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PubMed code 25699154

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50081052
PNG
(CHEMBL3421840)
Show SMILES C[C@H]1CN(C(=O)c2c(cnn12)-c1ccnc(c1)C#N)c1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C20H13ClF3N5O/c1-11-10-28(14-2-3-16(17(21)7-14)20(22,23)24)19(30)18-15(9-27-29(11)18)12-4-5-26-13(6-12)8-25/h2-7,9,11H,10H2,1H3/t11-/m0/s1
PDB

UniProtKB/SwissProt

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PC sid
UniChem

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Article
PubMed
n/an/a 6.90n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR2 receptor expressed in CHO cell membranes assessed as inhibition of glutamate responses after 30 mins b...


ACS Med Chem Lett 6: 104-7 (2015)


Article DOI: 10.1021/ml5005365
BindingDB Entry DOI: 10.7270/Q2R49SG1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50081051
PNG
(CHEMBL3421838)
Show SMILES C[C@H]1CN(C(=O)c2c(cnn12)-c1ccnc(C)c1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H17F3N4O/c1-12-9-14(7-8-24-12)17-10-25-27-13(2)11-26(19(28)18(17)27)16-5-3-15(4-6-16)20(21,22)23/h3-10,13H,11H2,1-2H3/t13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 8.90n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR2 receptor expressed in CHO cell membranes assessed as inhibition of glutamate responses after 30 mins b...


ACS Med Chem Lett 6: 104-7 (2015)


Article DOI: 10.1021/ml5005365
BindingDB Entry DOI: 10.7270/Q2R49SG1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50081048
PNG
(CHEMBL3421839)
Show SMILES CCC1CN(C(=O)c2c(cnn12)-c1ccnc(C)c1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H19F3N4O/c1-3-16-12-27(17-6-4-15(5-7-17)21(22,23)24)20(29)19-18(11-26-28(16)19)14-8-9-25-13(2)10-14/h4-11,16H,3,12H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 79n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR2 receptor expressed in CHO cell membranes assessed as inhibition of glutamate responses after 30 mins b...


ACS Med Chem Lett 6: 104-7 (2015)


Article DOI: 10.1021/ml5005365
BindingDB Entry DOI: 10.7270/Q2R49SG1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50081054
PNG
(CHEMBL3421841)
Show SMILES CC(O)c1ccc(cc1)N1C[C@H](C)n2ncc(c2C1=O)-c1ccnc(C)c1
Show InChI InChI=1S/C21H22N4O2/c1-13-10-17(8-9-22-13)19-11-23-25-14(2)12-24(21(27)20(19)25)18-6-4-16(5-7-18)15(3)26/h4-11,14-15,26H,12H2,1-3H3/t14-,15?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<5.01E+4n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR2 receptor expressed in CHO cell membranes assessed as inhibition of glutamate responses after 30 mins b...


ACS Med Chem Lett 6: 104-7 (2015)


Article DOI: 10.1021/ml5005365
BindingDB Entry DOI: 10.7270/Q2R49SG1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%