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PubMed code 26071861

Compile data set for download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095119
PNG
(CHEMBL3589200)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(cc2)\N=C2/C(=O)Nc3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C21H16ClN5O4S/c22-12-1-10-18-17(11-12)19(20(28)27-18)24-13-2-4-14(5-3-13)25-21(29)26-15-6-8-16(9-7-15)32(23,30)31/h1-11H,(H2,23,30,31)(H,24,27,28)(H2,25,26,29)
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n/an/a 310n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095118
PNG
(CHEMBL3589814)
Show SMILES Clc1ccc(NC(=O)Nc2ccc(cc2)\N=C2/C(=O)Nc3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C21H14Cl2N4O2/c22-12-1-4-15(5-2-12)25-21(29)26-16-8-6-14(7-9-16)24-19-17-11-13(23)3-10-18(17)27-20(19)28/h1-11H,(H,24,27,28)(H2,25,26,29)
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n/an/a 710n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095117
PNG
(CHEMBL3589813)
Show SMILES Clc1ccc2NC(=O)\C(=N/c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c2c1
Show InChI InChI=1S/C21H14Cl2N4O2/c22-12-2-1-3-16(10-12)26-21(29)25-15-7-5-14(6-8-15)24-19-17-11-13(23)4-9-18(17)27-20(19)28/h1-11H,(H,24,27,28)(H2,25,26,29)
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n/an/a 750n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095093
PNG
(CHEMBL3589749)
Show SMILES Fc1ccc2NC(=O)\C(=N/c3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)c2c1
Show InChI InChI=1S/C15H15N3O3/c1-20-9-6-7-11-13(8-9)21-15(17-11)18-12-5-3-2-4-10(12)16-14(18)19/h6-8H,2-5H2,1H3,(H,16,19)
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n/an/a 1.93E+3n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095092
PNG
(CHEMBL3589748)
Show SMILES Fc1ccc2NC(=O)\C(=N/c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c2c1
Show InChI InChI=1S/C14H11F2N3O2/c15-7-5-6-9-12(11(7)16)21-14(18-9)19-10-4-2-1-3-8(10)17-13(19)20/h5-6H,1-4H2,(H,17,20)
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n/an/a 1.99E+3n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095091
PNG
(CHEMBL3589746)
Show SMILES Fc1ccc2NC(=O)\C(=N/c3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)cc3)c2c1
Show InChI InChI=1S/C13H8N4O2/c18-12-15-8-4-1-2-5-9(8)17(12)13-16-11-10(19-13)6-3-7-14-11/h1-7H,(H,15,18)
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n/an/a 2.12E+3n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095090
PNG
(CHEMBL3589742)
Show SMILES Clc1ccc(NC(=O)Nc2ccc(cc2)\N=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C21H15ClN4O2/c22-13-5-7-15(8-6-13)24-21(28)25-16-11-9-14(10-12-16)23-19-17-3-1-2-4-18(17)26-20(19)27/h1-12H,(H,23,26,27)(H2,24,25,28)
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n/an/a 2.51E+3n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095089
PNG
(CHEMBL3589741)
Show SMILES Clc1cccc(NC(=O)Nc2ccc(cc2)\N=C2/C(=O)Nc3ccccc23)c1
Show InChI InChI=1S/C14H9N3O2/c18-13-15-9-5-1-3-7-11(9)17(13)14-16-10-6-2-4-8-12(10)19-14/h1-8H,(H,15,18)
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n/an/a 2.58E+3n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095094
PNG
(CHEMBL3589807)
Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)\N=C2/C(=O)Nc3ccc(F)cc23)cc1
Show InChI InChI=1S/C22H17FN4O3/c1-30-17-9-7-16(8-10-17)26-22(29)25-15-5-3-14(4-6-15)24-20-18-12-13(23)2-11-19(18)27-21(20)28/h2-12H,1H3,(H,24,27,28)(H2,25,26,29)
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n/an/a 2.67E+3n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095095
PNG
(CHEMBL3589812)
Show SMILES Fc1ccc(NC(=O)Nc2ccc(cc2)\N=C2/C(=O)Nc3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C14H7F2N3O2/c15-7-5-6-9-12(11(7)16)21-14(18-9)19-10-4-2-1-3-8(10)17-13(19)20/h1-6H,(H,17,20)
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n/an/a 3.92E+3n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095087
PNG
(CHEMBL3589738)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(cc2)\N=C2/C(=O)Nc3ccccc23)c1
Show InChI InChI=1S/C14H12FN3O2/c15-8-5-6-10-12(7-8)20-14(17-10)18-11-4-2-1-3-9(11)16-13(18)19/h5-7H,1-4H2,(H,16,19)
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n/an/a 4.26E+3n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095088
PNG
(CHEMBL3589739)
Show SMILES O=C(Nc1ccc(cc1)\N=C1/C(=O)Nc2ccccc12)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C22H15N5O2/c23-13-14-5-7-16(8-6-14)25-22(29)26-17-11-9-15(10-12-17)24-20-18-3-1-2-4-19(18)27-21(20)28/h1-12H,(H,24,27,28)(H2,25,26,29)
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n/an/a 5.09E+3n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50095086
PNG
(CHEMBL3589737)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)\N=C1/C(=O)Nc2ccccc12
Show InChI InChI=1S/C21H16N4O2/c26-20-19(17-8-4-5-9-18(17)25-20)22-15-10-12-16(13-11-15)24-21(27)23-14-6-2-1-3-7-14/h1-13H,(H,22,25,26)(H2,23,24,27)
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n/an/a 5.61E+3n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using biotinylated poly-GluTyr by ELISA reader


Eur J Med Chem 100: 89-97 (2015)


Article DOI: 10.1016/j.ejmech.2015.05.040
BindingDB Entry DOI: 10.7270/Q24M968J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%