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PubMed code 26910725

Compile data set for download or QSAR
Found 93 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161982
PNG
(CHEMBL3792690)
Show SMILES Clc1cccc(c1)-c1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C15H10ClNO2/c16-12-3-1-2-9(6-12)10-4-5-11-8-14(18)17-15(19)13(11)7-10/h1-7H,8H2,(H,17,18,19)
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n/an/a 1.70E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162054
PNG
(CHEMBL3792834)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H14N2O4S/c1-23(21,22)18-13-5-2-10(3-6-13)11-4-7-14-12(8-11)9-15(19)17-16(14)20/h2-8,18H,9H2,1H3,(H,17,19,20)
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n/an/a 1.90E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162054
PNG
(CHEMBL3792834)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H14N2O4S/c1-23(21,22)18-13-5-2-10(3-6-13)11-4-7-14-12(8-11)9-15(19)17-16(14)20/h2-8,18H,9H2,1H3,(H,17,19,20)
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161997
PNG
(CHEMBL3792519)
Show SMILES Ic1cccc2CC(=O)NC(=O)c12
Show InChI InChI=1S/C9H6INO2/c10-6-3-1-2-5-4-7(12)11-9(13)8(5)6/h1-3H,4H2,(H,11,12,13)
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161973
PNG
(CHEMBL3792448)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H10F3NO2/c17-16(18,19)12-4-1-9(2-5-12)10-3-6-13-11(7-10)8-14(21)20-15(13)22/h1-7H,8H2,(H,20,21,22)
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161976
PNG
(CHEMBL3792608)
Show SMILES COc1ccc(cc1F)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H12FNO3/c1-21-14-5-3-10(7-13(14)17)9-2-4-12-11(6-9)8-15(19)18-16(12)20/h2-7H,8H2,1H3,(H,18,19,20)
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161993
PNG
(CHEMBL3792475)
Show SMILES OC(=O)c1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C10H7NO4/c12-8-4-5-1-2-6(10(14)15)3-7(5)9(13)11-8/h1-3H,4H2,(H,14,15)(H,11,12,13)
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161982
PNG
(CHEMBL3792690)
Show SMILES Clc1cccc(c1)-c1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C15H10ClNO2/c16-12-3-1-2-9(6-12)10-4-5-11-8-14(18)17-15(19)13(11)7-10/h1-7H,8H2,(H,17,18,19)
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161973
PNG
(CHEMBL3792448)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H10F3NO2/c17-16(18,19)12-4-1-9(2-5-12)10-3-6-13-11(7-10)8-14(21)20-15(13)22/h1-7H,8H2,(H,20,21,22)
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161983
PNG
(CHEMBL3793043)
Show SMILES Clc1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H10ClNO2/c16-12-3-1-2-9(7-12)10-4-5-13-11(6-10)8-14(18)17-15(13)19/h1-7H,8H2,(H,17,18,19)
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161994
PNG
(CHEMBL3793011)
Show SMILES FC(F)(F)c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C10H6F3NO2/c11-10(12,13)6-1-2-7-5(3-6)4-8(15)14-9(7)16/h1-3H,4H2,(H,14,15,16)
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n/an/a 3.50E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161975
PNG
(CHEMBL3793616)
Show SMILES Fc1ccc(cc1Cl)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H9ClFNO2/c16-12-6-9(2-4-13(12)17)8-1-3-11-10(5-8)7-14(19)18-15(11)20/h1-6H,7H2,(H,18,19,20)
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n/an/a 4.10E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161976
PNG
(CHEMBL3792608)
Show SMILES COc1ccc(cc1F)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H12FNO3/c1-21-14-5-3-10(7-13(14)17)9-2-4-12-11(6-9)8-15(19)18-16(12)20/h2-7H,8H2,1H3,(H,18,19,20)
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n/an/a 4.30E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162055
PNG
(CHEMBL3793925)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C16H14N2O4S/c1-23(21,22)18-13-4-2-3-10(7-13)11-5-6-12-9-15(19)17-16(20)14(12)8-11/h2-8,18H,9H2,1H3,(H,17,19,20)
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n/an/a 4.50E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161981
PNG
(CHEMBL3793872)
