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PubMed code 25827399

Compile data set for download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079561
PNG
(CHEMBL3417485)
Show SMILES CN1CCN(CCOc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-n3ccc4ccc(F)cc34)c2)CC1
Show InChI InChI=1S/C30H30FN7O2/c1-35-11-13-36(14-12-35)15-16-40-26-19-32-30(33-20-26)24-4-2-3-22(17-24)21-38-29(39)8-7-28(34-38)37-10-9-23-5-6-25(31)18-27(23)37/h2-10,17-20H,11-16,21H2,1H3
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PubMed
n/an/a 1.70n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079560
PNG
(CHEMBL3417484)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(Cc4cccc(c4)-c4ncc(OCCN5CCOCC5)cn4)n3)c2c1
Show InChI InChI=1S/C29H27FN6O3/c30-24-5-4-22-8-9-35(26(22)17-24)27-6-7-28(37)36(33-27)20-21-2-1-3-23(16-21)29-31-18-25(19-32-29)39-15-12-34-10-13-38-14-11-34/h1-9,16-19H,10-15,20H2
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n/an/a 2.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a 4.20n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079566
PNG
(CHEMBL3414602)
Show SMILES COCCOc1ccc2c(OCCn3nc(ccc3=O)-n3ccc4ccc(F)cc34)ccnc2c1
Show InChI InChI=1S/C26H23FN4O4/c1-33-14-15-34-20-4-5-21-22(17-20)28-10-8-24(21)35-13-12-31-26(32)7-6-25(29-31)30-11-9-18-2-3-19(27)16-23(18)30/h2-11,16-17H,12-15H2,1H3
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n/an/a 4.60n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079563
PNG
(CHEMBL3417487)
Show SMILES COCCCOc1cnc(nc1)-c1cccc(Cn2nc(ccc2=O)-n2ccc3ccc(F)cc23)c1
Show InChI InChI=1S/C27H24FN5O3/c1-35-12-3-13-36-23-16-29-27(30-17-23)21-5-2-4-19(14-21)18-33-26(34)9-8-25(31-33)32-11-10-20-6-7-22(28)15-24(20)32/h2,4-11,14-17H,3,12-13,18H2,1H3
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n/an/a 5.20n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306682
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
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PubMed
n/an/a 7.10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079558
PNG
(CHEMBL3417482)
Show SMILES CN1CCN(CCCOC(=O)Nc2cccc(Cn3nc(ccc3=O)-n3ccc4ccc(F)cc34)c2)CC1
Show InChI InChI=1S/C28H31FN6O3/c1-32-13-15-33(16-14-32)11-3-17-38-28(37)30-24-5-2-4-21(18-24)20-35-27(36)9-8-26(31-35)34-12-10-22-6-7-23(29)19-25(22)34/h2,4-10,12,18-19H,3,11,13-17,20H2,1H3,(H,30,37)
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n/an/a 9n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079562
PNG
(CHEMBL3417486)
Show SMILES CN1CCN(CCCOc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-n3ccc4ccc(F)cc34)c2)CC1
Show InChI InChI=1S/C31H32FN7O2/c1-36-13-15-37(16-14-36)11-3-17-41-27-20-33-31(34-21-27)25-5-2-4-23(18-25)22-39-30(40)9-8-29(35-39)38-12-10-24-6-7-26(32)19-28(24)38/h2,4-10,12,18-21H,3,11,13-17,22H2,1H3
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n/an/a 9.80n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079559
PNG
(CHEMBL3417483)
Show SMILES CN1CCN(CCCCCOC(=O)Nc2cccc(Cn3nc(ccc3=O)-n3ccc4ccc(F)cc34)c2)CC1
Show InChI InChI=1S/C30H35FN6O3/c1-34-15-17-35(18-16-34)13-3-2-4-19-40-30(39)32-26-7-5-6-23(20-26)22-37-29(38)11-10-28(33-37)36-14-12-24-8-9-25(31)21-27(24)36/h5-12,14,20-21H,2-4,13,15-19,22H2,1H3,(H,32,39)
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n/an/a 10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079564
PNG
(CHEMBL3417488)
Show SMILES COc1cnc(nc1)-c1cccc(Cn2nc(ccc2=O)-n2ccc3ccc(F)cc23)c1
Show InChI InChI=1S/C24H18FN5O2/c1-32-20-13-26-24(27-14-20)18-4-2-3-16(11-18)15-30-23(31)8-7-22(28-30)29-10-9-17-5-6-19(25)12-21(17)29/h2-14H,15H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079551
PNG
(CHEMBL3417475)
Show SMILES CN(C)CCCCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3ccc(F)cc23)c1
Show InChI InChI=1S/C27H30FN5O3/c1-31(2)14-4-3-5-16-36-27(35)29-23-8-6-7-20(17-23)19-33-26(34)12-11-25(30-33)32-15-13-21-9-10-22(28)18-24(21)32/h6-13,15,17-18H,3-5,14,16,19H2,1-2H3,(H,29,35)
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n/an/a 17n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079555
PNG
(CHEMBL3417479)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(Cc4cccc(NC(=O)OCCCCn5cccn5)c4)n3)c2c1
Show InChI InChI=1S/C27H25FN6O3/c28-22-8-7-21-11-15-33(24(21)18-22)25-9-10-26(35)34(31-25)19-20-5-3-6-23(17-20)30-27(36)37-16-2-1-13-32-14-4-12-29-32/h3-12,14-15,17-18H,1-2,13,16,19H2,(H,30,36)
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n/an/a 19n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079556
PNG
(CHEMBL3417480)
Show SMILES CN1CCN(CCCCOC(=O)Nc2cccc(Cn3nc(ccc3=O)-n3ccc4ccc(F)cc34)c2)CC1
Show InChI InChI=1S/C29H33FN6O3/c1-33-14-16-34(17-15-33)12-2-3-18-39-29(38)31-25-6-4-5-22(19-25)21-36-28(37)10-9-27(32-36)35-13-11-23-7-8-24(30)20-26(23)35/h4-11,13,19-20H,2-3,12,14-18,21H2,1H3,(H,31,38)
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n/an/a 20n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079554
PNG
(CHEMBL3417478)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(Cc4cccc(NC(=O)OCCCCN5CCOCC5)c4)n3)c2c1
Show InChI InChI=1S/C28H30FN5O4/c29-23-7-6-22-10-12-33(25(22)19-23)26-8-9-27(35)34(31-26)20-21-4-3-5-24(18-21)30-28(36)38-15-2-1-11-32-13-16-37-17-14-32/h3-10,12,18-19H,1-2,11,13-17,20H2,(H,30,36)
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n/an/a 24n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079557
PNG
(CHEMBL3417481)
Show SMILES COC(=O)CCCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3ccc(F)cc23)c1
Show InChI InChI=1S/C26H25FN4O5/c1-35-25(33)7-2-3-14-36-26(34)28-21-6-4-5-18(15-21)17-31-24(32)11-10-23(29-31)30-13-12-19-8-9-20(27)16-22(19)30/h4-6,8-13,15-16H,2-3,7,14,17H2,1H3,(H,28,34)
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n/an/a 36n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079550
PNG
(CHEMBL3417474)
Show SMILES CN(C)CCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3ccc(F)cc23)c1
Show InChI InChI=1S/C25H26FN5O3/c1-29(2)12-4-14-34-25(33)27-21-6-3-5-18(15-21)17-31-24(32)10-9-23(28-31)30-13-11-19-7-8-20(26)16-22(19)30/h3,5-11,13,15-16H,4,12,14,17H2,1-2H3,(H,27,33)
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n/an/a 40n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079548
PNG
(CHEMBL3417472)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3ccc(F)cc23)c1
Show InChI InChI=1S/C26H28FN5O3/c1-30(2)13-3-4-15-35-26(34)28-22-7-5-6-19(16-22)18-32-25(33)11-10-24(29-32)31-14-12-20-8-9-21(27)17-23(20)31/h5-12,14,16-17H,3-4,13,15,18H2,1-2H3,(H,28,34)
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n/an/a 46n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079552
PNG
