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PubMed code 26736071

Compile data set for download or QSAR
Found 79 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149456
PNG
(CHEMBL3769702)
Show SMILES Cc1c(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cn12)C1CC1
Show InChI InChI=1S/C20H18F3N3O3/c1-12-19(13-2-3-13)25-17-9-4-14(10-26(12)17)24-18(27)11-28-15-5-7-16(8-6-15)29-20(21,22)23/h4-10,13H,2-3,11H2,1H3,(H,24,27)
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n/an/a 3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149457
PNG
(CHEMBL3771335)
Show SMILES Cc1nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cn2c1C
Show InChI InChI=1S/C18H16F3N3O3/c1-11-12(2)24-9-13(3-8-16(24)22-11)23-17(25)10-26-14-4-6-15(7-5-14)27-18(19,20)21/h3-9H,10H2,1-2H3,(H,23,25)
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n/an/a 3.80n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149456
PNG
(CHEMBL3769702)
Show SMILES Cc1c(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cn12)C1CC1
Show InChI InChI=1S/C20H18F3N3O3/c1-12-19(13-2-3-13)25-17-9-4-14(10-26(12)17)24-18(27)11-28-15-5-7-16(8-6-15)29-20(21,22)23/h4-10,13H,2-3,11H2,1H3,(H,24,27)
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n/an/a 6.30n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149444
PNG
(CHEMBL3770706)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc2oc(cc2c1=O)-c1ccc(Cl)cc1)C1CC1
Show InChI InChI=1S/C24H18ClN3O2/c1-14-23(16-2-3-16)26-22-9-8-18(13-28(14)22)27-11-10-20-19(24(27)29)12-21(30-20)15-4-6-17(25)7-5-15/h4-13,16H,2-3H2,1H3
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n/an/a 6.80n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149462
PNG
(CHEMBL3771182)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2csc(Cl)c2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN3O2S/c1-13-21(15-2-3-15)23-19-5-4-16(10-25(13)19)24-7-6-17(9-20(24)26)27-11-14-8-18(22)28-12-14/h4-10,12,15H,2-3,11H2,1H3
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n/an/a 7.5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149462
PNG
(CHEMBL3771182)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2csc(Cl)c2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN3O2S/c1-13-21(15-2-3-15)23-19-5-4-16(10-25(13)19)24-7-6-17(9-20(24)26)27-11-14-8-18(22)28-12-14/h4-10,12,15H,2-3,11H2,1H3
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n/an/a 7.70n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149457
PNG
(CHEMBL3771335)
Show SMILES Cc1nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cn2c1C
Show InChI InChI=1S/C18H16F3N3O3/c1-11-12(2)24-9-13(3-8-16(24)22-11)23-17(25)10-26-14-4-6-15(7-5-14)27-18(19,20)21/h3-9H,10H2,1-2H3,(H,23,25)
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149443
PNG
(CHEMBL3771307)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Br)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20BrN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3
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n/an/a 9.30n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149444
PNG
(CHEMBL3770706)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc2oc(cc2c1=O)-c1ccc(Cl)cc1)C1CC1
Show InChI InChI=1S/C24H18ClN3O2/c1-14-23(16-2-3-16)26-22-9-8-18(13-28(14)22)27-11-10-20-19(24(27)29)12-21(30-20)15-4-6-17(25)7-5-15/h4-13,16H,2-3H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149443
PNG
(CHEMBL3771307)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Br)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20BrN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149461
PNG
(CHEMBL3769762)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2csc(c2)C(F)(F)F)cc1=O)C1CC1
Show InChI InChI=1S/C22H18F3N3O2S/c1-13-21(15-2-3-15)26-19-5-4-16(10-28(13)19)27-7-6-17(9-20(27)29)30-11-14-8-18(31-12-14)22(23,24)25/h4-10,12,15H,2-3,11H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149461
PNG
(CHEMBL3769762)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2csc(c2)C(F)(F)F)cc1=O)C1CC1
Show InChI InChI=1S/C22H18F3N3O2S/c1-13-21(15-2-3-15)26-19-5-4-16(10-28(13)19)27-7-6-17(9-20(27)29)30-11-14-8-18(31-12-14)22(23,24)25/h4-10,12,15H,2-3,11H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149462
PNG
(CHEMBL3771182)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2csc(Cl)c2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN3O2S/c1-13-21(15-2-3-15)23-19-5-4-16(10-25(13)19)24-7-6-17(9-20(24)26)27-11-14-8-18(22)28-12-14/h4-10,12,15H,2-3,11H2,1H3
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n/an/a 19n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH (4 to 19 residues)-stimulated intracellular calcium mobilizat...