Show SMILES Clc1ccc(cc1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H10ClNO2/c16-12-4-1-9(2-5-12)10-3-6-13-11(7-10)8-14(18)17-15(13)19/h1-7H,8H2,(H,17,18,19)
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n/an/a 4.50E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161974
PNG
(CHEMBL3792897)
Show SMILES Fc1ccc(c(F)c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H9F2NO2/c16-10-2-4-11(13(17)7-10)8-1-3-12-9(5-8)6-14(19)18-15(12)20/h1-5,7H,6H2,(H,18,19,20)
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n/an/a 4.50E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161971
PNG
(CHEMBL3793413)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1nc2ccccc2s1
Show InChI InChI=1S/C16H10N2O2S/c19-14-8-10-7-9(5-6-11(10)15(20)18-14)16-17-12-3-1-2-4-13(12)21-16/h1-7H,8H2,(H,18,19,20)
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n/an/a 5.10E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161993
PNG
(CHEMBL3792475)
Show SMILES OC(=O)c1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C10H7NO4/c12-8-4-5-1-2-6(10(14)15)3-7(5)9(13)11-8/h1-3H,4H2,(H,14,15)(H,11,12,13)
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n/an/a 5.20E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161975
PNG
(CHEMBL3793616)
Show SMILES Fc1ccc(cc1Cl)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H9ClFNO2/c16-12-6-9(2-4-13(12)17)8-1-3-11-10(5-8)7-14(19)18-15(11)20/h1-6H,7H2,(H,18,19,20)
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n/an/a 5.30E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161967
PNG
(CHEMBL3794248)
Show SMILES [O-][N+](=O)c1cccc(c1)C(=O)c1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C16H10N2O5/c19-14-8-9-4-5-11(7-13(9)16(21)17-14)15(20)10-2-1-3-12(6-10)18(22)23/h1-7H,8H2,(H,17,19,21)
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n/an/a 5.40E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161974
PNG
(CHEMBL3792897)
Show SMILES Fc1ccc(c(F)c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H9F2NO2/c16-10-2-4-11(13(17)7-10)8-1-3-12-9(5-8)6-14(19)18-15(12)20/h1-5,7H,6H2,(H,18,19,20)
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n/an/a 5.50E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161984
PNG
(CHEMBL3792520)
Show SMILES CC(=O)c1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C17H13NO3/c1-10(19)11-3-2-4-12(7-11)13-5-6-15-14(8-13)9-16(20)18-17(15)21/h2-8H,9H2,1H3,(H,18,20,21)
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n/an/a 5.50E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161983
PNG
(CHEMBL3793043)
Show SMILES Clc1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H10ClNO2/c16-12-3-1-2-9(7-12)10-4-5-13-11(6-10)8-14(18)17-15(13)19/h1-7H,8H2,(H,17,18,19)
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n/an/a 5.60E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161981
PNG
(CHEMBL3793872)
Show SMILES Clc1ccc(cc1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H10ClNO2/c16-12-4-1-9(2-5-12)10-3-6-13-11(7-10)8-14(18)17-15(13)19/h1-7H,8H2,(H,17,18,19)
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n/an/a 6.40E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161980
PNG
(CHEMBL3794044)
Show SMILES Brc1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H10BrNO2/c16-12-3-1-2-9(7-12)10-4-5-13-11(6-10)8-14(18)17-15(13)19/h1-7H,8H2,(H,17,18,19)
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161994
PNG
(CHEMBL3793011)
Show SMILES FC(F)(F)c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C10H6F3NO2/c11-10(12,13)6-1-2-7-5(3-6)4-8(15)14-9(7)16/h1-3H,4H2,(H,14,15,16)
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n/an/a 7.00E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161979
PNG
(CHEMBL3792592)
Show SMILES Brc1ccc(cc1)-c1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C15H10BrNO2/c16-12-5-3-9(4-6-12)10-1-2-11-8-14(18)17-15(19)13(11)7-10/h1-7H,8H2,(H,17,18,19)
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n/an/a 7.10E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161997
PNG
(CHEMBL3792519)
Show SMILES Ic1cccc2CC(=O)NC(=O)c12
