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Found 17 Enz. Inhib. hit(s) with all data for entry = 50045985
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataKi:  250nMAssay Description:Binding affinity to human Zn2+-HDAC8 assessed as loss of activity by Fluor-de-Lys activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataKi:  7.00E+3nMAssay Description:Reversible-time dependent inhibition of human wild type HDAC8 by Fluor-de-Lys activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant HDAC6 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 6(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant HDAC6 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant HDAC1 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant HDAC3 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant HDAC2 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50:  149nMAssay Description:Inhibition of human recombinant HDAC3 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50:  255nMAssay Description:Inhibition of human recombinant HDAC2 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50:  371nMAssay Description:Inhibition of human recombinant HDAC1 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of human recombinant HDAC8 using MAZ1675 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50089657(CHEMBL3577298)
Affinity DataIC50:  3.84E+3nMAssay Description:Inhibition of human recombinant HDAC8 using MAZ1675 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50089658(CHEMBL3577299)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant HDAC6 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50089658(CHEMBL3577299)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant HDAC2 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50089658(CHEMBL3577299)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant HDAC1 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50089658(CHEMBL3577299)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant HDAC8 using MAZ1675 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50089658(CHEMBL3577299)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant HDAC3 using MAZ1600 as fluorogenic substrate measured every 5 mins by optimized homogenous fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed