,11-12,14,16H,4,6,8-10,13H2,1-3H3,(H2,21,22,24,26)/t14-,16+/m0/s1
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n/an/an/an/a 350n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041660
PNG
(CHEMBL3358445)
Show SMILES CCn1nccc1Oc1cc(C[C@H]2CC[C@@](C)(O)CC2)cnc1NC(=O)NC
Show InChI InChI=1S/C20H29N5O3/c1-4-25-17(7-10-23-25)28-16-12-15(13-22-18(16)24-19(26)21-3)11-14-5-8-20(2,27)9-6-14/h7,10,12-14,27H,4-6,8-9,11H2,1-3H3,(H2,21,22,24,26)/t14-,20+
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n/an/an/an/a 97n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041606
PNG
(CHEMBL3358432)
Show SMILES CCc1ncccc1Oc1cc(CC2CCCCC2)cnc1NC(=O)NC
Show InChI InChI=1S/C21H28N4O2/c1-3-17-18(10-7-11-23-17)27-19-13-16(12-15-8-5-4-6-9-15)14-24-20(19)25-21(26)22-2/h7,10-11,13-15H,3-6,8-9,12H2,1-2H3,(H2,22,24,25,26)
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n/an/an/an/a 14n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041609
PNG
(CHEMBL3358435)
Show SMILES CCn1nccc1Oc1cc(CCCC(C)(C)O)cnc1NC(=O)NC
Show InChI InChI=1S/C18H27N5O3/c1-5-23-15(8-10-21-23)26-14-11-13(7-6-9-18(2,3)25)12-20-16(14)22-17(24)19-4/h8,10-12,25H,5-7,9H2,1-4H3,(H2,19,20,22,24)
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n/an/an/an/a 370n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041662
PNG
(CHEMBL3358887)
Show SMILES CCn1nccc1Oc1cc(C[C@H]2C[C@H](O)C2)cnc1NC(=O)NC
Show InChI InChI=1S/C17H23N5O3/c1-3-22-15(4-5-20-22)25-14-9-12(6-11-7-13(23)8-11)10-19-16(14)21-17(24)18-2/h4-5,9-11,13,23H,3,6-8H2,1-2H3,(H2,18,19,21,24)/t11-,13-
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n/an/an/an/a 500n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
Hexokinase type IV


(Homo sapiens (Human))
BDBM50041574
PNG
(CHEMBL3358429)
Show SMILES CCc1ncccc1Oc1cc(CCO)cnc1NC(=O)NC
Show InChI InChI=1S/C16H20N4O3/c1-3-12-13(5-4-7-18-12)23-14-9-11(6-8-21)10-19-15(14)20-16(22)17-2/h4-5,7,9-10,21H,3,6,8H2,1-2H3,(H2,17,19,20,22)
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n/an/an/an/a 1.59E+3n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activation of human recombinant Glucokinase measured over 5 mins by G6-PD coupled assay in presence of 5 mM glucose


ACS Med Chem Lett 5: 1284-9 (2014)


Article DOI: 10.1021/ml500341w
BindingDB Entry DOI: 10.7270/Q2KD20JZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%