Show InChI InChI=1S/C9H6INO2/c10-6-3-1-2-5-4-7(12)11-9(13)8(5)6/h1-3H,4H2,(H,11,12,13)
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n/an/a 7.50E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161987
PNG
(CHEMBL3793467)
Show SMILES Ic1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C9H6INO2/c10-6-1-2-7-5(3-6)4-8(12)11-9(7)13/h1-3H,4H2,(H,11,12,13)
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n/an/a 7.60E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161980
PNG
(CHEMBL3794044)
Show SMILES Brc1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H10BrNO2/c16-12-3-1-2-9(7-12)10-4-5-13-11(6-10)8-14(18)17-15(13)19/h1-7H,8H2,(H,17,18,19)
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n/an/a 8.00E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161987
PNG
(CHEMBL3793467)
Show SMILES Ic1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C9H6INO2/c10-6-1-2-7-5(3-6)4-8(12)11-9(7)13/h1-3H,4H2,(H,11,12,13)
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n/an/a 9.30E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161970
PNG
(CHEMBL3793669)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1cnc2ccccc2c1
Show InChI InChI=1S/C18H12N2O2/c21-17-9-13-7-11(5-6-15(13)18(22)20-17)14-8-12-3-1-2-4-16(12)19-10-14/h1-8,10H,9H2,(H,20,21,22)
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n/an/a 9.30E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161998
PNG
(CHEMBL3794340)
Show SMILES Ic1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C9H6INO2/c10-6-2-1-5-3-8(12)11-9(13)7(5)4-6/h1-2,4H,3H2,(H,11,12,13)
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n/an/a 9.80E+3n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161991
PNG
(CHEMBL3792752)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1ccco1
Show InChI InChI=1S/C13H9NO3/c15-12-7-9-6-8(11-2-1-5-17-11)3-4-10(9)13(16)14-12/h1-6H,7H2,(H,14,15,16)
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162053
PNG
(CHEMBL3792917)
Show SMILES C=CC(=O)Nc1ccc(cc1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C18H14N2O3/c1-2-16(21)19-14-6-3-11(4-7-14)12-5-8-15-13(9-12)10-17(22)20-18(15)23/h2-9H,1,10H2,(H,19,21)(H,20,22,23)
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162050
PNG
(CHEMBL3793839)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H10N2O4/c18-14-8-11-6-10(4-5-13(11)15(19)16-14)9-2-1-3-12(7-9)17(20)21/h1-7H,8H2,(H,16,18,19)
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161988
PNG
(CHEMBL3793210)
Show SMILES Brc1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C9H6BrNO2/c10-6-1-2-7-5(3-6)4-8(12)11-9(7)13/h1-3H,4H2,(H,11,12,13)
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162052
PNG
(CHEMBL3794550)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C18H14N2O3/c1-2-16(21)19-14-5-3-4-11(8-14)12-6-7-13-10-17(22)20-18(23)15(13)9-12/h2-9H,1,10H2,(H,19,21)(H,20,22,23)
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161971
PNG
(CHEMBL3793413)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1nc2ccccc2s1
Show InChI InChI=1S/C16H10N2O2S/c19-14-8-10-7-9(5-6-11(10)15(20)18-14)16-17-12-3-1-2-4-13(12)21-16/h1-7H,8H2,(H,18,19,20)
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161968
PNG
(CHEMBL3794036)
Show SMILES [O-][N+](=O)c1cccc(c1)C(=O)c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H10N2O5/c19-14-8-11-6-10(4-5-13(11)16(21)17-14)15(20)9-2-1-3-12(7-9)18(22)23/h1-7H,8H2,(H,17,19,21)
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162051
PNG
(CHEMBL3792890)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C15H10N2O4/c18-14-8-11-5-4-10(7-13(11)15(19)16-14)9-2-1-3-12(6-9)17(20)21/h1-7H,8H2,(H,16,18,19)
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162046
PNG
(CHEMBL3793509)
Show SMILES Oc1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H11NO3/c17-12-3-1-2-9(7-12)10-4-5-13-11(6-10)8-14(18)16-15(13)19/h1-7,17H,8H2,(H,16,18,19)
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161992
PNG
(CHEMBL3794329)
Show SMILES O=C1Cc2ccc(cc2C(=O)N1)-c1ccco1
