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PubMed code 26638045

Compile data set for download or QSAR
Found 58 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(homo sapiens (human))
BDBM50161330
PNG
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Show SMILES CC(C)ON([C@H](C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
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n/an/a 0.800n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50138800
PNG
(CHEMBL3754094)
Show InChI InChI=1S/C21H28N2O4S/c1-15(2)14-23(20(16(3)4)21(24)22-25)28(26,27)19-12-10-18(11-13-19)17-8-6-5-7-9-17/h5-13,15-16,20,25H,14H2,1-4H3,(H,22,24)/t20-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50138800
PNG
(CHEMBL3754094)
Show InChI InChI=1S/C21H28N2O4S/c1-15(2)14-23(20(16(3)4)21(24)22-25)28(26,27)19-12-10-18(11-13-19)17-8-6-5-7-9-17/h5-13,15-16,20,25H,14H2,1-4H3,(H,22,24)/t20-/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50161330
PNG
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Show SMILES CC(C)ON([C@H](C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
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n/an/a 6.70n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50314228
PNG
((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(C)C)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C16H26N2O5S/c1-11(2)10-18(15(12(3)4)16(19)17-20)24(21,22)14-8-6-13(23-5)7-9-14/h6-9,11-12,15,20H,10H2,1-5H3,(H,17,19)/t15-/m1/s1
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n/an/a 7.20n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50314228
PNG
((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(C)C)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C16H26N2O5S/c1-11(2)10-18(15(12(3)4)16(19)17-20)24(21,22)14-8-6-13(23-5)7-9-14/h6-9,11-12,15,20H,10H2,1-5H3,(H,17,19)/t15-/m1/s1
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n/an/a 29n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50299053
PNG
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccccc1CC(=O)NO
Show InChI InChI=1S/C15H15NO5S/c1-21-12-6-8-13(9-7-12)22(19,20)14-5-3-2-4-11(14)10-15(17)16-18/h2-9,18H,10H2,1H3,(H,16,17)
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n/an/a 98n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50299053
PNG
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccccc1CC(=O)NO
Show InChI InChI=1S/C15H15NO5S/c1-21-12-6-8-13(9-7-12)22(19,20)14-5-3-2-4-11(14)10-15(17)16-18/h2-9,18H,10H2,1H3,(H,16,17)
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n/an/a 230n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50138798
PNG
(CHEMBL3754100)
Show InChI InChI=1S/C9H13BrN2O5S2/c1-6(2)17-12(5-8(13)11-14)19(15,16)9-4-3-7(10)18-9/h3-4,6,14H,5H2,1-2H3,(H,11,13)
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n/an/a 1.10E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50314228
PNG
((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(C)C)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C16H26N2O5S/c1-11(2)10-18(15(12(3)4)16(19)17-20)24(21,22)14-8-6-13(23-5)7-9-14/h6-9,11-12,15,20H,10H2,1-5H3,(H,17,19)/t15-/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ADAM17 after 30 mins using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50204382
PNG
(2-(benzyloxyamino)-N-hydroxyhexanamide | CHEMBL228...)
Show SMILES CCCCC(NOCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C13H20N2O3/c1-2-3-9-12(13(16)14-17)15-18-10-11-7-5-4-6-8-11/h4-8,12,15,17H,2-3,9-10H2,1H3,(H,14,16)
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n/an/a 1.10E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50204382
PNG
(2-(benzyloxyamino)-N-hydroxyhexanamide | CHEMBL228...)
