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PubMed code 26037808

Compile data set for download or QSAR
Found 75 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094943
PNG
(CHEMBL3589372)
Show SMILES CC(N1CCOCC1)c1nc2N(C(=S)N3CCCC3c2c(=O)[nH]1)c1ccccc1
Show InChI InChI=1/C21H25N5O2S/c1-14(24-10-12-28-13-11-24)18-22-19-17(20(27)23-18)16-8-5-9-25(16)21(29)26(19)15-6-3-2-4-7-15/h2-4,6-7,14,16H,5,8-13H2,1H3,(H,22,23,27)
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n/an/a 0.100n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094956
PNG
(CHEMBL3589370)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc([nH]c2=O)C(C)N1CCOCC1
Show InChI InChI=1/C17H25N5O2S/c1-3-21-15-13(12-5-4-6-22(12)17(21)25)16(23)19-14(18-15)11(2)20-7-9-24-10-8-20/h11-12H,3-10H2,1-2H3,(H,18,19,23)
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n/an/a 0.300n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094942
PNG
(CHEMBL3589371)
Show SMILES O=c1[nH]c(CN2CCOCC2)nc2N(C(=S)N3CCCC3c12)c1ccccc1
Show InChI InChI=1/C20H23N5O2S/c26-19-17-15-7-4-8-24(15)20(28)25(14-5-2-1-3-6-14)18(17)21-16(22-19)13-23-9-11-27-12-10-23/h1-3,5-6,15H,4,7-13H2,(H,21,22,26)
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n/an/a 0.5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094955
PNG
(CHEMBL3589324)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(CN1CCOCC1)[nH]c2=O
Show InChI InChI=1/C16H23N5O2S/c1-2-20-14-13(11-4-3-5-21(11)16(20)24)15(22)18-12(17-14)10-19-6-8-23-9-7-19/h11H,2-10H2,1H3,(H,17,18,22)
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n/an/a 0.800n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094948
PNG
(CHEMBL3589377)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)cc1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O2S/c1-3-28-23-20(19-5-4-10-29(19)24(28)32)22(27-11-13-31-14-12-27)18(15-25)21(26-23)16-6-8-17(30-2)9-7-16/h6-9,19H,3-5,10-14H2,1-2H3
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n/an/a 1.20n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094950
PNG
(CHEMBL3589379)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)c(OC)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C25H29N5O3S/c1-4-29-24-21(18-6-5-9-30(18)25(29)34)23(28-10-12-33-13-11-28)17(15-26)22(27-24)16-7-8-19(31-2)20(14-16)32-3/h7-8,14,18H,4-6,9-13H2,1-3H3
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n/an/a 1.90n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094949
PNG
(CHEMBL3589378)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)c(O)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O3S/c1-3-28-23-20(17-5-4-8-29(17)24(28)33)22(27-9-11-32-12-10-27)16(14-25)21(26-23)15-6-7-19(31-2)18(30)13-15/h6-7,13,17,30H,3-5,8-12H2,1-2H3
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n/an/a 3.80n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094947
PNG
(CHEMBL3589376)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1cccc(OC)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O2S/c1-3-28-23-20(19-8-5-9-29(19)24(28)32)22(27-10-12-31-13-11-27)18(15-25)21(26-23)16-6-4-7-17(14-16)30-2/h4,6-7,14,19H,3,5,8-13H2,1-2H3
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n/an/a 3.80n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094946
PNG
(CHEMBL3589375)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1cccc(O)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C23H25N5O2S/c1-2-27-22-19(18-7-4-8-28(18)23(27)31)21(26-9-11-30-12-10-26)17(14-24)20(25-22)15-5-3-6-16(29)13-15/h3,5-6,13,18,29H,2,4,7-12H2,1H3
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n/an/a 7.70n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094943
PNG
(CHEMBL3589372)
Show SMILES CC(N1CCOCC1)c1nc2N(C(=S)N3CCCC3c2c(=O)[nH]1)c1ccccc1
Show InChI InChI=1/C21H25N5O2S/c1-14(24-10-12-28-13-11-24)18-22-19-17(20(27)23-18)16-8-5-9-25(16)21(29)26(19)15-6-3-2-4-7-15/h2-4,6-7,14,16H,5,8-13H2,1H3,(H,22,23,27)
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n/an/a 56n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094956
PNG
(CHEMBL3589370)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc([nH]c2=O)C(C)N1CCOCC1
Show InChI InChI=1/C17H25N5O2S/c1-3-21-15-13(12-5-4-6-22(12)17(21)25)16(23)19-14(18-15)11(2)20-7-9-24-10-8-20/h11-12H,3-10H2,1-2H3,(H,18,19,23)
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n/an/a 67n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094942
PNG
(CHEMBL3589371)
Show SMILES O=c1[nH]c(CN2CCOCC2)nc2N(C(=S)N3CCCC3c12)c1ccccc1
Show InChI InChI=1/C20H23N5O2S/c26-19-17-15-7-4-8-24(15)20(28)25(14-5-2-1-3-6-14)18(17)21-16(22-19)13-23-9-11-27-12-10-23/h1-3,5-6,15H,4,7-13H2,(H,21,22,26)
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n/an/a 80n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094955
PNG
(CHEMBL3589324)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(CN1CCOCC1)[nH]c2=O
Show InChI InChI=1/C16H23N5O2S/c1-2-20-14-13(11-4-3-5-21(11)16(20)24)15(22)18-12(17-14)10-19-6-8-23-9-7-19/h11H,2-10H2,1H3,(H,17,18,22)
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n/an/a 93n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094951
PNG
(CHEMBL3589320)
Show SMILES CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1cccc(OC)c1)N1CCOCC1
Show InChI InChI=1/C22H27N5O2S/c1-3-26-21-18(17-8-5-9-27(17)22(26)30)20(25-10-12-29-13-11-25)23-19(24-21)15-6-4-7-16(14-15)28-2/h4,6-7,14,17H,3,5,8-13H2,1-2H3
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n/an/a 234n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094943
PNG
(CHEMBL3589372)
Show SMILES CC(N1CCOCC1)c1nc2N(C(=S)N3CCCC3c2c(=O)[nH]1)c1ccccc1
Show InChI InChI=1/C21H25N5O2S/c1-14(24-10-12-28-13-11-24)18-22-19-17(20(27)23-18)16-8-5-9-25(16)21(29)26(19)15-6-3-2-4-7-15/h2-4,6-7,14,16H,5,8-13H2,1H3,(H,22,23,27)
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n/an/a 320n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094948
PNG
(CHEMBL3589377)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)cc1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O2S/c1-3-28-23-20(19-5-4-10-29(19)24(28)32)22(27-11-13-31-14-12-27)18(15-25)21(26-23)16-6-8-17(30-2)9-7-16/h6-9,19H,3-5,10-14H2,1-2H3
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n/an/a 340n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094952
PNG
(CHEMBL3589321)
Show SMILES CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1ccc(OC)cc1)N1CCOCC1
Show InChI InChI=1/C22H27N5O2S/c1-3-26-21-18(17-5-4-10-27(17)22(26)30)20(25-11-13-29-14-12-25)23-19(24-21)15-6-8-16(28-2)9-7-15/h6-9,17H,3-5,10-14H2,1-2H3
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n/an/a 387n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094950
PNG
(CHEMBL3589379)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)c(OC)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C25H29N5O3S/c1-4-29-24-21(18-6-5-9-30(18)25(29)34)23(28-10-12-33-13-11-28)17(15-26)22(27-24)16-7-8-19(31-2)20(14-16)32-3/h7-8,14,18H,4-6,9-13H2,1-3H3
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Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094947
PNG
(CHEMBL3589376)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1cccc(OC)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O2S/c1-3-28-23-20(19-8-5-9-29(19)24(28)32)22(27-10-12-31-13-11-27)18(15-25)21(26-23)16-6-4-7-17(14-16)30-2/h4,6-7,14,19H,3,5,8-13H2,1-2H3
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n/an/a 560n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094954
PNG
(CHEMBL3589323)
Show SMILES COc1ccc(cc1)-c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C26H27N5O2S/c1-32-20-11-9-18(10-12-20)23-27-24(29-14-16-33-17-15-29)22-21-8-5-13-30(21)26(34)31(25(22)28-23)19-6-3-2-4-7-19/h2-4,6-7,9-12,21H,5,8,13-17H2,1H3
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n/an/a 678n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094953
PNG
(CHEMBL3589322)
Show SMILES COc1cccc(c1)-c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C26H27N5O2S/c1-32-20-10-5-7-18(17-20)23-27-24(29-13-15-33-16-14-29)22-21-11-6-12-30(21)26(34)31(25(22)28-23)19-8-3-2-4-9-19/h2-5,7-10,17,21H,6,11-16H2,1H3
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n/an/a 695n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094949
PNG
(CHEMBL3589378)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)c(O)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O3S/c1-3-28-23-20(17-5-4-8-29(17)24(28)33)22(27-9-11-32-12-10-27)16(14-25)21(26-23)15-6-7-19(31-2)18(30)13-15/h6-7,13,17,30H,3-5,8-12H2,1-2H3
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n/an/a 780n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094956
PNG
(CHEMBL3589370)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc([nH]c2=O)C(C)N1CCOCC1
Show InChI InChI=1/C17H25N5O2S/c1-3-21-15-13(12-5-4-6-22(12)17(21)25)16(23)19-14(18-15)11(2)20-7-9-24-10-8-20/h11-12H,3-10H2,1-2H3,(H,18,19,23)
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n/an/a 880n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094946
PNG
(CHEMBL3589375)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1cccc(O)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C23H25N5O2S/c1-2-27-22-19(18-7-4-8-28(18)23(27)31)21(26-9-11-30-12-10-26)17(14-24)20(25-22)15-5-3-6-16(29)13-15/h3,5-6,13,18,29H,2,4,7-12H2,1H3
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n/an/a 890n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094955
PNG
(CHEMBL3589324)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(CN1CCOCC1)[nH]c2=O
Show InChI InChI=1/C16H23N5O2S/c1-2-20-14-13(11-4-3-5-21(11)16(20)24)15(22)18-12(17-14)10-19-6-8-23-9-7-19/h11H,2-10H2,1H3,(H,17,18,22)
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n/an/a 1.02E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094943
PNG
(CHEMBL3589372)
Show SMILES CC(N1CCOCC1)c1nc2N(C(=S)N3CCCC3c2c(=O)[nH]1)c1ccccc1
Show InChI InChI=1/C21H25N5O2S/c1-14(24-10-12-28-13-11-24)18-22-19-17(20(27)23-18)16-8-5-9-25(16)21(29)26(19)15-6-3-2-4-7-15/h2-4,6-7,14,16H,5,8-13H2,1H3,(H,22,23,27)
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n/an/a 1.34E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094942
PNG
(CHEMBL3589371)
Show SMILES O=c1[nH]c(CN2CCOCC2)nc2N(C(=S)N3CCCC3c12)c1ccccc1
Show InChI InChI=1/C20H23N5O2S/c26-19-17-15-7-4-8-24(15)20(28)25(14-5-2-1-3-6-14)18(17)21-16(22-19)13-23-9-11-27-12-10-23/h1-3,5-6,15H,4,7-13H2,(H,21,22,26)
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n/an/a 1.68E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094948
PNG
(CHEMBL3589377)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)cc1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O2S/c1-3-28-23-20(19-5-4-10-29(19)24(28)32)22(27-11-13-31-14-12-27)18(15-25)21(26-23)16-6-8-17(30-2)9-7-16/h6-9,19H,3-5,10-14H2,1-2H3
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n/an/a 1.81E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094944
PNG
(CHEMBL3589373)
Show SMILES S=C1N2CCCC2c2c(nc(CN3CCOCC3)nc2N1c1ccccc1)N1CCOCC1
Show InChI InChI=1/C24H30N6O2S/c33-24-29-8-4-7-19(29)21-22(28-11-15-32-16-12-28)25-20(17-27-9-13-31-14-10-27)26-23(21)30(24)18-5-2-1-3-6-18/h1-3,5-6,19H,4,7-17H2
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n/an/a 2.34E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094950
PNG
(CHEMBL3589379)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)c(OC)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C25H29N5O3S/c1-4-29-24-21(18-6-5-9-30(18)25(29)34)23(28-10-12-33-13-11-28)17(15-26)22(27-24)16-7-8-19(31-2)20(14-16)32-3/h7-8,14,18H,4-6,9-13H2,1-3H3
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n/an/a 2.61E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094956
PNG
(CHEMBL3589370)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc([nH]c2=O)C(C)N1CCOCC1
Show InChI InChI=1/C17H25N5O2S/c1-3-21-15-13(12-5-4-6-22(12)17(21)25)16(23)19-14(18-15)11(2)20-7-9-24-10-8-20/h11-12H,3-10H2,1-2H3,(H,18,19,23)
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n/an/a 2.67E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094947
PNG
(CHEMBL3589376)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1cccc(OC)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O2S/c1-3-28-23-20(19-8-5-9-29(19)24(28)32)22(27-10-12-31-13-11-27)18(15-25)21(26-23)16-6-4-7-17(14-16)30-2/h4,6-7,14,19H,3,5,8-13H2,1-2H3
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n/an/a 2.74E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094946
PNG
(CHEMBL3589375)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1cccc(O)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C23H25N5O2S/c1-2-27-22-19(18-7-4-8-28(18)23(27)31)21(26-9-11-30-12-10-26)17(14-24)20(25-22)15-5-3-6-16(29)13-15/h3,5-6,13,18,29H,2,4,7-12H2,1H3
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n/an/a 3.55E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094949
PNG
(CHEMBL3589378)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)c(O)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O3S/c1-3-28-23-20(17-5-4-8-29(17)24(28)33)22(27-9-11-32-12-10-27)16(14-25)21(26-23)15-6-7-19(31-2)18(30)13-15/h6-7,13,17,30H,3-5,8-12H2,1-2H3
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n/an/a 3.97E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094942
PNG
(CHEMBL3589371)
Show SMILES O=c1[nH]c(CN2CCOCC2)nc2N(C(=S)N3CCCC3c12)c1ccccc1
Show InChI InChI=1/C20H23N5O2S/c26-19-17-15-7-4-8-24(15)20(28)25(14-5-2-1-3-6-14)18(17)21-16(22-19)13-23-9-11-27-12-10-23/h1-3,5-6,15H,4,7-13H2,(H,21,22,26)
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n/an/a 4.43E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094956
PNG
(CHEMBL3589370)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc([nH]c2=O)C(C)N1CCOCC1
Show InChI InChI=1/C17H25N5O2S/c1-3-21-15-13(12-5-4-6-22(12)17(21)25)16(23)19-14(18-15)11(2)20-7-9-24-10-8-20/h11-12H,3-10H2,1-2H3,(H,18,19,23)
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n/an/a 4.56E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094955
PNG
(CHEMBL3589324)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(CN1CCOCC1)[nH]c2=O
Show InChI InChI=1/C16H23N5O2S/c1-2-20-14-13(11-4-3-5-21(11)16(20)24)15(22)18-12(17-14)10-19-6-8-23-9-7-19/h11H,2-10H2,1H3,(H,17,18,22)
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n/an/a 5.25E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094945
PNG
(CHEMBL3589374)
Show SMILES CC(N1CCOCC1)c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C25H32N6O2S/c1-18(28-10-14-32-15-11-28)22-26-23(29-12-16-33-17-13-29)21-20-8-5-9-30(20)25(34)31(24(21)27-22)19-6-3-2-4-7-19/h2-4,6-7,18,20H,5,8-17H2,1H3
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n/an/a 5.49E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094942
PNG
(CHEMBL3589371)
Show SMILES O=c1[nH]c(CN2CCOCC2)nc2N(C(=S)N3CCCC3c12)c1ccccc1
Show InChI InChI=1/C20H23N5O2S/c26-19-17-15-7-4-8-24(15)20(28)25(14-5-2-1-3-6-14)18(17)21-16(22-19)13-23-9-11-27-12-10-23/h1-3,5-6,15H,4,7-13H2,(H,21,22,26)
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n/an/a 5.78E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094955
PNG
(CHEMBL3589324)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(CN1CCOCC1)[nH]c2=O
Show InChI InChI=1/C16H23N5O2S/c1-2-20-14-13(11-4-3-5-21(11)16(20)24)15(22)18-12(17-14)10-19-6-8-23-9-7-19/h11H,2-10H2,1H3,(H,17,18,22)
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n/an/a 7.64E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094948
PNG
(CHEMBL3589377)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)cc1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O2S/c1-3-28-23-20(19-5-4-10-29(19)24(28)32)22(27-11-13-31-14-12-27)18(15-25)21(26-23)16-6-8-17(30-2)9-7-16/h6-9,19H,3-5,10-14H2,1-2H3
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n/an/a 8.46E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094949
PNG
(CHEMBL3589378)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)c(O)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O3S/c1-3-28-23-20(17-5-4-8-29(17)24(28)33)22(27-9-11-32-12-10-27)16(14-25)21(26-23)15-6-7-19(31-2)18(30)13-15/h6-7,13,17,30H,3-5,8-12H2,1-2H3
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n/an/a 8.56E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094950
PNG
(CHEMBL3589379)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)c(OC)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C25H29N5O3S/c1-4-29-24-21(18-6-5-9-30(18)25(29)34)23(28-10-12-33-13-11-28)17(15-26)22(27-24)16-7-8-19(31-2)20(14-16)32-3/h7-8,14,18H,4-6,9-13H2,1-3H3
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n/an/a 8.75E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094943
PNG
(CHEMBL3589372)
Show SMILES CC(N1CCOCC1)c1nc2N(C(=S)N3CCCC3c2c(=O)[nH]1)c1ccccc1
Show InChI InChI=1/C21H25N5O2S/c1-14(24-10-12-28-13-11-24)18-22-19-17(20(27)23-18)16-8-5-9-25(16)21(29)26(19)15-6-3-2-4-7-15/h2-4,6-7,14,16H,5,8-13H2,1H3,(H,22,23,27)
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n/an/a 9.45E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094947
PNG
(CHEMBL3589376)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1cccc(OC)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O2S/c1-3-28-23-20(19-8-5-9-29(19)24(28)32)22(27-10-12-31-13-11-27)18(15-25)21(26-23)16-6-4-7-17(14-16)30-2/h4,6-7,14,19H,3,5,8-13H2,1-2H3
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n/an/a 9.76E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094948
PNG
(CHEMBL3589377)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)cc1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O2S/c1-3-28-23-20(19-5-4-10-29(19)24(28)32)22(27-11-13-31-14-12-27)18(15-25)21(26-23)16-6-8-17(30-2)9-7-16/h6-9,19H,3-5,10-14H2,1-2H3
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n/an/a 1.26E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094952
PNG
(CHEMBL3589321)
Show SMILES CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1ccc(OC)cc1)N1CCOCC1
Show InChI InChI=1/C22H27N5O2S/c1-3-26-21-18(17-5-4-10-27(17)22(26)30)20(25-11-13-29-14-12-25)23-19(24-21)15-6-8-16(28-2)9-7-15/h6-9,17H,3-5,10-14H2,1-2H3
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n/an/a 1.36E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094953
PNG
(CHEMBL3589322)
Show SMILES COc1cccc(c1)-c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C26H27N5O2S/c1-32-20-10-5-7-18(17-20)23-27-24(29-13-15-33-16-14-29)22-21-11-6-12-30(21)26(34)31(25(22)28-23)19-8-3-2-4-9-19/h2-5,7-10,17,21H,6,11-16H2,1H3