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149458
PNG
(CHEMBL3770396)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cn2)cc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-22(15-2-3-15)25-20-7-6-18(12-27(14)20)26-9-8-19(10-21(26)28)29-13-17-5-4-16(23)11-24-17/h4-12,15H,2-3,13H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149453
PNG
(CHEMBL3770359)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149453
PNG
(CHEMBL3770359)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH (4 to 19 residues)-stimulated intracellular calcium mobilizat...


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149458
PNG
(CHEMBL3770396)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cn2)cc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-22(15-2-3-15)25-20-7-6-18(12-27(14)20)26-9-8-19(10-21(26)28)29-13-17-5-4-16(23)11-24-17/h4-12,15H,2-3,13H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149463
PNG
(CHEMBL3769582)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccsc2)cc1=O)C1CC1
Show InChI InChI=1S/C21H19N3O2S/c1-14-21(16-2-3-16)22-19-5-4-17(11-24(14)19)23-8-6-18(10-20(23)25)26-12-15-7-9-27-13-15/h4-11,13,16H,2-3,12H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149453
PNG
(CHEMBL3770359)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149460
PNG
(CHEMBL3770954)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccccc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H21N3O2/c1-16-23(18-7-8-18)24-21-10-9-19(14-26(16)21)25-12-11-20(13-22(25)27)28-15-17-5-3-2-4-6-17/h2-6,9-14,18H,7-8,15H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149459
PNG
(CHEMBL3769602)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20FN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149447
PNG
(CHEMBL3769550)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cc2)nc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-21(16-4-5-16)24-19-9-8-18(12-27(14)19)26-11-10-20(25-22(26)28)29-13-15-2-6-17(23)7-3-15/h2-3,6-12,16H,4-5,13H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149447
PNG
(CHEMBL3769550)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cc2)nc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-21(16-4-5-16)24-19-9-8-18(12-27(14)19)26-11-10-20(25-22(26)28)29-13-15-2-6-17(23)7-3-15/h2-3,6-12,16H,4-5,13H2,1H3
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n/an/a 37n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149444
PNG
(CHEMBL3770706)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc2oc(cc2c1=O)-c1ccc(Cl)cc1)C1CC1
Show InChI InChI=1S/C24H18ClN3O2/c1-14-23(16-2-3-16)26-22-9-8-18(13-28(14)22)27-11-10-20-19(24(27)29)12-21(30-20)15-4-6-17(25)7-5-15/h4-13,16H,2-3H2,1H3
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n/an/a 42n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH (4 to 19 residues)-stimulated intracellular calcium mobilizat...