Show SMILES CCCCC(NOCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C13H20N2O3/c1-2-3-9-12(13(16)14-17)15-18-10-11-7-5-4-6-8-11/h4-8,12,15,17H,2-3,9-10H2,1H3,(H,14,16)
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n/an/a 1.90E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Pseudomonas aeruginosa pseudolysin pretreated with compound for 1 hr followed by the addition of 1.73 uM bradykinin like substrate by s...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50138799
PNG
(CHEMBL3752513)
Show InChI InChI=1S/C19H26N2O6S/c1-26-16-2-4-17(5-3-16)28(24,25)21(12-18(22)20-23)27-19-9-13-6-14(10-19)8-15(7-13)11-19/h2-5,13-15,23H,6-12H2,1H3,(H,20,22)
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n/an/a 2.00E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50138799
PNG
(CHEMBL3752513)
Show InChI InChI=1S/C19H26N2O6S/c1-26-16-2-4-17(5-3-16)28(24,25)21(12-18(22)20-23)27-19-9-13-6-14(10-19)8-15(7-13)11-19/h2-5,13-15,23H,6-12H2,1H3,(H,20,22)
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n/an/a 2.00E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50138801
PNG
(CHEMBL3753984)
Show SMILES ONC(=O)CCNS(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C15H16N2O4S/c18-15(17-19)10-11-16-22(20,21)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
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n/an/a 2.40E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50138798
PNG
(CHEMBL3754100)
Show InChI InChI=1S/C9H13BrN2O5S2/c1-6(2)17-12(5-8(13)11-14)19(15,16)9-4-3-7(10)18-9/h3-4,6,14H,5H2,1-2H3,(H,11,13)
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n/an/a 3.30E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50138798
PNG
(CHEMBL3754100)
Show InChI InChI=1S/C9H13BrN2O5S2/c1-6(2)17-12(5-8(13)11-14)19(15,16)9-4-3-7(10)18-9/h3-4,6,14H,5H2,1-2H3,(H,11,13)
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n/an/a 6.20E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50138796
PNG
(CHEMBL3751971)
Show InChI InChI=1S/C25H22N2O7S/c28-23(26-31)16-17-6-1-4-9-22(17)35(32,33)19-12-10-18(11-13-19)34-15-5-14-27-24(29)20-7-2-3-8-21(20)25(27)30/h1-4,6-13,31H,5,14-16H2,(H,26,28)
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n/an/a 7.00E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50138797
PNG
(CHEMBL3752374)
Show InChI InChI=1S/C25H21N3O6/c29-22(16-10-12-18(13-11-16)34-17-6-2-1-3-7-17)26-21(23(30)27-33)14-15-28-24(31)19-8-4-5-9-20(19)25(28)32/h1-13,21,33H,14-15H2,(H,26,29)(H,27,30)/t21-/m1/s1
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n/an/a 8.20E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50138797
PNG
(CHEMBL3752374)
Show InChI InChI=1S/C25H21N3O6/c29-22(16-10-12-18(13-11-16)34-17-6-2-1-3-7-17)26-21(23(30)27-33)14-15-28-24(31)19-8-4-5-9-20(19)25(28)32/h1-13,21,33H,14-15H2,(H,26,29)(H,27,30)/t21-/m1/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50204382
PNG
(2-(benzyloxyamino)-N-hydroxyhexanamide | CHEMBL228...)
Show SMILES CCCCC(NOCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C13H20N2O3/c1-2-3-9-12(13(16)14-17)15-18-10-11-7-5-4-6-8-11/h4-8,12,15,17H,2-3,9-10H2,1H3,(H,14,16)
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n/an/a 9.50E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50138797
PNG
(CHEMBL3752374)
Show InChI InChI=1S/C25H21N3O6/c29-22(16-10-12-18(13-11-16)34-17-6-2-1-3-7-17)26-21(23(30)27-33)14-15-28-24(31)19-8-4-5-9-20(19)25(28)32/h1-13,21,33H,14-15H2,(H,26,29)(H,27,30)/t21-/m1/s1
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n/an/a 9.50E+3n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ADAM17 after 30 mins using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50138796
PNG
(CHEMBL3751971)
Show InChI InChI=1S/C25H22N2O7S/c28-23(26-31)16-17-6-1-4-9-22(17)35(32,33)19-12-10-18(11-13-19)34-15-5-14-27-24(29)20-7-2-3-8-21(20)25(27)30/h1-4,6-13,31H,5,14-16H2,(H,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50138796
PNG
(CHEMBL3751971)
Show InChI InChI=1S/C25H22N2O7S/c28-23(26-31)16-17-6-1-4-9-22(17)35(32,33)19-12-10-18(11-13-19)34-15-5-14-27-24(29)20-7-2-3-8-21(20)25(27)30/h1-4,6-13,31H,5,14-16H2,(H,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50161330
PNG
