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PubMed code 25699405

Compile data set for download or QSAR
Found 57 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078374
PNG
(CHEMBL3414926)
Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cc(C)no1
Show InChI InChI=1S/C24H22FN5O3/c1-14-8-22(33-29-14)18-11-20(25)24-28-27-23(30(24)13-18)15(2)16-4-5-21-17(9-16)10-19(12-26-21)32-7-6-31-3/h4-5,8-13,15H,6-7H2,1-3H3/t15-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078377
PNG
(CHEMBL3414922)
Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cn(C)cn1
Show InChI InChI=1S/C22H19FN6O/c1-13(14-4-5-19-15(6-14)7-17(30-3)9-24-19)21-26-27-22-18(23)8-16(10-29(21)22)20-11-28(2)12-25-20/h4-13H,1-3H3/t13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078375
PNG
(CHEMBL3414925)
Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cc(C)no1
Show InChI InChI=1S/C22H18FN5O2/c1-12-6-20(30-27-12)16-9-18(23)22-26-25-21(28(22)11-16)13(2)14-4-5-19-15(7-14)8-17(29-3)10-24-19/h4-11,13H,1-3H3/t13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078385
PNG
(CHEMBL3414914)
Show SMILES COc1cnc2ccc(cc2c1)C(F)(F)c1nnc2c(F)cc(cn12)-c1cscn1
Show InChI InChI=1S/C20H12F3N5OS/c1-29-14-5-11-4-13(2-3-16(11)24-7-14)20(22,23)19-27-26-18-15(21)6-12(8-28(18)19)17-9-30-10-25-17/h2-10H,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078381
PNG
(CHEMBL3414918)
Show SMILES COc1cnc2ccc(cc2c1)[C@@](C)(F)c1nnc2c(F)cc(cn12)-c1cc(C)no1
Show InChI InChI=1S/C22H17F2N5O2/c1-12-6-19(31-28-12)14-9-17(23)20-26-27-21(29(20)11-14)22(2,24)15-4-5-18-13(7-15)8-16(30-3)10-25-18/h4-11H,1-3H3/t22-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078376
PNG
(CHEMBL3414923)
Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cnn(C)c1
Show InChI InChI=1S/C22H19FN6O/c1-13(14-4-5-20-15(6-14)7-18(30-3)10-24-20)21-26-27-22-19(23)8-16(12-29(21)22)17-9-25-28(2)11-17/h4-13H,1-3H3/t13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078386
PNG
(CHEMBL3414913)
Show SMILES COc1cnc2ccc(cc2c1)C(F)(F)c1nnc2c(F)cc(cn12)-c1cc(C)no1
Show InChI InChI=1S/C21H14F3N5O2/c1-11-5-18(31-28-11)13-8-16(22)19-26-27-20(29(19)10-13)21(23,24)14-3-4-17-12(6-14)7-15(30-2)9-25-17/h3-10H,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078381
PNG
(CHEMBL3414918)
Show SMILES COc1cnc2ccc(cc2c1)[C@@](C)(F)c1nnc2c(F)cc(cn12)-c1cc(C)no1
Show InChI InChI=1S/C22H17F2N5O2/c1-12-6-19(31-28-12)14-9-17(23)20-26-27-21(29(20)11-14)22(2,24)15-4-5-18-13(7-15)8-16(30-3)10-25-18/h4-11H,1-3H3/t22-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078382
PNG
(CHEMBL3414917)
Show SMILES COc1cnc2ccc(cc2c1)[C@@](C)(F)c1nnc2c(F)cc(cn12)-c1cc(C)ns1
Show InChI InChI=1S/C22H17F2N5OS/c1-12-6-19(31-28-12)14-9-17(23)20-26-27-21(29(20)11-14)22(2,24)15-4-5-18-13(7-15)8-16(30-3)10-25-18/h4-11H,1-3H3/t22-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078389
PNG
(CHEMBL3414738)
Show SMILES Fc1cc(cn2c(nnc12)C(F)(F)c1ccc2ncccc2c1)-c1cscn1
Show InChI InChI=1S/C19H10F3N5S/c20-14-7-12(16-9-28-10-24-16)8-27-17(14)25-26-18(27)19(21,22)13-3-4-15-11(6-13)2-1-5-23-15/h1-10H
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078377