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149460
PNG
(CHEMBL3770954)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccccc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H21N3O2/c1-16-23(18-7-8-18)24-21-10-9-19(14-26(16)21)25-12-11-20(13-22(25)27)28-15-17-5-3-2-4-6-17/h2-6,9-14,18H,7-8,15H2,1H3
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n/an/a 42n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149459
PNG
(CHEMBL3769602)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20FN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3
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n/an/a 47n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149463
PNG
(CHEMBL3769582)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccsc2)cc1=O)C1CC1
Show InChI InChI=1S/C21H19N3O2S/c1-14-21(16-2-3-16)22-19-5-4-17(11-24(14)19)23-8-6-18(10-20(23)25)26-12-15-7-9-27-13-15/h4-11,13,16H,2-3,12H2,1H3
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n/an/a 54n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149445
PNG
(CHEMBL3770680)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc2OC(CCc2c1=O)c1ccc(Cl)cc1)C1CC1
Show InChI InChI=1S/C25H22ClN3O2/c1-15-24(17-2-3-17)27-23-11-8-19(14-29(15)23)28-13-12-22-20(25(28)30)9-10-21(31-22)16-4-6-18(26)7-5-16/h4-8,11-14,17,21H,2-3,9-10H2,1H3
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n/an/a 62n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149441
PNG
(CHEMBL3770865)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(cc2)C(F)(F)F)cc1=O)C1CC1
Show InChI InChI=1S/C24H20F3N3O2/c1-15-23(17-4-5-17)28-21-9-8-19(13-30(15)21)29-11-10-20(12-22(29)31)32-14-16-2-6-18(7-3-16)24(25,26)27/h2-3,6-13,17H,4-5,14H2,1H3
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n/an/a 72n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149440
PNG
(CHEMBL3769585)
Show SMILES Cc1nc2ccc(cn2c1C)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C21H19N3O2/c1-15-16(2)24-13-18(8-9-20(24)22-15)23-11-10-19(12-21(23)25)26-14-17-6-4-3-5-7-17/h3-13H,14H2,1-2H3
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n/an/a 78n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149440
PNG
(CHEMBL3769585)
Show SMILES Cc1nc2ccc(cn2c1C)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C21H19N3O2/c1-15-16(2)24-13-18(8-9-20(24)22-15)23-11-10-19(12-21(23)25)26-14-17-6-4-3-5-7-17/h3-13H,14H2,1-2H3
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n/an/a 80n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149441
PNG
(CHEMBL3770865)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(cc2)C(F)(F)F)cc1=O)C1CC1
Show InChI InChI=1S/C24H20F3N3O2/c1-15-23(17-4-5-17)28-21-9-8-19(13-30(15)21)29-11-10-20(12-22(29)31)32-14-16-2-6-18(7-3-16)24(25,26)27/h2-3,6-13,17H,4-5,14H2,1H3
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n/an/a 82n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149449
PNG
(CHEMBL3770135)
Show SMILES Cc1c(nc2ccc(cn12)-n1ncc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-22(16-4-5-16)25-20-9-8-18(12-26(14)20)27-21(28)10-19(11-24-27)29-13-15-2-6-17(23)7-3-15/h2-3,6-12,16H,4-5,13H2,1H3
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n/an/a 92n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149445
PNG
(CHEMBL3770680)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc2OC(CCc2c1=O)c1ccc(Cl)cc1)C1CC1
Show InChI InChI=1S/C25H22ClN3O2/c1-15-24(17-2-3-17)27-23-11-8-19(14-29(15)23)28-13-12-22-20(25(28)30)9-10-21(31-22)16-4-6-18(26)7-5-16/h4-8,11-14,17,21H,2-3,9-10H2,1H3
