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PubMed code 25699713

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50078539
PNG
(CHEMBL3414950)
Show SMILES CCCC(CCC)C(N)P(O)(O)=O
Show InChI InChI=1S/C8H20NO3P/c1-3-5-7(6-4-2)8(9)13(10,11)12/h7-8H,3-6,9H2,1-2H3,(H2,10,11,12)
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Article
PubMed
4.90E+3n/an/an/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Human MetAP1b using Met-pNA as substrate


J Med Chem 58: 2350-7 (2015)


Article DOI: 10.1021/jm501790e
BindingDB Entry DOI: 10.7270/Q2C53NJX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50337147
PNG
((RS)-1-amino-3-cyclohexylpropylphosphonic acid | C...)
Show SMILES NC(CCC1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C9H20NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h8-9H,1-7,10H2,(H2,11,12,13)
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9.90E+3n/an/an/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Human MetAP1b using Met-pNA as substrate


J Med Chem 58: 2350-7 (2015)


Article DOI: 10.1021/jm501790e
BindingDB Entry DOI: 10.7270/Q2C53NJX
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50078540
PNG
(CHEMBL1673077)
Show SMILES CCCC(C)C(N)P(O)(O)=O
Show InChI InChI=1S/C6H16NO3P/c1-3-4-5(2)6(7)11(8,9)10/h5-6H,3-4,7H2,1-2H3,(H2,8,9,10)
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5.48E+4n/an/an/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Human MetAP1b using Met-pNA as substrate


J Med Chem 58: 2350-7 (2015)


Article DOI: 10.1021/jm501790e
BindingDB Entry DOI: 10.7270/Q2C53NJX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50316031
PNG
(CHEMBL1090366 | amino(phenyl)methylphosphonic acid)
Show SMILES NC(c1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C7H10NO3P/c8-7(12(9,10)11)6-4-2-1-3-5-6/h1-5,7H,8H2,(H2,9,10,11)
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1.12E+5n/an/an/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Human MetAP1b using Met-pNA as substrate


J Med Chem 58: 2350-7 (2015)


Article DOI: 10.1021/jm501790e
BindingDB Entry DOI: 10.7270/Q2C53NJX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50337150
PNG
((RS)-1-amino-2-cyclohexylethylphosphonic acid | CH...)
Show SMILES NC(CC1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C8H18NO3P/c9-8(13(10,11)12)6-7-4-2-1-3-5-7/h7-8H,1-6,9H2,(H2,10,11,12)
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>5.00E+5n/an/an/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Human MetAP1b using Met-pNA as substrate


J Med Chem 58: 2350-7 (2015)


Article DOI: 10.1021/jm501790e
BindingDB Entry DOI: 10.7270/Q2C53NJX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50078541
PNG
(CHEMBL3414949)
Show SMILES NC(C1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C7H16NO3P/c8-7(12(9,10)11)6-4-2-1-3-5-6/h6-7H,1-5,8H2,(H2,9,10,11)
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PubMed
>5.00E+5n/an/an/an/an/an/an/an/a



CSIR-Indian Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of Human MetAP1b using Met-pNA as substrate


J Med Chem 58: 2350-7 (2015)


Article DOI: 10.1021/jm501790e
BindingDB Entry DOI: 10.7270/Q2C53NJX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
* indicates data uncertainty>20%