PNG
(CHEMBL3414922)
Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cn(C)cn1
Show InChI InChI=1S/C22H19FN6O/c1-13(14-4-5-19-15(6-14)7-17(30-3)9-24-19)21-26-27-22-18(23)8-16(10-29(21)22)20-11-28(2)12-25-20/h4-13H,1-3H3/t13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078383
PNG
(CHEMBL3414577)
Show SMILES Cc1cc(sn1)-c1cc(F)c2nnc(n2c1)[C@](C)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C21H15F2N5S/c1-12-8-18(29-27-12)14-10-16(22)19-25-26-20(28(19)11-14)21(2,23)15-5-6-17-13(9-15)4-3-7-24-17/h3-11H,1-2H3/t21-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078382
PNG
(CHEMBL3414917)
Show SMILES COc1cnc2ccc(cc2c1)[C@@](C)(F)c1nnc2c(F)cc(cn12)-c1cc(C)ns1
Show InChI InChI=1S/C22H17F2N5OS/c1-12-6-19(31-28-12)14-9-17(23)20-26-27-21(29(20)11-14)22(2,24)15-4-5-18-13(7-15)8-16(30-3)10-25-18/h4-11H,1-3H3/t22-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078374
PNG
(CHEMBL3414926)
Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cc(C)no1
Show InChI InChI=1S/C24H22FN5O3/c1-14-8-22(33-29-14)18-11-20(25)24-28-27-23(30(24)13-18)15(2)16-4-5-21-17(9-16)10-19(12-26-21)32-7-6-31-3/h4-5,8-13,15H,6-7H2,1-3H3/t15-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078380
PNG
(CHEMBL3414919)
Show SMILES COc1cnc2ccc(cc2c1)[C@@](C)(F)c1nnc2c(F)cc(cn12)-c1cnn(C)c1
Show InChI InChI=1S/C22H18F2N6O/c1-22(24,16-4-5-19-13(6-16)7-17(31-3)10-25-19)21-28-27-20-18(23)8-14(12-30(20)21)15-9-26-29(2)11-15/h4-12H,1-3H3/t22-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078375
PNG
(CHEMBL3414925)
Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cc(C)no1
Show InChI InChI=1S/C22H18FN5O2/c1-12-6-20(30-27-12)16-9-18(23)22-26-25-21(28(22)11-16)13(2)14-4-5-19-15(7-14)8-17(29-3)10-24-19/h4-11,13H,1-3H3/t13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078383
PNG
(CHEMBL3414577)
Show SMILES Cc1cc(sn1)-c1cc(F)c2nnc(n2c1)[C@](C)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C21H15F2N5S/c1-12-8-18(29-27-12)14-10-16(22)19-25-26-20(28(19)11-14)21(2,23)15-5-6-17-13(9-15)4-3-7-24-17/h3-11H,1-2H3/t21-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078389
PNG
(CHEMBL3414738)
Show SMILES Fc1cc(cn2c(nnc12)C(F)(F)c1ccc2ncccc2c1)-c1cscn1
Show InChI InChI=1S/C19H10F3N5S/c20-14-7-12(16-9-28-10-24-16)8-27-17(14)25-26-18(27)19(21,22)13-3-4-15-11(6-13)2-1-5-23-15/h1-10H
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078380
PNG
(CHEMBL3414919)
Show SMILES COc1cnc2ccc(cc2c1)[C@@](C)(F)c1nnc2c(F)cc(cn12)-c1cnn(C)c1
Show InChI InChI=1S/C22H18F2N6O/c1-22(24,16-4-5-19-13(6-16)7-17(31-3)10-25-19)21-28-27-20-18(23)8-14(12-30(20)21)15-9-26-29(2)11-15/h4-12H,1-3H3/t22-/m1/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078379
PNG
(CHEMBL3414920)
Show SMILES C[C@H](c1nnc2c(F)cc(cn12)-c1cc(C)ns1)c1ccc2ncccc2c1
Show InChI InChI=1S/C21H16FN5S/c1-12-8-19(28-26-12)16-10-17(22)21-25-24-20(27(21)11-16)13(2)14-5-6-18-15(9-14)4-3-7-23-18/h3-11,13H,1-2H3/t13-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078418
PNG
(CHEMBL3414731)