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Show SMILES CC(C)ON([C@H](C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ADAM17 after 30 mins using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50138797
PNG
(CHEMBL3752374)
Show InChI InChI=1S/C25H21N3O6/c29-22(16-10-12-18(13-11-16)34-17-6-2-1-3-7-17)26-21(23(30)27-33)14-15-28-24(31)19-8-4-5-9-20(19)25(28)32/h1-13,21,33H,14-15H2,(H,26,29)(H,27,30)/t21-/m1/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50299053
PNG
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccccc1CC(=O)NO
Show InChI InChI=1S/C15H15NO5S/c1-21-12-6-8-13(9-7-12)22(19,20)14-5-3-2-4-11(14)10-15(17)16-18/h2-9,18H,10H2,1H3,(H,16,17)
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n/an/a 1.70E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50138801
PNG
(CHEMBL3753984)
Show SMILES ONC(=O)CCNS(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C15H16N2O4S/c18-15(17-19)10-11-16-22(20,21)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
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n/an/a 2.60E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50138800
PNG
(CHEMBL3754094)
Show InChI InChI=1S/C21H28N2O4S/c1-15(2)14-23(20(16(3)4)21(24)22-25)28(26,27)19-12-10-18(11-13-19)17-8-6-5-7-9-17/h5-13,15-16,20,25H,14H2,1-4H3,(H,22,24)/t20-/m1/s1
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n/an/a 2.90E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50138798
PNG
(CHEMBL3754100)
Show InChI InChI=1S/C9H13BrN2O5S2/c1-6(2)17-12(5-8(13)11-14)19(15,16)9-4-3-7(10)18-9/h3-4,6,14H,5H2,1-2H3,(H,11,13)
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n/an/a 2.90E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50299053
PNG
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccccc1CC(=O)NO
Show InChI InChI=1S/C15H15NO5S/c1-21-12-6-8-13(9-7-12)22(19,20)14-5-3-2-4-11(14)10-15(17)16-18/h2-9,18H,10H2,1H3,(H,16,17)
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UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Pseudomonas aeruginosa pseudolysin pretreated with compound for 1 hr followed by the addition of 1.73 uM bradykinin like substrate by s...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50138798
PNG
(CHEMBL3754100)
Show InChI InChI=1S/C9H13BrN2O5S2/c1-6(2)17-12(5-8(13)11-14)19(15,16)9-4-3-7(10)18-9/h3-4,6,14H,5H2,1-2H3,(H,11,13)
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n/an/a 2.90E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 15 mins followed by the addition of 75 uM Abz-Ala-Gly-leu-Ala-p-n...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50138801
PNG
(CHEMBL3753984)
Show SMILES ONC(=O)CCNS(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C15H16N2O4S/c18-15(17-19)10-11-16-22(20,21)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
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n/an/a 3.00E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50138801
PNG
(CHEMBL3753984)
Show SMILES ONC(=O)CCNS(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C15H16N2O4S/c18-15(17-19)10-11-16-22(20,21)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
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n/an/a 3.00E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 15 mins followed by the addition of 75 uM Abz-Ala-Gly-leu-Ala-p-n...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50138801
PNG
(CHEMBL3753984)
Show SMILES ONC(=O)CCNS(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C15H16N2O4S/c18-15(17-19)10-11-16-22(20,21)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
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n/an/a 3.00E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50138798
PNG
(CHEMBL3754100)
Show InChI InChI=1S/C9H13BrN2O5S2/c1-6(2)17-12(5-8(13)11-14)19(15,16)9-4-3-7(10)18-9/h3-4,6,14H,5H2,1-2H3,(H,11,13)
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n/an/a 3.10E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Pseudomonas aeruginosa pseudolysin pretreated with compound for 1 hr followed by the addition of 1.73 uM bradykinin like substrate by s...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50204382
PNG
(2-(benzyloxyamino)-N-hydroxyhexanamide | CHEMBL228...)
