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PubMed code 25921265

Compile data set for download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen


(Homo sapiens (human))
BDBM50093542
PNG
(CHEMBL3585742)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(F)cc2)nc2ccc(cc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C25H26FN7O3/c1-31-21-12-16(24(35)29-18(13-28)4-2-3-11-27)5-10-20(21)30-22(31)14-33-23(34)15-32(25(33)36)19-8-6-17(26)7-9-19/h5-10,12,18H,2-4,11,14-15,27H2,1H3,(H,29,35)/t18-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50093541
PNG
(CHEMBL3585745)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccncc3)cc2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C29H29N9O4/c1-36-22(14-19-16-33-26(35-27(19)36)28(40)34-20(15-31)4-2-3-11-30)17-38-25(39)18-37(29(38)41)21-5-7-23(8-6-21)42-24-9-12-32-13-10-24/h5-10,12-14,16,20H,2-4,11,17-18,30H2,1H3,(H,34,40)/t20-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50093542
PNG
(CHEMBL3585742)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(F)cc2)nc2ccc(cc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C25H26FN7O3/c1-31-21-12-16(24(35)29-18(13-28)4-2-3-11-27)5-10-20(21)30-22(31)14-33-23(34)15-32(25(33)36)19-8-6-17(26)7-9-19/h5-10,12,18H,2-4,11,14-15,27H2,1H3,(H,29,35)/t18-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50093540
PNG
(CHEMBL3585746)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccncc3)cc2)nc2ccc(cc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C30H30N8O4/c1-36-26-16-20(29(40)34-21(17-32)4-2-3-13-31)5-10-25(26)35-27(36)18-38-28(39)19-37(30(38)41)22-6-8-23(9-7-22)42-24-11-14-33-15-12-24/h5-12,14-16,21H,2-4,13,18-19,31H2,1H3,(H,34,40)/t21-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093546
PNG
(CHEMBL3585741)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc3n(Cc4ccncc4)c(=O)oc3c2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C31H30N10O5/c1-38-23(12-20-15-35-27(37-28(20)38)29(43)36-21(14-33)4-2-3-9-32)17-41-26(42)18-39(30(41)44)22-5-6-24-25(13-22)46-31(45)40(24)16-19-7-10-34-11-8-19/h5-8,10-13,15,21H,2-4,9,16-18,32H2,1H3,(H,36,43)/t21-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093543
PNG
(CHEMBL3585747)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)nc2cc(ccc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C31H31N7O4/c1-36-27-15-10-21(30(40)34-22(18-33)7-5-6-16-32)17-26(27)35-28(36)19-38-29(39)20-37(31(38)41)23-11-13-25(14-12-23)42-24-8-3-2-4-9-24/h2-4,8-15,17,22H,5-7,16,19-20,32H2,1H3,(H,34,40)/t22-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093545
PNG
(CHEMBL3585743)
Show SMILES NCCCC[C@H](NC(=O)c1nc2cc(CN3C(=O)CN(C3=O)c3ccc(F)cc3)ccc2o1)C#N
Show InChI InChI=1S/C24H23FN6O4/c25-16-5-7-18(8-6-16)30-14-21(32)31(24(30)34)13-15-4-9-20-19(11-15)29-23(35-20)22(33)28-17(12-27)3-1-2-10-26/h4-9,11,17H,1-3,10,13-14,26H2,(H,28,33)/t17-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50009171
PNG
(CHEMBL3238362)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(F)cc2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C24H25FN8O3/c1-31-19(13-33-20(34)14-32(24(33)36)18-7-5-16(25)6-8-18)10-15-12-28-21(30-22(15)31)23(35)29-17(11-27)4-2-3-9-26/h5-8,10,12,17H,2-4,9,13-14,26H2,1H3,(H,29,35)/t17-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50009200
PNG
(CHEMBL3238374)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C30H30N8O4/c1-36-23(15-20-17-33-27(35-28(20)36)29(40)34-21(16-32)7-5-6-14-31)18-38-26(39)19-37(30(38)41)22-10-12-25(13-11-22)42-24-8-3-2-4-9-24/h2-4,8-13,15,17,21H,5-7,14,18-19,31H2,1H3,(H,34,40)/t21-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093547
PNG
(CHEMBL3585740)
Show SMILES CC(C)Cn1c2ccc(cc2oc1=O)N1CC(=O)N(Cc2cc3cnc(nc3n2C)C(=O)N[C@@H](CCCCN)C#N)C1=O
Show InChI InChI=1S/C29H33N9O5/c1-17(2)14-37-22-8-7-20(11-23(22)43-29(37)42)36-16-24(39)38(28(36)41)15-21-10-18-13-32-25(34-26(18)35(21)3)27(40)33-19(12-31)6-4-5-9-30/h7-8,10-11,13,17,19H,4-6,9,14-16,30H2,1-3H3,(H,33,40)/t19-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093549
PNG
(CHEMBL3585738)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc3n(C)c(=O)oc3c2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C26H27N9O5/c1-32-18(9-15-12-29-22(31-23(15)32)24(37)30-16(11-28)5-3-4-8-27)13-35-21(36)14-34(25(35)38)17-6-7-19-20(10-17)40-26(39)33(19)2/h6-7,9-10,12,16H,3-5,8,13-14,27H2,1-2H3,(H,30,37)/t16-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50009200
PNG