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n/an/a 94n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149464
PNG
(CHEMBL3771336)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2cccs2)cc1=O)C1CC1
Show InChI InChI=1S/C21H19N3O2S/c1-14-21(15-4-5-15)22-19-7-6-16(12-24(14)19)23-9-8-17(11-20(23)25)26-13-18-3-2-10-27-18/h2-3,6-12,15H,4-5,13H2,1H3
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n/an/a 95n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149449
PNG
(CHEMBL3770135)
Show SMILES Cc1c(nc2ccc(cn12)-n1ncc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-22(16-4-5-16)25-20-9-8-18(12-26(14)20)27-21(28)10-19(11-24-27)29-13-15-2-6-17(23)7-3-15/h2-3,6-12,16H,4-5,13H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149439
PNG
(CHEMBL3771000)
Show SMILES CCc1nc2ccc(cn2c1C)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C22H21N3O2/c1-3-20-16(2)25-14-18(9-10-21(25)23-20)24-12-11-19(13-22(24)26)27-15-17-7-5-4-6-8-17/h4-14H,3,15H2,1-2H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149439
PNG
(CHEMBL3771000)
Show SMILES CCc1nc2ccc(cn2c1C)-n1ccc(OCc2ccccc2)cc1=O
Show InChI InChI=1S/C22H21N3O2/c1-3-20-16(2)25-14-18(9-10-21(25)23-20)24-12-11-19(13-22(24)26)27-15-17-7-5-4-6-8-17/h4-14H,3,15H2,1-2H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149464
PNG
(CHEMBL3771336)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2cccs2)cc1=O)C1CC1
Show InChI InChI=1S/C21H19N3O2S/c1-14-21(15-4-5-15)22-19-7-6-16(12-24(14)19)23-9-8-17(11-20(23)25)26-13-18-3-2-10-27-18/h2-3,6-12,15H,4-5,13H2,1H3
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n/an/a 130n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149447
PNG
(CHEMBL3769550)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cc2)nc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-21(16-4-5-16)24-19-9-8-18(12-27(14)19)26-11-10-20(25-22(26)28)29-13-15-2-6-17(23)7-3-15/h2-3,6-12,16H,4-5,13H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH (4 to 19 residues)-stimulated intracellular calcium mobilizat...


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149448
PNG
(CHEMBL3769460)
Show SMILES Cc1c(nc2ccc(cn12)-n1cnc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-22(16-4-5-16)25-19-9-8-18(11-26(14)19)27-13-24-20(10-21(27)28)29-12-15-2-6-17(23)7-3-15/h2-3,6-11,13,16H,4-5,12H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149448
PNG
(CHEMBL3769460)
Show SMILES Cc1c(nc2ccc(cn12)-n1cnc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-22(16-4-5-16)25-19-9-8-18(11-26(14)19)27-13-24-20(10-21(27)28)29-12-15-2-6-17(23)7-3-15/h2-3,6-11,13,16H,4-5,12H2,1H3
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n/an/a 150n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149295
PNG
(CHEMBL3769682)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccccn2)cc1=O)C1CC1
Show InChI InChI=1S/C22H20N4O2/c1-15-22(16-5-6-16)24-20-8-7-18(13-26(15)20)25-11-9-19(12-21(25)27)28-14-17-4-2-3-10-23-17/h2-4,7-13,16H,5-6,14H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149446
PNG
(CHEMBL3770175)
Show SMILES Cc1c(nc2ccc(cn12)-n1cc(C)c(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C24H22ClN3O2/c1-15-12-28(23(29)11-21(15)30-14-17-3-7-19(25)8-4-17)20-9-10-22-26-24(18-5-6-18)16(2)27(22)13-20/h3-4,7-13,18H,5-6,14H2,1-2H3
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n/an/a 150n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149033
PNG
(CHEMBL3769758)
Show SMILES Cc1c(CC#N)nc2ccc(cn12)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C22H17FN4O2/c1-15-20(8-10-24)25-21-7-6-18(13-27(15)21)26-11-9-19(12-22(26)28)29-14-16-2-4-17(23)5-3-16/h2-7,9,11-13H,8,14H2,1H3
