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PubMed code 26235950

Compile data set for download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 57n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 120n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117640
PNG
(CHEMBL3613639)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)S(F)(F)(F)(F)F)cc1
Show InChI InChI=1S/C20H24F5N3O3S2/c1-15(2)27-11-13-28(14-12-27)32(30,31)18-7-5-17(6-8-18)26-20(29)16-3-9-19(10-4-16)33(21,22,23,24)25/h3-10,15H,11-14H2,1-2H3,(H,26,29)
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n/an/a 260n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Mus musculus)
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 320n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117639
PNG
(CHEMBL3613640)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F4N3O3S/c1-14(2)27-9-11-28(12-10-27)32(30,31)17-6-4-16(5-7-17)26-20(29)18-8-3-15(13-19(18)22)21(23,24)25/h3-8,13-14H,9-12H2,1-2H3,(H,26,29)
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n/an/a 370n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117639
PNG
(CHEMBL3613640)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F4N3O3S/c1-14(2)27-9-11-28(12-10-27)32(30,31)17-6-4-16(5-7-17)26-20(29)18-8-3-15(13-19(18)22)21(23,24)25/h3-8,13-14H,9-12H2,1-2H3,(H,26,29)
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n/an/a 380n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117640
PNG
(CHEMBL3613639)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)S(F)(F)(F)(F)F)cc1
Show InChI InChI=1S/C20H24F5N3O3S2/c1-15(2)27-11-13-28(14-12-27)32(30,31)18-7-5-17(6-8-18)26-20(29)16-3-9-19(10-4-16)33(21,22,23,24)25/h3-10,15H,11-14H2,1-2H3,(H,26,29)
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Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117646
PNG
(CHEMBL3613628)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(C)(C)C)cc1
Show InChI InChI=1S/C24H33N3O3S/c1-18(2)26-14-16-27(17-15-26)31(29,30)22-12-10-21(11-13-22)25-23(28)19-6-8-20(9-7-19)24(3,4)5/h6-13,18H,14-17H2,1-5H3,(H,25,28)
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n/an/a 390n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 420n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117638
PNG
(CHEMBL3613641)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C22H23F6N3O3S/c1-14(2)30-9-11-31(12-10-30)35(33,34)17-6-4-16(5-7-17)29-20(32)18-8-3-15(21(23,24)25)13-19(18)22(26,27)28/h3-8,13-14H,9-12H2,1-2H3,(H,29,32)
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Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117638
PNG
(CHEMBL3613641)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C22H23F6N3O3S/c1-14(2)30-9-11-31(12-10-30)35(33,34)17-6-4-16(5-7-17)29-20(32)18-8-3-15(21(23,24)25)13-19(18)22(26,27)28/h3-8,13-14H,9-12H2,1-2H3,(H,29,32)
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n/an/a 540n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 570n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117645
PNG
(CHEMBL3613629)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H24F3N3O3S/c1-15(2)26-11-13-27(14-12-26)31(29,30)19-9-7-18(8-10-19)25-20(28)16-3-5-17(6-4-16)21(22,23)24/h3-10,15H,11-14H2,1-2H3,(H,25,28)
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n/an/a 710n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117650
PNG
(CHEMBL3613638)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C1CCCC1
Show InChI InChI=1S/C23H26F3N3O3S/c24-23(25,26)18-7-5-17(6-8-18)22(30)27-19-9-11-21(12-10-19)33(31,32)29-15-13-28(14-16-29)20-3-1-2-4-20/h5-12,20H,1-4,13-16H2,(H,27,30)
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n/an/a 800n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117652
PNG
(CHEMBL3613636)
Show SMILES CCN(CC)C1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H28F3N3O3S/c1-3-28(4-2)20-13-15-29(16-14-20)33(31,32)21-11-9-19(10-12-21)27-22(30)17-5-7-18(8-6-17)23(24,25)26/h5-12,20H,3-4,13-16H2,1-2H3,(H,27,30)
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n/an/a 910n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117647
PNG
(CHEMBL3613627)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2Cl)cc1
Show InChI InChI=1S/C25H27ClN4O3S/c1-18(2)29-14-16-30(17-15-29)34(32,33)22-11-9-21(10-12-22)28-25(31)20-7-5-19(6-8-20)24-23(26)4-3-13-27-24/h3-13,18H,14-17H2,1-2H3,(H,28,31)
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n/an/a 930n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117637
PNG
(CHEMBL3613643)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2N)C(F)(F)F)cc1
Show InChI InChI=1S/C21H25F3N4O3S/c1-14(2)27-9-11-28(12-10-27)32(30,31)17-6-4-16(5-7-17)26-20(29)18-8-3-15(13-19(18)25)21(22,23)24/h3-8,13-14H,9-12,25H2,1-2H3,(H,26,29)
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n/an/a 930n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117645
PNG
(CHEMBL3613629)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H24F3N3O3S/c1-15(2)26-11-13-27(14-12-26)31(29,30)19-9-7-18(8-10-19)25-20(28)16-3-5-17(6-4-16)21(22,23)24/h3-10,15H,11-14H2,1-2H3,(H,25,28)
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n/an/a 940n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117646
PNG
(CHEMBL3613628)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(C)(C)C)cc1
Show InChI InChI=1S/C24H33N3O3S/c1-18(2)26-14-16-27(17-15-26)31(29,30)22-12-10-21(11-13-22)25-23(28)19-6-8-20(9-7-19)24(3,4)5/h6-13,18H,14-17H2,1-5H3,(H,25,28)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117651
PNG
(CHEMBL3613637)
Show SMILES CCN(C)C1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H26F3N3O3S/c1-3-27(2)19-12-14-28(15-13-19)32(30,31)20-10-8-18(9-11-20)26-21(29)16-4-6-17(7-5-16)22(23,24)25/h4-11,19H,3,12-15H2,1-2H3,(H,26,29)
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n/an/a 1.28E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117654
PNG
(CHEMBL3613634)
Show SMILES CC(C)N1CCCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H26F3N3O3S/c1-16(2)27-12-3-13-28(15-14-27)32(30,31)20-10-8-19(9-11-20)26-21(29)17-4-6-18(7-5-17)22(23,24)25/h4-11,16H,3,12-15H2,1-2H3,(H,26,29)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117644
PNG
(CHEMBL3613630)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H24F3N3O3S/c1-15(2)26-10-12-27(13-11-26)31(29,30)19-8-6-18(7-9-19)25-20(28)16-4-3-5-17(14-16)21(22,23)24/h3-9,14-15H,10-13H2,1-2H3,(H,25,28)
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n/an/a 1.94E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117653
PNG
(CHEMBL3613635)
Show SMILES CN(C)C1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H24F3N3O3S/c1-26(2)18-11-13-27(14-12-18)31(29,30)19-9-7-17(8-10-19)25-20(28)15-3-5-16(6-4-15)21(22,23)24/h3-10,18H,11-14H2,1-2H3,(H,25,28)
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n/an/a 2.11E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117644
PNG
(CHEMBL3613630)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H24F3N3O3S/c1-15(2)26-10-12-27(13-11-26)31(29,30)19-8-6-18(7-9-19)25-20(28)16-4-3-5-17(14-16)21(22,23)24/h3-9,14-15H,10-13H2,1-2H3,(H,25,28)
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n/an/a 2.17E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117637
PNG
(CHEMBL3613643)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2N)C(F)(F)F)cc1
Show InChI InChI=1S/C21H25F3N4O3S/c1-14(2)27-9-11-28(12-10-27)32(30,31)17-6-4-16(5-7-17)26-20(29)18-8-3-15(13-19(18)25)21(22,23)24/h3-8,13-14H,9-12,25H2,1-2H3,(H,26,29)
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n/an/a 2.92E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117647
PNG
(CHEMBL3613627)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2Cl)cc1
Show InChI InChI=1S/C25H27ClN4O3S/c1-18(2)29-14-16-30(17-15-29)34(32,33)22-11-9-21(10-12-22)28-25(31)20-7-5-19(6-8-20)24-23(26)4-3-13-27-24/h3-13,18H,14-17H2,1-2H3,(H,28,31)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117641