Show SMILES COc1ccc2c(OCc3nnc4c(F)cc(cn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C23H17FN4O2/c1-29-17-7-8-18-20(12-17)25-10-9-21(18)30-14-22-26-27-23-19(24)11-16(13-28(22)23)15-5-3-2-4-6-15/h2-13H,14H2,1H3
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n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078385
PNG
(CHEMBL3414914)
Show SMILES COc1cnc2ccc(cc2c1)C(F)(F)c1nnc2c(F)cc(cn12)-c1cscn1
Show InChI InChI=1S/C20H12F3N5OS/c1-29-14-5-11-4-13(2-3-16(11)24-7-14)20(22,23)19-27-26-18-15(21)6-12(8-28(18)19)17-9-30-10-25-17/h2-10H,1H3
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n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078386
PNG
(CHEMBL3414913)
Show SMILES COc1cnc2ccc(cc2c1)C(F)(F)c1nnc2c(F)cc(cn12)-c1cc(C)no1
Show InChI InChI=1S/C21H14F3N5O2/c1-11-5-18(31-28-11)13-8-16(22)19-26-27-20(29(19)10-13)21(23,24)14-3-4-17-12(6-14)7-15(30-2)9-25-17/h3-10H,1-2H3
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n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078404
PNG
(CHEMBL3414736)
Show SMILES Cc1cc(on1)-c1cc(F)c2nnc(n2c1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H12F3N5O/c1-11-7-17(29-27-11)13-9-15(21)18-25-26-19(28(18)10-13)20(22,23)14-4-5-16-12(8-14)3-2-6-24-16/h2-10H,1H3
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n/an/a 9n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24470
PNG
(7-methoxy-4-({6-phenyl-[1,2,4]triazolo[4,3-a]pyrid...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3
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n/an/a 9n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078404
PNG
(CHEMBL3414736)
Show SMILES Cc1cc(on1)-c1cc(F)c2nnc(n2c1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H12F3N5O/c1-11-7-17(29-27-11)13-9-15(21)18-25-26-19(28(18)10-13)20(22,23)14-4-5-16-12(8-14)3-2-6-24-16/h2-10H,1H3
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n/an/a 9n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078378
PNG
(CHEMBL3414921)
Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cc(C)ns1
Show InChI InChI=1S/C22H18FN5OS/c1-12-6-20(30-27-12)16-9-18(23)22-26-25-21(28(22)11-16)13(2)14-4-5-19-15(7-14)8-17(29-3)10-24-19/h4-11,13H,1-3H3/t13-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078414
PNG
(CHEMBL3414742)
Show SMILES COc1cnc2ccc(Cc3nnc4c(F)cc(cn34)-c3cnn(C)c3)cc2c1
Show InChI InChI=1S/C21H17FN6O/c1-27-11-16(9-24-27)15-8-18(22)21-26-25-20(28(21)12-15)6-13-3-4-19-14(5-13)7-17(29-2)10-23-19/h3-5,7-12H,6H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078403
PNG
(CHEMBL3414737)
Show SMILES Cc1ncc(s1)-c1cc(F)c2nnc(n2c1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H12F3N5S/c1-11-25-9-17(29-11)13-8-15(21)18-26-27-19(28(18)10-13)20(22,23)14-4-5-16-12(7-14)3-2-6-24-16/h2-10H,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078384
PNG
(CHEMBL3414915)
Show SMILES COc1cnc2ccc(cc2c1)C(F)(F)c1nnc2c(F)cc(cn12)-c1cnn(C)c1
Show InChI InChI=1S/C21H15F3N6O/c1-29-10-14(8-26-29)13-7-17(22)19-27-28-20(30(19)11-13)21(23,24)15-3-4-18-12(5-15)6-16(31-2)9-25-18/h3-11H,1-2H3
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n/an/a 12n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078405
PNG
(CHEMBL3414735)
Show SMILES Fc1cc(cn2c(nnc12)C(F)(F)c1ccc2ncccc2c1)-c1ccccn1
Show InChI InChI=1S/C21H12F3N5/c22-16-11-14(17-5-1-2-8-25-17)12-29-19(16)27-28-20(29)21(23,24)15-6-7-18-13(10-15)4-3-9-26-18/h1-12H
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078379
PNG
(CHEMBL3414920)
Show SMILES C[C@H](c1nnc2c(F)cc(cn12)-c1cc(C)ns1)c1ccc2ncccc2c1
Show InChI InChI=1S/C21H16FN5S/c1-12-8-19(28-26-12)16-10-17(22)21-25-24-20(27(21)11-16)13(2)14-5-6-18-15(9-14)4-3-7-23-18/h3-11,13H,1-2H3/t13-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078384
PNG
(CHEMBL3414915)
Show SMILES COc1cnc2ccc(cc2c1)C(F)(F)c1nnc2c(F)cc(cn12)-c1cnn(C)c1
Show InChI InChI=1S/C21H15F3N6O/c1-29-10-14(8-26-29)13-7-17(22)19-27-28-20(30(19)11-13)21(23,24)15-3-4-18-12(5-15)6-16(31-2)9-25-18/h3-11H,1-2H3
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n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078376
PNG
(CHEMBL3414923)
Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cnn(C)c1
Show InChI InChI=1S/C22H19FN6O/c1-13(14-4-5-20-15(6-14)7-18(30-3)10-24-20)21-26-27-22-19(23)8-16(12-29(21)22)17-9-25-28(2)11-17/h4-13H,1-3H3/t13-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078388
PNG
(CHEMBL3414739)
Show SMILES Cn1cc(cn1)-c1cc(F)c2nnc(n2c1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H13F3N6/c1-28-10-14(9-25-28)13-8-16(21)18-26-27-19(29(18)11-13)20(22,23)15-4-5-17-12(7-15)3-2-6-24-17/h2-11H,1H3
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n/an/a 15n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078415
PNG
(CHEMBL3414741)
Show SMILES Cn1cc(cn1)-c1cc(F)c2nnc(Cc3ccc4ncccc4c3)n2c1
Show InChI InChI=1S/C20H15FN6/c1-26-11-16(10-23-26)15-9-17(21)20-25-24-19(27(20)12-15)8-13-4-5-18-14(7-13)3-2-6-22-18/h2-7,9-12H,8H2,1H3
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078388
PNG
(CHEMBL3414739)
Show SMILES Cn1cc(cn1)-c1cc(F)c2nnc(n2c1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H13F3N6/c1-28-10-14(9-25-28)13-8-16(21)18-26-27-19(29(18)11-13)20(22,23)15-4-5-17-12(7-15)3-2-6-24-17/h2-11H,1H3
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n/an/a 22n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078378
PNG
(CHEMBL3414921)
Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)c1nnc2c(F)cc(cn12)-c1cc(C)ns1
Show InChI InChI=1S/C22H18FN5OS/c1-12-6-20(30-27-12)16-9-18(23)22-26-25-21(28(22)11-16)13(2)14-4-5-19-15(7-14)8-17(29-3)10-24-19/h4-11,13H,1-3H3/t13-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078416
PNG
(CHEMBL3414734)
Show SMILES Fc1cc(cn2c(nnc12)C(F)(F)c1ccc2ncccc2c1)-c1ccccc1
Show InChI InChI=1S/C22H13F3N4/c23-18-12-16(14-5-2-1-3-6-14)13-29-20(18)27-28-21(29)22(24,25)17-8-9-19-15(11-17)7-4-10-26-19/h1-13H
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n/an/a 23n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078387
PNG
(CHEMBL3414740)
Show SMILES Fc1cc(cn2c(nnc12)C(F)(F)c1ccc2ncccc2c1)-c1cnn(c1)C1CC1
Show InChI InChI=1S/C22H15F3N6/c23-18-9-14(15-10-27-31(12-15)17-4-5-17)11-30-20(18)28-29-21(30)22(24,25)16-3-6-19-13(8-16)2-1-7-26-19/h1-3,6-12,17H,4-5H2
