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PubMed code 25778995

Compile data set for download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50089076
PNG
(CHEMBL3577642)
Show SMILES COc1ccc(NC(=O)COc2ccc(\C=C3/N=C(N(C3=O)c3ccc(OC)cc3)c3ccccc3)cc2)cc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-16-10-24(11-17-26)33-30(36)21-40-28-14-8-22(9-15-28)20-29-32(37)35(25-12-18-27(39-2)19-13-25)31(34-29)23-6-4-3-5-7-23/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
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n/an/a 2.30n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50088858
PNG
(CHEMBL3577566)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(C)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-11-15-25(16-12-22)33-30(36)21-39-27-17-13-23(14-18-27)19-29-32(37)35(26-9-6-10-28(20-26)38-2)31(34-29)24-7-4-3-5-8-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 3.20n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50088791
PNG
(CHEMBL3577634)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(Cl)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-27-12-6-11-25(19-27)35-30(22-7-3-2-4-8-22)34-28(31(35)37)17-21-13-15-26(16-14-21)39-20-29(36)33-24-10-5-9-23(32)18-24/h2-19H,20H2,1H3,(H,33,36)/b28-17-
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n/an/a 3.40n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50089074
PNG
(CHEMBL3577643)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3Cl)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-24-17-13-23(14-18-24)35-30(22-7-3-2-4-8-22)34-28(31(35)37)19-21-11-15-25(16-12-21)39-20-29(36)33-27-10-6-5-9-26(27)32/h2-19H,20H2,1H3,(H,33,36)/b28-19-
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n/an/a 3.5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50088791
PNG
(CHEMBL3577634)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(Cl)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-27-12-6-11-25(19-27)35-30(22-7-3-2-4-8-22)34-28(31(35)37)17-21-13-15-26(16-14-21)39-20-29(36)33-24-10-5-9-23(32)18-24/h2-19H,20H2,1H3,(H,33,36)/b28-17-
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n/an/a 3.70n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50088855
PNG
(CHEMBL3577632)
Show SMILES COc1ccc(NC(=O)COc2ccc(\C=C3/N=C(N(C3=O)c3cccc(OC)c3)c3ccccc3)cc2)cc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-17-13-24(14-18-26)33-30(36)21-40-27-15-11-22(12-16-27)19-29-32(37)35(25-9-6-10-28(20-25)39-2)31(34-29)23-7-4-3-5-8-23/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 4.30n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50088855
PNG
(CHEMBL3577632)
Show SMILES COc1ccc(NC(=O)COc2ccc(\C=C3/N=C(N(C3=O)c3cccc(OC)c3)c3ccccc3)cc2)cc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-17-13-24(14-18-26)33-30(36)21-40-27-15-11-22(12-16-27)19-29-32(37)35(25-9-6-10-28(20-25)39-2)31(34-29)23-7-4-3-5-8-23/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 4.30n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50088858
PNG
(CHEMBL3577566)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(C)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-11-15-25(16-12-22)33-30(36)21-39-27-17-13-23(14-18-27)19-29-32(37)35(26-9-6-10-28(20-26)38-2)31(34-29)24-7-4-3-5-8-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 4.5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50088896
PNG
(CHEMBL3577645)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(Cl)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-26-17-13-25(14-18-26)35-30(22-5-3-2-4-6-22)34-28(31(35)37)19-21-7-15-27(16-8-21)39-20-29(36)33-24-11-9-23(32)10-12-24/h2-19H,20H2,1H3,(H,33,36)/b28-19-
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n/an/a 4.5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50088897
PNG
(CHEMBL3577644)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(Cl)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-26-16-12-25(13-17-26)35-30(22-6-3-2-4-7-22)34-28(31(35)37)18-21-10-14-27(15-11-21)39-20-29(36)33-24-9-5-8-23(32)19-24/h2-19H,20H2,1H3,(H,33,36)/b28-18-
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n/an/a 4.5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50089083
PNG
(CHEMBL3577635)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(Cl)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-27-9-5-8-25(19-27)35-30(22-6-3-2-4-7-22)34-28(31(35)37)18-21-10-16-26(17-11-21)39-20-29(36)33-24-14-12-23(32)13-15-24/h2-19H,20H2,1H3,(H,33,36)/b28-18-
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n/an/a 4.60n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50089083
PNG
(CHEMBL3577635)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(Cl)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-27-9-5-8-25(19-27)35-30(22-6-3-2-4-7-22)34-28(31(35)37)18-21-10-16-26(17-11-21)39-20-29(36)33-24-14-12-23(32)13-15-24/h2-19H,20H2,1H3,(H,33,36)/b28-18-
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n/an/a 4.60n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50089074
PNG
(CHEMBL3577643)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3Cl)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-24-17-13-23(14-18-24)35-30(22-7-3-2-4-8-22)34-28(31(35)37)19-21-11-15-25(16-12-21)39-20-29(36)33-27-10-6-5-9-26(27)32/h2-19H,20H2,1H3,(H,33,36)/b28-19-
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n/an/a 4.70n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50088857
PNG
(CHEMBL3577567)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3OC)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-12-8-11-24(20-26)35-31(23-9-4-3-5-10-23)34-28(32(35)37)19-22-15-17-25(18-16-22)40-21-30(36)33-27-13-6-7-14-29(27)39-2/h3-20H,21H2,1-2H3,(H,33,36)/b28-19-
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n/an/a 4.70n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50088854
PNG
(CHEMBL3577633)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3Cl)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-25-11-7-10-23(19-25)35-30(22-8-3-2-4-9-22)34-28(31(35)37)18-21-14-16-24(17-15-21)39-20-29(36)33-27-13-6-5-12-26(27)32/h2-19H,20H2,1H3,(H,33,36)/b28-18-
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n/an/a 5.30n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50088856
PNG
(CHEMBL3577631)
Show SMILES COc1cccc(NC(=O)COc2ccc(\C=C3/N=C(N(C3=O)c3cccc(OC)c3)c3ccccc3)cc2)c1
Show InChI InChI=1S/C32H27N3O5/c1-38-27-12-6-10-24(19-27)33-30(36)21-40-26-16-14-22(15-17-26)18-29-32(37)35(25-11-7-13-28(20-25)39-2)31(34-29)23-8-4-3-5-9-23/h3-20H,21H2,1-2H3,(H,33,36)/b29-18-
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n/an/a 5.40n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50088854
PNG
(CHEMBL3577633)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3Cl)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-25-11-7-10-23(19-25)35-30(22-8-3-2-4-9-22)34-28(31(35)37)18-21-14-16-24(17-15-21)39-20-29(36)33-27-13-6-5-12-26(27)32/h2-19H,20H2,1H3,(H,33,36)/b28-18-
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n/an/a 5.60n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50088856
PNG
(CHEMBL3577631)
Show SMILES COc1cccc(NC(=O)COc2ccc(\C=C3/N=C(N(C3=O)c3cccc(OC)c3)c3ccccc3)cc2)c1
Show InChI InChI=1S/C32H27N3O5/c1-38-27-12-6-10-24(19-27)33-30(36)21-40-26-16-14-22(15-17-26)18-29-32(37)35(25-11-7-13-28(20-25)39-2)31(34-29)23-8-4-3-5-9-23/h3-20H,21H2,1-2H3,(H,33,36)/b29-18-
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n/an/a 6.5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50088897
PNG
(CHEMBL3577644)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(Cl)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-26-16-12-25(13-17-26)35-30(22-6-3-2-4-7-22)34-28(31(35)37)18-21-10-14-27(15-11-21)39-20-29(36)33-24-9-5-8-23(32)19-24/h2-19H,20H2,1H3,(H,33,36)/b28-18-
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n/an/a 7n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/a 18n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088859
PNG
(CHEMBL3577565)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(C)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-8-6-11-25(18-22)33-30(36)21-39-27-16-14-23(15-17-27)19-29-32(37)35(26-12-7-13-28(20-26)38-2)31(34-29)24-9-4-3-5-10-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 20n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50089077
PNG
(CHEMBL3577641)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(OC)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-17-13-25(14-18-26)35-31(23-7-4-3-5-8-23)34-29(32(35)37)19-22-11-15-27(16-12-22)40-21-30(36)33-24-9-6-10-28(20-24)39-2/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 21n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089077
PNG
(CHEMBL3577641)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(OC)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-17-13-25(14-18-26)35-31(23-7-4-3-5-8-23)34-29(32(35)37)19-22-11-15-27(16-12-22)40-21-30(36)33-24-9-6-10-28(20-24)39-2/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 21n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50089082
PNG
(CHEMBL3577636)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H25N3O4/c1-37-26-18-14-25(15-19-26)34-30(23-8-4-2-5-9-23)33-28(31(34)36)20-22-12-16-27(17-13-22)38-21-29(35)32-24-10-6-3-7-11-24/h2-20H,21H2,1H3,(H,32,35)/b28-20-
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n/an/a 23n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50089081
PNG
(CHEMBL3577637)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3C)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-8-6-7-11-28(22)33-30(36)21-39-27-16-12-23(13-17-27)20-29-32(37)35(25-14-18-26(38-2)19-15-25)31(34-29)24-9-4-3-5-10-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
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n/an/a 23n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50089077
PNG
