BindingDB logo
myBDB logout

PubMed code 26906474

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosyl-DNA phosphodiesterase 1 (TDP1)


(Homo sapiens (Human))
BDBM50148027
PNG
(CHEMBL3765705)
Show SMILES OCCNCCCn1c2-c3cc4OCOc4cc3C(=O)c2c2ccc(F)cc2c1=O
Show InChI InChI=1S/C22H19FN2O5/c23-12-2-3-13-16(8-12)22(28)25(6-1-4-24-5-7-26)20-14-9-17-18(30-11-29-17)10-15(14)21(27)19(13)20/h2-3,8-10,24,26H,1,4-7,11H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.20E+3n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single-stranded DNA oligonucleotide containing 3'-phosphotyrosine (N14Y) as su...


Bioorg Med Chem 24: 1469-79 (2016)


Article DOI: 10.1016/j.bmc.2016.02.015
BindingDB Entry DOI: 10.7270/Q2G162PC
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (TDP1)


(Homo sapiens (Human))
BDBM50148028
PNG
(CHEMBL3763597)
Show SMILES OCCNCCCn1c2-c3cc4OCOc4cc3C(=O)c2c2ccc(Cl)cc2c1=O
Show InChI InChI=1S/C22H19ClN2O5/c23-12-2-3-13-16(8-12)22(28)25(6-1-4-24-5-7-26)20-14-9-17-18(30-11-29-17)10-15(14)21(27)19(13)20/h2-3,8-10,24,26H,1,4-7,11H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.30E+3n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single-stranded DNA oligonucleotide containing 3'-phosphotyrosine (N14Y) as su...


Bioorg Med Chem 24: 1469-79 (2016)


Article DOI: 10.1016/j.bmc.2016.02.015
BindingDB Entry DOI: 10.7270/Q2G162PC
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50148027
PNG
(CHEMBL3765705)
Show SMILES OCCNCCCn1c2-c3cc4OCOc4cc3C(=O)c2c2ccc(F)cc2c1=O
Show InChI InChI=1S/C22H19FN2O5/c23-12-2-3-13-16(8-12)22(28)25(6-1-4-24-5-7-26)20-14-9-17-18(30-11-29-17)10-15(14)21(27)19(13)20/h2-3,8-10,24,26H,1,4-7,11H2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.30E+3n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using alpha32P-cordycepin-30-labeled 19-mer single-stranded oligonucleotide DNA containing 5'-phosphotyrosine (Y...


Bioorg Med Chem 24: 1469-79 (2016)


Article DOI: 10.1016/j.bmc.2016.02.015
BindingDB Entry DOI: 10.7270/Q2G162PC
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50148028
PNG
(CHEMBL3763597)
Show SMILES OCCNCCCn1c2-c3cc4OCOc4cc3C(=O)c2c2ccc(Cl)cc2c1=O
Show InChI InChI=1S/C22H19ClN2O5/c23-12-2-3-13-16(8-12)22(28)25(6-1-4-24-5-7-26)20-14-9-17-18(30-11-29-17)10-15(14)21(27)19(13)20/h2-3,8-10,24,26H,1,4-7,11H2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.90E+3n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using alpha32P-cordycepin-30-labeled 19-mer single-stranded oligonucleotide DNA containing 5'-phosphotyrosine (Y...


Bioorg Med Chem 24: 1469-79 (2016)


Article DOI: 10.1016/j.bmc.2016.02.015
BindingDB Entry DOI: 10.7270/Q2G162PC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%