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n/an/a 24n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078387
PNG
(CHEMBL3414740)
Show SMILES Fc1cc(cn2c(nnc12)C(F)(F)c1ccc2ncccc2c1)-c1cnn(c1)C1CC1
Show InChI InChI=1S/C22H15F3N6/c23-18-9-14(15-10-27-31(12-15)17-4-5-17)11-30-20(18)28-29-21(30)22(24,25)16-3-6-19-13(8-16)2-1-7-26-19/h1-3,6-12,17H,4-5H2
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n/an/a 25n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078373
PNG
(CHEMBL3414929)
Show SMILES CC[C@H](c1nnc2c(F)cc(cn12)-c1cc(C)no1)c1ccc2ncc(OC)cc2c1
Show InChI InChI=1S/C23H20FN5O2/c1-4-18(14-5-6-20-15(8-14)9-17(30-3)11-25-20)22-26-27-23-19(24)10-16(12-29(22)23)21-7-13(2)28-31-21/h5-12,18H,4H2,1-3H3/t18-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078419
PNG
(CHEMBL3414730)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C23H18N4O2/c1-28-18-8-9-19-20(13-18)24-12-11-21(19)29-15-23-26-25-22-10-7-17(14-27(22)23)16-5-3-2-4-6-16/h2-14H,15H2,1H3
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n/an/a 31n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078405
PNG
(CHEMBL3414735)
Show SMILES Fc1cc(cn2c(nnc12)C(F)(F)c1ccc2ncccc2c1)-c1ccccn1
Show InChI InChI=1S/C21H12F3N5/c22-16-11-14(17-5-1-2-8-25-17)12-29-19(16)27-28-20(29)21(23,24)15-6-7-18-13(10-15)4-3-9-26-18/h1-12H
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n/an/a 32n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078403
PNG
(CHEMBL3414737)
Show SMILES Cc1ncc(s1)-c1cc(F)c2nnc(n2c1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H12F3N5S/c1-11-25-9-17(29-11)13-8-15(21)18-26-27-19(28(18)10-13)20(22,23)14-4-5-16-12(7-14)3-2-6-24-16/h2-10H,1H3
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n/an/a 35n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078413
PNG
(CHEMBL3414743)
Show SMILES Cn1cc(cn1)-c1cc(F)c2nnc(Cc3ccc4ncc(O)cc4c3)n2c1
Show InChI InChI=1S/C20H15FN6O/c1-26-10-15(8-23-26)14-7-17(21)20-25-24-19(27(20)11-14)5-12-2-3-18-13(4-12)6-16(28)9-22-18/h2-4,6-11,28H,5H2,1H3
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n/an/a 51n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078410
PNG
(CHEMBL3414912)
Show SMILES Cn1cc(cn1)-c1cc(F)c2nnc(Cc3ccc4nc(N)sc4c3)n2c1
Show InChI InChI=1S/C18H14FN7S/c1-25-8-12(7-21-25)11-6-13(19)17-24-23-16(26(17)9-11)5-10-2-3-14-15(4-10)27-18(20)22-14/h2-4,6-9H,5H2,1H3,(H2,20,22)
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n/an/a 52n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164491
PNG
(US9066954, 437)
Show SMILES Fc1cc(cn2c(Cc3ccc4ncccc4c3)nnc12)-c1ccccc1
Show InChI InChI=1S/C22H15FN4/c23-19-13-18(16-5-2-1-3-6-16)14-27-21(25-26-22(19)27)12-15-8-9-20-17(11-15)7-4-10-24-20/h1-11,13-14H,12H2
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n/an/a 60n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078373
PNG
(CHEMBL3414929)
Show SMILES CC[C@H](c1nnc2c(F)cc(cn12)-c1cc(C)no1)c1ccc2ncc(OC)cc2c1
Show InChI InChI=1S/C23H20FN5O2/c1-4-18(14-5-6-20-15(8-14)9-17(30-3)11-25-20)22-26-27-23-19(24)10-16(12-29(22)23)21-7-13(2)28-31-21/h5-12,18H,4H2,1-3H3/t18-/m0/s1