(CHEMBL3238374)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C30H30N8O4/c1-36-23(15-20-17-33-27(35-28(20)36)29(40)34-21(16-32)7-5-6-14-31)18-38-26(39)19-37(30(38)41)22-10-12-25(13-11-22)42-24-8-3-2-4-9-24/h2-4,8-13,15,17,21H,5-7,14,18-19,31H2,1H3,(H,34,40)/t21-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093548
PNG
(CHEMBL3585739)
Show SMILES CCCn1c2ccc(cc2oc1=O)N1CC(=O)N(Cc2cc3cnc(nc3n2C)C(=O)N[C@@H](CCCCN)C#N)C1=O
Show InChI InChI=1S/C28H31N9O5/c1-3-10-35-21-8-7-19(12-22(21)42-28(35)41)36-16-23(38)37(27(36)40)15-20-11-17-14-31-24(33-25(17)34(20)2)26(39)32-18(13-30)6-4-5-9-29/h7-8,11-12,14,18H,3-6,9-10,15-16,29H2,1-2H3,(H,32,39)/t18-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093550
PNG
(CHEMBL3585737)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc3oc(=O)n(Cc4ccncc4)c3c2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C31H30N10O5/c1-38-23(12-20-15-35-27(37-28(20)38)29(43)36-21(14-33)4-2-3-9-32)17-41-26(42)18-39(30(41)44)22-5-6-25-24(13-22)40(31(45)46-25)16-19-7-10-34-11-8-19/h5-8,10-13,15,21H,2-4,9,16-18,32H2,1H3,(H,36,43)/t21-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of urokinase (unknown origin) using Pyr-Gly-Arg-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093544
PNG
(CHEMBL3585744)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)nc2ccc(cc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C31H31N7O4/c1-36-27-17-21(30(40)34-22(18-33)7-5-6-16-32)10-15-26(27)35-28(36)19-38-29(39)20-37(31(38)41)23-11-13-25(14-12-23)42-24-8-3-2-4-9-24/h2-4,8-15,17,22H,5-7,16,19-20,32H2,1H3,(H,34,40)/t22-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093552
PNG
(CHEMBL3585735)
Show SMILES CCCn1c2cc(ccc2oc1=O)N1CC(=O)N(Cc2cc3cnc(nc3n2C)C(=O)N[C@@H](CCCCN)C#N)C1=O
Show InChI InChI=1S/C28H31N9O5/c1-3-10-35-21-12-19(7-8-22(21)42-28(35)41)36-16-23(38)37(27(36)40)15-20-11-17-14-31-24(33-25(17)34(20)2)26(39)32-18(13-30)6-4-5-9-29/h7-8,11-12,14,18H,3-6,9-10,15-16,29H2,1-2H3,(H,32,39)/t18-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of urokinase (unknown origin) using Pyr-Gly-Arg-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093551
PNG
(CHEMBL3585736)
Show SMILES CC(C)Cn1c2cc(ccc2oc1=O)N1CC(=O)N(Cc2cc3cnc(nc3n2C)C(=O)N[C@@H](CCCCN)C#N)C1=O
Show InChI InChI=1S/C29H33N9O5/c1-17(2)14-37-22-11-20(7-8-23(22)43-29(37)42)36-16-24(39)38(28(36)41)15-21-10-18-13-32-25(34-26(18)35(21)3)27(40)33-19(12-31)6-4-5-9-30/h7-8,10-11,13,17,19H,4-6,9,14-16,30H2,1-3H3,(H,33,40)/t19-/m0/s1
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n/an/a 29n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50009171
PNG
(CHEMBL3238362)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(F)cc2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C24H25FN8O3/c1-31-19(13-33-20(34)14-32(24(33)36)18-7-5-16(25)6-8-18)10-15-12-28-21(30-22(15)31)23(35)29-17(11-27)4-2-3-9-26/h5-8,10,12,17H,2-4,9,13-14,26H2,1H3,(H,29,35)/t17-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093553
PNG
(CHEMBL3585734)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc3oc(=O)n(C)c3c2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C26H27N9O5/c1-32-18(9-15-12-29-22(31-23(15)32)24(37)30-16(11-28)5-3-4-8-27)13-35-21(36)14-34(25(35)38)17-6-7-20-19(10-17)33(2)26(39)40-20/h6-7,9-10,12,16H,3-5,8,13-14,27H2,1-2H3,(H,30,37)/t16-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of urokinase (unknown origin) using Pyr-Gly-Arg-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093540
PNG
(CHEMBL3585746)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccncc3)cc2)nc2ccc(cc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C30H30N8O4/c1-36-26-16-20(29(40)34-21(17-32)4-2-3-13-31)5-10-25(26)35-27(36)18-38-28(39)19-37(30(38)41)22-6-8-23(9-7-22)42-24-11-14-33-15-12-24/h5-12,14-16,21H,2-4,13,18-19,31H2,1H3,(H,34,40)/t21-/m0/s1
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n/an/a 56n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of urokinase (unknown origin) using Pyr-Gly-Arg-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM50093541
PNG
(CHEMBL3585745)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccncc3)cc2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C29H29N9O4/c1-36-22(14-19-16-33-26(35-27(19)36)28(40)34-20(15-31)4-2-3-11-30)17-38-25(39)18-37(29(38)41)21-5-7-23(8-6-21)42-24-9-12-32-13-10-24/h5-10,12-14,16,20H,2-4,11,17-18,30H2,1H3,(H,34,40)/t20-/m0/s1
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n/an/a 74n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of urokinase (unknown origin) using Pyr-Gly-Arg-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%