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PubMed code 25845281

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074676
PNG
(CHEMBL3410091)
Show SMILES NC(=O)c1sc(nc1OCC1CC1)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C17H18N4O3S/c18-14(22)13-16(24-8-9-1-2-9)21-17(25-13)11-5-6-19-12(7-11)20-15(23)10-3-4-10/h5-7,9-10H,1-4,8H2,(H2,18,22)(H,19,20,23)
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n/an/a 0.290n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074675
PNG
(CHEMBL3410092)
Show SMILES NC(=O)c1sc(nc1OC1CCC1)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C17H18N4O3S/c18-14(22)13-16(24-11-2-1-3-11)21-17(25-13)10-6-7-19-12(8-10)20-15(23)9-4-5-9/h6-9,11H,1-5H2,(H2,18,22)(H,19,20,23)
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n/an/a 0.370n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074677
PNG
(CHEMBL3410090)
Show SMILES CC(C)Oc1nc(sc1C(N)=O)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C16H18N4O3S/c1-8(2)23-15-12(13(17)21)24-16(20-15)10-5-6-18-11(7-10)19-14(22)9-3-4-9/h5-9H,3-4H2,1-2H3,(H2,17,21)(H,18,19,22)
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n/an/a 0.450n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074576
PNG
(CHEMBL3410111)
Show SMILES CC(C)Oc1nc(ncc1C(N)=O)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C17H19N5O3/c1-9(2)25-17-12(14(18)23)8-20-15(22-17)11-5-6-19-13(7-11)21-16(24)10-3-4-10/h5-10H,3-4H2,1-2H3,(H2,18,23)(H,19,21,24)
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n/an/a 0.830n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074681
PNG
(CHEMBL3410089)
Show SMILES COc1nc(sc1C(N)=O)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C14H14N4O3S/c1-21-13-10(11(15)19)22-14(18-13)8-4-5-16-9(6-8)17-12(20)7-2-3-7/h4-7H,2-3H2,1H3,(H2,15,19)(H,16,17,20)
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n/an/a 1.10n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074595
PNG
(CHEMBL3410096)
Show SMILES O=C(Nc1cc(ccn1)-c1ccc2c(CCCNC2=O)c1)C1CC1
Show InChI InChI=1S/C19H19N3O2/c23-18(12-3-4-12)22-17-11-14(7-9-20-17)13-5-6-16-15(10-13)2-1-8-21-19(16)24/h5-7,9-12H,1-4,8H2,(H,21,24)(H,20,22,23)
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n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074663
PNG
(CHEMBL3410094)
Show SMILES O=C(Nc1cc(ccn1)-c1ccc2C(=O)NCCc2c1)C1CC1
Show InChI InChI=1S/C18H17N3O2/c22-17(11-1-2-11)21-16-10-13(5-7-19-16)12-3-4-15-14(9-12)6-8-20-18(15)23/h3-5,7,9-11H,1-2,6,8H2,(H,20,23)(H,19,21,22)
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n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074581
PNG
(CHEMBL3410107)
Show SMILES CC(C)Oc1cc(ncc1C(N)=O)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C18H20N4O3/c1-10(2)25-15-8-14(21-9-13(15)17(19)23)12-5-6-20-16(7-12)22-18(24)11-3-4-11/h5-11H,3-4H2,1-2H3,(H2,19,23)(H,20,22,24)
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n/an/a 4.40n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074593
PNG
(CHEMBL3410097)
Show SMILES O=C(Nc1cc(ccn1)-c1ccc2c(OCCNC2=O)c1)C1CC1
Show InChI InChI=1S/C18H17N3O3/c22-17(11-1-2-11)21-16-10-13(5-6-19-16)12-3-4-14-15(9-12)24-8-7-20-18(14)23/h3-6,9-11H,1-2,7-8H2,(H,20,23)(H,19,21,22)
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n/an/a 4.70n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074578
PNG
(CHEMBL3410110)
Show SMILES COc1nc(ncc1C(N)=O)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C15H15N5O3/c1-23-15-10(12(16)21)7-18-13(20-15)9-4-5-17-11(6-9)19-14(22)8-2-3-8/h4-8H,2-3H2,1H3,(H2,16,21)(H,17,19,22)
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n/an/a 5.90n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074582
PNG
(CHEMBL3410106)
Show SMILES NC(=O)c1cnc(cc1OCC(F)(F)F)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C17H15F3N4O3/c18-17(19,20)8-27-13-6-12(23-7-11(13)15(21)25)10-3-4-22-14(5-10)24-16(26)9-1-2-9/h3-7,9H,1-2,8H2,(H2,21,25)(H,22,24,26)
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n/an/a 6.80n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074584
PNG
(CHEMBL3410104)
Show SMILES COc1cc(cnc1C(N)=O)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C16H16N4O3/c1-23-12-6-11(8-19-14(12)15(17)21)10-4-5-18-13(7-10)20-16(22)9-2-3-9/h4-9H,2-3H2,1H3,(H2,17,21)(H,18,20,22)
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n/an/a 7n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074587
PNG
(CHEMBL3410101)
Show SMILES O=C(Nc1cc(ccn1)-c1ccc2ncccc2c1)C1CC1
Show InChI InChI=1S/C18H15N3O/c22-18(12-3-4-12)21-17-11-14(7-9-20-17)13-5-6-16-15(10-13)2-1-8-19-16/h1-2,5-12H,3-4H2,(H,20,21,22)
