BindingDB logo
myBDB logout

PubMed code 26288260

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50121335
PNG
(CHEMBL3622099)
Show SMILES CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1
Show InChI InChI=1S/C25H33BrN4/c1-2-12-30(23-9-7-22(26)8-10-23)19-18-29-16-14-28(15-17-29)13-11-21-20-27-25-6-4-3-5-24(21)25/h3-10,20,27H,2,11-19H2,1H3
Reactome pathway
KEGG

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.720n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D4 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.960n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
6.80n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50121337
PNG
(CHEMBL3622097)
Show SMILES Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1
Show InChI InChI=1S/C22H27BrN4/c23-19-5-7-20(8-6-19)24-10-12-27-15-13-26(14-16-27)11-9-18-17-25-22-4-2-1-3-21(18)22/h1-8,17,24-25H,9-16H2
Reactome pathway
KEGG

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D4 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121337
PNG
(CHEMBL3622097)
Show SMILES Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1
Show InChI InChI=1S/C22H27BrN4/c23-19-5-7-20(8-6-19)24-10-12-27-15-13-26(14-16-27)11-9-18-17-25-22-4-2-1-3-21(18)22/h1-8,17,24-25H,9-16H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
48n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2S receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121335
PNG
(CHEMBL3622099)
Show SMILES CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1
Show InChI InChI=1S/C25H33BrN4/c1-2-12-30(23-9-7-22(26)8-10-23)19-18-29-16-14-28(15-17-29)13-11-21-20-27-25-6-4-3-5-24(21)25/h3-10,20,27H,2,11-19H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
51n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2S receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121337
PNG
(CHEMBL3622097)
Show SMILES Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1
Show InChI InChI=1S/C22H27BrN4/c23-19-5-7-20(8-6-19)24-10-12-27-15-13-26(14-16-27)11-9-18-17-25-22-4-2-1-3-21(18)22/h1-8,17,24-25H,9-16H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
53n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121335
PNG
(CHEMBL3622099)
Show SMILES CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1
Show InChI InChI=1S/C25H33BrN4/c1-2-12-30(23-9-7-22(26)8-10-23)19-18-29-16-14-28(15-17-29)13-11-21-20-27-25-6-4-3-5-24(21)25/h3-10,20,27H,2,11-19H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
58n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50121335
PNG
(CHEMBL3622099)
Show SMILES CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1
Show InChI InChI=1S/C25H33BrN4/c1-2-12-30(23-9-7-22(26)8-10-23)19-18-29-16-14-28(15-17-29)13-11-21-20-27-25-6-4-3-5-24(21)25/h3-10,20,27H,2,11-19H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
89n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121336
PNG
(CHEMBL3622098)
Show SMILES CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(OC)cc1
Show InChI InChI=1S/C26H36N4O/c1-3-13-30(23-8-10-24(31-2)11-9-23)20-19-29-17-15-28(16-18-29)14-12-22-21-27-26-7-5-4-6-25(22)26/h4-11,21,27H,3,12-20H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
120n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50121337
PNG
(CHEMBL3622097)
Show SMILES Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1
Show InChI InChI=1S/C22H27BrN4/c23-19-5-7-20(8-6-19)24-10-12-27-15-13-26(14-16-27)11-9-18-17-25-22-4-2-1-3-21(18)22/h1-8,17,24-25H,9-16H2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
200n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121339
PNG
(CHEMBL3622095)
Show SMILES CCCN(CCN1CCN(Cc2cc3ccccc3[nH]2)CC1)c1ccc(Br)cc1
Show InChI InChI=1S/C24H31BrN4/c1-2-11-29(23-9-7-21(25)8-10-23)17-16-27-12-14-28(15-13-27)19-22-18-20-5-3-4-6-24(20)26-22/h3-10,18,26H,2,11-17,19H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
220n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50121335
PNG
(CHEMBL3622099)
Show SMILES CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1
Show InChI InChI=1S/C25H33BrN4/c1-2-12-30(23-9-7-22(26)8-10-23)19-18-29-16-14-28(15-17-29)13-11-21-20-27-25-6-4-3-5-24(21)25/h3-10,20,27H,2,11-19H2,1H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
250n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50121336
PNG
(CHEMBL3622098)
Show SMILES CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(OC)cc1
Show InChI InChI=1S/C26H36N4O/c1-3-13-30(23-8-10-24(31-2)11-9-23)20-19-29-17-15-28(16-18-29)14-12-22-21-27-26-7-5-4-6-25(22)26/h4-11,21,27H,3,12-20H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
280n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121338
PNG
(CHEMBL3622096)
Show SMILES COc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1
Show InChI InChI=1S/C23H30N4O/c1-28-21-8-6-20(7-9-21)24-11-13-27-16-14-26(15-17-27)12-10-19-18-25-23-5-3-2-4-22(19)23/h2-9,18,24-25H,10-17H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
430n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50121337
PNG
(CHEMBL3622097)
Show SMILES Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1
Show InChI InChI=1S/C22H27BrN4/c23-19-5-7-20(8-6-19)24-10-12-27-15-13-26(14-16-27)11-9-18-17-25-22-4-2-1-3-21(18)22/h1-8,17,24-25H,9-16H2
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
480n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121340
PNG
(CHEMBL3622094)
Show SMILES CCCN(CCN1CCN(Cc2cc3ccccc3[nH]2)CC1)c1ccc(OC)cc1
Show InChI InChI=1S/C25H34N4O/c1-3-12-29(23-8-10-24(30-2)11-9-23)18-17-27-13-15-28(16-14-27)20-22-19-21-6-4-5-7-25(21)26-22/h4-11,19,26H,3,12-18,20H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
520n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50121339
PNG
(CHEMBL3622095)
Show SMILES CCCN(CCN1CCN(Cc2cc3ccccc3[nH]2)CC1)c1ccc(Br)cc1
Show InChI InChI=1S/C24H31BrN4/c1-2-11-29(23-9-7-21(25)8-10-23)17-16-27-12-14-28(15-13-27)19-22-18-20-5-3-4-6-24(20)26-22/h3-10,18,26H,2,11-17,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
600n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50121338
PNG
(CHEMBL3622096)
Show SMILES COc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1
Show InChI InChI=1S/C23H30N4O/c1-28-21-8-6-20(7-9-21)24-11-13-27-16-14-26(15-17-27)12-10-19-18-25-23-5-3-2-4-22(19)23/h2-9,18,24-25H,10-17H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
620n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121341
PNG
(CHEMBL3622093)
Show SMILES Brc1ccc(NCCN2CCN(Cc3cc4ccccc4[nH]3)CC2)cc1
Show InChI InChI=1S/C21H25BrN4/c22-18-5-7-19(8-6-18)23-9-10-25-11-13-26(14-12-25)16-20-15-17-3-1-2-4-21(17)24-20/h1-8,15,23-24H,9-14,16H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
920n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121343
PNG
(CHEMBL3622103)
Show SMILES CCCN(CCN1CCN(Cc2cc3ccccc3[nH]2)CC1)Cc1ccc(Br)cc1
Show InChI InChI=1S/C25H33BrN4/c1-2-11-29(19-21-7-9-23(26)10-8-21)15-12-28-13-16-30(17-14-28)20-24-18-22-5-3-4-6-25(22)27-24/h3-10,18,27H,2,11-17,19-20H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
920n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50121343
PNG
(CHEMBL3622103)
Show SMILES CCCN(CCN1CCN(Cc2cc3ccccc3[nH]2)CC1)Cc1ccc(Br)cc1
Show InChI InChI=1S/C25H33BrN4/c1-2-11-29(19-21-7-9-23(26)10-8-21)15-12-28-13-16-30(17-14-28)20-24-18-22-5-3-4-6-25(22)27-24/h3-10,18,27H,2,11-17,19-20H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
930n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50121340
PNG
(CHEMBL3622094)
Show SMILES CCCN(CCN1CCN(Cc2cc3ccccc3[nH]2)CC1)c1ccc(OC)cc1
Show InChI InChI=1S/C25H34N4O/c1-3-12-29(23-8-10-24(30-2)11-9-23)18-17-27-13-15-28(16-14-27)20-22-19-21-6-4-5-7-25(21)26-22/h4-11,19,26H,3,12-18,20H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.30E+3n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50121335
PNG
(CHEMBL3622099)
Show SMILES CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1