PNG
(CHEMBL3613633)
Show SMILES CN(C)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C16H15F3N2O3S/c1-21(2)25(23,24)14-9-7-13(8-10-14)20-15(22)11-3-5-12(6-4-11)16(17,18)19/h3-10H,1-2H3,(H,20,22)
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n/an/a 4.22E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117649
PNG
(CHEMBL3613625)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C20H25N3O3S/c1-16(2)22-12-14-23(15-13-22)27(25,26)19-10-8-18(9-11-19)21-20(24)17-6-4-3-5-7-17/h3-11,16H,12-15H2,1-2H3,(H,21,24)
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n/an/a 4.30E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117648
PNG
(CHEMBL3613626)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H28N4O3S/c1-19(2)28-15-17-29(18-16-28)33(31,32)23-12-10-22(11-13-23)27-25(30)21-8-6-20(7-9-21)24-5-3-4-14-26-24/h3-14,19H,15-18H2,1-2H3,(H,27,30)
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n/an/a 4.93E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117641
PNG
(CHEMBL3613633)
Show SMILES CN(C)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C16H15F3N2O3S/c1-21(2)25(23,24)14-9-7-13(8-10-14)20-15(22)11-3-5-12(6-4-11)16(17,18)19/h3-10H,1-2H3,(H,20,22)
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n/an/a 5.74E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117648
PNG
(CHEMBL3613626)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)-c2ccccn2)cc1
Show InChI InChI=1S/C25H28N4O3S/c1-19(2)28-15-17-29(18-16-28)33(31,32)23-12-10-22(11-13-23)27-25(30)21-8-6-20(7-9-21)24-5-3-4-14-26-24/h3-14,19H,15-18H2,1-2H3,(H,27,30)
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n/an/a 6.49E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117649
PNG
(CHEMBL3613625)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C20H25N3O3S/c1-16(2)22-12-14-23(15-13-22)27(25,26)19-10-8-18(9-11-19)21-20(24)17-6-4-3-5-7-17/h3-11,16H,12-15H2,1-2H3,(H,21,24)
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n/an/a 8.53E+3n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117642
PNG
(CHEMBL3613632)
Show SMILES CC(C)N1CCN(CC1)C(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N3O2/c1-15(2)27-11-13-28(14-12-27)21(30)17-5-9-19(10-6-17)26-20(29)16-3-7-18(8-4-16)22(23,24)25/h3-10,15H,11-14H2,1-2H3,(H,26,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Rattus norvegicus)
BDBM50117643
PNG
(CHEMBL3613631)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NS(=O)(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H24F3N3O4S2/c1-15(2)25-11-13-26(14-12-25)32(29,30)19-9-5-17(6-10-19)24-31(27,28)18-7-3-16(4-8-18)20(21,22)23/h3-10,15,24H,11-14H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 min...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117642
PNG
(CHEMBL3613632)
Show SMILES CC(C)N1CCN(CC1)C(=O)c1ccc(NC(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H24F3N3O2/c1-15(2)27-11-13-28(14-12-27)21(30)17-5-9-19(10-6-17)26-20(29)16-3-7-18(8-4-16)22(23,24)25/h3-10,15H,11-14H2,1-2H3,(H,26,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50117643
PNG
(CHEMBL3613631)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NS(=O)(=O)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H24F3N3O4S2/c1-15(2)25-11-13-26(14-12-25)32(29,30)19-9-5-17(6-10-19)24-31(27,28)18-7-3-16(4-8-18)20(21,22)23/h3-10,15,24H,11-14H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 3


(Homo sapiens (Human))
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV3 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50117636
PNG
(CHEMBL3613642)
Show SMILES CC(C)N1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Renovis, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPM8 receptor expressed in HEK293 cells assessed as inhibition of menthol-stimulated calcium flux after 10 mins


Bioorg Med Chem Lett 25: 4011-5 (2015)


Article DOI: 10.1016/j.bmcl.2015.06.098
BindingDB Entry DOI: 10.7270/Q2PG1THP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%