Show SMILES CCCCC(NOCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C13H20N2O3/c1-2-3-9-12(13(16)14-17)15-18-10-11-7-5-4-6-8-11/h4-8,12,15,17H,2-3,9-10H2,1H3,(H,14,16)
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n/an/a 3.40E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50138796
PNG
(CHEMBL3751971)
Show InChI InChI=1S/C25H22N2O7S/c28-23(26-31)16-17-6-1-4-9-22(17)35(32,33)19-12-10-18(11-13-19)34-15-5-14-27-24(29)20-7-2-3-8-21(20)25(27)30/h1-4,6-13,31H,5,14-16H2,(H,26,28)
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n/an/a 3.80E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Pseudomonas aeruginosa pseudolysin pretreated with compound for 1 hr followed by the addition of 1.73 uM bradykinin like substrate by s...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50138799
PNG
(CHEMBL3752513)
Show InChI InChI=1S/C19H26N2O6S/c1-26-16-2-4-17(5-3-16)28(24,25)21(12-18(22)20-23)27-19-9-13-6-14(10-19)8-15(7-13)11-19/h2-5,13-15,23H,6-12H2,1H3,(H,20,22)
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n/an/a 5.10E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50161330
PNG
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Show SMILES CC(C)ON([C@H](C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
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n/an/a 5.70E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50299053
PNG
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccccc1CC(=O)NO
Show InChI InChI=1S/C15H15NO5S/c1-21-12-6-8-13(9-7-12)22(19,20)14-5-3-2-4-11(14)10-15(17)16-18/h2-9,18H,10H2,1H3,(H,16,17)
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n/an/a 6.70E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ADAM17 after 30 mins using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50138801
PNG
(CHEMBL3753984)
Show SMILES ONC(=O)CCNS(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C15H16N2O4S/c18-15(17-19)10-11-16-22(20,21)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
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n/an/a 7.90E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Pseudomonas aeruginosa pseudolysin pretreated with compound for 1 hr followed by the addition of 1.73 uM bradykinin like substrate by s...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50204382
PNG
(2-(benzyloxyamino)-N-hydroxyhexanamide | CHEMBL228...)
Show SMILES CCCCC(NOCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C13H20N2O3/c1-2-3-9-12(13(16)14-17)15-18-10-11-7-5-4-6-8-11/h4-8,12,15,17H,2-3,9-10H2,1H3,(H,14,16)
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n/an/a 8.10E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50138799
PNG
(CHEMBL3752513)
Show InChI InChI=1S/C19H26N2O6S/c1-26-16-2-4-17(5-3-16)28(24,25)21(12-18(22)20-23)27-19-9-13-6-14(10-19)8-15(7-13)11-19/h2-5,13-15,23H,6-12H2,1H3,(H,20,22)
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n/an/a 9.00E+4n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 15 mins followed by the addition of 75 uM Abz-Ala-Gly-leu-Ala-p-n...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50204382
PNG
(2-(benzyloxyamino)-N-hydroxyhexanamide | CHEMBL228...)
Show SMILES CCCCC(NOCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C13H20N2O3/c1-2-3-9-12(13(16)14-17)15-18-10-11-7-5-4-6-8-11/h4-8,12,15,17H,2-3,9-10H2,1H3,(H,14,16)
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n/an/a 1.00E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ADAM17 after 30 mins using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50314228
PNG
((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(C)C)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C16H26N2O5S/c1-11(2)10-18(15(12(3)4)16(19)17-20)24(21,22)14-8-6-13(23-5)7-9-14/h6-9,11-12,15,20H,10H2,1-5H3,(H,17,19)/t15-/m1/s1
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n/an/a 1.03E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50138798
PNG
(CHEMBL3754100)
Show InChI InChI=1S/C9H13BrN2O5S2/c1-6(2)17-12(5-8(13)11-14)19(15,16)9-4-3-7(10)18-9/h3-4,6,14H,5H2,1-2H3,(H,11,13)
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n/an/a 1.14E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ADAM17 after 30 mins using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50138796
PNG
(CHEMBL3751971)
Show InChI InChI=1S/C25H22N2O7S/c28-23(26-31)16-17-6-1-4-9-22(17)35(32,33)19-12-10-18(11-13-19)34-15-5-14-27-24(29)20-7-2-3-8-21(20)25(27)30/h1-4,6-13,31H,5,14-16H2,(H,26,28)
