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PubMed code 25537530

Compile data set for download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060547
PNG
(CHEMBL3394472)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c12
Show InChI InChI=1S/C24H20FN5O2/c25-15-6-10-17(11-7-15)28-23(32)24(12-13-24)22(31)27-16-8-4-14(5-9-16)18-2-1-3-19-20(18)21(26)30-29-19/h1-11H,12-13H2,(H,27,31)(H,28,32)(H3,26,29,30)
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n/an/a 1n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060544
PNG
(CHEMBL3394469)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)c12
Show InChI InChI=1S/C24H19F2N5O2/c25-13-4-6-14(7-5-13)28-22(32)24(10-11-24)23(33)29-15-8-9-16(18(26)12-15)17-2-1-3-19-20(17)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)
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n/an/a 1.80n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060531
PNG
(CHEMBL3394457)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)c12
Show InChI InChI=1S/C24H18F2N4O3/c25-13-4-6-14(7-5-13)28-22(31)24(10-11-24)23(32)29-15-8-9-16(18(26)12-15)17-2-1-3-19-20(17)21(27)30-33-19/h1-9,12H,10-11H2,(H2,27,30)(H,28,31)(H,29,32)
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n/an/a 2.80n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060545
PNG
(CHEMBL3394470)
Show SMILES Cc1ccc(NC(=O)C2(CC2)C(=O)Nc2ccc(c(F)c2)-c2cccc3[nH]nc(N)c23)cc1
Show InChI InChI=1S/C25H22FN5O2/c1-14-5-7-15(8-6-14)28-23(32)25(11-12-25)24(33)29-16-9-10-17(19(26)13-16)18-3-2-4-20-21(18)22(27)31-30-20/h2-10,13H,11-12H2,1H3,(H,28,32)(H,29,33)(H3,27,30,31)
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n/an/a 3.70n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50021574
PNG
(BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
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n/an/a 3.70n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060546
PNG
(CHEMBL3394471)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(Cl)cc4)cc3F)c12
Show InChI InChI=1S/C24H19ClFN5O2/c25-13-4-6-14(7-5-13)28-22(32)24(10-11-24)23(33)29-15-8-9-16(18(26)12-15)17-2-1-3-19-20(17)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)
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n/an/a 4.5n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060552
PNG
(CHEMBL3394476)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)c(F)c3)c12
Show InChI InChI=1S/C24H19F2N5O2/c25-14-5-7-15(8-6-14)28-22(32)24(10-11-24)23(33)29-18-9-4-13(12-17(18)26)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)
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n/an/a 5.10n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060508
PNG
(CHEMBL3394450)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c12
Show InChI InChI=1S/C24H19FN4O3/c25-15-6-10-17(11-7-15)28-23(31)24(12-13-24)22(30)27-16-8-4-14(5-9-16)18-2-1-3-19-20(18)21(26)29-32-19/h1-11H,12-13H2,(H2,26,29)(H,27,30)(H,28,31)
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n/an/a 5.20n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060553
PNG
(CHEMBL3394477)
Show SMILES Cc1cc(NC(=O)C2(CC2)C(=O)Nc2ccc(F)cc2)ccc1-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C25H22FN5O2/c1-14-13-17(9-10-18(14)19-3-2-4-20-21(19)22(27)31-30-20)29-24(33)25(11-12-25)23(32)28-16-7-5-15(26)6-8-16/h2-10,13H,11-12H2,1H3,(H,28,32)(H,29,33)(H3,27,30,31)
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n/an/a 6n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060509
PNG
(CHEMBL3394451)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(Cl)cc4)cc3)c12
Show InChI InChI=1S/C24H19ClN4O3/c25-15-6-10-17(11-7-15)28-23(31)24(12-13-24)22(30)27-16-8-4-14(5-9-16)18-2-1-3-19-20(18)21(26)29-32-19/h1-11H,12-13H2,(H2,26,29)(H,27,30)(H,28,31)
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n/an/a 6.70n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060505
PNG
(CHEMBL3394447)
Show SMILES Cc1ccc(NC(=O)C2(CC2)C(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1
Show InChI InChI=1S/C25H22N4O3/c1-15-5-9-17(10-6-15)27-23(30)25(13-14-25)24(31)28-18-11-7-16(8-12-18)19-3-2-4-20-21(19)22(26)29-32-20/h2-12H,13-14H2,1H3,(H2,26,29)(H,27,30)(H,28,31)
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n/an/a 17n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060527
PNG
(CHEMBL3394454)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)c(Cl)c4)cc3)c12
Show InChI InChI=1S/C24H18ClFN4O3/c25-17-12-15(8-9-18(17)26)29-23(32)24(10-11-24)22(31)28-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(27)30-33-19/h1-9,12H,10-11H2,(H2,27,30)(H,28,31)(H,29,32)
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n/an/a 20n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060549
PNG
(CHEMBL3394474)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4F)cc3)c12
Show InChI InChI=1S/C24H19F2N5O2/c25-14-6-9-18(17(26)12-14)29-23(33)24(10-11-24)22(32)28-15-7-4-13(5-8-15)16-2-1-3-19-20(16)21(27)31-30-19/h1-9,12H,10-11H2,(H,28,32)(H,29,33)(H3,27,30,31)
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n/an/a 24n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060528
PNG
(CHEMBL3394455)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4F)cc3)c12
Show InChI InChI=1S/C24H18F2N4O3/c25-14-6-9-18(17(26)12-14)29-23(32)24(10-11-24)22(31)28-15-7-4-13(5-8-15)16-2-1-3-19-20(16)21(27)30-33-19/h1-9,12H,10-11H2,(H2,27,30)(H,28,31)(H,29,32)
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n/an/a 43n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060548
PNG
(CHEMBL3394473)
Show SMILES COc1cc(NC(=O)C2(CC2)C(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)ccc1F
Show InChI InChI=1S/C25H22FN5O3/c1-34-20-13-16(9-10-18(20)26)29-24(33)25(11-12-25)23(32)28-15-7-5-14(6-8-15)17-3-2-4-19-21(17)22(27)31-30-19/h2-10,13H,11-12H2,1H3,(H,28,32)(H,29,33)(H3,27,30,31)
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n/an/a 50n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060513
PNG
(CHEMBL3394453)
Show SMILES COc1cc(NC(=O)C2(CC2)C(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)ccc1F
Show InChI InChI=1S/C25H21FN4O4/c1-33-20-13-16(9-10-18(20)26)29-24(32)25(11-12-25)23(31)28-15-7-5-14(6-8-15)17-3-2-4-19-21(17)22(27)30-34-19/h2-10,13H,11-12H2,1H3,(H2,27,30)(H,28,31)(H,29,32)
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n/an/a 58n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060529
PNG
(CHEMBL3394456)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)c(F)c4)cc3)c12
Show InChI InChI=1S/C24H18F2N4O3/c25-17-9-8-15(12-18(17)26)29-23(32)24(10-11-24)22(31)28-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(27)30-33-19/h1-9,12H,10-11H2,(H2,27,30)(H,28,31)(H,29,32)
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n/an/a 76n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060556
PNG
(CHEMBL3394480)
Show SMILES CN1CCN(Cc2cc(NC(=O)C3(CC3)C(=O)Nc3ccc(cc3)-c3cccc4[nH]nc(N)c34)ccc2Cl)CC1
Show InChI InChI=1S/C30H32ClN7O2/c1-37-13-15-38(16-14-37)18-20-17-22(9-10-24(20)31)34-29(40)30(11-12-30)28(39)33-21-7-5-19(6-8-21)23-3-2-4-25-26(23)27(32)36-35-25/h2-10,17H,11-16,18H2,1H3,(H,33,39)(H,34,40)(H3,32,35,36)
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n/an/a 112n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060540
PNG
(CHEMBL3394465)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)CC(=O)Nc4ccc(F)cc4)cc3)c12
Show InChI InChI=1S/C22H17FN4O3/c23-14-6-10-16(11-7-14)26-20(29)12-19(28)25-15-8-4-13(5-9-15)17-2-1-3-18-21(17)22(24)27-30-18/h1-11H,12H2,(H2,24,27)(H,25,28)(H,26,29)
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n/an/a 138n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060534
PNG
(CHEMBL3394459)
Show SMILES CN1CCN(Cc2cc(NC(=O)C3(CC3)C(=O)Nc3ccc(cc3)-c3cccc4onc(N)c34)ccc2Cl)CC1
Show InChI InChI=1S/C30H31ClN6O3/c1-36-13-15-37(16-14-36)18-20-17-22(9-10-24(20)31)34-29(39)30(11-12-30)28(38)33-21-7-5-19(6-8-21)23-3-2-4-25-26(23)27(32)35-40-25/h2-10,17H,11-16,18H2,1H3,(H2,32,35)(H,33,38)(H,34,39)
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n/an/a 199n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060551
PNG
(CHEMBL3394475)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)c(c4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C25H19F4N5O2/c26-18-9-8-15(12-17(18)25(27,28)29)32-23(36)24(10-11-24)22(35)31-14-6-4-13(5-7-14)16-2-1-3-19-20(16)21(30)34-33-19/h1-9,12H,10-11H2,(H,31,35)(H,32,36)(H3,30,33,34)
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n/an/a 228n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060541
PNG
(CHEMBL3394466)
Show SMILES CC(C(=O)Nc1ccc(F)cc1)C(=O)Nc1ccc(cc1)-c1cccc2onc(N)c12
Show InChI InChI=1S/C23H19FN4O3/c1-13(23(30)27-17-11-7-15(24)8-12-17)22(29)26-16-9-5-14(6-10-16)18-3-2-4-19-20(18)21(25)28-31-19/h2-13H,1H3,(H2,25,28)(H,26,29)(H,27,30)
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n/an/a 561n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060510
PNG
(CHEMBL3394452)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(cc4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C25H19F3N4O3/c26-25(27,28)15-6-10-17(11-7-15)31-23(34)24(12-13-24)22(33)30-16-8-4-14(5-9-16)18-2-1-3-19-20(18)21(29)32-35-19/h1-11H,12-13H2,(H2,29,32)(H,30,33)(H,31,34)
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n/an/a 566n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060507
PNG
(CHEMBL3394449)
Show SMILES COc1cc(NC(=O)C2(CC2)C(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc(OC)c1OC
Show InChI InChI=1S/C27H26N4O6/c1-34-20-13-17(14-21(35-2)23(20)36-3)30-26(33)27(11-12-27)25(32)29-16-9-7-15(8-10-16)18-5-4-6-19-22(18)24(28)31-37-19/h4-10,13-14H,11-12H2,1-3H3,(H2,28,31)(H,29,32)(H,30,33)
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n/an/a>1.00E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060532
PNG
(CHEMBL3394458)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)C2(CC2)C(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1F
Show InChI InChI=1S/C29H29FN6O3/c1-35-13-15-36(16-14-35)23-10-9-20(17-22(23)30)33-28(38)29(11-12-29)27(37)32-19-7-5-18(6-8-19)21-3-2-4-24-25(21)26(31)34-39-24/h2-10,17H,11-16H2,1H3,(H2,31,34)(H,32,37)(H,33,38)
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n/an/a>1.00E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50060508
PNG
(CHEMBL3394450)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c12
Show InChI InChI=1S/C24H19FN4O3/c25-15-6-10-17(11-7-15)28-23(31)24(12-13-24)22(30)27-16-8-4-14(5-9-16)18-2-1-3-19-20(18)21(26)29-32-19/h1-11H,12-13H2,(H2,26,29)(H,27,30)(H,28,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified VEGFR2 (unknown origin) after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060543
PNG
(CHEMBL3394468)
Show SMILES CC(C)(C(=O)Nc1ccc(F)cc1)C(=O)Nc1ccc(cc1)-c1cccc2onc(N)c12
Show InChI InChI=1S/C24H21FN4O3/c1-24(2,23(31)28-17-12-8-15(25)9-13-17)22(30)27-16-10-6-14(7-11-16)18-4-3-5-19-20(18)21(26)29-32-19/h3-13H,1-2H3,(H2,26,29)(H,27,30)(H,28,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060539
PNG
(CHEMBL3394464)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(cc4)-c4cnn(c4)C4CCNCC4)cc3)c12
Show InChI InChI=1S/C32H31N7O3/c33-29-28-26(2-1-3-27(28)42-38-29)21-6-10-24(11-7-21)37-31(41)32(14-15-32)30(40)36-23-8-4-20(5-9-23)22-18-35-39(19-22)25-12-16-34-17-13-25/h1-11,18-19,25,34H,12-17H2,(H2,33,38)(H,36,40)(H,37,41)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060557