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n/an/a 170n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149033
PNG
(CHEMBL3769758)
Show SMILES Cc1c(CC#N)nc2ccc(cn12)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C22H17FN4O2/c1-15-20(8-10-24)25-21-7-6-18(13-27(15)21)26-11-9-19(12-22(26)28)29-14-16-2-4-17(23)5-3-16/h2-7,9,11-13H,8,14H2,1H3
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n/an/a 180n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149446
PNG
(CHEMBL3770175)
Show SMILES Cc1c(nc2ccc(cn12)-n1cc(C)c(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C24H22ClN3O2/c1-15-12-28(23(29)11-21(15)30-14-17-3-7-19(25)8-4-17)20-9-10-22-26-24(18-5-6-18)16(2)27(22)13-20/h3-4,7-13,18H,5-6,14H2,1-2H3
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n/an/a 210n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149295
PNG
(CHEMBL3769682)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccccn2)cc1=O)C1CC1
Show InChI InChI=1S/C22H20N4O2/c1-15-22(16-5-6-16)24-20-8-7-18(13-26(15)20)25-11-9-19(12-21(25)27)28-14-17-4-2-3-10-23-17/h2-4,7-13,16H,5-6,14H2,1H3
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n/an/a 240n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149450
PNG
(CHEMBL3770776)
Show SMILES Cc1c(nc2ccc(cn12)-n1cccc(Oc2ccc(OC(F)(F)F)cc2)c1=O)C1CC1
Show InChI InChI=1S/C23H18F3N3O3/c1-14-21(15-4-5-15)27-20-11-6-16(13-29(14)20)28-12-2-3-19(22(28)30)31-17-7-9-18(10-8-17)32-23(24,25)26/h2-3,6-13,15H,4-5H2,1H3
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n/an/a 240n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149442
PNG
(CHEMBL3769899)
Show SMILES CC(C)c1ccc(COc2ccn(-c3ccc4nc(C5CC5)c(C)n4c3)c(=O)c2)cc1
Show InChI InChI=1S/C26H27N3O2/c1-17(2)20-6-4-19(5-7-20)16-31-23-12-13-28(25(30)14-23)22-10-11-24-27-26(21-8-9-21)18(3)29(24)15-22/h4-7,10-15,17,21H,8-9,16H2,1-3H3
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n/an/a 240n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149450
PNG
(CHEMBL3770776)
Show SMILES Cc1c(nc2ccc(cn12)-n1cccc(Oc2ccc(OC(F)(F)F)cc2)c1=O)C1CC1
Show InChI InChI=1S/C23H18F3N3O3/c1-14-21(15-4-5-15)27-20-11-6-16(13-29(14)20)28-12-2-3-19(22(28)30)31-17-7-9-18(10-8-17)32-23(24,25)26/h2-3,6-13,15H,4-5H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149442
PNG
(CHEMBL3769899)
Show SMILES CC(C)c1ccc(COc2ccn(-c3ccc4nc(C5CC5)c(C)n4c3)c(=O)c2)cc1
Show InChI InChI=1S/C26H27N3O2/c1-17(2)20-6-4-19(5-7-20)16-31-23-12-13-28(25(30)14-23)22-10-11-24-27-26(21-8-9-21)18(3)29(24)15-22/h4-7,10-15,17,21H,8-9,16H2,1-3H3
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n/an/a 410n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149451
PNG
(CHEMBL3771133)
Show SMILES Cc1c(nc2ccc(cn12)-n1cccc(OCc2ccc(Cl)cc2)c1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-15-22(17-6-7-17)25-21-11-10-19(13-27(15)21)26-12-2-3-20(23(26)28)29-14-16-4-8-18(24)9-5-16/h2-5,8-13,17H,6-7,14H2,1H3
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n/an/a 650n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149452
PNG
(CHEMBL3769964)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H18F3N3O3/c1-14-22(15-2-3-15)27-20-9-4-16(13-29(14)20)28-11-10-19(12-21(28)30)31-17-5-7-18(8-6-17)32-23(24,25)26/h4-13,15H,2-3H2,1H3
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n/an/a 950n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149451
PNG
(CHEMBL3771133)
Show SMILES Cc1c(nc2ccc(cn12)-n1cccc(OCc2ccc(Cl)cc2)c1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-15-22(17-6-7-17)25-21-11-10-19(13-27(15)21)26-12-2-3-20(23(26)28)29-14-16-4-8-18(24)9-5-16/h2-5,8-13,17H,6-7,14H2,1H3