Show InChI InChI=1S/C13H9NO3/c15-12-7-8-3-4-9(11-2-1-5-17-11)6-10(8)13(16)14-12/h1-6H,7H2,(H,14,15,16)
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162049
PNG
(CHEMBL3793974)
Show SMILES Oc1ccc(cc1)-c1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C15H11NO3/c17-12-5-3-9(4-6-12)10-1-2-11-8-14(18)16-15(19)13(11)7-10/h1-7,17H,8H2,(H,16,18,19)
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161966
PNG
(CHEMBL3792741)
Show SMILES CCOC(=O)C1C(=O)NC(=O)c2ccc(Br)cc12
Show InChI InChI=1S/C12H10BrNO4/c1-2-18-12(17)9-8-5-6(13)3-4-7(8)10(15)14-11(9)16/h3-5,9H,2H2,1H3,(H,14,15,16)
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161984
PNG
(CHEMBL3792520)
Show SMILES CC(=O)c1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C17H13NO3/c1-10(19)11-3-2-4-12(7-11)13-5-6-15-14(8-13)9-16(20)18-17(15)21/h2-8H,9H2,1H3,(H,18,20,21)
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n/an/a 1.50E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162047
PNG
(CHEMBL3794188)
Show SMILES Oc1cccc(c1)-c1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C15H11NO3/c17-12-3-1-2-9(6-12)10-4-5-11-8-14(18)16-15(19)13(11)7-10/h1-7,17H,8H2,(H,16,18,19)
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n/an/a 1.50E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161985
PNG
(CHEMBL3792845)
Show SMILES NC(=O)c1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H12N2O3/c17-15(20)11-3-1-2-9(6-11)10-4-5-13-12(7-10)8-14(19)18-16(13)21/h1-7H,8H2,(H2,17,20)(H,18,19,21)
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161977
PNG
(CHEMBL3794489)
Show SMILES COc1ccc(OC)c(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C17H15NO4/c1-21-12-4-6-15(22-2)14(9-12)10-3-5-13-11(7-10)8-16(19)18-17(13)20/h3-7,9H,8H2,1-2H3,(H,18,19,20)
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162044
PNG
(CHEMBL3793459)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1cccnc1
Show InChI InChI=1S/C14H10N2O2/c17-13-7-11-6-9(10-2-1-5-15-8-10)3-4-12(11)14(18)16-13/h1-6,8H,7H2,(H,16,17,18)
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162066
PNG
(CHEMBL3793606)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H14N2O4S/c1-23(21,22)18-13-4-2-3-10(8-13)11-5-6-14-12(7-11)9-15(19)17-16(14)20/h2-8,18H,9H2,1H3,(H,17,19,20)
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n/an/a 1.80E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161995
PNG
(CHEMBL3793979)
Show SMILES [O-][N+](=O)c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C9H6N2O4/c12-8-4-5-3-6(11(14)15)1-2-7(5)9(13)10-8/h1-3H,4H2,(H,10,12,13)
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n/an/a 1.90E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162065
PNG
(CHEMBL3793030)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1cccc2CC(=O)NC(=O)c12
Show InChI InChI=1S/C15H10N2O4/c18-13-8-10-4-2-6-12(14(10)15(19)16-13)9-3-1-5-11(7-9)17(20)21/h1-7H,8H2,(H,16,18,19)
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n/an/a 1.90E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162045
PNG
(CHEMBL3794268)
Show SMILES O=C1Cc2ccc(cc2C(=O)N1)-c1cccnc1
Show InChI InChI=1S/C14H10N2O2/c17-13-7-10-4-3-9(6-12(10)14(18)16-13)11-2-1-5-15-8-11/h1-6,8H,7H2,(H,16,17,18)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161986
PNG
(CHEMBL3793425)
Show SMILES OC(=O)c1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H11NO4/c18-14-8-12-7-10(4-5-13(12)15(19)17-14)9-2-1-3-11(6-9)16(20)21/h1-7H,8H2,(H,20,21)(H,17,18,19)
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162044
PNG
(CHEMBL3793459)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1cccnc1
Show InChI InChI=1S/C14H10N2O2/c17-13-7-11-6-9(10-2-1-5-15-8-10)3-4-12(11)14(18)16-13/h1-6,8H,7H2,(H,16,17,18)
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162043
PNG
(CHEMBL3793861)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1ccccc1
Show InChI InChI=1S/C15H11NO2/c17-14-9-12-8-11(10-4-2-1-3-5-10)6-7-13(12)15(18)16-14/h1-8H,9H2,(H,16,17,18)
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50322995
PNG
(CHEMBL1210769 | cid_349435 | isoquinoline-1,3(2H,4...)
Show SMILES O=C1Cc2ccccc2C(=O)N1
Show InChI InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)9(12)10-8/h1-4H,5H2,(H,10,11,12)
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162050
PNG
(CHEMBL3793839)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H10N2O4/c18-14-8-11-6-10(4-5-13(11)15(19)16-14)9-2-1-3-12(7-9)17(20)21/h1-7H,8H2,(H,16,18,19)
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161991
PNG
(CHEMBL3792752)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1ccco1
Show InChI InChI=1S/C13H9NO3/c15-12-7-9-6-8(11-2-1-5-17-11)3-4-10(9)13(16)14-12/h1-6H,7H2,(H,14,15,16)
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162066
PNG
(CHEMBL3793606)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H14N2O4S/c1-23(21,22)18-13-4-2-3-10(8-13)11-5-6-14-12(7-11)9-15(19)17-16(14)20/h2-8,18H,9H2,1H3,(H,17,19,20)
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162048
PNG
(CHEMBL3793108)
Show SMILES Oc1cccc(c1)-c1cccc2CC(=O)NC(=O)c12
Show InChI InChI=1S/C15H11NO3/c17-11-5-1-3-9(7-11)12-6-2-4-10-8-13(18)16-15(19)14(10)12/h1-7,17H,8H2,(H,16,18,19)
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n/an/a 2.60E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162070
PNG
(CHEMBL3793154)
Show SMILES OC(=O)c1ccc(cc1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H11NO4/c18-14-8-12-7-11(5-6-13(12)15(19)17-14)9-1-3-10(4-2-9)16(20)21/h1-7H,8H2,(H,20,21)(H,17,18,19)
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162046
PNG
(CHEMBL3793509)
Show SMILES Oc1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H11NO3/c17-12-3-1-2-9(7-12)10-4-5-13-11(6-10)8-14(18)16-15(13)19/h1-7,17H,8H2,(H,16,18,19)
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n/an/a 3.50E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162067
PNG
(CHEMBL3794008)
Show SMILES Nc1ccc(cc1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H12N2O2/c16-12-4-1-9(2-5-12)10-3-6-13-11(7-10)8-14(18)17-15(13)19/h1-7H,8,16H2,(H,17,18,19)
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n/an/a 3.60E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161978
PNG
(CHEMBL3794517)
Show SMILES COc1cccc(OC)c1-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C17H15NO4/c1-21-13-4-3-5-14(22-2)16(13)10-6-7-12-11(8-10)9-15(19)18-17(12)20/h3-8H,9H2,1-2H3,(H,18,19,20)
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n/an/a>3.70E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161989
PNG
(CHEMBL3793399)
Show SMILES Brc1cccc2C(=O)NC(=O)Cc12
Show InChI InChI=1S/C9H6BrNO2/c10-7-3-1-2-5-6(7)4-8(12)11-9(5)13/h1-3H,4H2,(H,11,12,13)
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n/an/a>3.70E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162058
PNG
(CHEMBL3794519)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1cccc2C(=O)NC(=O)Cc12
Show InChI InChI=1S/C15H10N2O4/c18-14-8-13-11(5-2-6-12(13)15(19)16-14)9-3-1-4-10(7-9)17(20)21/h1-7H,8H2,(H,16,18,19)
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n/an/a>3.70E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162067
PNG
(CHEMBL3794008)
Show SMILES Nc1ccc(cc1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H12N2O2/c16-12-4-1-9(2-5-12)10-3-6-13-11(7-10)8-14(18)17-15(13)19/h1-7H,8,16H2,(H,17,18,19)
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n/an/a 4.00E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162069
PNG
(CHEMBL3792554)
Show SMILES Nc1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H12N2O2/c16-12-3-1-2-9(7-12)10-4-5-13-11(6-10)8-14(18)17-15(13)19/h1-7H,8,16H2,(H,17,18,19)
