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Found 33 Enz. Inhib. hit(s) with all data for entry = 50046996
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142747(CHEMBL3758589)
Affinity DataIC50:  170nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142706(CHEMBL3759622)
Affinity DataIC50:  170nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142751(CHEMBL3759086)
Affinity DataIC50:  182nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142706(CHEMBL3759622)
Affinity DataIC50:  190nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142688(CHEMBL3759494)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142689(CHEMBL3759314)
Affinity DataIC50:  220nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142748(CHEMBL3758897)
Affinity DataIC50:  237nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142689(CHEMBL3759314)
Affinity DataIC50:  240nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142750(CHEMBL3759252)
Affinity DataIC50:  255nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142752(CHEMBL3759142)
Affinity DataIC50:  257nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142746(CHEMBL3759807)
Affinity DataIC50:  290nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142750(CHEMBL3759252)
Affinity DataIC50:  330nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142688(CHEMBL3759494)
Affinity DataIC50:  370nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142749(CHEMBL3758401)
Affinity DataIC50:  657nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142751(CHEMBL3759086)
Affinity DataIC50:  820nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142748(CHEMBL3758897)
Affinity DataIC50:  930nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142747(CHEMBL3758589)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142746(CHEMBL3759807)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142749(CHEMBL3758401)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142752(CHEMBL3759142)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142745(CHEMBL3759141)
Affinity DataIC50:  1.15E+3nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142710(CHEMBL3760012)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142706(CHEMBL3759622)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of IL-1beta-activated m-PGES-1 in microsome of human A549 cells assessed as PGE2 formation preincubated for 15 mins followed by PGH2 addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142745(CHEMBL3759141)
Affinity DataIC50:  1.74E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142688(CHEMBL3759494)
Affinity DataIC50:  1.93E+3nMAssay Description:Inhibition of IL-1beta-activated m-PGES-1 in microsome of human A549 cells assessed as PGE2 formation preincubated for 15 mins followed by PGH2 addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142710(CHEMBL3760012)
Affinity DataIC50:  2.04E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142708(CHEMBL3760011)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142712(CHEMBL3758769)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142707(CHEMBL3759148)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142708(CHEMBL3760011)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142707(CHEMBL3759148)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142712(CHEMBL3758769)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Second University Of Naples

Curated by ChEMBL
LigandPNGBDBM50142689(CHEMBL3759314)
Affinity DataIC50:  1.38E+4nMAssay Description:Inhibition of IL-1beta-activated m-PGES-1 in microsome of human A549 cells assessed as PGE2 formation preincubated for 15 mins followed by PGH2 addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed