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PubMed code 26048791

Compile data set for download or QSAR
Found 93 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50106206
PNG
(CHEMBL3598099)
Show SMILES C[C@@H](OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H28F3N3O6S/c1-13(20(21,22)23)30-19(27)26-9-7-16(8-10-26)31-14-3-5-15(6-4-14)32-17-11-25-18(12-24-17)33(2,28)29/h11-16H,3-10H2,1-2H3/t13-,14-,15-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50106206
PNG
(CHEMBL3598099)
Show SMILES C[C@@H](OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H28F3N3O6S/c1-13(20(21,22)23)30-19(27)26-9-7-16(8-10-26)31-14-3-5-15(6-4-14)32-17-11-25-18(12-24-17)33(2,28)29/h11-16H,3-10H2,1-2H3/t13-,14-,15-/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [3H]-Astemizole from human ERG


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106150
PNG
(CHEMBL3598081)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H35NO6S/c1-23(2,3)30-22(25)24-15-13-20(14-16-24)29-18-7-5-17(6-8-18)28-19-9-11-21(12-10-19)31(4,26)27/h9-12,17-18,20H,5-8,13-16H2,1-4H3/t17-,18-
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n/an/an/an/a 16n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106208
PNG
(CHEMBL3598101)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)cn1
Show InChI InChI=1S/C20H25F6N3O6S/c1-36(31,32)16-11-27-15(10-28-16)34-13-4-2-12(3-5-13)33-14-6-8-29(9-7-14)18(30)35-17(19(21,22)23)20(24,25)26/h10-14,17H,2-9H2,1H3/t12-,13-
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n/an/an/an/a 1.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106209
PNG
(CHEMBL3598102)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC2CCOC2)cn1
Show InChI InChI=1S/C21H31N3O7S/c1-32(26,27)20-13-22-19(12-23-20)30-16-4-2-15(3-5-16)29-17-6-9-24(10-7-17)21(25)31-18-8-11-28-14-18/h12-13,15-18H,2-11,14H2,1H3/t15-,16-,18?
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n/an/an/an/a 427n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106127
PNG
(CHEMBL3598115)
Show SMILES CC(F)Cc1nc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)no1
Show InChI InChI=1S/C22H32FN5O5S/c1-15(23)11-20-26-19(27-33-20)14-28-9-7-18(8-10-28)31-16-3-5-17(6-4-16)32-21-12-25-22(13-24-21)34(2,29)30/h12-13,15-18H,3-11,14H2,1-2H3/t15?,16-,17-
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n/an/an/an/a 276n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106198
PNG
(CHEMBL3598095)
Show SMILES CC1(CC1)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C21H31N3O6S/c1-21(9-10-21)30-20(25)24-11-7-17(8-12-24)28-15-3-5-16(6-4-15)29-18-13-23-19(14-22-18)31(2,26)27/h13-17H,3-12H2,1-2H3/t15-,16-
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n/an/an/an/a 138n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106213
PNG
(CHEMBL3598106)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)C2(CC2)C(F)(F)F)cn1
Show InChI InChI=1S/C21H28F3N3O5S/c1-33(29,30)18-13-25-17(12-26-18)32-15-4-2-14(3-5-15)31-16-6-10-27(11-7-16)19(28)20(8-9-20)21(22,23)24/h12-16H,2-11H2,1H3/t14-,15-
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n/an/an/an/a 1.38E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106219
PNG
(CHEMBL3598117)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)OC1CCC(CC1)Oc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H35NO6S/c1-23(2,3)30-22(25)24-15-13-20(14-16-24)29-18-7-5-17(6-8-18)28-19-9-11-21(12-10-19)31(4,26)27/h9-12,17-18,20H,5-8,13-16H2,1-4H3
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n/an/an/an/a>200n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106125
PNG
(CHEMBL3598113)
Show SMILES CC(C)c1nc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)no1
Show InChI InChI=1S/C22H33N5O5S/c1-15(2)22-25-19(26-32-22)14-27-10-8-18(9-11-27)30-16-4-6-17(7-5-16)31-20-12-24-21(13-23-20)33(3,28)29/h12-13,15-18H,4-11,14H2,1-3H3/t16-,17-
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n/an/an/an/a 9.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106152
PNG