PNG
(CHEMBL3394481)
Show SMILES Nc1n[nH]c2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)c4ccccc34)c12
Show InChI InChI=1S/C28H22FN5O2/c29-16-8-10-17(11-9-16)31-26(35)28(14-15-28)27(36)32-22-13-12-19(18-4-1-2-5-20(18)22)21-6-3-7-23-24(21)25(30)34-33-23/h1-13H,14-15H2,(H,31,35)(H,32,36)(H3,30,33,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060537
PNG
(CHEMBL3394462)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(cc4)-c4cnn(c4)C4CCOCC4)cc3)c12
Show InChI InChI=1S/C32H30N6O4/c33-29-28-26(2-1-3-27(28)42-37-29)21-6-10-24(11-7-21)36-31(40)32(14-15-32)30(39)35-23-8-4-20(5-9-23)22-18-34-38(19-22)25-12-16-41-17-13-25/h1-11,18-19,25H,12-17H2,(H2,33,37)(H,35,39)(H,36,40)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060538
PNG
(CHEMBL3394463)
Show SMILES Cn1cc(cn1)-c1ccc(NC(=O)C2(CC2)C(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1
Show InChI InChI=1S/C28H24N6O3/c1-34-16-19(15-30-34)17-5-9-20(10-6-17)31-26(35)28(13-14-28)27(36)32-21-11-7-18(8-12-21)22-3-2-4-23-24(22)25(29)33-37-23/h2-12,15-16H,13-14H2,1H3,(H2,29,33)(H,31,35)(H,32,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060536
PNG
(CHEMBL3394461)
Show SMILES CC(=O)c1ccc(s1)-c1ccc(NC(=O)C2(CC2)C(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1
Show InChI InChI=1S/C30H24N4O4S/c1-17(35)24-13-14-25(39-24)19-7-11-21(12-8-19)33-29(37)30(15-16-30)28(36)32-20-9-5-18(6-10-20)22-3-2-4-23-26(22)27(31)34-38-23/h2-14H,15-16H2,1H3,(H2,31,34)(H,32,36)(H,33,37)
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n/an/a>1.00E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060506
PNG
(CHEMBL3394448)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)C4(CC4)C(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C24H19FN4O3/c25-15-3-1-4-17(13-15)28-23(31)24(11-12-24)22(30)27-16-9-7-14(8-10-16)18-5-2-6-19-20(18)21(26)29-32-19/h1-10,13H,11-12H2,(H2,26,29)(H,27,30)(H,28,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060555
PNG
(CHEMBL3394479)
Show SMILES CN(C)Cc1cc(NC(=O)C2(CC2)C(=O)Nc2ccc(F)cc2)ccc1-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C27H27FN6O2/c1-34(2)15-16-14-19(10-11-20(16)21-4-3-5-22-23(21)24(29)33-32-22)31-26(36)27(12-13-27)25(35)30-18-8-6-17(28)7-9-18/h3-11,14H,12-13,15H2,1-2H3,(H,30,35)(H,31,36)(H3,29,32,33)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060542
PNG
(CHEMBL3394467)
Show SMILES CC(C)C(C(=O)Nc1ccc(F)cc1)C(=O)Nc1ccc(cc1)-c1cccc2onc(N)c12
Show InChI InChI=1S/C25H23FN4O3/c1-14(2)21(25(32)29-18-12-8-16(26)9-13-18)24(31)28-17-10-6-15(7-11-17)19-4-3-5-20-22(19)23(27)30-33-20/h3-14,21H,1-2H3,(H2,27,30)(H,28,31)(H,29,32)
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China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060554
PNG
(CHEMBL3394478)
Show SMILES COc1cc(NC(=O)C2(CC2)C(=O)Nc2ccc(F)cc2)ccc1-c1cccc2[nH]nc(N)c12
Show InChI InChI=1S/C25H22FN5O3/c1-34-20-13-16(9-10-17(20)18-3-2-4-19-21(18)22(27)31-30-19)29-24(33)25(11-12-25)23(32)28-15-7-5-14(26)6-8-15/h2-10,13H,11-12H2,1H3,(H,28,32)(H,29,33)(H3,27,30,31)
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n/an/a>1.00E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50060535
PNG
(CHEMBL3394460)
Show SMILES Cn1nccc1-c1ccc(NC(=O)C2(CC2)C(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1
Show InChI InChI=1S/C28H24N6O3/c1-34-22(13-16-30-34)18-7-11-20(12-8-18)32-27(36)28(14-15-28)26(35)31-19-9-5-17(6-10-19)21-3-2-4-23-24(21)25(29)33-37-23/h2-13,16H,14-15H2,1H3,(H2,29,33)(H,31,35)(H,32,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant c-MET (unknown origin) using poly (Glu, Tyr) substrate after 60 mins by ELISA


Bioorg Med Chem 23: 564-78 (2015)


Article DOI: 10.1016/j.bmc.2014.12.002
BindingDB Entry DOI: 10.7270/Q2VT1TRT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%