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PubMed code 26252962

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PA/PB1


(Hepatitis C virus)
BDBM105203
PNG
(6-(4-Fluorophenyl)-3-hydroxy-5-[4-(1H-1, 2, 3, 4-t...)
Show SMILES Oc1cc(-c2ccc(cc2)-c2nnn[nH]2)c([nH]c1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C18H12FN5O2/c19-13-7-5-11(6-8-13)16-14(9-15(25)18(26)20-16)10-1-3-12(4-2-10)17-21-23-24-22-17/h1-9,25H,(H,20,26)(H,21,22,23,24)
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PC cid
PC sid
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Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Inhibition of Influenza A/Puerto Rico/8/34 (H1N1) PA N-terminal domain endonuclease activity expressed in Escherichia coli BL21 (RIL) cells using (6-...


Bioorg Med Chem 23: 5466-75 (2015)


Article DOI: 10.1016/j.bmc.2015.07.046
BindingDB Entry DOI: 10.7270/Q2N87CK3
More data for this
Ligand-Target Pair
PA/PB1


(Hepatitis C virus)
BDBM50109350
PNG
(CHEMBL3600948)
Show SMILES Oc1ccc(\C=N\Nc2ccc(Cl)cc2)c(O)c1O
Show InChI InChI=1S/C13H11ClN2O3/c14-9-2-4-10(5-3-9)16-15-7-8-1-6-11(17)13(19)12(8)18/h1-7,16-19H/b15-7+
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PubMed
n/an/a 8.30E+3n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Inhibition of Influenza A/Perto Rico/8/34 (PR8) (H1N1) PA N-terminal domain (1 to 197) endonuclease activity expressed in Escherichia coli Rosetta (D...


Bioorg Med Chem 23: 5466-75 (2015)


Article DOI: 10.1016/j.bmc.2015.07.046
BindingDB Entry DOI: 10.7270/Q2N87CK3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
PA/PB1


(Hepatitis C virus)
BDBM50109353
PNG
(CHEMBL3600947)
Show SMILES Oc1ccc(C(=O)COc2ccc(F)cc2)c(O)c1O
Show InChI InChI=1S/C14H11FO5/c15-8-1-3-9(4-2-8)20-7-12(17)10-5-6-11(16)14(19)13(10)18/h1-6,16,18-19H,7H2
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PubMed
n/an/a 9.70E+3n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Inhibition of Influenza A/Perto Rico/8/34 (PR8) (H1N1) PA N-terminal domain (1 to 197) endonuclease activity expressed in Escherichia coli Rosetta (D...


Bioorg Med Chem 23: 5466-75 (2015)


Article DOI: 10.1016/j.bmc.2015.07.046
BindingDB Entry DOI: 10.7270/Q2N87CK3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
PA/PB1


(Hepatitis C virus)
BDBM50109352
PNG
(CHEMBL2424783)
Show SMILES Oc1c(C=O)cc(Cc2ccccc2Cl)cc1[N+]([O-])=O
Show InChI InChI=1S/C14H10ClNO4/c15-12-4-2-1-3-10(12)5-9-6-11(8-17)14(18)13(7-9)16(19)20/h1-4,6-8,18H,5H2
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PC cid
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PubMed
n/an/a 6.30E+4n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Inhibition of Influenza A/Perto Rico/8/34 (PR8) (H1N1) PA N-terminal domain (1 to 197) endonuclease activity expressed in Escherichia coli Rosetta (D...


Bioorg Med Chem 23: 5466-75 (2015)


Article DOI: 10.1016/j.bmc.2015.07.046
BindingDB Entry DOI: 10.7270/Q2N87CK3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
* indicates data uncertainty>20%