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PubMed code 25589918

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein delta homolog 1


(Homo sapiens)
BDBM50042942
PNG
(CHEMBL3355003)
Show SMILES CC(C)n1nc(cc1C1CCN(C)CC1)-c1cnc2[nH]cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C20H24F3N5/c1-12(2)28-18(13-4-6-27(3)7-5-13)9-17(26-28)14-8-15-16(20(21,22)23)11-25-19(15)24-10-14/h8-13H,4-7H2,1-3H3,(H,24,25)
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
0.170n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of DLK (unknown origin) by RT-FRET assay


ACS Med Chem Lett 6: 11-2 (2015)


Article DOI: 10.1021/ml500347s
BindingDB Entry DOI: 10.7270/Q26W9CQT
More data for this
Ligand-Target Pair
Protein delta homolog 1


(Homo sapiens)
BDBM50042940
PNG
(CHEMBL3355005)
Show SMILES CC(C)n1nc(cc1[C@@H]1[C@H]2CN(C[C@@H]12)C1COC1)-c1cnc2[nH]cc(c2c1)C(F)(F)F
Show InChI InChI=1S/C22H24F3N5O/c1-11(2)30-19(20-15-7-29(8-16(15)20)13-9-31-10-13)4-18(28-30)12-3-14-17(22(23,24)25)6-27-21(14)26-5-12/h3-6,11,13,15-16,20H,7-10H2,1-2H3,(H,26,27)/t15-,16+,20+
KEGG

UniProtKB/SwissProt

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PC sid
UniChem

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Article
PubMed
0.400n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of DLK (unknown origin) by RT-FRET assay


ACS Med Chem Lett 6: 11-2 (2015)


Article DOI: 10.1021/ml500347s
BindingDB Entry DOI: 10.7270/Q26W9CQT
More data for this
Ligand-Target Pair
Protein delta homolog 1


(Homo sapiens)
BDBM50042941
PNG
(CHEMBL3355004)
Show SMILES CC(C)n1nc(cc1C1CCN(C1)C1COC1)-c1cnc2[nH]cc(F)c2c1
Show InChI InChI=1S/C20H24FN5O/c1-12(2)26-19(13-3-4-25(9-13)15-10-27-11-15)6-18(24-26)14-5-16-17(21)8-23-20(16)22-7-14/h5-8,12-13,15H,3-4,9-11H2,1-2H3,(H,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

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Article
PubMed
110n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of DLK (unknown origin) by RT-FRET assay


ACS Med Chem Lett 6: 11-2 (2015)


Article DOI: 10.1021/ml500347s
BindingDB Entry DOI: 10.7270/Q26W9CQT
More data for this
Ligand-Target Pair
Protein delta homolog 1


(Homo sapiens)
BDBM50042939
PNG
(CHEMBL3355006)
Show SMILES CC(C)n1nc(cc1[C@@H]1[C@H]2CN(C[C@@H]12)C1COC1)-c1cnc(N)c2cn[nH]c12
Show InChI InChI=1S/C20H25N7O/c1-10(2)27-17(18-14-6-26(7-15(14)18)11-8-28-9-11)3-16(25-27)12-4-22-20(21)13-5-23-24-19(12)13/h3-5,10-11,14-15,18H,6-9H2,1-2H3,(H2,21,22)(H,23,24)/t14-,15+,18+
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
270n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of DLK (unknown origin) by RT-FRET assay


ACS Med Chem Lett 6: 11-2 (2015)


Article DOI: 10.1021/ml500347s
BindingDB Entry DOI: 10.7270/Q26W9CQT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%