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n/an/a 1.46E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094951
PNG
(CHEMBL3589320)
Show SMILES CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1cccc(OC)c1)N1CCOCC1
Show InChI InChI=1/C22H27N5O2S/c1-3-26-21-18(17-8-5-9-27(17)22(26)30)20(25-10-12-29-13-11-25)23-19(24-21)15-6-4-7-16(14-15)28-2/h4,6-7,14,17H,3,5,8-13H2,1-2H3
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n/an/a 1.46E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094950
PNG
(CHEMBL3589379)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)c(OC)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C25H29N5O3S/c1-4-29-24-21(18-6-5-9-30(18)25(29)34)23(28-10-12-33-13-11-28)17(15-26)22(27-24)16-7-8-19(31-2)20(14-16)32-3/h7-8,14,18H,4-6,9-13H2,1-3H3
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n/an/a 1.56E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094947
PNG
(CHEMBL3589376)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1cccc(OC)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O2S/c1-3-28-23-20(19-8-5-9-29(19)24(28)32)22(27-10-12-31-13-11-27)18(15-25)21(26-23)16-6-4-7-17(14-16)30-2/h4,6-7,14,19H,3,5,8-13H2,1-2H3
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n/an/a 1.85E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094952
PNG
(CHEMBL3589321)
Show SMILES CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1ccc(OC)cc1)N1CCOCC1
Show InChI InChI=1/C22H27N5O2S/c1-3-26-21-18(17-5-4-10-27(17)22(26)30)20(25-11-13-29-14-12-25)23-19(24-21)15-6-8-16(28-2)9-7-15/h6-9,17H,3-5,10-14H2,1-2H3
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n/an/a 2.01E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094951
PNG
(CHEMBL3589320)
Show SMILES CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1cccc(OC)c1)N1CCOCC1
Show InChI InChI=1/C22H27N5O2S/c1-3-26-21-18(17-8-5-9-27(17)22(26)30)20(25-10-12-29-13-11-25)23-19(24-21)15-6-4-7-16(14-15)28-2/h4,6-7,14,17H,3,5,8-13H2,1-2H3
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n/an/a 2.08E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094946
PNG
(CHEMBL3589375)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1cccc(O)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C23H25N5O2S/c1-2-27-22-19(18-7-4-8-28(18)23(27)31)21(26-9-11-30-12-10-26)17(14-24)20(25-22)15-5-3-6-16(29)13-15/h3,5-6,13,18,29H,2,4,7-12H2,1H3
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n/an/a 2.36E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094951
PNG
(CHEMBL3589320)
Show SMILES CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1cccc(OC)c1)N1CCOCC1
Show InChI InChI=1/C22H27N5O2S/c1-3-26-21-18(17-8-5-9-27(17)22(26)30)20(25-10-12-29-13-11-25)23-19(24-21)15-6-4-7-16(14-15)28-2/h4,6-7,14,17H,3,5,8-13H2,1-2H3
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n/an/a 2.62E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094949
PNG
(CHEMBL3589378)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)c(O)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O3S/c1-3-28-23-20(17-5-4-8-29(17)24(28)33)22(27-9-11-32-12-10-27)16(14-25)21(26-23)15-6-7-19(31-2)18(30)13-15/h6-7,13,17,30H,3-5,8-12H2,1-2H3
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n/an/a 2.69E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094945
PNG
(CHEMBL3589374)
Show SMILES CC(N1CCOCC1)c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C25H32N6O2S/c1-18(28-10-14-32-15-11-28)22-26-23(29-12-16-33-17-13-29)21-20-8-5-9-30(20)25(34)31(24(21)27-22)19-6-3-2-4-7-19/h2-4,6-7,18,20H,5,8-17H2,1H3
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n/an/a 2.86E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094954
PNG
(CHEMBL3589323)