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n/an/a 4.20E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161986
PNG
(CHEMBL3793425)
Show SMILES OC(=O)c1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H11NO4/c18-14-8-12-7-10(4-5-13(12)15(19)17-14)9-2-1-3-11(6-9)16(20)21/h1-7H,8H2,(H,20,21)(H,17,18,19)
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n/an/a 4.20E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161992
PNG
(CHEMBL3794329)
Show SMILES O=C1Cc2ccc(cc2C(=O)N1)-c1ccco1
Show InChI InChI=1S/C13H9NO3/c15-12-7-8-3-4-9(11-2-1-5-17-11)6-10(8)13(16)14-12/h1-6H,7H2,(H,14,15,16)
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162069
PNG
(CHEMBL3792554)
Show SMILES Nc1cccc(c1)-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C15H12N2O2/c16-12-3-1-2-9(7-12)10-4-5-13-11(6-10)8-14(18)17-15(13)19/h1-7H,8,16H2,(H,17,18,19)
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n/an/a 5.50E+4n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162042
PNG
(CHEMBL1928097)
Show SMILES ON1C(=O)Cc2ccc(cc2C1=O)-c1ccco1
Show InChI InChI=1S/C13H9NO4/c15-12-7-8-3-4-9(11-2-1-5-18-11)6-10(8)13(16)14(12)17/h1-6,17H,7H2
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162068
PNG
(CHEMBL3793891)
Show SMILES Nc1cccc(c1)-c1ccc2CC(=O)NC(=O)c2c1
Show InChI InChI=1S/C15H12N2O2/c16-12-3-1-2-9(6-12)10-4-5-11-8-14(18)17-15(19)13(11)7-10/h1-7H,8,16H2,(H,17,18,19)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161961
PNG
(CHEMBL3793579)
Show SMILES Nc1c2c(CC(=O)NC2=O)nn1-c1cccnc1
Show InChI InChI=1S/C11H9N5O2/c12-10-9-7(4-8(17)14-11(9)18)15-16(10)6-2-1-3-13-5-6/h1-3,5H,4,12H2,(H,14,17,18)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161996
PNG
(CHEMBL3792469)
Show SMILES OC(=O)c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C10H7NO4/c12-8-4-6-3-5(10(14)15)1-2-7(6)9(13)11-8/h1-3H,4H2,(H,14,15)(H,11,12,13)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (TDP1)


(Homo sapiens (Human))
BDBM50161990
PNG
(CHEMBL1928103)
Show SMILES ON1C(=O)Cc2cc(ccc2C1=O)-c1ccco1
Show InChI InChI=1S/C13H9NO4/c15-12-7-9-6-8(11-2-1-5-18-11)3-4-10(9)13(16)14(12)17/h1-6,17H,7H2
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded oligonucleotide DNA containing 3'-phophotyrosine (N14Y) as sub...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161963
PNG
(CHEMBL3794399)
Show SMILES O=C1NC(=O)c2ccc(-c3ccco3)c3cccc1c23
Show InChI InChI=1S/C16H9NO3/c18-15-11-4-1-3-10-9(13-5-2-8-20-13)6-7-12(14(10)11)16(19)17-15/h1-8H,(H,17,18,19)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162041
PNG
(CHEMBL3793523)
Show SMILES O=C1Cc2c(cccc2C(=O)N1)-c1ccco1
Show InChI InChI=1S/C13H9NO3/c15-12-7-10-8(11-5-2-6-17-11)3-1-4-9(10)13(16)14-12/h1-6H,7H2,(H,14,15,16)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161964
PNG
(CHEMBL3793391)
Show SMILES Brc1ccc2C(=O)NC(=O)c3cccc1c23
Show InChI InChI=1S/C12H6BrNO2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,(H,14,15,16)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161970
PNG
(CHEMBL3793669)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1cnc2ccccc2c1
Show InChI InChI=1S/C18H12N2O2/c21-17-9-13-7-11(5-6-15(13)18(22)20-17)14-8-12-3-1-2-4-16(12)19-10-14/h1-8,10H,9H2,(H,20,21,22)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161972
PNG
(CHEMBL3793886)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H15NO2/c23-20-13-18-12-17(9-10-19(18)21(24)22-20)16-8-4-7-15(11-16)14-5-2-1-3-6-14/h1-12H,13H2,(H,22,23,24)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161962
PNG
(CHEMBL3793241)
Show SMILES Nc1c2c(CC(=O)NC2=O)nn1-c1ccc(F)cc1
Show InChI InChI=1S/C12H9FN4O2/c13-6-1-3-7(4-2-6)17-11(14)10-8(16-17)5-9(18)15-12(10)19/h1-4H,5,14H2,(H,15,18,19)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161960
PNG
(CHEMBL3794195)
Show SMILES Nc1c2c(CC(=O)NC2=O)nn1-c1ccccc1
Show InChI InChI=1S/C12H10N4O2/c13-11-10-8(6-9(17)14-12(10)18)15-16(11)7-4-2-1-3-5-7/h1-5H,6,13H2,(H,14,17,18)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162043
PNG
(CHEMBL3793861)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1ccccc1
Show InChI InChI=1S/C15H11NO2/c17-14-9-12-8-11(10-4-2-1-3-5-10)6-7-13(12)15(18)16-14/h1-8H,9H2,(H,16,17,18)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human TDP2 expressed in DT40 cells (TDP2-knockout) using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins ...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (TDP1)


(Homo sapiens (Human))
BDBM50161991
PNG
(CHEMBL3792752)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1ccco1
Show InChI InChI=1S/C13H9NO3/c15-12-7-9-6-8(11-2-1-5-17-11)3-4-10(9)13(16)14-12/h1-6H,7H2,(H,14,15,16)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded oligonucleotide DNA containing 3'-phophotyrosine (N14Y) as sub...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161969
PNG
(CHEMBL3792579)
Show SMILES O=C1Cc2cc(Cc3ccccc3)ccc2C(=O)N1
Show InChI InChI=1S/C16H13NO2/c18-15-10-13-9-12(6-7-14(13)16(19)17-15)8-11-4-2-1-3-5-11/h1-7,9H,8,10H2,(H,17,18,19)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161965
PNG
(CHEMBL3793103)
Show SMILES O=c1[nH]c2cc(ccc2c(=O)[nH]1)-c1ccccc1
Show InChI InChI=1S/C14H10N2O2/c17-13-11-7-6-10(9-4-2-1-3-5-9)8-12(11)15-14(18)16-13/h1-8H,(H2,15,16,17,18)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1


(Homo sapiens (Human))
BDBM50161991
PNG
(CHEMBL3792752)
Show SMILES O=C1Cc2cc(ccc2C(=O)N1)-c1ccco1
Show InChI InChI=1S/C13H9NO3/c15-12-7-9-6-8(11-2-1-5-17-11)3-4-10(9)13(16)14-12/h1-6H,7H2,(H,14,15,16)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant TDP1 (unknown origin) using 5'-[32P]-labeled single stranded oligonucleotide DNA containing 3'-phophotyrosine (N14Y) as sub...


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161990
PNG
(CHEMBL1928103)
Show SMILES ON1C(=O)Cc2cc(ccc2C1=O)-c1ccco1
Show InChI InChI=1S/C13H9NO4/c15-12-7-9-6-8(11-2-1-5-18-11)3-4-10(9)13(16)14(12)17/h1-6,17H,7H2
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50161959
PNG
(CHEMBL3793472)
Show SMILES CC(=O)Nc1c2c(CC(=O)NC2=O)nn1-c1ccccc1
Show InChI InChI=1S/C14H12N4O3/c1-8(19)15-13-12-10(7-11(20)16-14(12)21)17-18(13)9-5-3-2-4-6-9/h2-6H,7H2,1H3,(H,15,19)(H,16,20,21)
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n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50162071
PNG
(CHEMBL3793508)
Show SMILES OC(=O)c1ccccc1-c1ccc2C(=O)NC(=O)Cc2c1
Show InChI InChI=1S/C16H11NO4/c18-14-8-10-7-9(5-6-12(10)15(19)17-14)11-3-1-2-4-13(11)16(20)21/h1-7H,8H2,(H,20,21)(H,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.11E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of recombinant human TDP2 using 18-mer single stranded oligonucleotide DNA as substrate incubated for 15 mins by PAGE assay


J Med Chem 59: 2734-46 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01973
BindingDB Entry DOI: 10.7270/Q20P11XD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%