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n/an/a 67n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078411
PNG
(CHEMBL3414745)
Show SMILES CC(=O)Nc1nc2ccc(Cc3nnc4c(F)cc(cn34)-c3cnn(C)c3)cc2s1
Show InChI InChI=1S/C20H16FN7OS/c1-11(29)23-20-24-16-4-3-12(5-17(16)30-20)6-18-25-26-19-15(21)7-13(10-28(18)19)14-8-22-27(2)9-14/h3-5,7-10H,6H2,1-2H3,(H,23,24,29)
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n/an/a 67n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078406
PNG
(CHEMBL3414928)
Show SMILES COc1cnc2ccc(cc2c1)C1(CC1)c1nnc2c(F)cc(cn12)-c1cc(C)no1
Show InChI InChI=1S/C23H18FN5O2/c1-13-7-20(31-28-13)15-10-18(24)21-26-27-22(29(21)12-15)23(5-6-23)16-3-4-19-14(8-16)9-17(30-2)11-25-19/h3-4,7-12H,5-6H2,1-2H3
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n/an/a 93n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078412
PNG
(CHEMBL3414744)
Show SMILES Cn1cc(cn1)-c1cc(F)c2nnc(Cc3ccc4nccnc4c3)n2c1
Show InChI InChI=1S/C19H14FN7/c1-26-10-14(9-23-26)13-8-15(20)19-25-24-18(27(19)11-13)7-12-2-3-16-17(6-12)22-5-4-21-16/h2-6,8-11H,7H2,1H3
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n/an/a 182n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078417
PNG
(CHEMBL3414732)
Show SMILES C(c1nnc2ccc(cn12)-c1ccccc1)c1ccc2ncccc2c1
Show InChI InChI=1S/C22H16N4/c1-2-5-17(6-3-1)19-9-11-21-24-25-22(26(21)15-19)14-16-8-10-20-18(13-16)7-4-12-23-20/h1-13,15H,14H2
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n/an/a 210n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078408
PNG
(CHEMBL3414924)
Show SMILES COc1cnc2ccc(cc2c1)[C@@H](C)c1nnc2c(F)cc(cn12)-c1cc(C)no1
Show InChI InChI=1S/C22H18FN5O2/c1-12-6-20(30-27-12)16-9-18(23)22-26-25-21(28(22)11-16)13(2)14-4-5-19-15(7-14)8-17(29-3)10-24-19/h4-11,13H,1-3H3/t13-/m1/s1
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n/an/a 370n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078407
PNG
(CHEMBL3414927)
Show SMILES Cc1cc(on1)-c1cc(F)c2nnc(n2c1)C(C)(C)c1ccc2ncc(O)cc2c1
Show InChI InChI=1S/C22H18FN5O2/c1-12-6-19(30-27-12)14-9-17(23)20-25-26-21(28(20)11-14)22(2,3)15-4-5-18-13(7-15)8-16(29)10-24-18/h4-11,29H,1-3H3
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n/an/a>400n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50078409
PNG
(CHEMBL3414916)
Show SMILES Cc1cc(sn1)-c1cc(F)c2nnc(n2c1)[C@@](C)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C21H15F2N5S/c1-12-8-18(29-27-12)14-10-16(22)19-25-26-20(28(19)11-14)21(2,23)15-5-6-17-13(9-15)4-3-7-24-17/h3-11H,1-2H3/t21-/m0/s1
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n/an/a 780n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24469
PNG
(4-({6-phenyl-[1,2,4]triazolo[3,4-a]pyridin-3-yl}me...)
Show SMILES Oc1ccc(Cc2nnc3ccc(cn23)-c2ccccc2)cc1
Show InChI InChI=1S/C19H15N3O/c23-17-9-6-14(7-10-17)12-19-21-20-18-11-8-16(13-22(18)19)15-4-2-1-3-5-15/h1-11,13,23H,12H2
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n/an/a 2.10E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay


J Med Chem 58: 2417-30 (2015)


Article DOI: 10.1021/jm501913a
BindingDB Entry DOI: 10.7270/Q2MP5502
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%