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n/an/a 1.32E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50138799
PNG
(CHEMBL3752513)
Show InChI InChI=1S/C19H26N2O6S/c1-26-16-2-4-17(5-3-16)28(24,25)21(12-18(22)20-23)27-19-9-13-6-14(10-19)8-15(7-13)11-19/h2-5,13-15,23H,6-12H2,1H3,(H,20,22)
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n/an/a 1.42E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Pseudomonas aeruginosa pseudolysin pretreated with compound for 1 hr followed by the addition of 1.73 uM bradykinin like substrate by s...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50299053
PNG
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccccc1CC(=O)NO
Show InChI InChI=1S/C15H15NO5S/c1-21-12-6-8-13(9-7-12)22(19,20)14-5-3-2-4-11(14)10-15(17)16-18/h2-9,18H,10H2,1H3,(H,16,17)
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n/an/a 1.46E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50138796
PNG
(CHEMBL3751971)
Show InChI InChI=1S/C25H22N2O7S/c28-23(26-31)16-17-6-1-4-9-22(17)35(32,33)19-12-10-18(11-13-19)34-15-5-14-27-24(29)20-7-2-3-8-21(20)25(27)30/h1-4,6-13,31H,5,14-16H2,(H,26,28)
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n/an/a 1.50E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ADAM17 after 30 mins using FS-6 as substrate by fluorometry


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50138800
PNG
(CHEMBL3754094)
Show InChI InChI=1S/C21H28N2O4S/c1-15(2)14-23(20(16(3)4)21(24)22-25)28(26,27)19-12-10-18(11-13-19)17-8-6-5-7-9-17/h5-13,15-16,20,25H,14H2,1-4H3,(H,22,24)/t20-/m1/s1
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n/an/a 2.26E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Pseudomonas aeruginosa pseudolysin pretreated with compound for 1 hr followed by the addition of 1.73 uM bradykinin like substrate by s...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50138800
PNG
(CHEMBL3754094)
Show InChI InChI=1S/C21H28N2O4S/c1-15(2)14-23(20(16(3)4)21(24)22-25)28(26,27)19-12-10-18(11-13-19)17-8-6-5-7-9-17/h5-13,15-16,20,25H,14H2,1-4H3,(H,22,24)/t20-/m1/s1
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n/an/a 2.43E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 15 mins followed by the addition of 75 uM Abz-Ala-Gly-leu-Ala-p-n...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50161330
PNG
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Show SMILES CC(C)ON([C@H](C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
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n/an/a 4.16E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 15 mins followed by the addition of 75 uM Abz-Ala-Gly-leu-Ala-p-n...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50138799
PNG
(CHEMBL3752513)
Show InChI InChI=1S/C19H26N2O6S/c1-26-16-2-4-17(5-3-16)28(24,25)21(12-18(22)20-23)27-19-9-13-6-14(10-19)8-15(7-13)11-19/h2-5,13-15,23H,6-12H2,1H3,(H,20,22)
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n/an/a 4.38E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50138800
PNG
(CHEMBL3754094)
Show InChI InChI=1S/C21H28N2O4S/c1-15(2)14-23(20(16(3)4)21(24)22-25)28(26,27)19-12-10-18(11-13-19)17-8-6-5-7-9-17/h5-13,15-16,20,25H,14H2,1-4H3,(H,22,24)/t20-/m1/s1
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n/an/a 6.08E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Pseudolysin


(Pseudomonas aeruginosa)
BDBM50161330
PNG
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Show SMILES CC(C)ON([C@H](C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
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n/an/a 7.98E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Pseudomonas aeruginosa pseudolysin pretreated with compound for 1 hr followed by the addition of 1.73 uM bradykinin like substrate by s...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
Thermolysin


(Bacillus thermoproteolyticus)
BDBM50161330
PNG
((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Show SMILES CC(C)ON([C@H](C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1
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n/an/a 8.00E+5n/an/an/an/an/an/a



UiT The Arctic University of Norway

Curated by ChEMBL


Assay Description
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...


Eur J Med Chem 108: 141-53 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.019
BindingDB Entry DOI: 10.7270/Q2HT2R63
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%