(CHEMBL3598083)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H34FNO6S/c1-23(2,3)31-22(26)25-13-11-18(12-14-25)29-16-5-7-17(8-6-16)30-21-10-9-19(15-20(21)24)32(4,27)28/h9-10,15-18H,5-8,11-14H2,1-4H3/t16-,17-
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n/an/an/an/a 8.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106203
PNG
(CHEMBL3598096)
Show SMILES C[C@H](CF)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C20H30FN3O6S/c1-14(11-21)28-20(25)24-9-7-17(8-10-24)29-15-3-5-16(6-4-15)30-18-12-23-19(13-22-18)31(2,26)27/h12-17H,3-11H2,1-2H3/t14-,15-,16-/m1/s1
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n/an/an/an/a 37n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106211
PNG
(CHEMBL3598104)
Show SMILES CCC(F)(F)C(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C20H29F2N3O5S/c1-3-20(21,22)19(26)25-10-8-16(9-11-25)29-14-4-6-15(7-5-14)30-17-12-24-18(13-23-17)31(2,27)28/h12-16H,3-11H2,1-2H3/t14-,15-
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n/an/an/an/a 5.30n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106154
PNG
(CHEMBL3598085)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1)C#N
Show InChI InChI=1S/C23H32N2O4/c1-23(2,3)29-22(26)25-14-12-21(13-15-25)28-20-10-8-19(9-11-20)27-18-6-4-17(16-24)5-7-18/h4-7,19-21H,8-15H2,1-3H3/t19-,20-
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n/an/an/an/a 334n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106159
PNG
(CHEMBL3598090)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C21H33N3O6S/c1-21(2,3)30-20(25)24-11-9-17(10-12-24)28-15-5-7-16(8-6-15)29-18-13-23-19(14-22-18)31(4,26)27/h13-17H,5-12H2,1-4H3/t15-,16-
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n/an/an/an/a 94n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106163
PNG
(CHEMBL3598094)
Show SMILES CC(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C20H31N3O6S/c1-14(2)27-20(24)23-10-8-17(9-11-23)28-15-4-6-16(7-5-15)29-18-12-22-19(13-21-18)30(3,25)26/h12-17H,4-11H2,1-3H3/t15-,16-
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n/an/an/an/a 93n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106151
PNG
(CHEMBL3598082)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@H](CC1)Oc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H35NO6S/c1-23(2,3)30-22(25)24-15-13-20(14-16-24)29-18-7-5-17(6-8-18)28-19-9-11-21(12-10-19)31(4,26)27/h9-12,17-18,20H,5-8,13-16H2,1-4H3/t17-,18+
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n/an/an/an/a 1.39E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106160
PNG
(CHEMBL3598091)
Show SMILES CC(C)S(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC(C)(C)C)cn1
Show InChI InChI=1S/C23H37N3O6S/c1-16(2)33(28,29)21-15-24-20(14-25-21)31-18-8-6-17(7-9-18)30-19-10-12-26(13-11-19)22(27)32-23(3,4)5/h14-19H,6-13H2,1-5H3/t17-,18-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106205
PNG
(CHEMBL3598098)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC(CF)CF)cn1
Show InChI InChI=1S/C20H29F2N3O6S/c1-32(27,28)19-13-23-18(12-24-19)30-15-4-2-14(3-5-15)29-16-6-8-25(9-7-16)20(26)31-17(10-21)11-22/h12-17H,2-11H2,1H3/t14-,15-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106212
PNG
(CHEMBL3598105)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)C2(CCCC2)C(F)(F)F)cn1
Show InChI InChI=1S/C23H32F3N3O5S/c1-35(31,32)20-15-27-19(14-28-20)34-17-6-4-16(5-7-17)33-18-8-12-29(13-9-18)21(30)22(23(24,25)26)10-2-3-11-22/h14-18H,2-13H2,1H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106125
PNG
(CHEMBL3598113)
Show SMILES CC(C)c1nc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)no1
Show InChI InChI=1S/C22H33N5O5S/c1-15(2)22-25-19(26-32-22)14-27-10-8-18(9-11-27)30-16-4-6-17(7-5-16)31-20-12-24-21(13-23-20)33(3,28)29/h12-13,15-18H,4-11,14H2,1-3H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106127
PNG
(CHEMBL3598115)
Show SMILES CC(F)Cc1nc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)no1
Show InChI InChI=1S/C22H32FN5O5S/c1-15(23)11-20-26-19(27-33-20)14-28-9-7-18(8-10-28)31-16-3-5-17(6-4-16)32-21-12-25-22(13-24-21)34(2,29)30/h12-13,15-18H,3-11,14H2,1-2H3/t15?,16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106124