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n/an/a 990n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149455
PNG
(CHEMBL3769838)
Show SMILES Cc1c(cc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cn12)C1CC1
Show InChI InChI=1S/C21H19F3N2O3/c1-13-19(14-2-3-14)10-16-5-4-15(11-26(13)16)25-20(27)12-28-17-6-8-18(9-7-17)29-21(22,23)24/h4-11,14H,2-3,12H2,1H3,(H,25,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149409
PNG
(CHEMBL3770348)
Show SMILES COCc1nc2ccc(cn2c1C)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C22H20FN3O3/c1-15-20(14-28-2)24-21-8-7-18(12-26(15)21)25-10-9-19(11-22(25)27)29-13-16-3-5-17(23)6-4-16/h3-12H,13-14H2,1-2H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149434
PNG
(CHEMBL3770539)
Show SMILES Cc1c(CO)nc2ccc(cn12)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C21H18FN3O3/c1-14-19(12-26)23-20-7-6-17(11-25(14)20)24-9-8-18(10-21(24)27)28-13-15-2-4-16(22)5-3-15/h2-11,26H,12-13H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149454
PNG
(CHEMBL3769548)
Show SMILES Cc1oc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc2c1C
Show InChI InChI=1S/C19H16F3NO4/c1-11-12(2)26-17-8-3-13(9-16(11)17)23-18(24)10-25-14-4-6-15(7-5-14)27-19(20,21)22/h3-9H,10H2,1-2H3,(H,23,24)
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149435
PNG
(CHEMBL3769816)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C(=O)C1CC1
Show InChI InChI=1S/C24H20FN3O3/c1-15-23(24(30)17-4-5-17)26-21-9-8-19(13-28(15)21)27-11-10-20(12-22(27)29)31-14-16-2-6-18(25)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149436
PNG
(CHEMBL3770750)
Show SMILES CC(=O)c1nc2ccc(cn2c1C)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C22H18FN3O3/c1-14-22(15(2)27)24-20-8-7-18(12-26(14)20)25-10-9-19(11-21(25)28)29-13-16-3-5-17(23)6-4-16/h3-12H,13H2,1-2H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149452
PNG
(CHEMBL3769964)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H18F3N3O3/c1-14-22(15-2-3-15)27-20-9-4-16(13-29(14)20)28-11-10-19(12-21(28)30)31-17-5-7-18(8-6-17)32-23(24,25)26/h4-13,15H,2-3H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149407
PNG
(CHEMBL3769928)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccncc2)cc1=O)C1CC1
Show InChI InChI=1S/C22H20N4O2/c1-15-22(17-2-3-17)24-20-5-4-18(13-26(15)20)25-11-8-19(12-21(25)27)28-14-16-6-9-23-10-7-16/h4-13,17H,2-3,14H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149434
PNG
(CHEMBL3770539)
Show SMILES Cc1c(CO)nc2ccc(cn12)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C21H18FN3O3/c1-14-19(12-26)23-20-7-6-17(11-25(14)20)24-9-8-18(10-21(24)27)28-13-15-2-4-16(22)5-3-15/h2-11,26H,12-13H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149407
PNG
(CHEMBL3769928)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccncc2)cc1=O)C1CC1
Show InChI InChI=1S/C22H20N4O2/c1-15-22(17-2-3-17)24-20-5-4-18(13-26(15)20)25-11-8-19(12-21(25)27)28-14-16-6-9-23-10-7-16/h4-13,17H,2-3,14H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149436
PNG
(CHEMBL3770750)
Show SMILES CC(=O)c1nc2ccc(cn2c1C)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C22H18FN3O3/c1-14-22(15(2)27)24-20-8-7-18(12-26(14)20)25-10-9-19(11-21(25)28)29-13-16-3-5-17(23)6-4-16/h3-12H,13H2,1-2H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149405
PNG
(CHEMBL3770454)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2cccnc2)cc1=O)C1CC1