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n/an/a 7.5n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074640
PNG
(CHEMBL3410095)
Show SMILES O=C(Nc1cc(ccn1)-c1ccc2C(=O)NCc2c1)C1CC1
Show InChI InChI=1S/C17H15N3O2/c21-16(10-1-2-10)20-15-8-12(5-6-18-15)11-3-4-14-13(7-11)9-19-17(14)22/h3-8,10H,1-2,9H2,(H,19,22)(H,18,20,21)
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n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074692
PNG
(CHEMBL3410087)
Show SMILES NC(=O)c1cnc(s1)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C13H12N4O2S/c14-11(18)9-6-16-13(20-9)8-3-4-15-10(5-8)17-12(19)7-1-2-7/h3-7H,1-2H2,(H2,14,18)(H,15,17,19)
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074583
PNG
(CHEMBL3410105)
Show SMILES COc1cc(ncc1C(N)=O)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C16H16N4O3/c1-23-13-7-12(19-8-11(13)15(17)21)10-4-5-18-14(6-10)20-16(22)9-2-3-9/h4-9H,2-3H2,1H3,(H2,17,21)(H,18,20,22)
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n/an/a 22n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074580
PNG
(CHEMBL3410108)
Show SMILES Cn1nc(cc1-c1ccnc(NC(=O)C2CC2)c1)C(N)=O
Show InChI InChI=1S/C14H15N5O2/c1-19-11(7-10(18-19)13(15)20)9-4-5-16-12(6-9)17-14(21)8-2-3-8/h4-8H,2-3H2,1H3,(H2,15,20)(H,16,17,21)
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n/an/a 24n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074671
PNG
(CHEMBL3410093)
Show SMILES COc1sc(nc1C(N)=O)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C14H14N4O3S/c1-21-14-10(11(15)19)18-13(22-14)8-4-5-16-9(6-8)17-12(20)7-2-3-7/h4-7H,2-3H2,1H3,(H2,15,19)(H,16,17,20)
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n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074579
PNG
(CHEMBL3410109)
Show SMILES NC(=O)c1cnc(cn1)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C14H13N5O2/c15-13(20)11-7-17-10(6-18-11)9-3-4-16-12(5-9)19-14(21)8-1-2-8/h3-8H,1-2H2,(H2,15,20)(H,16,19,21)
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n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074691
PNG
(CHEMBL3410088)
Show SMILES Cc1nc(sc1C(N)=O)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C14H14N4O2S/c1-7-11(12(15)19)21-14(17-7)9-4-5-16-10(6-9)18-13(20)8-2-3-8/h4-6,8H,2-3H2,1H3,(H2,15,19)(H,16,18,20)
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n/an/a 37n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074588
PNG
(CHEMBL3410100)
Show SMILES O=C(Nc1cc(ccn1)-c1ccc2ccncc2c1)C1CC1
Show InChI InChI=1S/C18H15N3O/c22-18(13-2-3-13)21-17-10-15(6-8-20-17)14-4-1-12-5-7-19-11-16(12)9-14/h1,4-11,13H,2-3H2,(H,20,21,22)
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n/an/a 74n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074585
PNG
(CHEMBL3410103)
Show SMILES NC(=O)c1ccc(cn1)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C15H14N4O2/c16-14(20)12-4-3-11(8-18-12)10-5-6-17-13(7-10)19-15(21)9-1-2-9/h3-9H,1-2H2,(H2,16,20)(H,17,19,21)
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n/an/a 90n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074575
PNG
(CHEMBL3410112)
Show SMILES NC(=O)c1ccc(nn1)-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C14H13N5O2/c15-13(20)11-4-3-10(18-19-11)9-5-6-16-12(7-9)17-14(21)8-1-2-8/h3-8H,1-2H2,(H2,15,20)(H,16,17,21)
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n/an/a 140n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074589
PNG
(CHEMBL3410099)
Show SMILES O=C(Nc1cc(ccn1)-c1ccc2cccnc2c1)C1CC1
Show InChI InChI=1S/C18H15N3O/c22-18(13-4-5-13)21-17-11-15(7-9-20-17)14-6-3-12-2-1-8-19-16(12)10-14/h1-3,6-11,13H,4-5H2,(H,20,21,22)
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n/an/a 240n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074586
PNG
(CHEMBL3410102)
Show SMILES O=C(Nc1cc(ccn1)-c1ccc2ccccc2c1)C1CC1
Show InChI InChI=1S/C19H16N2O/c22-19(14-6-7-14)21-18-12-17(9-10-20-18)16-8-5-13-3-1-2-4-15(13)11-16/h1-5,8-12,14H,6-7H2,(H,20,21,22)
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n/an/a 610n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50074591
PNG
(CHEMBL3410098)
Show SMILES O=C(Nc1cc(ccn1)-c1ccc2NC(=O)CCCc2c1)C1CC1
Show InChI InChI=1S/C19H19N3O2/c23-18-3-1-2-15-10-13(6-7-16(15)21-18)14-8-9-20-17(11-14)22-19(24)12-4-5-12/h6-12H,1-5H2,(H,21,23)(H,20,22,24)
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n/an/a 730n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GSK3beta (unknown origin) activity by competitive binding assay


Bioorg Med Chem Lett 25: 1856-63 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.046
BindingDB Entry DOI: 10.7270/Q2222WH5
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%