Show SMILES COc1ccc(cc1)-c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C26H27N5O2S/c1-32-20-11-9-18(10-12-20)23-27-24(29-14-16-33-17-15-29)22-21-8-5-13-30(21)26(34)31(25(22)28-23)19-6-3-2-4-7-19/h2-4,6-7,9-12,21H,5,8,13-17H2,1H3
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n/an/a 5.69E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094952
PNG
(CHEMBL3589321)
Show SMILES CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1ccc(OC)cc1)N1CCOCC1
Show InChI InChI=1/C22H27N5O2S/c1-3-26-21-18(17-5-4-10-27(17)22(26)30)20(25-11-13-29-14-12-25)23-19(24-21)15-6-8-16(28-2)9-7-15/h6-9,17H,3-5,10-14H2,1-2H3
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n/an/a 5.84E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094953
PNG
(CHEMBL3589322)
Show SMILES COc1cccc(c1)-c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C26H27N5O2S/c1-32-20-10-5-7-18(17-20)23-27-24(29-13-15-33-16-14-29)22-21-11-6-12-30(21)26(34)31(25(22)28-23)19-8-3-2-4-9-19/h2-5,7-10,17,21H,6,11-16H2,1H3
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n/an/a 7.14E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094954
PNG
(CHEMBL3589323)
Show SMILES COc1ccc(cc1)-c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C26H27N5O2S/c1-32-20-11-9-18(10-12-20)23-27-24(29-14-16-33-17-15-29)22-21-8-5-13-30(21)26(34)31(25(22)28-23)19-6-3-2-4-7-19/h2-4,6-7,9-12,21H,5,8,13-17H2,1H3
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n/an/a 7.83E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094944
PNG
(CHEMBL3589373)
Show SMILES S=C1N2CCCC2c2c(nc(CN3CCOCC3)nc2N1c1ccccc1)N1CCOCC1
Show InChI InChI=1/C24H30N6O2S/c33-24-29-8-4-7-19(29)21-22(28-11-15-32-16-12-28)25-20(17-27-9-13-31-14-10-27)26-23(21)30(24)18-5-2-1-3-6-18/h1-3,5-6,19H,4,7-17H2
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n/an/a 7.88E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094946
PNG
(CHEMBL3589375)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1cccc(O)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C23H25N5O2S/c1-2-27-22-19(18-7-4-8-28(18)23(27)31)21(26-9-11-30-12-10-26)17(14-24)20(25-22)15-5-3-6-16(29)13-15/h3,5-6,13,18,29H,2,4,7-12H2,1H3
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n/an/a 8.16E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta


(Homo sapiens (Human))
BDBM50094954
PNG
(CHEMBL3589323)
Show SMILES COc1ccc(cc1)-c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C26H27N5O2S/c1-32-20-11-9-18(10-12-20)23-27-24(29-14-16-33-17-15-29)22-21-8-5-13-30(21)26(34)31(25(22)28-23)19-6-3-2-4-7-19/h2-4,6-7,9-12,21H,5,8,13-17H2,1H3
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n/an/a 8.55E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of Glu-tagged PI3KC2beta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094951
PNG
(CHEMBL3589320)
Show SMILES CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1cccc(OC)c1)N1CCOCC1
Show InChI InChI=1/C22H27N5O2S/c1-3-26-21-18(17-8-5-9-27(17)22(26)30)20(25-10-12-29-13-11-25)23-19(24-21)15-6-4-7-16(14-15)28-2/h4,6-7,14,17H,3,5,8-13H2,1-2H3
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n/an/a 9.16E+4n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094953
PNG
(CHEMBL3589322)
Show SMILES COc1cccc(c1)-c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C26H27N5O2S/c1-32-20-10-5-7-18(17-20)23-27-24(29-13-15-33-16-14-29)22-21-11-6-12-30(21)26(34)31(25(22)28-23)19-8-3-2-4-9-19/h2-5,7-10,17,21H,6,11-16H2,1H3
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n/an/a 1.13E+5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094944
PNG
(CHEMBL3589373)
Show SMILES S=C1N2CCCC2c2c(nc(CN3CCOCC3)nc2N1c1ccccc1)N1CCOCC1
Show InChI InChI=1/C24H30N6O2S/c33-24-29-8-4-7-19(29)21-22(28-11-15-32-16-12-28)25-20(17-27-9-13-31-14-10-27)26-23(21)30(24)18-5-2-1-3-6-18/h1-3,5-6,19H,4,7-17H2
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n/an/a 1.20E+5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094952
PNG
(CHEMBL3589321)
Show SMILES CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1ccc(OC)cc1)N1CCOCC1
Show InChI InChI=1/C22H27N5O2S/c1-3-26-21-18(17-5-4-10-27(17)22(26)30)20(25-11-13-29-14-12-25)23-19(24-21)15-6-8-16(28-2)9-7-15/h6-9,17H,3-5,10-14H2,1-2H3
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n/an/a 1.26E+5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50094945
PNG
(CHEMBL3589374)
Show SMILES CC(N1CCOCC1)c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C25H32N6O2S/c1-18(28-10-14-32-15-11-28)22-26-23(29-12-16-33-17-13-29)21-20-8-5-9-30(20)25(34)31(24(21)27-22)19-6-3-2-4-7-19/h2-4,6-7,18,20H,5,8-17H2,1H3
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n/an/a 1.55E+5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged p110delta (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094944
PNG
(CHEMBL3589373)
Show SMILES S=C1N2CCCC2c2c(nc(CN3CCOCC3)nc2N1c1ccccc1)N1CCOCC1
Show InChI InChI=1/C24H30N6O2S/c33-24-29-8-4-7-19(29)21-22(28-11-15-32-16-12-28)25-20(17-27-9-13-31-14-10-27)26-23(21)30(24)18-5-2-1-3-6-18/h1-3,5-6,19H,4,7-17H2
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n/an/a 3.23E+5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094954
PNG
(CHEMBL3589323)
Show SMILES COc1ccc(cc1)-c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C26H27N5O2S/c1-32-20-11-9-18(10-12-20)23-27-24(29-14-16-33-17-15-29)22-21-8-5-13-30(21)26(34)31(25(22)28-23)19-6-3-2-4-7-19/h2-4,6-7,9-12,21H,5,8,13-17H2,1H3
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n/an/a 3.46E+5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50094945
PNG
(CHEMBL3589374)
Show SMILES CC(N1CCOCC1)c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C25H32N6O2S/c1-18(28-10-14-32-15-11-28)22-26-23(29-12-16-33-17-13-29)21-20-8-5-9-30(20)25(34)31(24(21)27-22)19-6-3-2-4-7-19/h2-4,6-7,18,20H,5,8-17H2,1H3
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n/an/a 4.18E+5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human p110beta expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094953
PNG
(CHEMBL3589322)
Show SMILES COc1cccc(c1)-c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C26H27N5O2S/c1-32-20-10-5-7-18(17-20)23-27-24(29-13-15-33-16-14-29)22-21-11-6-12-30(21)26(34)31(25(22)28-23)19-8-3-2-4-9-19/h2-5,7-10,17,21H,6,11-16H2,1H3
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n/an/a 4.66E+5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094944
PNG
(CHEMBL3589373)
Show SMILES S=C1N2CCCC2c2c(nc(CN3CCOCC3)nc2N1c1ccccc1)N1CCOCC1
Show InChI InChI=1/C24H30N6O2S/c33-24-29-8-4-7-19(29)21-22(28-11-15-32-16-12-28)25-20(17-27-9-13-31-14-10-27)26-23(21)30(24)18-5-2-1-3-6-18/h1-3,5-6,19H,4,7-17H2
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.82E+5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50094945
PNG
(CHEMBL3589374)
Show SMILES CC(N1CCOCC1)c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1/C25H32N6O2S/c1-18(28-10-14-32-15-11-28)22-26-23(29-12-16-33-17-13-29)21-20-8-5-9-30(20)25(34)31(24(21)27-22)19-6-3-2-4-7-19/h2-4,6-7,18,20H,5,8-17H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.68E+5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged p110gamma (unknown origin) expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Eur J Med Chem 99: 1-13 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.036
BindingDB Entry DOI: 10.7270/Q2SF2XWT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%