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PubMed code 26890116

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 6


(Homo sapiens (human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 29n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate ...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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Article
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n/an/a 34n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal GST-tagged HDAC7 (518 to 991 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate incubate...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase 2


(Homo sapiens (human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 100n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC2 using Fluor de Lys Green as substrate incubated for 30 mins by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase 8


(Homo sapiens (human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 240n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate incubated ...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase 1


(Homo sapiens (human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 260n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as subst...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase


(Homo sapiens (human)-Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 280n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of HDAC in human HeLa nuclear extract using BOC-Ac-Lys-AMC as substrate incubated for 90 mins by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase 9


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 320n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9 using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 3/Nuclear receptor corepressor 2


(Homo sapiens (human)-Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 350n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/human recombinant N-terminal GST-tagged NCOR2 (395 to 489...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 11


(Homo sapiens (human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 360n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged HDAC11 (1 to 347 residues) using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescen...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 380n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant C-terminal His-tagged HDAC5 (657 to 1123 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate incubat...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 460n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human HDAC10 using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 490n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant C-terminal His-tagged, N-terminal GST-tagged HDAC4 (627 to 1084 residues) expressed in insect cells using RHK-K(Ac)-A...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 580n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate incubated ...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate ...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of HDAC in human HeLa nuclear extract using BOC-Ac-Lys-AMC as substrate incubated for 90 mins by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50161468
PNG
(CHEMBL3794127)
Show SMILES CC(C)=C(c1ccccc1)c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C19H19NO2/c1-14(2)19(16-6-4-3-5-7-16)17-11-8-15(9-12-17)10-13-18(21)20-22/h3-13,22H,1-2H3,(H,20,21)/b13-10+
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n/an/a 2.50E+3n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of HDAC in human HeLa cells using BOC-Ac-Lys-AMC as substrate incubated for 4 hrs by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50161468
PNG
(CHEMBL3794127)
Show SMILES CC(C)=C(c1ccccc1)c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C19H19NO2/c1-14(2)19(16-6-4-3-5-7-16)17-11-8-15(9-12-17)10-13-18(21)20-22/h3-13,22H,1-2H3,(H,20,21)/b13-10+
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of HDAC in human HeLa nuclear extract using BOC-Ac-Lys-AMC as substrate incubated for 90 mins by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 3/Nuclear receptor corepressor 2


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 3.90E+3n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/human recombinant N-terminal GST-tagged NCOR2 (395 to 489...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 5.20E+3n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC2 using Fluor de Lys Green as substrate incubated for 30 mins by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 5.40E+3n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as subst...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 6.40E+3n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of HDAC in human HeLa cells using BOC-Ac-Lys-AMC as substrate incubated for 4 hrs by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 8.00E+3n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant C-terminal His-tagged HDAC5 (657 to 1123 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate incubat...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50293361
PNG
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)
Show SMILES COc1ccc(cc1)-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+
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n/an/a 8.70E+3n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of HDAC in human HeLa cells using BOC-Ac-Lys-AMC as substrate incubated for 4 hrs by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 8.90E+3n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9 using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone Deacetylase 10 (HDAC10)


(Homo sapiens (human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 1.02E+4n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human HDAC10 using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 1.09E+4n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal GST-tagged HDAC7 (518 to 991 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate incubate...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (human))
BDBM50161468
PNG
(CHEMBL3794127)
Show SMILES CC(C)=C(c1ccccc1)c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C19H19NO2/c1-14(2)19(16-6-4-3-5-7-16)17-11-8-15(9-12-17)10-13-18(21)20-22/h3-13,22H,1-2H3,(H,20,21)/b13-10+
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n/an/a 1.18E+4n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC2 using Fluor de Lys Green as substrate incubated for 30 mins by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 11


(Homo sapiens (human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 1.62E+4n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal His-tagged HDAC11 (1 to 347 residues) using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescen...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50161828
PNG
(CHEMBL3793310)
Show SMILES Cc1[nH]c2ccccc2c1\C=C\c1ccccc1-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C26H22N2O2/c1-18-22(24-8-4-5-9-25(24)27-18)16-15-20-6-2-3-7-23(20)21-13-10-19(11-14-21)12-17-26(29)28-30/h2-17,27,30H,1H3,(H,28,29)/b16-15+,17-12+
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n/an/a 1.71E+4n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant C-terminal His-tagged, N-terminal GST-tagged HDAC4 (627 to 1084 residues) expressed in insect cells using RHK-K(Ac)-A...


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50293361
PNG
(CHEMBL561209 | N-Hydroxy-E-3-(4'-methoxybiphenyl-4...)
Show SMILES COc1ccc(cc1)-c1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C16H15NO3/c1-20-15-9-7-14(8-10-15)13-5-2-12(3-6-13)4-11-16(18)17-19/h2-11,19H,1H3,(H,17,18)/b11-4+
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n/an/a 3.26E+4n/an/an/an/an/an/a



University of Milan

Curated by ChEMBL


Assay Description
Inhibition of HDAC in human HeLa nuclear extract using BOC-Ac-Lys-AMC as substrate incubated for 90 mins by fluorescence assay


Eur J Med Chem 112: 99-105 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.001
BindingDB Entry DOI: 10.7270/Q2HM5BB0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%