(CHEMBL3577641)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(OC)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-17-13-25(14-18-26)35-31(23-7-4-3-5-8-23)34-29(32(35)37)19-22-11-15-27(16-12-22)40-21-30(36)33-24-9-6-10-28(20-24)39-2/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 23n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089082
PNG
(CHEMBL3577636)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H25N3O4/c1-37-26-18-14-25(15-19-26)34-30(23-8-4-2-5-9-23)33-28(31(34)36)20-22-12-16-27(17-13-22)38-21-29(35)32-24-10-6-3-7-11-24/h2-20H,21H2,1H3,(H,32,35)/b28-20-
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n/an/a 23n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089079
PNG
(CHEMBL3577639)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(C)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-8-12-25(13-9-22)33-30(36)21-39-28-16-10-23(11-17-28)20-29-32(37)35(26-14-18-27(38-2)19-15-26)31(34-29)24-6-4-3-5-7-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
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n/an/a 23n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089076
PNG
(CHEMBL3577642)
Show SMILES COc1ccc(NC(=O)COc2ccc(\C=C3/N=C(N(C3=O)c3ccc(OC)cc3)c3ccccc3)cc2)cc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-16-10-24(11-17-26)33-30(36)21-40-28-14-8-22(9-15-28)20-29-32(37)35(25-12-18-27(39-2)19-13-25)31(34-29)23-6-4-3-5-7-23/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
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n/an/a 23n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089074
PNG
(CHEMBL3577643)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3Cl)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-24-17-13-23(14-18-24)35-30(22-7-3-2-4-8-22)34-28(31(35)37)19-21-11-15-25(16-12-21)39-20-29(36)33-27-10-6-5-9-26(27)32/h2-19H,20H2,1H3,(H,33,36)/b28-19-
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n/an/a 24n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088858
PNG
(CHEMBL3577566)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(C)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-11-15-25(16-12-22)33-30(36)21-39-27-17-13-23(14-18-27)19-29-32(37)35(26-9-6-10-28(20-26)38-2)31(34-29)24-7-4-3-5-8-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 25n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089081
PNG
(CHEMBL3577637)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3C)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-8-6-7-11-28(22)33-30(36)21-39-27-16-12-23(13-17-27)20-29-32(37)35(25-14-18-26(38-2)19-15-25)31(34-29)24-9-4-3-5-10-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
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n/an/a 32n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50089078
PNG
(CHEMBL3577640)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3OC)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O5/c1-38-25-18-14-24(15-19-25)35-31(23-8-4-3-5-9-23)34-28(32(35)37)20-22-12-16-26(17-13-22)40-21-30(36)33-27-10-6-7-11-29(27)39-2/h3-20H,21H2,1-2H3,(H,33,36)/b28-20-
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n/an/a 34n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088897
PNG
(CHEMBL3577644)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(Cl)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-26-16-12-25(13-17-26)35-30(22-6-3-2-4-7-22)34-28(31(35)37)18-21-10-14-27(15-11-21)39-20-29(36)33-24-9-5-8-23(32)19-24/h2-19H,20H2,1H3,(H,33,36)/b28-18-
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n/an/a 35n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50088895
PNG
(CHEMBL3577563)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H25N3O4/c1-37-27-14-8-13-25(20-27)34-30(23-9-4-2-5-10-23)33-28(31(34)36)19-22-15-17-26(18-16-22)38-21-29(35)32-24-11-6-3-7-12-24/h2-20H,21H2,1H3,(H,32,35)/b28-19-
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n/an/a 35n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/a 37n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088894
PNG
(CHEMBL3577564)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3C)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-9-6-7-14-28(22)33-30(36)21-39-26-17-15-23(16-18-26)19-29-32(37)35(25-12-8-13-27(20-25)38-2)31(34-29)24-10-4-3-5-11-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 43n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50088859
PNG
(CHEMBL3577565)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(C)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-8-6-11-25(18-22)33-30(36)21-39-27-16-14-23(15-17-27)19-29-32(37)35(26-12-7-13-28(20-26)38-2)31(34-29)24-9-4-3-5-10-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 43n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089078
PNG
(CHEMBL3577640)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3OC)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O5/c1-38-25-18-14-24(15-19-25)35-31(23-8-4-3-5-9-23)34-28(32(35)37)20-22-12-16-26(17-13-22)40-21-30(36)33-27-10-6-7-11-29(27)39-2/h3-20H,21H2,1-2H3,(H,33,36)/b28-20-