Show InChI InChI=1S/C22H20N4O2/c1-15-22(17-4-5-17)24-20-7-6-18(13-26(15)20)25-10-8-19(11-21(25)27)28-14-16-3-2-9-23-12-16/h2-3,6-13,17H,4-5,14H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149438
PNG
(CHEMBL3769670)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C#N
Show InChI InChI=1S/C21H15FN4O2/c1-14-19(11-23)24-20-7-6-17(12-26(14)20)25-9-8-18(10-21(25)27)28-13-15-2-4-16(22)5-3-15/h2-10,12H,13H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149438
PNG
(CHEMBL3769670)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C#N
Show InChI InChI=1S/C21H15FN4O2/c1-14-19(11-23)24-20-7-6-17(12-26(14)20)25-9-8-18(10-21(25)27)28-13-15-2-4-16(22)5-3-15/h2-10,12H,13H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149437
PNG
(CHEMBL3770850)
Show SMILES CN(C)C(=O)c1nc2ccc(cn2c1C)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C23H21FN4O3/c1-15-22(23(30)26(2)3)25-20-9-8-18(13-28(15)20)27-11-10-19(12-21(27)29)31-14-16-4-6-17(24)7-5-16/h4-13H,14H2,1-3H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149435
PNG
(CHEMBL3769816)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C(=O)C1CC1
Show InChI InChI=1S/C24H20FN3O3/c1-15-23(24(30)17-4-5-17)26-21-9-8-19(13-28(15)21)27-11-10-20(12-22(27)29)31-14-16-2-6-18(25)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149454
PNG
(CHEMBL3769548)
Show SMILES Cc1oc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc2c1C
Show InChI InChI=1S/C19H16F3NO4/c1-11-12(2)26-17-8-3-13(9-16(11)17)23-18(24)10-25-14-4-6-15(7-5-14)27-19(20,21)22/h3-9H,10H2,1-2H3,(H,23,24)
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149455
PNG
(CHEMBL3769838)
Show SMILES Cc1c(cc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cn12)C1CC1
Show InChI InChI=1S/C21H19F3N2O3/c1-13-19(14-2-3-14)10-16-5-4-15(11-26(13)16)25-20(27)12-28-17-6-8-18(9-7-17)29-21(22,23)24/h4-11,14H,2-3,12H2,1H3,(H,25,27)
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149409
PNG
(CHEMBL3770348)
Show SMILES COCc1nc2ccc(cn2c1C)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C22H20FN3O3/c1-15-20(14-28-2)24-21-8-7-18(12-26(15)21)25-10-9-19(11-22(25)27)29-13-16-3-5-17(23)6-4-16/h3-12H,13-14H2,1-2H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149405
PNG
(CHEMBL3770454)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2cccnc2)cc1=O)C1CC1
Show InChI InChI=1S/C22H20N4O2/c1-15-22(17-4-5-17)24-20-7-6-18(13-26(15)20)25-10-8-19(11-21(25)27)28-14-16-3-2-9-23-12-16/h2-3,6-13,17H,4-5,14H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149406
PNG
(CHEMBL3770975)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2cncnc2)cc1=O)C1CC1
Show InChI InChI=1S/C21H19N5O2/c1-14-21(16-2-3-16)24-19-5-4-17(11-26(14)19)25-7-6-18(8-20(25)27)28-12-15-9-22-13-23-10-15/h4-11,13,16H,2-3,12H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149437
PNG
(CHEMBL3770850)
Show SMILES CN(C)C(=O)c1nc2ccc(cn2c1C)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C23H21FN4O3/c1-15-22(23(30)26(2)3)25-20-9-8-18(13-28(15)20)27-11-10-19(12-21(27)29)31-14-16-4-6-17(24)7-5-16/h4-13H,14H2,1-3H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50149406
PNG
(CHEMBL3770975)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2cncnc2)cc1=O)C1CC1
Show InChI InChI=1S/C21H19N5O2/c1-14-21(16-2-3-16)24-19-5-4-17(11-26(14)19)25-7-6-18(8-20(25)27)28-12-15-9-22-13-23-10-15/h4-11,13,16H,2-3,12H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
1,3-beta-glucan synthase component GLS2


(Saccharomyces cerevisiae)
BDBM50149453
PNG
(CHEMBL3770359)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp test


J Med Chem 59: 1116-39 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%