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PubMed code 27096038

Compile data set for download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012105
PNG
(CHEMBL3263667)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H38N6O4/c1-22-6-2-3-7-27(22)36-16-18-37(19-17-36)28-12-11-24(30(40)33-13-5-15-38-14-4-8-29(38)39)20-25(28)34-31(41)26-21-42-32(35-26)23-9-10-23/h2-3,6-7,11-12,20-21,23H,4-5,8-10,13-19H2,1H3,(H,33,40)(H,34,41)
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n/an/an/an/a<100n/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF a...


ACS Med Chem Lett 7: 345-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00082
BindingDB Entry DOI: 10.7270/Q2HQ41T6
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50173579
PNG
(CHEMBL3809148)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)cc1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H36FN5O3/c1-23-6-2-3-7-28(23)36-18-20-37(21-19-36)29-14-11-25(31(40)34-15-5-17-38-16-4-8-30(38)39)22-27(29)35-32(41)24-9-12-26(33)13-10-24/h2-3,6-7,9-14,22H,4-5,8,15-21H2,1H3,(H,34,40)(H,35,41)
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n/an/an/an/a 100n/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunoss...


ACS Med Chem Lett 7: 345-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00082
BindingDB Entry DOI: 10.7270/Q2HQ41T6
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50173579
PNG
(CHEMBL3809148)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)cc1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H36FN5O3/c1-23-6-2-3-7-28(23)36-18-20-37(21-19-36)29-14-11-25(31(40)34-15-5-17-38-16-4-8-30(38)39)22-27(29)35-32(41)24-9-12-26(33)13-10-24/h2-3,6-7,9-14,22H,4-5,8,15-21H2,1H3,(H,34,40)(H,35,41)
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n/an/an/an/a 100n/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF a...


ACS Med Chem Lett 7: 345-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00082
BindingDB Entry DOI: 10.7270/Q2HQ41T6
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012120
PNG
(CHEMBL3263691)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCc1nn[nH]n1
Show InChI InChI=1S/C29H33N9O3/c1-19-5-2-3-6-24(19)37-13-15-38(16-14-37)25-11-10-21(27(39)30-12-4-7-26-33-35-36-34-26)17-22(25)31-28(40)23-18-41-29(32-23)20-8-9-20/h2-3,5-6,10-11,17-18,20H,4,7-9,12-16H2,1H3,(H,30,39)(H,31,40)(H,33,34,35,36)
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n/an/an/an/a 100n/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunoss...


ACS Med Chem Lett 7: 345-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00082
BindingDB Entry DOI: 10.7270/Q2HQ41T6
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50173580
PNG
(CHEMBL3808949)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCCNC(=O)NCC=C
Show InChI InChI=1S/C30H36N6O4/c1-3-13-32-30(39)33-15-7-14-31-28(37)23-11-12-26(24(21-23)34-29(38)27-10-6-20-40-27)36-18-16-35(17-19-36)25-9-5-4-8-22(25)2/h3-6,8-12,20-21H,1,7,13-19H2,2H3,(H,31,37)(H,34,38)(H2,32,33,39)
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n/an/an/an/a<100n/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF a...


ACS Med Chem Lett 7: 345-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00082
BindingDB Entry DOI: 10.7270/Q2HQ41T6
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50173581
PNG
(CHEMBL3809644)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)N[C@H]1CCC[C@H](O)C1
Show InChI InChI=1S/C31H37N5O4/c1-20-5-2-3-8-27(20)35-13-15-36(16-14-35)28-12-11-22(29(38)32-23-6-4-7-24(37)18-23)17-25(28)33-30(39)26-19-40-31(34-26)21-9-10-21/h2-3,5,8,11-12,17,19,21,23-24,37H,4,6-7,9-10,13-16,18H2,1H3,(H,32,38)(H,33,39)/t23-,24-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF a...


ACS Med Chem Lett 7: 345-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00082
BindingDB Entry DOI: 10.7270/Q2HQ41T6
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012120
PNG
(CHEMBL3263691)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCc1nn[nH]n1
Show InChI InChI=1S/C29H33N9O3/c1-19-5-2-3-6-24(19)37-13-15-38(16-14-37)25-11-10-21(27(39)30-12-4-7-26-33-35-36-34-26)17-22(25)31-28(40)23-18-41-29(32-23)20-8-9-20/h2-3,5-6,10-11,17-18,20H,4,7-9,12-16H2,1H3,(H,30,39)(H,31,40)(H,33,34,35,36)
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n/an/an/an/a<100n/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF a...


ACS Med Chem Lett 7: 345-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00082
BindingDB Entry DOI: 10.7270/Q2HQ41T6
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50173578
PNG
(CHEMBL3263694)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C30H35N5O4/c1-22-7-2-3-8-25(22)33-16-18-34(19-17-33)26-12-11-23(21-24(26)32-30(38)27-9-5-20-39-27)29(37)31-13-6-15-35-14-4-10-28(35)36/h2-3,5,7-9,11-12,20-21H,4,6,10,13-19H2,1H3,(H,31,37)(H,32,38)
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n/an/an/an/a<100n/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF a...


ACS Med Chem Lett 7: 345-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00082
BindingDB Entry DOI: 10.7270/Q2HQ41T6
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50173578
PNG
(CHEMBL3263694)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C30H35N5O4/c1-22-7-2-3-8-25(22)33-16-18-34(19-17-33)26-12-11-23(21-24(26)32-30(38)27-9-5-20-39-27)29(37)31-13-6-15-35-14-4-10-28(35)36/h2-3,5,7-9,11-12,20-21H,4,6,10,13-19H2,1H3,(H,31,37)(H,32,38)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunoss...


ACS Med Chem Lett 7: 345-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00082
BindingDB Entry DOI: 10.7270/Q2HQ41T6
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Homo sapiens)
BDBM50012105
PNG
(CHEMBL3263667)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H38N6O4/c1-22-6-2-3-7-27(22)36-16-18-37(19-17-36)28-12-11-24(30(40)33-13-5-15-38-14-4-8-29(38)39)20-25(28)34-31(41)26-21-42-32(35-26)23-9-10-23/h2-3,6-7,11-12,20-21,23H,4-5,8-10,13-19H2,1H3,(H,33,40)(H,34,41)
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n/an/an/an/a 100n/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunoss...


ACS Med Chem Lett 7: 345-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00082
BindingDB Entry DOI: 10.7270/Q2HQ41T6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%