(CHEMBL3417476)
Show SMILES CN(C)CCOCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3ccc(F)cc23)c1
Show InChI InChI=1S/C26H28FN5O4/c1-30(2)12-13-35-14-15-36-26(34)28-22-5-3-4-19(16-22)18-32-25(33)9-8-24(29-32)31-11-10-20-6-7-21(27)17-23(20)31/h3-11,16-17H,12-15,18H2,1-2H3,(H,28,34)
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n/an/a 51n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079569
PNG
(CHEMBL3417493)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3ccc(cc23)C(F)(F)F)c1
Show InChI InChI=1S/C27H28F3N5O3/c1-33(2)13-3-4-15-38-26(37)31-22-7-5-6-19(16-22)18-35-25(36)11-10-24(32-35)34-14-12-20-8-9-21(17-23(20)34)27(28,29)30/h5-12,14,16-17H,3-4,13,15,18H2,1-2H3,(H,31,37)
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n/an/a 85n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079574
PNG
(CHEMBL3417498)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3c(F)cc(F)cc23)c1
Show InChI InChI=1S/C26H27F2N5O3/c1-31(2)11-3-4-13-36-26(35)29-20-7-5-6-18(14-20)17-33-25(34)9-8-24(30-33)32-12-10-21-22(28)15-19(27)16-23(21)32/h5-10,12,14-16H,3-4,11,13,17H2,1-2H3,(H,29,35)
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n/an/a 89n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079543
PNG
(CHEMBL3417467)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(Nc3cccc(F)c3)ccc2=O)c1
Show InChI InChI=1S/C24H28FN5O3/c1-29(2)13-3-4-14-33-24(32)27-20-9-5-7-18(15-20)17-30-23(31)12-11-22(28-30)26-21-10-6-8-19(25)16-21/h5-12,15-16H,3-4,13-14,17H2,1-2H3,(H,26,28)(H,27,32)
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n/an/a 100n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079571
PNG
(CHEMBL3417495)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3ccc(C)cc23)c1
Show InChI InChI=1S/C27H31N5O3/c1-20-9-10-22-13-15-31(24(22)17-20)25-11-12-26(33)32(29-25)19-21-7-6-8-23(18-21)28-27(34)35-16-5-4-14-30(2)3/h6-13,15,17-18H,4-5,14,16,19H2,1-3H3,(H,28,34)
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n/an/a 151n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079540
PNG
(CHEMBL3417464)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(Nc3cccc(c3)C(F)(F)F)ccc2=O)c1
Show InChI InChI=1S/C25H28F3N5O3/c1-32(2)13-3-4-14-36-24(35)30-20-9-5-7-18(15-20)17-33-23(34)12-11-22(31-33)29-21-10-6-8-19(16-21)25(26,27)28/h5-12,15-16H,3-4,13-14,17H2,1-2H3,(H,29,31)(H,30,35)
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n/an/a 160n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079572
PNG
(CHEMBL3417496)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3c(F)cccc23)c1
Show InChI InChI=1S/C26H28FN5O3/c1-30(2)14-3-4-16-35-26(34)28-20-8-5-7-19(17-20)18-32-25(33)12-11-24(29-32)31-15-13-21-22(27)9-6-10-23(21)31/h5-13,15,17H,3-4,14,16,18H2,1-2H3,(H,28,34)
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n/an/a 190n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079549
PNG
(CHEMBL3417473)
Show SMILES CN(C)CCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3ccc(F)cc23)c1
Show InChI InChI=1S/C24H24FN5O3/c1-28(2)12-13-33-24(32)26-20-5-3-4-17(14-20)16-30-23(31)9-8-22(27-30)29-11-10-18-6-7-19(25)15-21(18)29/h3-11,14-15H,12-13,16H2,1-2H3,(H,26,32)
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n/an/a 191n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079546
PNG
(CHEMBL3417470)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(Nc3cc(F)cc(F)c3)ccc2=O)c1
Show InChI InChI=1S/C24H27F2N5O3/c1-30(2)10-3-4-11-34-24(33)28-20-7-5-6-17(12-20)16-31-23(32)9-8-22(29-31)27-21-14-18(25)13-19(26)15-21/h5-9,12-15H,3-4,10-11,16H2,1-2H3,(H,27,29)(H,28,33)
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n/an/a 200n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079539
PNG
(CHEMBL3417461)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(Nc3cccc(C)c3)ccc2=O)c1
Show InChI InChI=1S/C25H31N5O3/c1-19-8-6-10-21(16-19)26-23-12-13-24(31)30(28-23)18-20-9-7-11-22(17-20)27-25(32)33-15-5-4-14-29(2)3/h6-13,16-17H,4-5,14-15,18H2,1-3H3,(H,26,28)(H,27,32)
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n/an/a 210n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079545
PNG
(CHEMBL3417469)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(Nc3cccc(Cl)c3)ccc2=O)c1
Show InChI InChI=1S/C24H28ClN5O3/c1-29(2)13-3-4-14-33-24(32)27-20-9-5-7-18(15-20)17-30-23(31)12-11-22(28-30)26-21-10-6-8-19(25)16-21/h5-12,15-16H,3-4,13-14,17H2,1-2H3,(H,26,28)(H,27,32)
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n/an/a 300n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079573
PNG
(CHEMBL3417497)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3cc(F)ccc23)c1
Show InChI InChI=1S/C26H28FN5O3/c1-30(2)13-3-4-15-35-26(34)28-22-7-5-6-19(16-22)18-32-25(33)11-10-24(29-32)31-14-12-20-17-21(27)8-9-23(20)31/h5-12,14,16-17H,3-4,13,15,18H2,1-2H3,(H,28,34)
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n/an/a 320n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079537
PNG
(CHEMBL3417459)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(Nc3ccccc3)ccc2=O)c1
Show InChI InChI=1S/C24H29N5O3/c1-28(2)15-6-7-16-32-24(31)26-21-12-8-9-19(17-21)18-29-23(30)14-13-22(27-29)25-20-10-4-3-5-11-20/h3-5,8-14,17H,6-7,15-16,18H2,1-2H3,(H,25,27)(H,26,31)
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n/an/a 360n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079547
PNG
(CHEMBL3417471)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3ccccc23)c1
Show InChI InChI=1S/C26H29N5O3/c1-29(2)15-5-6-17-34-26(33)27-22-10-7-8-20(18-22)19-31-25(32)13-12-24(28-31)30-16-14-21-9-3-4-11-23(21)30/h3-4,7-14,16,18H,5-6,15,17,19H2,1-2H3,(H,27,33)
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n/an/a 370n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079570
PNG
(CHEMBL3417494)
Show SMILES COc1ccc2ccn(-c3ccc(=O)n(Cc4cccc(NC(=O)OCCCCN(C)C)c4)n3)c2c1
Show InChI InChI=1S/C27H31N5O4/c1-30(2)14-4-5-16-36-27(34)28-22-8-6-7-20(17-22)19-32-26(33)12-11-25(29-32)31-15-13-21-9-10-23(35-3)18-24(21)31/h6-13,15,17-18H,4-5,14,16,19H2,1-3H3,(H,28,34)
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n/an/a 583n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079544
PNG
(CHEMBL3417468)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(Nc3ccc(F)cc3)ccc2=O)c1
Show InChI InChI=1S/C24H28FN5O3/c1-29(2)14-3-4-15-33-24(32)27-21-7-5-6-18(16-21)17-30-23(31)13-12-22(28-30)26-20-10-8-19(25)9-11-20/h5-13,16H,3-4,14-15,17H2,1-2H3,(H,26,28)(H,27,32)
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n/an/a 900n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of AXL (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens)
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of EPHA2 (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of TYRO3 (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of FLT1 (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of EGFR (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of IGF1R (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079538
PNG
(CHEMBL3417460)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(Nc3ccccc3C)ccc2=O)c1
Show InChI InChI=1S/C25H31N5O3/c1-19-9-4-5-12-22(19)27-23-13-14-24(31)30(28-23)18-20-10-8-11-21(17-20)26-25(32)33-16-7-6-15-29(2)3/h4-5,8-14,17H,6-7,15-16,18H2,1-3H3,(H,26,32)(H,27,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of EGFR T790M/L858R mutant (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4 (HER4)


(Homo sapiens (Human))
BDBM50079565
PNG
(CHEMBL3417489)
Show SMILES Fc1ccc2ccn(-c3ccc(=O)n(CCOc4ccnc5cc(OCCCN6CCOCC6)ccc45)n3)c2c1
Show InChI InChI=1S/C30H30FN5O4/c31-23-3-2-22-9-12-35(27(22)20-23)29-6-7-30(37)36(33-29)15-19-40-28-8-10-32-26-21-24(4-5-25(26)28)39-16-1-11-34-13-17-38-18-14-34/h2-10,12,20-21H,1,11,13-19H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ERBB4 (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079541
PNG
(CHEMBL3417465)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(Nc3ccc(cc3)C(F)(F)F)ccc2=O)c1
Show InChI InChI=1S/C25H28F3N5O3/c1-32(2)14-3-4-15-36-24(35)30-21-7-5-6-18(16-21)17-33-23(34)13-12-22(31-33)29-20-10-8-19(9-11-20)25(26,27)28/h5-13,16H,3-4,14-15,17H2,1-2H3,(H,29,31)(H,30,35)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079542
PNG
(CHEMBL3417466)
Show SMILES CN(C)CCCCOC(=O)Nc1cccc(Cn2nc(Nc3ccccc3F)ccc2=O)c1
Show InChI InChI=1S/C24H28FN5O3/c1-29(2)14-5-6-15-33-24(32)26-19-9-7-8-18(16-19)17-30-23(31)13-12-22(28-30)27-21-11-4-3-10-20(21)25/h3-4,7-13,16H,5-6,14-15,17H2,1-2H3,(H,26,32)(H,27,28)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079553
PNG
(CHEMBL3417477)
Show SMILES CCOC(=O)Nc1cccc(Cn2nc(ccc2=O)-n2ccc3ccc(F)cc23)c1
Show InChI InChI=1S/C22H19FN4O3/c1-2-30-22(29)24-18-5-3-4-15(12-18)14-27-21(28)9-8-20(25-27)26-11-10-16-6-7-17(23)13-19(16)26/h3-13H,2,14H2,1H3,(H,24,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079536
PNG
(CHEMBL3417490)
Show SMILES Nc1ccc(Cn2nc(Nc3ccccc3)ccc2=O)cc1
Show InChI InChI=1S/C17H16N4O/c18-14-8-6-13(7-9-14)12-21-17(22)11-10-16(20-21)19-15-4-2-1-3-5-15/h1-11H,12,18H2,(H,19,20)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin)


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079568
PNG
(CHEMBL3417492)
Show SMILES CN(C)CCCCOC(=O)Nc1ccccc1Cn1nc(Nc2ccccc2C)ccc1=O
Show InChI InChI=1S/C25H31N5O3/c1-19-10-4-6-12-21(19)26-23-14-15-24(31)30(28-23)18-20-11-5-7-13-22(20)27-25(32)33-17-9-8-16-29(2)3/h4-7,10-15H,8-9,16-18H2,1-3H3,(H,26,28)(H,27,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50079567
PNG
(CHEMBL3417491)
Show SMILES CN(C)CCCCOC(=O)Nc1ccc(Cn2nc(Nc3ccccc3C)ccc2=O)cc1
Show InChI InChI=1S/C25H31N5O3/c1-19-8-4-5-9-22(19)27-23-14-15-24(31)30(28-23)18-20-10-12-21(13-11-20)26-25(32)33-17-7-6-16-29(2)3/h4-5,8-15H,6-7,16-18H2,1-3H3,(H,26,32)(H,27,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method


Eur J Med Chem 95: 302-12 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.041
BindingDB Entry DOI: 10.7270/Q2GQ70G4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%