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PubMed code 26398140

Compile data set for download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM11639
PNG
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
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n/an/a 870n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173518
PNG
(1-(4-Methanesulfonylphenyl)-3-(4-hydroxyphenyl)-5-...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)-c1ccc(O)cc1
Show InChI InChI=1S/C23H17F3N2O3S/c1-32(30,31)20-12-8-18(9-13-20)28-22(16-2-6-17(7-3-16)23(24,25)26)14-21(27-28)15-4-10-19(29)11-5-15/h2-14,29H,1H3
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n/an/a 970n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173509
PNG
(3-(4-Ethoxyphenyl)-1-(4-methanesulfonylphenyl)-5-(...)
Show SMILES CCOc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H23F3N2O3S/c1-3-33-21-12-6-17(7-13-21)23-16-24(18-4-8-19(9-5-18)25(26,27)28)30(29-23)20-10-14-22(15-11-20)34(2,31)32/h4-15,24H,3,16H2,1-2H3
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n/an/a 970n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173507
PNG
(1-(4-Methanesulfonylphenyl)-3-(p-tolyl)-5-(4-trifl...)
Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H21F3N2O2S/c1-16-3-5-17(6-4-16)22-15-23(18-7-9-19(10-8-18)24(25,26)27)29(28-22)20-11-13-21(14-12-20)32(2,30)31/h3-14,23H,15H2,1-2H3
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n/an/a 1.11E+3n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173529
PNG
(1-(4-Aminosulfonylphenyl)-3-(3,4-difluorophenyl)-5...)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H14F5N3O2S/c23-18-10-3-14(11-19(18)24)20-12-21(13-1-4-15(5-2-13)22(25,26)27)30(29-20)16-6-8-17(9-7-16)33(28,31)32/h1-12H,(H2,28,31,32)
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n/an/a 1.34E+3n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173514
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-methoxyphenyl)-5-(4...)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C23H20F3N3O3S/c1-32-19-10-4-15(5-11-19)21-14-22(16-2-6-17(7-3-16)23(24,25)26)29(28-21)18-8-12-20(13-9-18)33(27,30)31/h2-13,22H,14H2,1H3,(H2,27,30,31)
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173523
PNG
(3-(3,4-Difluorophenyl)-1-(4-methanesulfonylphenyl)...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C23H15F5N2O2S/c1-33(31,32)18-9-7-17(8-10-18)30-22(14-2-5-16(6-3-14)23(26,27)28)13-21(29-30)15-4-11-19(24)20(25)12-15/h2-13H,1H3
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Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM22360
PNG
(2-(acetyloxy)benzoate | 2-(acetyloxy)benzoic acid ...)
Show SMILES CC(=O)Oc1ccccc1C(O)=O
Show InChI InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173521
PNG
(3-(4-ethoxyphenyl)-1-(4-methanesulfonylphenyl)-5-[...)
Show SMILES CCOc1ccc(cc1)-c1cc(-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H21F3N2O3S/c1-3-33-21-12-6-17(7-13-21)23-16-24(18-4-8-19(9-5-18)25(26,27)28)30(29-23)20-10-14-22(15-11-20)34(2,31)32/h4-16H,3H2,1-2H3
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n/an/a 1.71E+3n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173512
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-hydroxyphenyl)-5-(4...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(O)cc1
Show InChI InChI=1S/C22H18F3N3O3S/c23-22(24,25)16-5-1-15(2-6-16)21-13-20(14-3-9-18(29)10-4-14)27-28(21)17-7-11-19(12-8-17)32(26,30)31/h1-12,21,29H,13H2,(H2,26,30,31)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173516
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-fluorophenyl)-5-(4-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C22H17F4N3O2S/c23-17-7-3-14(4-8-17)20-13-21(15-1-5-16(6-2-15)22(24,25)26)29(28-20)18-9-11-19(12-10-18)32(27,30)31/h1-12,21H,13H2,(H2,27,30,31)
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n/an/a 2.17E+3n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173527
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-ethoxyphenyl)-5-(4-...)
Show SMILES CCOc1ccc(cc1)-c1cc(-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C24H20F3N3O3S/c1-2-33-20-11-5-16(6-12-20)22-15-23(17-3-7-18(8-4-17)24(25,26)27)30(29-22)19-9-13-21(14-10-19)34(28,31)32/h3-15H,2H2,1H3,(H2,28,31,32)
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Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173519
PNG
(1-(4-Methanesulfonylphenyl)-3-(p-tolyl)-5-(4-trifl...)
Show SMILES Cc1ccc(cc1)-c1cc(-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H19F3N2O2S/c1-16-3-5-17(6-4-16)22-15-23(18-7-9-19(10-8-18)24(25,26)27)29(28-22)20-11-13-21(14-12-20)32(2,30)31/h3-15H,1-2H3
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n/an/a 2.90E+3n/an/an/an/an/an/a



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Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173524
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-hydroxyphenyl)-5-(4...)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)-c1ccc(O)cc1
Show InChI InChI=1S/C22H16F3N3O3S/c23-22(24,25)16-5-1-15(2-6-16)21-13-20(14-3-9-18(29)10-4-14)27-28(21)17-7-11-19(12-8-17)32(26,30)31/h1-13,29H,(H2,26,30,31)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173517
PNG
(1-(4-Aminosulfonylphenyl)-3-(3,4-difluorophenyl)-5...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H16F5N3O2S/c23-18-10-3-14(11-19(18)24)20-12-21(13-1-4-15(5-2-13)22(25,26)27)30(29-20)16-6-8-17(9-7-16)33(28,31)32/h1-11,21H,12H2,(H2,28,31,32)
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Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173522
PNG
(3-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)-5-(...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C23H16F4N2O2S/c1-32(30,31)20-12-10-19(11-13-20)29-22(16-2-6-17(7-3-16)23(25,26)27)14-21(28-29)15-4-8-18(24)9-5-15/h2-14H,1H3
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173515
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-ethoxyphenyl)-5-(4-...)
Show SMILES CCOc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C24H22F3N3O3S/c1-2-33-20-11-5-16(6-12-20)22-15-23(17-3-7-18(8-4-17)24(25,26)27)30(29-22)19-9-13-21(14-10-19)34(28,31)32/h3-14,23H,2,15H2,1H3,(H2,28,31,32)
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n/an/a 4.50E+3n/an/an/an/an/an/a



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Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173510
PNG
(3-(4-Fluorophenyl)-1-(4-Methanesulfonylphenyl)-5-(...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C23H18F4N2O2S/c1-32(30,31)20-12-10-19(11-13-20)29-22(16-2-6-17(7-3-16)23(25,26)27)14-21(28-29)15-4-8-18(24)9-5-15/h2-13,22H,14H2,1H3
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n/an/a 4.80E+3n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173520
PNG
(1-(4-methanesulfonylphenyl)-3-(4-methoxyphenyl)-5-...)
Show SMILES COc1ccc(cc1)-c1cc(-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H19F3N2O3S/c1-32-20-11-5-16(6-12-20)22-15-23(17-3-7-18(8-4-17)24(25,26)27)29(28-22)19-9-13-21(14-10-19)33(2,30)31/h3-15H,1-2H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



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Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173509
PNG
(3-(4-Ethoxyphenyl)-1-(4-methanesulfonylphenyl)-5-(...)
Show SMILES CCOc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H23F3N2O3S/c1-3-33-21-12-6-17(7-13-21)23-16-24(18-4-8-19(9-5-18)25(26,27)28)30(29-23)20-10-14-22(15-11-20)34(2,31)32/h4-15,24H,3,16H2,1-2H3
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173525
PNG
(1-(4-Aminosulfonylphenyl)-3-(p-tolyl)-5-(4-trifluo...)
Show SMILES Cc1ccc(cc1)-c1cc(-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C23H18F3N3O2S/c1-15-2-4-16(5-3-15)21-14-22(17-6-8-18(9-7-17)23(24,25)26)29(28-21)19-10-12-20(13-11-19)32(27,30)31/h2-14H,1H3,(H2,27,30,31)
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173512
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-hydroxyphenyl)-5-(4...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(O)cc1
Show InChI InChI=1S/C22H18F3N3O3S/c23-22(24,25)16-5-1-15(2-6-16)21-13-20(14-3-9-18(29)10-4-14)27-28(21)17-7-11-19(12-8-17)32(26,30)31/h1-12,21,29H,13H2,(H2,26,30,31)
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173518
PNG
(1-(4-Methanesulfonylphenyl)-3-(4-hydroxyphenyl)-5-...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)-c1ccc(O)cc1
Show InChI InChI=1S/C23H17F3N2O3S/c1-32(30,31)20-12-8-18(9-13-20)28-22(16-2-6-17(7-3-16)23(24,25)26)14-21(27-28)15-4-10-19(29)11-5-15/h2-14,29H,1H3
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173529
PNG
(1-(4-Aminosulfonylphenyl)-3-(3,4-difluorophenyl)-5...)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H14F5N3O2S/c23-18-10-3-14(11-19(18)24)20-12-21(13-1-4-15(5-2-13)22(25,26)27)30(29-20)16-6-8-17(9-7-16)33(28,31)32/h1-12H,(H2,28,31,32)
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173507
PNG
(1-(4-Methanesulfonylphenyl)-3-(p-tolyl)-5-(4-trifl...)
Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H21F3N2O2S/c1-16-3-5-17(6-4-16)22-15-23(18-7-9-19(10-8-18)24(25,26)27)29(28-22)20-11-13-21(14-12-20)32(2,30)31/h3-14,23H,15H2,1-2H3
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM11639
PNG
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
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n/an/a 6.70E+3n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173506
PNG
(1-(4-Methanesulfonylphenyl)-3-(4-hydroxyphenyl)-5-...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(O)cc1
Show InChI InChI=1S/C23H19F3N2O3S/c1-32(30,31)20-12-8-18(9-13-20)28-22(16-2-6-17(7-3-16)23(24,25)26)14-21(27-28)15-4-10-19(29)11-5-15/h2-13,22,29H,14H2,1H3
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173528
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-fluorophenyl)-5-(4-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C22H15F4N3O2S/c23-17-7-3-14(4-8-17)20-13-21(15-1-5-16(6-2-15)22(24,25)26)29(28-20)18-9-11-19(12-10-18)32(27,30)31/h1-13H,(H2,27,30,31)
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 7.20E+3n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173523
PNG
(3-(3,4-Difluorophenyl)-1-(4-methanesulfonylphenyl)...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C23H15F5N2O2S/c1-33(31,32)18-9-7-17(8-10-18)30-22(14-2-5-16(6-3-14)23(26,27)28)13-21(29-30)15-4-11-19(24)20(25)12-15/h2-13H,1H3
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173526
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-methoxyphenyl)-5-(4...)
Show SMILES COc1ccc(cc1)-c1cc(-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C23H18F3N3O3S/c1-32-19-10-4-15(5-11-19)21-14-22(16-2-6-17(7-3-16)23(24,25)26)29(28-21)18-8-12-20(13-9-18)33(27,30)31/h2-14H,1H3,(H2,27,30,31)
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173521
PNG
(3-(4-ethoxyphenyl)-1-(4-methanesulfonylphenyl)-5-[...)
Show SMILES CCOc1ccc(cc1)-c1cc(-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H21F3N2O3S/c1-3-33-21-12-6-17(7-13-21)23-16-24(18-4-8-19(9-5-18)25(26,27)28)30(29-23)20-10-14-22(15-11-20)34(2,31)32/h4-16H,3H2,1-2H3
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173513
PNG
(1-(4-Aminosulfonylphenyl)-3-(p-tolyl)-5-(4-trifluo...)
Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C23H20F3N3O2S/c1-15-2-4-16(5-3-15)21-14-22(17-6-8-18(9-7-17)23(24,25)26)29(28-21)19-10-12-20(13-11-19)32(27,30)31/h2-13,22H,14H2,1H3,(H2,27,30,31)
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173514
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-methoxyphenyl)-5-(4...)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C23H20F3N3O3S/c1-32-19-10-4-15(5-11-19)21-14-22(16-2-6-17(7-3-16)23(24,25)26)29(28-21)18-8-12-20(13-9-18)33(27,30)31/h2-13,22H,14H2,1H3,(H2,27,30,31)
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173511
PNG
(3-(3,4-Difluoroluorophenyl)-1-(4-methanesulfonylph...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(F)c(F)c1
Show InChI InChI=1S/C23H17F5N2O2S/c1-33(31,32)18-9-7-17(8-10-18)30-22(14-2-5-16(6-3-14)23(26,27)28)13-21(29-30)15-4-11-19(24)20(25)12-15/h2-12,22H,13H2,1H3
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173524
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-hydroxyphenyl)-5-(4...)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)-c1ccc(O)cc1
Show InChI InChI=1S/C22H16F3N3O3S/c23-22(24,25)16-5-1-15(2-6-16)21-13-20(14-3-9-18(29)10-4-14)27-28(21)17-7-11-19(12-8-17)32(26,30)31/h1-13,29H,(H2,26,30,31)
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173516
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-fluorophenyl)-5-(4-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C22H17F4N3O2S/c23-17-7-3-14(4-8-17)20-13-21(15-1-5-16(6-2-15)22(24,25)26)29(28-20)18-9-11-19(12-10-18)32(27,30)31/h1-12,21H,13H2,(H2,27,30,31)
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Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173527
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-ethoxyphenyl)-5-(4-...)
Show SMILES CCOc1ccc(cc1)-c1cc(-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C24H20F3N3O3S/c1-2-33-20-11-5-16(6-12-20)22-15-23(17-3-7-18(8-4-17)24(25,26)27)30(29-22)19-9-13-21(14-10-19)34(28,31)32/h3-15H,2H2,1H3,(H2,28,31,32)
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n/an/a 1.07E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM173508
PNG
(1-(4-Methanesulfonylphenyl)-3-(4-methoxyphenyl)-5-...)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H21F3N2O3S/c1-32-20-11-5-16(6-12-20)22-15-23(17-3-7-18(8-4-17)24(25,26)27)29(28-22)19-9-13-21(14-10-19)33(2,30)31/h3-14,23H,15H2,1-2H3
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n/an/a 1.08E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173515
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-ethoxyphenyl)-5-(4-...)
Show SMILES CCOc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C24H22F3N3O3S/c1-2-33-20-11-5-16(6-12-20)22-15-23(17-3-7-18(8-4-17)24(25,26)27)30(29-22)19-9-13-21(14-10-19)34(28,31)32/h3-14,23H,2,15H2,1H3,(H2,28,31,32)
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n/an/a 1.13E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173519
PNG
(1-(4-Methanesulfonylphenyl)-3-(p-tolyl)-5-(4-trifl...)
Show SMILES Cc1ccc(cc1)-c1cc(-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H19F3N2O2S/c1-16-3-5-17(6-4-16)22-15-23(18-7-9-19(10-8-18)24(25,26)27)29(28-22)20-11-13-21(14-12-20)32(2,30)31/h3-15H,1-2H3
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n/an/a 1.18E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173517
PNG
(1-(4-Aminosulfonylphenyl)-3-(3,4-difluorophenyl)-5...)
Show SMILES NS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H16F5N3O2S/c23-18-10-3-14(11-19(18)24)20-12-21(13-1-4-15(5-2-13)22(25,26)27)30(29-20)16-6-8-17(9-7-16)33(28,31)32/h1-11,21H,12H2,(H2,28,31,32)
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n/an/a 1.24E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173522
PNG
(3-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)-5-(...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C23H16F4N2O2S/c1-32(30,31)20-12-10-19(11-13-20)29-22(16-2-6-17(7-3-16)23(25,26)27)14-21(28-29)15-4-8-18(24)9-5-15/h2-14H,1H3
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n/an/a 1.43E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173520
PNG
(1-(4-methanesulfonylphenyl)-3-(4-methoxyphenyl)-5-...)
Show SMILES COc1ccc(cc1)-c1cc(-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H19F3N2O3S/c1-32-20-11-5-16(6-12-20)22-15-23(17-3-7-18(8-4-17)24(25,26)27)29(28-22)19-9-13-21(14-10-19)33(2,30)31/h3-15H,1-2H3
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n/an/a 1.51E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173510
PNG
(3-(4-Fluorophenyl)-1-(4-Methanesulfonylphenyl)-5-(...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C23H18F4N2O2S/c1-32(30,31)20-12-10-19(11-13-20)29-22(16-2-6-17(7-3-16)23(25,26)27)14-21(28-29)15-4-8-18(24)9-5-15/h2-13,22H,14H2,1H3
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n/an/a 1.64E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173506
PNG
(1-(4-Methanesulfonylphenyl)-3-(4-hydroxyphenyl)-5-...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(O)cc1
Show InChI InChI=1S/C23H19F3N2O3S/c1-32(30,31)20-12-8-18(9-13-20)28-22(16-2-6-17(7-3-16)23(24,25)26)14-21(27-28)15-4-10-19(29)11-5-15/h2-13,22,29H,14H2,1H3
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n/an/a 1.73E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173525
PNG
(1-(4-Aminosulfonylphenyl)-3-(p-tolyl)-5-(4-trifluo...)
Show SMILES Cc1ccc(cc1)-c1cc(-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C23H18F3N3O2S/c1-15-2-4-16(5-3-15)21-14-22(17-6-8-18(9-7-17)23(24,25)26)29(28-21)19-10-12-20(13-11-19)32(27,30)31/h2-14H,1H3,(H2,27,30,31)
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n/an/a 1.81E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173528
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-fluorophenyl)-5-(4-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C22H15F4N3O2S/c23-17-7-3-14(4-8-17)20-13-21(15-1-5-16(6-2-15)22(24,25)26)29(28-20)18-9-11-19(12-10-18)32(27,30)31/h1-13H,(H2,27,30,31)
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n/an/a 1.94E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173526
PNG
(1-(4-Aminosulfonylphenyl)-3-(4-methoxyphenyl)-5-(4...)
Show SMILES COc1ccc(cc1)-c1cc(-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C23H18F3N3O3S/c1-32-19-10-4-15(5-11-19)21-14-22(16-2-6-17(7-3-16)23(24,25)26)29(28-21)18-8-12-20(13-9-18)33(27,30)31/h2-14H,1H3,(H2,27,30,31)
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n/an/a 2.13E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173513
PNG
(1-(4-Aminosulfonylphenyl)-3-(p-tolyl)-5-(4-trifluo...)
Show SMILES Cc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C23H20F3N3O2S/c1-15-2-4-16(5-3-15)21-14-22(17-6-8-18(9-7-17)23(24,25)26)29(28-21)19-10-12-20(13-11-19)32(27,30)31/h2-13,22H,14H2,1H3,(H2,27,30,31)
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n/an/a 2.25E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173511
PNG
(3-(3,4-Difluoroluorophenyl)-1-(4-methanesulfonylph...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(F)c(F)c1
Show InChI InChI=1S/C23H17F5N2O2S/c1-33(31,32)18-9-7-17(8-10-18)30-22(14-2-5-16(6-3-14)23(26,27)28)13-21(29-30)15-4-11-19(24)20(25)12-15/h2-12,22H,13H2,1H3
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n/an/a 2.31E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM173508
PNG
(1-(4-Methanesulfonylphenyl)-3-(4-methoxyphenyl)-5-...)
Show SMILES COc1ccc(cc1)C1=NN(C(C1)c1ccc(cc1)C(F)(F)F)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H21F3N2O3S/c1-32-20-11-5-16(6-12-20)22-15-23(17-3-7-18(8-4-17)24(25,26)27)29(28-22)19-9-13-21(14-10-19)33(2,30)31/h3-14,23H,15H2,1-2H3
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n/an/a 2.41E+4n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
Cyclooxygenase-2 (COX-2)


(Homo sapiens (Human))
BDBM22360
PNG
(2-(acetyloxy)benzoate | 2-(acetyloxy)benzoic acid ...)
Show SMILES CC(=O)Oc1ccccc1C(O)=O
Show InChI InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Beni-Suef University



Assay Description
The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...


Bioorg Chem 63: 13-23 (2015)


Article DOI: 10.1016/j.bioorg.2015.09.002
BindingDB Entry DOI: 10.7270/Q28G8JGV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%