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PubMed code 25589919

Compile data set for download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50042943
PNG
(CHEMBL3355008)
Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(Cl)c(Cl)c2)c(F)c1
Show InChI InChI=1S/C21H17Cl2FN2O3/c1-2-29-19-8-14(11-25-21(19)28)12-3-4-13(18(24)7-12)9-20(27)26-15-5-6-16(22)17(23)10-15/h3-8,10-11H,2,9H2,1H3,(H,25,28)(H,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>500n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human RET kinase in TT cells by TRET Kinase cell-based mechanistic assay


ACS Med Chem Lett 6: 13-4 (2015)


Article DOI: 10.1021/ml500402t
BindingDB Entry DOI: 10.7270/Q2377BB7
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM50042943
PNG
(CHEMBL3355008)
Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(Cl)c(Cl)c2)c(F)c1
Show InChI InChI=1S/C21H17Cl2FN2O3/c1-2-29-19-8-14(11-25-21(19)28)12-3-4-13(18(24)7-12)9-20(27)26-15-5-6-16(22)17(23)10-15/h3-8,10-11H,2,9H2,1H3,(H,25,28)(H,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>500n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of RET kinase-mediated proliferative activity against human TT cells by cell-based proliferation assay


ACS Med Chem Lett 6: 13-4 (2015)


Article DOI: 10.1021/ml500402t
BindingDB Entry DOI: 10.7270/Q2377BB7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%