PNG
(CHEMBL3598112)
Show SMILES CC(C)c1noc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)n1
Show InChI InChI=1S/C22H33N5O5S/c1-15(2)22-25-20(32-26-22)14-27-10-8-18(9-11-27)30-16-4-6-17(7-5-16)31-19-12-24-21(13-23-19)33(3,28)29/h12-13,15-18H,4-11,14H2,1-3H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106207
PNG
(CHEMBL3598100)
Show SMILES C[C@H](OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H28F3N3O6S/c1-13(20(21,22)23)30-19(27)26-9-7-16(8-10-26)31-14-3-5-15(6-4-14)32-17-11-25-18(12-24-17)33(2,28)29/h11-16H,3-10H2,1-2H3/t13-,14-,15-/m0/s1
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106216
PNG
(CHEMBL3598109)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC3(CCC3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C22H32F3N3O4S/c1-33(29,30)20-14-26-19(13-27-20)32-17-5-3-16(4-6-17)31-18-7-11-28(12-8-18)15-21(9-2-10-21)22(23,24)25/h13-14,16-18H,2-12,15H2,1H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106211
PNG
(CHEMBL3598104)
Show SMILES CCC(F)(F)C(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C20H29F2N3O5S/c1-3-20(21,22)19(26)25-10-8-16(9-11-25)29-14-4-6-15(7-5-14)30-17-12-24-18(13-23-17)31(2,27)28/h12-16H,3-11H2,1-2H3/t14-,15-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106124
PNG
(CHEMBL3598112)
Show SMILES CC(C)c1noc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)n1
Show InChI InChI=1S/C22H33N5O5S/c1-15(2)22-25-20(32-26-22)14-27-10-8-18(9-11-27)30-16-4-6-17(7-5-16)31-19-12-24-21(13-23-19)33(3,28)29/h12-13,15-18H,4-11,14H2,1-3H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364559
PNG
(CHEMBL1951032)
Show SMILES COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106152
PNG
(CHEMBL3598083)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H34FNO6S/c1-23(2,3)31-22(26)25-13-11-18(12-14-25)29-16-5-7-17(8-6-16)30-21-10-9-19(15-20(21)24)32(4,27)28/h9-10,15-18H,5-8,11-14H2,1-4H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106154
PNG
(CHEMBL3598085)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1)C#N
Show InChI InChI=1S/C23H32N2O4/c1-23(2,3)29-22(26)25-14-12-21(13-15-25)28-20-10-8-19(9-11-20)27-18-6-4-17(16-24)5-7-18/h4-7,19-21H,8-15H2,1-3H3/t19-,20-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106157
PNG
(CHEMBL3598088)
Show SMILES CC(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(nc1C)S(C)(=O)=O
Show InChI InChI=1S/C22H34N2O6S/c1-15(2)28-22(25)24-13-11-19(12-14-24)29-17-5-7-18(8-6-17)30-20-9-10-21(23-16(20)3)31(4,26)27/h9-10,15,17-19H,5-8,11-14H2,1-4H3/t17-,18-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106158
PNG
(CHEMBL3598089)
Show SMILES CN(C)C(=O)c1ccc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC(C)(C)C)nc1C
Show InChI InChI=1S/C25H39N3O5/c1-17-21(23(29)27(5)6)11-12-22(26-17)32-19-9-7-18(8-10-19)31-20-13-15-28(16-14-20)24(30)33-25(2,3)4/h11-12,18-20H,7-10,13-16H2,1-6H3/t18-,19-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106159
PNG
(CHEMBL3598090)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C21H33N3O6S/c1-21(2,3)30-20(25)24-11-9-17(10-12-24)28-15-5-7-16(8-6-15)29-18-13-23-19(14-22-18)31(4,26)27/h13-17H,5-12H2,1-4H3/t15-,16-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106215
PNG
(CHEMBL3598108)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC3(CC3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C21H30F3N3O4S/c1-32(28,29)19-13-25-18(12-26-19)31-16-4-2-15(3-5-16)30-17-6-10-27(11-7-17)14-20(8-9-20)21(22,23)24/h12-13,15-17H,2-11,14H2,1H3/t15-,16-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50106206
PNG
(CHEMBL3598099)
Show SMILES C[C@@H](OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H28F3N3O6S/c1-13(20(21,22)23)30-19(27)26-9-7-16(8-10-26)31-14-3-5-15(6-4-14)32-17-11-25-18(12-24-17)33(2,28)29/h11-16H,3-10H2,1-2H3/t13-,14-,15-/m1/s1
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364559
PNG
(CHEMBL1951032)
Show SMILES COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106153
PNG
(CHEMBL3598084)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(c(F)c1)S(C)(=O)=O
Show InChI InChI=1S/C23H34FNO6S/c1-23(2,3)31-22(26)25-13-11-18(12-14-25)29-16-5-7-17(8-6-16)30-19-9-10-21(20(24)15-19)32(4,27)28/h9-10,15-18H,5-8,11-14H2,1-4H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106162
PNG
(CHEMBL3598093)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(nn1)S(C)(=O)=O
Show InChI InChI=1S/C21H33N3O6S/c1-21(2,3)30-20(25)24-13-11-17(12-14-24)28-15-5-7-16(8-6-15)29-18-9-10-19(23-22-18)31(4,26)27/h9-10,15-17H,5-8,11-14H2,1-4H3/t15-,16-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106204
PNG
(CHEMBL3598097)
Show SMILES C[C@@H](CF)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C20H30FN3O6S/c1-14(11-21)28-20(25)24-9-7-17(8-10-24)29-15-3-5-16(6-4-15)30-18-12-23-19(13-22-18)31(2,26)27/h12-17H,3-11H2,1-2H3/t14-,15-,16-/m0/s1
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106205
PNG
(CHEMBL3598098)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC(CF)CF)cn1
Show InChI InChI=1S/C20H29F2N3O6S/c1-32(27,28)19-13-23-18(12-24-19)30-15-4-2-14(3-5-15)29-16-6-8-25(9-7-16)20(26)31-17(10-21)11-22/h12-17H,2-11H2,1H3/t14-,15-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106212
PNG
(CHEMBL3598105)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)C2(CCCC2)C(F)(F)F)cn1
Show InChI InChI=1S/C23H32F3N3O5S/c1-35(31,32)20-15-27-19(14-28-20)34-17-6-4-16(5-7-17)33-18-8-12-29(13-9-18)21(30)22(23(24,25)26)10-2-3-11-22/h14-18H,2-13H2,1H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106218
PNG
(CHEMBL3598111)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC3(F)CCCC3)CC2)cn1
Show InChI InChI=1S/C22H34FN3O4S/c1-31(27,28)21-15-24-20(14-25-21)30-18-6-4-17(5-7-18)29-19-8-12-26(13-9-19)16-22(23)10-2-3-11-22/h14-15,17-19H,2-13,16H2,1H3/t17-,18-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50056004
PNG
(CHEMBL3326667)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2(C)CC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O6S/c1-13-15(4-5-16(25-13)33(3,28)29)31-19-17(22)18(23-12-24-19)30-14-6-10-26(11-7-14)20(27)32-21(2)8-9-21/h4-5,12,14H,6-11H2,1-3H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106163
PNG
(CHEMBL3598094)
Show SMILES CC(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C20H31N3O6S/c1-14(2)27-20(24)23-10-8-17(9-11-23)28-15-4-6-16(7-5-15)29-18-12-22-19(13-21-18)30(3,25)26/h12-17H,4-11H2,1-3H3/t15-,16-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106207
PNG
(CHEMBL3598100)
Show SMILES C[C@H](OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H28F3N3O6S/c1-13(20(21,22)23)30-19(27)26-9-7-16(8-10-26)31-14-3-5-15(6-4-14)32-17-11-25-18(12-24-17)33(2,28)29/h11-16H,3-10H2,1-2H3/t13-,14-,15-/m0/s1
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106218
PNG
(CHEMBL3598111)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC3(F)CCCC3)CC2)cn1
Show InChI InChI=1S/C22H34FN3O4S/c1-31(27,28)21-15-24-20(14-25-21)30-18-6-4-17(5-7-18)29-19-8-12-26(13-9-19)16-22(23)10-2-3-11-22/h14-15,17-19H,2-13,16H2,1H3/t17-,18-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106156
PNG
(CHEMBL3598087)
Show SMILES CC(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(nc1)S(C)(=O)=O
Show InChI InChI=1S/C21H32N2O6S/c1-15(2)27-21(24)23-12-10-18(11-13-23)28-16-4-6-17(7-5-16)29-19-8-9-20(22-14-19)30(3,25)26/h8-9,14-18H,4-7,10-13H2,1-3H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106158
PNG
(CHEMBL3598089)
Show SMILES CN(C)C(=O)c1ccc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC(C)(C)C)nc1C
Show InChI InChI=1S/C25H39N3O5/c1-17-21(23(29)27(5)6)11-12-22(26-17)32-19-9-7-18(8-10-19)31-20-13-15-28(16-14-20)24(30)33-25(2,3)4/h11-12,18-20H,7-10,13-16H2,1-6H3/t18-,19-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106163
PNG
(CHEMBL3598094)
Show SMILES CC(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C20H31N3O6S/c1-14(2)27-20(24)23-10-8-17(9-11-23)28-15-4-6-16(7-5-15)29-18-12-22-19(13-21-18)30(3,25)26/h12-17H,4-11H2,1-3H3/t15-,16-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106198
PNG
(CHEMBL3598095)
Show SMILES CC1(CC1)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C21H31N3O6S/c1-21(9-10-21)30-20(25)24-11-7-17(8-12-24)28-15-3-5-16(6-4-15)29-18-13-23-19(14-22-18)31(2,26)27/h13-17H,3-12H2,1-2H3/t15-,16-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106206
PNG
(CHEMBL3598099)
Show SMILES C[C@@H](OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H28F3N3O6S/c1-13(20(21,22)23)30-19(27)26-9-7-16(8-10-26)31-14-3-5-15(6-4-14)32-17-11-25-18(12-24-17)33(2,28)29/h11-16H,3-10H2,1-2H3/t13-,14-,15-/m1/s1
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106207
PNG
(CHEMBL3598100)
Show SMILES C[C@H](OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H28F3N3O6S/c1-13(20(21,22)23)30-19(27)26-9-7-16(8-10-26)31-14-3-5-15(6-4-14)32-17-11-25-18(12-24-17)33(2,28)29/h11-16H,3-10H2,1-2H3/t13-,14-,15-/m0/s1
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n/an/an/an/a 53n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106208
PNG
(CHEMBL3598101)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)cn1
Show InChI InChI=1S/C20H25F6N3O6S/c1-36(31,32)16-11-27-15(10-28-16)34-13-4-2-12(3-5-13)33-14-6-8-29(9-7-14)18(30)35-17(19(21,22)23)20(24,25)26/h10-14,17H,2-9H2,1H3/t12-,13-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106206
PNG
(CHEMBL3598099)
Show SMILES C[C@@H](OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H28F3N3O6S/c1-13(20(21,22)23)30-19(27)26-9-7-16(8-10-26)31-14-3-5-15(6-4-14)32-17-11-25-18(12-24-17)33(2,28)29/h11-16H,3-10H2,1-2H3/t13-,14-,15-/m1/s1
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106124
PNG
(CHEMBL3598112)
Show SMILES CC(C)c1noc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)n1
Show InChI InChI=1S/C22H33N5O5S/c1-15(2)22-25-20(32-26-22)14-27-10-8-18(9-11-27)30-16-4-6-17(7-5-16)31-19-12-24-21(13-23-19)33(3,28)29/h12-13,15-18H,4-11,14H2,1-3H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106126
PNG
(CHEMBL3598114)
Show SMILES CC(F)Cc1noc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)n1
Show InChI InChI=1S/C22H32FN5O5S/c1-15(23)11-19-26-21(33-27-19)14-28-9-7-18(8-10-28)31-16-3-5-17(6-4-16)32-20-12-25-22(13-24-20)34(2,29)30/h12-13,15-18H,3-11,14H2,1-2H3/t15?,16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Uncharacterized protein


(Canis lupus familiaris)
BDBM50106206
PNG
(CHEMBL3598099)
Show SMILES C[C@@H](OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H28F3N3O6S/c1-13(20(21,22)23)30-19(27)26-9-7-16(8-10-26)31-14-3-5-15(6-4-14)32-17-11-25-18(12-24-17)33(2,28)29/h11-16H,3-10H2,1-2H3/t13-,14-,15-/m1/s1
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n/an/an/an/a 6.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at canine GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106135
PNG
(CHEMBL3598116)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)OC1CCCC(C1)Oc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H35NO6S/c1-23(2,3)30-22(25)24-14-12-18(13-15-24)29-20-7-5-6-19(16-20)28-17-8-10-21(11-9-17)31(4,26)27/h8-11,18-20H,5-7,12-16H2,1-4H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106151
PNG
(CHEMBL3598082)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@H](CC1)Oc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H35NO6S/c1-23(2,3)30-22(25)24-15-13-20(14-16-24)29-18-7-5-17(6-8-18)28-19-9-11-21(12-10-19)31(4,26)27/h9-12,17-18,20H,5-8,13-16H2,1-4H3/t17-,18+
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106157
PNG
(CHEMBL3598088)
Show SMILES CC(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(nc1C)S(C)(=O)=O
Show InChI InChI=1S/C22H34N2O6S/c1-15(2)28-22(25)24-13-11-19(12-14-24)29-17-5-7-18(8-6-17)30-20-9-10-21(23-16(20)3)31(4,26)27/h9-10,15,17-19H,5-8,11-14H2,1-4H3/t17-,18-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106210
PNG
(CHEMBL3598103)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)Oc2ccccc2)cn1
Show InChI InChI=1S/C23H29N3O6S/c1-33(28,29)22-16-24-21(15-25-22)31-19-9-7-18(8-10-19)30-20-11-13-26(14-12-20)23(27)32-17-5-3-2-4-6-17/h2-6,15-16,18-20H,7-14H2,1H3/t18-,19-
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n/an/an/an/a 9.60n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106213
PNG
(CHEMBL3598106)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)C2(CC2)C(F)(F)F)cn1
Show InChI InChI=1S/C21H28F3N3O5S/c1-33(29,30)18-13-25-17(12-26-18)32-15-4-2-14(3-5-15)31-16-6-10-27(11-7-16)19(28)20(8-9-20)21(22,23)24/h12-16H,2-11H2,1H3/t14-,15-
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n/an/an/an/a 107n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106161
PNG
(CHEMBL3598092)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)C#N
Show InChI InChI=1S/C21H30N4O4/c1-21(2,3)29-20(26)25-10-8-18(9-11-25)27-16-4-6-17(7-5-16)28-19-14-23-15(12-22)13-24-19/h13-14,16-18H,4-11H2,1-3H3/t16-,17-
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n/an/an/an/a 144n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106153
PNG
(CHEMBL3598084)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(c(F)c1)S(C)(=O)=O
Show InChI InChI=1S/C23H34FNO6S/c1-23(2,3)31-22(26)25-13-11-18(12-14-25)29-16-5-7-17(8-6-16)30-19-9-10-21(20(24)15-19)32(4,27)28/h9-10,15-18H,5-8,11-14H2,1-4H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106155
PNG
(CHEMBL3598086)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C22H34N2O6S/c1-22(2,3)30-21(25)24-13-11-18(12-14-24)28-16-5-7-17(8-6-16)29-20-10-9-19(15-23-20)31(4,26)27/h9-10,15-18H,5-8,11-14H2,1-4H3/t16-,17-
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n/an/an/an/a 110n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106162
PNG
(CHEMBL3598093)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(nn1)S(C)(=O)=O
Show InChI InChI=1S/C21H33N3O6S/c1-21(2,3)30-20(25)24-13-11-17(12-14-24)28-15-5-7-16(8-6-15)29-18-9-10-19(23-22-18)31(4,26)27/h9-10,15-17H,5-8,11-14H2,1-4H3/t15-,16-
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n/an/an/an/a 1.16E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106211
PNG
(CHEMBL3598104)
Show SMILES CCC(F)(F)C(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C20H29F2N3O5S/c1-3-20(21,22)19(26)25-10-8-16(9-11-25)29-14-4-6-15(7-5-14)30-17-12-24-18(13-23-17)31(2,27)28/h12-16H,3-11H2,1-2H3/t14-,15-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106154
PNG
(CHEMBL3598085)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1)C#N
Show InChI InChI=1S/C23H32N2O4/c1-23(2,3)29-22(26)25-14-12-21(13-15-25)28-20-10-8-19(9-11-20)27-18-6-4-17(16-24)5-7-18/h4-7,19-21H,8-15H2,1-3H3/t19-,20-
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n/an/an/an/a 8.60n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106159
PNG
(CHEMBL3598090)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C21H33N3O6S/c1-21(2,3)30-20(25)24-11-9-17(10-12-24)28-15-5-7-16(8-6-15)29-18-13-23-19(14-22-18)31(4,26)27/h13-17H,5-12H2,1-4H3/t15-,16-
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n/an/an/an/a 5.90n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106160
PNG
(CHEMBL3598091)
Show SMILES CC(C)S(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC(C)(C)C)cn1
Show InChI InChI=1S/C23H37N3O6S/c1-16(2)33(28,29)21-15-24-20(14-25-21)31-18-8-6-17(7-9-18)30-19-10-12-26(13-11-19)22(27)32-23(3,4)5/h14-19H,6-13H2,1-5H3/t17-,18-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106214
PNG
(CHEMBL3598107)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC(F)(F)F)CC2)cn1
Show InChI InChI=1S/C18H26F3N3O4S/c1-29(25,26)17-11-22-16(10-23-17)28-14-4-2-13(3-5-14)27-15-6-8-24(9-7-15)12-18(19,20)21/h10-11,13-15H,2-9,12H2,1H3/t13-,14-
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n/an/an/an/a 776n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106215
PNG
(CHEMBL3598108)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC3(CC3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C21H30F3N3O4S/c1-32(28,29)19-13-25-18(12-26-19)31-16-4-2-15(3-5-16)30-17-6-10-27(11-7-17)14-20(8-9-20)21(22,23)24/h12-13,15-17H,2-11,14H2,1H3/t15-,16-
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n/an/an/an/a 63n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106217
PNG
(CHEMBL3598110)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC3(CCCC3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C23H34F3N3O4S/c1-34(30,31)21-15-27-20(14-28-21)33-18-6-4-17(5-7-18)32-19-8-12-29(13-9-19)16-22(23(24,25)26)10-2-3-11-22/h14-15,17-19H,2-13,16H2,1H3/t17-,18-
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n/an/an/an/a 49n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106152
PNG
(CHEMBL3598083)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H34FNO6S/c1-23(2,3)31-22(26)25-13-11-18(12-14-25)29-16-5-7-17(8-6-16)30-21-10-9-19(15-20(21)24)32(4,27)28/h9-10,15-18H,5-8,11-14H2,1-4H3/t16-,17-
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n/an/an/an/a 227n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106125
PNG
(CHEMBL3598113)
Show SMILES CC(C)c1nc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)no1
Show InChI InChI=1S/C22H33N5O5S/c1-15(2)22-25-19(26-32-22)14-27-10-8-18(9-11-27)30-16-4-6-17(7-5-16)31-20-12-24-21(13-23-20)33(3,28)29/h12-13,15-18H,4-11,14H2,1-3H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106126
PNG
(CHEMBL3598114)
Show SMILES CC(F)Cc1noc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)n1
Show InChI InChI=1S/C22H32FN5O5S/c1-15(23)11-19-26-21(33-27-19)14-28-9-7-18(8-10-28)31-16-3-5-17(6-4-16)32-20-12-25-22(13-24-20)34(2,29)30/h12-13,15-18H,3-11,14H2,1-2H3/t15?,16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106150
PNG
(CHEMBL3598081)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H35NO6S/c1-23(2,3)30-22(25)24-15-13-20(14-16-24)29-18-7-5-17(6-8-18)28-19-9-11-21(12-10-19)31(4,26)27/h9-12,17-18,20H,5-8,13-16H2,1-4H3/t17-,18-
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n/an/an/an/a 94n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106203
PNG
(CHEMBL3598096)
Show SMILES C[C@H](CF)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C20H30FN3O6S/c1-14(11-21)28-20(25)24-9-7-17(8-10-24)29-15-3-5-16(6-4-15)30-18-12-23-19(13-22-18)31(2,26)27/h12-17H,3-11H2,1-2H3/t14-,15-,16-/m1/s1
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n/an/an/an/a 317n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106208
PNG
(CHEMBL3598101)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)cn1
Show InChI InChI=1S/C20H25F6N3O6S/c1-36(31,32)16-11-27-15(10-28-16)34-13-4-2-12(3-5-13)33-14-6-8-29(9-7-14)18(30)35-17(19(21,22)23)20(24,25)26/h10-14,17H,2-9H2,1H3/t12-,13-
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n/an/an/an/a 11n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106210
PNG
(CHEMBL3598103)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)Oc2ccccc2)cn1
Show InChI InChI=1S/C23H29N3O6S/c1-33(28,29)22-16-24-21(15-25-22)31-19-9-7-18(8-10-19)30-20-11-13-26(14-12-20)23(27)32-17-5-3-2-4-6-17/h2-6,15-16,18-20H,7-14H2,1H3/t18-,19-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106126
PNG
(CHEMBL3598114)
Show SMILES CC(F)Cc1noc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)n1
Show InChI InChI=1S/C22H32FN5O5S/c1-15(23)11-19-26-21(33-27-19)14-28-9-7-18(8-10-28)31-16-3-5-17(6-4-16)32-20-12-25-22(13-24-20)34(2,29)30/h12-13,15-18H,3-11,14H2,1-2H3/t15?,16-,17-
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n/an/an/an/a 11n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106127
PNG
(CHEMBL3598115)
Show SMILES CC(F)Cc1nc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)no1
Show InChI InChI=1S/C22H32FN5O5S/c1-15(23)11-20-26-19(27-33-20)14-28-9-7-18(8-10-28)31-16-3-5-17(6-4-16)32-21-12-25-22(13-24-21)34(2,29)30/h12-13,15-18H,3-11,14H2,1-2H3/t15?,16-,17-
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n/an/an/an/a 30n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50056004
PNG
(CHEMBL3326667)
Show SMILES Cc1nc(ccc1Oc1ncnc(OC2CCN(CC2)C(=O)OC2(C)CC2)c1F)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN4O6S/c1-13-15(4-5-16(25-13)33(3,28)29)31-19-17(22)18(23-12-24-19)30-14-6-10-26(11-7-14)20(27)32-21(2)8-9-21/h4-5,12,14H,6-11H2,1-3H3
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n/an/an/an/a 14n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106155