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n/an/a 43n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50089079
PNG
(CHEMBL3577639)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(C)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-8-12-25(13-9-22)33-30(36)21-39-28-16-10-23(11-17-28)20-29-32(37)35(26-14-18-27(38-2)19-15-26)31(34-29)24-6-4-3-5-7-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
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n/an/a 43n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50088896
PNG
(CHEMBL3577645)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(Cl)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-26-17-13-25(14-18-26)35-30(22-5-3-2-4-6-22)34-28(31(35)37)19-21-7-15-27(16-8-21)39-20-29(36)33-24-11-9-23(32)10-12-24/h2-19H,20H2,1H3,(H,33,36)/b28-19-
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n/an/a 44n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50088894
PNG
(CHEMBL3577564)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3C)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-9-6-7-14-28(22)33-30(36)21-39-26-17-15-23(16-18-26)19-29-32(37)35(25-12-8-13-27(20-25)38-2)31(34-29)24-10-4-3-5-11-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 44n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088857
PNG
(CHEMBL3577567)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3OC)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-12-8-11-24(20-26)35-31(23-9-4-3-5-10-23)34-28(32(35)37)19-22-15-17-25(18-16-22)40-21-30(36)33-27-13-6-7-14-29(27)39-2/h3-20H,21H2,1-2H3,(H,33,36)/b28-19-
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n/an/a 46n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088896
PNG
(CHEMBL3577645)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(Cl)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-26-17-13-25(14-18-26)35-30(22-5-3-2-4-6-22)34-28(31(35)37)19-21-7-15-27(16-8-21)39-20-29(36)33-24-11-9-23(32)10-12-24/h2-19H,20H2,1H3,(H,33,36)/b28-19-
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n/an/a 47n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50088857
PNG
(CHEMBL3577567)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3OC)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-12-8-11-24(20-26)35-31(23-9-4-3-5-10-23)34-28(32(35)37)19-22-15-17-25(18-16-22)40-21-30(36)33-27-13-6-7-14-29(27)39-2/h3-20H,21H2,1-2H3,(H,33,36)/b28-19-
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n/an/a 54n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50088895
PNG
(CHEMBL3577563)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H25N3O4/c1-37-27-14-8-13-25(20-27)34-30(23-9-4-2-5-10-23)33-28(31(34)36)19-22-15-17-26(18-16-22)38-21-29(35)32-24-11-6-3-7-12-24/h2-20H,21H2,1H3,(H,32,35)/b28-19-
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n/an/a 54n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50089081
PNG
(CHEMBL3577637)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3C)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-8-6-7-11-28(22)33-30(36)21-39-27-16-12-23(13-17-27)20-29-32(37)35(25-14-18-26(38-2)19-15-25)31(34-29)24-9-4-3-5-10-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
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n/an/a 56n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088856
PNG
(CHEMBL3577631)
Show SMILES COc1cccc(NC(=O)COc2ccc(\C=C3/N=C(N(C3=O)c3cccc(OC)c3)c3ccccc3)cc2)c1
Show InChI InChI=1S/C32H27N3O5/c1-38-27-12-6-10-24(19-27)33-30(36)21-40-26-16-14-22(15-17-26)18-29-32(37)35(25-11-7-13-28(20-25)39-2)31(34-29)23-8-4-3-5-9-23/h3-20H,21H2,1-2H3,(H,33,36)/b29-18-
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n/an/a 57n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088895
PNG
(CHEMBL3577563)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H25N3O4/c1-37-27-14-8-13-25(20-27)34-30(23-9-4-2-5-10-23)33-28(31(34)36)19-22-15-17-26(18-16-22)38-21-29(35)32-24-11-6-3-7-12-24/h2-20H,21H2,1H3,(H,32,35)/b28-19-
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n/an/a 65n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50088894
PNG
(CHEMBL3577564)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3C)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-9-6-7-14-28(22)33-30(36)21-39-26-17-15-23(16-18-26)19-29-32(37)35(25-12-8-13-27(20-25)38-2)31(34-29)24-10-4-3-5-11-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 66n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088855
PNG
(CHEMBL3577632)
Show SMILES COc1ccc(NC(=O)COc2ccc(\C=C3/N=C(N(C3=O)c3cccc(OC)c3)c3ccccc3)cc2)cc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-17-13-24(14-18-26)33-30(36)21-40-27-15-11-22(12-16-27)19-29-32(37)35(25-9-6-10-28(20-25)39-2)31(34-29)23-7-4-3-5-8-23/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 76n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50089080
PNG
