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PubMed code 26101562

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50095296
PNG
(CHEMBL3589082 | US9278953, 1)
Show SMILES CCn1ncc2c(F)cc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1/C20H21FN4O2/c1-3-25-17-10-12(9-15(21)13(17)11-23-25)16-6-5-14(18(26)24-16)20(2)7-4-8-22-19(20)27/h5-6,9-11H,3-4,7-8H2,1-2H3,(H,22,27)(H,24,26)/t20-/s2
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Article
PubMed
2n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP3 receptor by MicroBeta plate-based scintillation counting/SPA binding assay


ACS Med Chem Lett 6: 626-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00188
BindingDB Entry DOI: 10.7270/Q2GX4D9S
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50095295
PNG
(CHEMBL3589083 | US9278953, 2)
Show SMILES Cn1ncc2c(Cl)cc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1/C19H19ClN4O2/c1-19(6-3-7-21-18(19)26)13-4-5-15(23-17(13)25)11-8-14(20)12-10-22-24(2)16(12)9-11/h4-5,8-10H,3,6-7H2,1-2H3,(H,21,26)(H,23,25)/t19-/s2
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Article
PubMed
3.60n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP3 receptor by MicroBeta plate-based scintillation counting/SPA binding assay


ACS Med Chem Lett 6: 626-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00188
BindingDB Entry DOI: 10.7270/Q2GX4D9S
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50095294
PNG
(CHEMBL3589084 | US9278953, 7)
Show SMILES Cn1cnc2cc(cc(Cl)c12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1/C19H19ClN4O2/c1-19(6-3-7-21-18(19)26)12-4-5-14(23-17(12)25)11-8-13(20)16-15(9-11)22-10-24(16)2/h4-5,8-10H,3,6-7H2,1-2H3,(H,21,26)(H,23,25)/t19-/s2
PDB

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UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
7.80n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP3 receptor by MicroBeta plate-based scintillation counting/SPA binding assay


ACS Med Chem Lett 6: 626-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00188
BindingDB Entry DOI: 10.7270/Q2GX4D9S
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50095293
PNG
(CHEMBL3589085 | US9278953, 13)
Show SMILES CCn1ncc2c(C)cc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCNC1=O
Show InChI InChI=1/C20H22N4O2/c1-4-24-17-10-13(9-12(2)14(17)11-22-24)16-6-5-15(18(25)23-16)20(3)7-8-21-19(20)26/h5-6,9-11H,4,7-8H2,1-3H3,(H,21,26)(H,23,25)/t20-/s2
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
32n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human EP3 receptor by MicroBeta plate-based scintillation counting/SPA binding assay


ACS Med Chem Lett 6: 626-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00188
BindingDB Entry DOI: 10.7270/Q2GX4D9S
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%