Show InChI InChI=1S/C25H33BrN4/c1-2-12-30(23-9-7-22(26)8-10-23)19-18-29-16-14-28(15-17-29)13-11-21-20-27-25-6-4-3-5-24(21)25/h3-10,20,27H,2,11-19H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.30E+3n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50121332
PNG
(CHEMBL3622101)
Show SMILES Brc1ccc(CNCCN2CCN(Cc3cc4ccccc4[nH]3)CC2)cc1
Show InChI InChI=1S/C22H27BrN4/c23-20-7-5-18(6-8-20)16-24-9-10-26-11-13-27(14-12-26)17-21-15-19-3-1-2-4-22(19)25-21/h1-8,15,24-25H,9-14,16-17H2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.80E+3n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50121341
PNG
(CHEMBL3622093)
Show SMILES Brc1ccc(NCCN2CCN(Cc3cc4ccccc4[nH]3)CC2)cc1
Show InChI InChI=1S/C21H25BrN4/c22-18-5-7-19(8-6-18)23-9-10-25-11-13-26(14-12-25)16-20-15-17-3-1-2-4-21(17)24-20/h1-8,15,23-24H,9-14,16H2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.30E+3n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50121337
PNG
(CHEMBL3622097)
Show SMILES Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1
Show InChI InChI=1S/C22H27BrN4/c23-19-5-7-20(8-6-19)24-10-12-27-15-13-26(14-16-27)11-9-18-17-25-22-4-2-1-3-21(18)22/h1-8,17,24-25H,9-16H2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.60E+3n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121333
PNG
(CHEMBL3622100)
Show SMILES COc1ccc(CNCCN2CCN(Cc3cc4ccccc4[nH]3)CC2)cc1
Show InChI InChI=1S/C23H30N4O/c1-28-22-8-6-19(7-9-22)17-24-10-11-26-12-14-27(15-13-26)18-21-16-20-4-2-3-5-23(20)25-21/h2-9,16,24-25H,10-15,17-18H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.00E+3n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121330
PNG
(CHEMBL3622102)
Show SMILES CCCN(CCN1CCN(Cc2cc3ccccc3[nH]2)CC1)Cc1ccc(OC)cc1
Show InChI InChI=1S/C26H36N4O/c1-3-12-29(20-22-8-10-25(31-2)11-9-22)16-13-28-14-17-30(18-15-28)21-24-19-23-6-4-5-7-26(23)27-24/h4-11,19,27H,3,12-18,20-21H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.10E+3n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50121333
PNG
(CHEMBL3622100)
Show SMILES COc1ccc(CNCCN2CCN(Cc3cc4ccccc4[nH]3)CC2)cc1
Show InChI InChI=1S/C23H30N4O/c1-28-22-8-6-19(7-9-22)17-24-10-11-26-12-14-27(15-13-26)18-21-16-20-4-2-3-5-23(20)25-21/h2-9,16,24-25H,10-15,17-18H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.30E+3n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50121330
PNG
(CHEMBL3622102)
Show SMILES CCCN(CCN1CCN(Cc2cc3ccccc3[nH]2)CC1)Cc1ccc(OC)cc1
Show InChI InChI=1S/C26H36N4O/c1-3-12-29(20-22-8-10-25(31-2)11-9-22)16-13-28-14-17-30(18-15-28)21-24-19-23-6-4-5-7-26(23)27-24/h4-11,19,27H,3,12-18,20-21H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.60E+3n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121332
PNG
(CHEMBL3622101)
Show SMILES Brc1ccc(CNCCN2CCN(Cc3cc4ccccc4[nH]3)CC2)cc1
Show InChI InChI=1S/C22H27BrN4/c23-20-7-5-18(6-8-20)16-24-9-10-26-11-13-27(14-12-26)17-21-15-19-3-1-2-4-22(19)25-21/h1-8,15,24-25H,9-14,16-17H2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.20E+3n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50121342
PNG
(CHEMBL3622092)
Show SMILES COc1ccc(NCCN2CCN(Cc3cc4ccccc4[nH]3)CC2)cc1
Show InChI InChI=1S/C22H28N4O/c1-27-21-8-6-19(7-9-21)23-10-11-25-12-14-26(15-13-25)17-20-16-18-4-2-3-5-22(18)24-20/h2-9,16,23-24H,10-15,17H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
7.50E+3n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50121342
PNG
(CHEMBL3622092)
Show SMILES COc1ccc(NCCN2CCN(Cc3cc4ccccc4[nH]3)CC2)cc1
Show InChI InChI=1S/C22H28N4O/c1-27-21-8-6-19(7-9-21)23-10-11-25-12-14-26(15-13-25)17-20-16-18-4-2-3-5-22(18)24-20/h2-9,16,23-24H,10-15,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.80E+4n/an/an/an/an/an/an/an/a



Universit degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells


ACS Med Chem Lett 6: 882-7 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00131
BindingDB Entry DOI: 10.7270/Q2708376
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%