PNG
(CHEMBL3598086)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C22H34N2O6S/c1-22(2,3)30-21(25)24-13-11-18(12-14-24)28-16-5-7-17(8-6-16)29-20-10-9-19(15-23-20)31(4,26)27/h9-10,15-18H,5-8,11-14H2,1-4H3/t16-,17-
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n/an/an/an/a 47n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106161
PNG
(CHEMBL3598092)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)C#N
Show InChI InChI=1S/C21H30N4O4/c1-21(2,3)29-20(26)25-10-8-18(9-11-25)27-16-4-6-17(7-5-16)28-19-14-23-15(12-22)13-24-19/h13-14,16-18H,4-11H2,1-3H3/t16-,17-
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n/an/an/an/a 8.30n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50106206
PNG
(CHEMBL3598099)
Show SMILES C[C@@H](OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H28F3N3O6S/c1-13(20(21,22)23)30-19(27)26-9-7-16(8-10-26)31-14-3-5-15(6-4-14)32-17-11-25-18(12-24-17)33(2,28)29/h11-16H,3-10H2,1-2H3/t13-,14-,15-/m1/s1
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n/an/an/an/a 38n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by serum shift assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106156
PNG
(CHEMBL3598087)
Show SMILES CC(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1ccc(nc1)S(C)(=O)=O
Show InChI InChI=1S/C21H32N2O6S/c1-15(2)27-21(24)23-12-10-18(11-13-23)28-16-4-6-17(7-5-16)29-19-8-9-20(22-14-19)30(3,25)26/h8-9,14-18H,4-7,10-13H2,1-3H3/t16-,17-
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106161
PNG
(CHEMBL3598092)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)C#N
Show InChI InChI=1S/C21H30N4O4/c1-21(2,3)29-20(26)25-10-8-18(9-11-25)27-16-4-6-17(7-5-16)28-19-14-23-15(12-22)13-24-19/h13-14,16-18H,4-11H2,1-3H3/t16-,17-
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n/an/an/an/a 28n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106204
PNG
(CHEMBL3598097)
Show SMILES C[C@@H](CF)OC(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C20H30FN3O6S/c1-14(11-21)28-20(25)24-9-7-17(8-10-24)29-15-3-5-16(6-4-15)30-18-12-23-19(13-22-18)31(2,26)27/h12-17H,3-11H2,1-2H3/t14-,15-,16-/m0/s1
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n/an/an/an/a 356n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106209
PNG
(CHEMBL3598102)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC2CCOC2)cn1
Show InChI InChI=1S/C21H31N3O7S/c1-32(26,27)20-13-22-19(12-23-20)30-16-4-2-15(3-5-16)29-17-6-9-24(10-7-17)21(25)31-18-8-11-28-14-18/h12-13,15-18H,2-11,14H2,1H3/t15-,16-,18?
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n/an/an/an/a 1.50E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106214
PNG
(CHEMBL3598107)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC(F)(F)F)CC2)cn1
Show InChI InChI=1S/C18H26F3N3O4S/c1-29(25,26)17-11-22-16(10-23-17)28-14-4-2-13(3-5-14)27-15-6-8-24(9-7-15)12-18(19,20)21/h10-11,13-15H,2-9,12H2,1H3/t13-,14-
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n/an/an/an/a 1.96E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106216
PNG
(CHEMBL3598109)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC3(CCC3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C22H32F3N3O4S/c1-33(29,30)20-14-26-19(13-27-20)32-17-5-3-16(4-6-17)31-18-7-11-28(12-8-18)15-21(9-2-10-21)22(23,24)25/h13-14,16-18H,2-12,15H2,1H3/t16-,17-
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n/an/an/an/a 80n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50106217
PNG
(CHEMBL3598110)
Show SMILES CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC3(CCCC3)C(F)(F)F)CC2)cn1
Show InChI InChI=1S/C23H34F3N3O4S/c1-34(30,31)21-15-27-20(14-28-21)33-18-6-4-17(5-7-18)32-19-8-12-29(13-9-19)16-22(23(24,25)26)10-2-3-11-22/h14-15,17-19H,2-13,16H2,1H3/t17-,18-
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n/an/an/an/a 101n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by HTRF cAMP assay


Bioorg Med Chem Lett 25: 3034-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.102
BindingDB Entry DOI: 10.7270/Q2SB47JS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%