(CHEMBL3577638)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(C)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-7-6-10-25(19-22)33-30(36)21-39-28-15-11-23(12-16-28)20-29-32(37)35(26-13-17-27(38-2)18-14-26)31(34-29)24-8-4-3-5-9-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
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n/an/a 77n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50089080
PNG
(CHEMBL3577638)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(C)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-7-6-10-25(19-22)33-30(36)21-39-28-15-11-23(12-16-28)20-29-32(37)35(26-13-17-27(38-2)18-14-26)31(34-29)24-8-4-3-5-9-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
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n/an/a 78n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50088859
PNG
(CHEMBL3577565)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(C)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-8-6-11-25(18-22)33-30(36)21-39-27-16-14-23(15-17-27)19-29-32(37)35(26-12-7-13-28(20-26)38-2)31(34-29)24-9-4-3-5-10-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-19-
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n/an/a 87n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088854
PNG
(CHEMBL3577633)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3Cl)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-25-11-7-10-23(19-25)35-30(22-8-3-2-4-9-22)34-28(31(35)37)18-21-14-16-24(17-15-21)39-20-29(36)33-27-13-6-5-12-26(27)32/h2-19H,20H2,1H3,(H,33,36)/b28-18-
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n/an/a 87n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50089078
PNG
(CHEMBL3577640)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3OC)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O5/c1-38-25-18-14-24(15-19-25)35-31(23-8-4-3-5-9-23)34-28(32(35)37)20-22-12-16-26(17-13-22)40-21-30(36)33-27-10-6-7-11-29(27)39-2/h3-20H,21H2,1-2H3,(H,33,36)/b28-20-
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n/an/a 89n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50088791
PNG
(CHEMBL3577634)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(Cl)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-27-12-6-11-25(19-27)35-30(22-7-3-2-4-8-22)34-28(31(35)37)17-21-13-15-26(16-14-21)39-20-29(36)33-24-10-5-9-23(32)18-24/h2-19H,20H2,1H3,(H,33,36)/b28-17-
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n/an/a 89n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089080
PNG
(CHEMBL3577638)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3cccc(C)c3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-7-6-10-25(19-22)33-30(36)21-39-28-15-11-23(12-16-28)20-29-32(37)35(26-13-17-27(38-2)18-14-26)31(34-29)24-8-4-3-5-9-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
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n/an/a 89n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50089083
PNG
(CHEMBL3577635)
Show SMILES COc1cccc(c1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(Cl)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H24ClN3O4/c1-38-27-9-5-8-25(19-27)35-30(22-6-3-2-4-7-22)34-28(31(35)37)18-21-10-16-26(17-11-21)39-20-29(36)33-24-14-12-23(32)13-15-24/h2-19H,20H2,1H3,(H,33,36)/b28-18-
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n/an/a 95n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK1 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/a 110n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of ERK2 (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50089079
PNG
(CHEMBL3577639)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccc(C)cc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C32H27N3O4/c1-22-8-12-25(13-9-22)33-30(36)21-39-28-16-10-23(11-17-28)20-29-32(37)35(26-14-18-27(38-2)19-15-26)31(34-29)24-6-4-3-5-7-24/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
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n/an/a 345n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50089076
PNG
(CHEMBL3577642)
Show SMILES COc1ccc(NC(=O)COc2ccc(\C=C3/N=C(N(C3=O)c3ccc(OC)cc3)c3ccccc3)cc2)cc1
Show InChI InChI=1S/C32H27N3O5/c1-38-26-16-10-24(11-17-26)33-30(36)21-40-28-14-8-22(9-15-28)20-29-32(37)35(25-12-18-27(39-2)19-13-25)31(34-29)23-6-4-3-5-7-23/h3-20H,21H2,1-2H3,(H,33,36)/b29-20-
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n/an/a 345n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50089082
PNG
(CHEMBL3577636)
Show SMILES COc1ccc(cc1)N1C(=O)\C(=C\c2ccc(OCC(=O)Nc3ccccc3)cc2)N=C1c1ccccc1
Show InChI InChI=1S/C31H25N3O4/c1-37-26-18-14-25(15-19-26)34-30(23-8-4-2-5-9-23)33-28(31(34)36)20-22-12-16-27(17-13-22)38-21-29(35)32-24-10-6-3-7-11-24/h2-20H,21H2,1H3,(H,32,35)/b28-20-
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n/an/a 354n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of p38alpha MAP kinase (unknown origin) using GFP-ATF2 as substrate after 1 hr by TR-FRET assay


Eur J Med Chem 94: 397-404 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.008
BindingDB Entry DOI: 10.7270/Q2BZ67SV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%