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PubMed code 27112449

Compile data set for download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GPR24


(RAT)
BDBM50163480
PNG
(CHEMBL3792707)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2csc(Cl)c2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN3O2S/c1-24-18-9-15(4-5-17(18)23-21(24)14-2-3-14)25-7-6-16(10-20(25)26)27-11-13-8-19(22)28-12-13/h4-10,12,14H,2-3,11H2,1H3
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n/an/a 9.30n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163476
PNG
(CHEMBL3792516)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)s2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN3O2S/c1-24-18-10-14(4-6-17(18)23-21(24)13-2-3-13)25-9-8-15(11-20(25)26)27-12-16-5-7-19(22)28-16/h4-11,13H,2-3,12H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163481
PNG
(CHEMBL3794306)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(s2)C(F)(F)F)cc1=O)C1CC1
Show InChI InChI=1S/C22H18F3N3O2S/c1-27-18-10-14(4-6-17(18)26-21(27)13-2-3-13)28-9-8-15(11-20(28)29)30-12-16-5-7-19(31-16)22(23,24)25/h4-11,13H,2-3,12H2,1H3
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163480
PNG
(CHEMBL3792707)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2csc(Cl)c2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN3O2S/c1-24-18-9-15(4-5-17(18)23-21(24)14-2-3-14)25-7-6-16(10-20(25)26)27-11-13-8-19(22)28-12-13/h4-10,12,14H,2-3,11H2,1H3
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163481
PNG
(CHEMBL3794306)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(s2)C(F)(F)F)cc1=O)C1CC1
Show InChI InChI=1S/C22H18F3N3O2S/c1-27-18-10-14(4-6-17(18)26-21(27)13-2-3-13)28-9-8-15(11-20(28)29)30-12-16-5-7-19(31-16)22(23,24)25/h4-11,13H,2-3,12H2,1H3
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n/an/a 16n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163478
PNG
(CHEMBL3794345)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2cc(Cl)cs2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN3O2S/c1-24-19-9-15(4-5-18(19)23-21(24)13-2-3-13)25-7-6-16(10-20(25)26)27-11-17-8-14(22)12-28-17/h4-10,12-13H,2-3,11H2,1H3
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n/an/a 17n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163467
PNG
(CHEMBL3792697)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2cc(cs2)C(F)(F)F)cc1=O)C1CC1
Show InChI InChI=1S/C22H18F3N3O2S/c1-27-19-9-15(4-5-18(19)26-21(27)13-2-3-13)28-7-6-16(10-20(28)29)30-11-17-8-14(12-31-17)22(23,24)25/h4-10,12-13H,2-3,11H2,1H3
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n/an/a 17n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163478
PNG
(CHEMBL3794345)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2cc(Cl)cs2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN3O2S/c1-24-19-9-15(4-5-18(19)23-21(24)13-2-3-13)25-7-6-16(10-20(25)26)27-11-17-8-14(22)12-28-17/h4-10,12-13H,2-3,11H2,1H3
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n/an/a 18n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163481
PNG
(CHEMBL3794306)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(s2)C(F)(F)F)cc1=O)C1CC1
Show InChI InChI=1S/C22H18F3N3O2S/c1-27-18-10-14(4-6-17(18)26-21(27)13-2-3-13)28-9-8-15(11-20(28)29)30-12-16-5-7-19(31-16)22(23,24)25/h4-11,13H,2-3,12H2,1H3
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n/an/a 18n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as change in MCH(4 to 19)-stimulated Ca2+ concentration by Ca2+ mobilization assay


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163476
PNG
(CHEMBL3792516)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)s2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN3O2S/c1-24-18-10-14(4-6-17(18)23-21(24)13-2-3-13)25-9-8-15(11-20(25)26)27-12-16-5-7-19(22)28-16/h4-11,13H,2-3,12H2,1H3
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n/an/a 19n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163490
PNG
(CHEMBL3793944)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-26-21-12-18(8-9-20(21)25-23(26)16-4-5-16)27-11-10-19(13-22(27)28)29-14-15-2-6-17(24)7-3-15/h2-3,6-13,16H,4-5,14H2,1H3
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n/an/a 21n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163476
PNG
(CHEMBL3792516)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)s2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN3O2S/c1-24-18-10-14(4-6-17(18)23-21(24)13-2-3-13)25-9-8-15(11-20(25)26)27-12-16-5-7-19(22)28-16/h4-11,13H,2-3,12H2,1H3
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n/an/a 24n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as change in MCH(4 to 19)-stimulated Ca2+ concentration by Ca2+ mobilization assay


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50149453
PNG
(CHEMBL3770359)
Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3
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n/an/a 26n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163466
PNG
(CHEMBL3793767)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20FN3O2/c1-26-21-12-18(8-9-20(21)25-23(26)16-4-5-16)27-11-10-19(13-22(27)28)29-14-15-2-6-17(24)7-3-15/h2-3,6-13,16H,4-5,14H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163492
PNG
(CHEMBL3793111)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccsc2)cc1=O)C1CC1
Show InChI InChI=1S/C21H19N3O2S/c1-23-19-10-16(4-5-18(19)22-21(23)15-2-3-15)24-8-6-17(11-20(24)25)26-12-14-7-9-27-13-14/h4-11,13,15H,2-3,12H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163470
PNG
(CHEMBL3794150)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2csc(c2)C(F)(F)F)cc1=O)C1CC1
Show InChI InChI=1S/C22H18F3N3O2S/c1-27-18-9-15(4-5-17(18)26-21(27)14-2-3-14)28-7-6-16(10-20(28)29)30-11-13-8-19(31-12-13)22(23,24)25/h4-10,12,14H,2-3,11H2,1H3
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n/an/a 29n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163492
PNG
(CHEMBL3793111)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccsc2)cc1=O)C1CC1
Show InChI InChI=1S/C21H19N3O2S/c1-23-19-10-16(4-5-18(19)22-21(23)15-2-3-15)24-8-6-17(11-20(24)25)26-12-14-7-9-27-13-14/h4-11,13,15H,2-3,12H2,1H3
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50161850
PNG
(CHEMBL3793625)
Show SMILES CCn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C24H22ClN3O2/c1-2-27-22-13-19(9-10-21(22)26-24(27)17-5-6-17)28-12-11-20(14-23(28)29)30-15-16-3-7-18(25)8-4-16/h3-4,7-14,17H,2,5-6,15H2,1H3
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n/an/a 34n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163465
PNG
(CHEMBL3793182)
Show SMILES CCCc1nc2ccc(cc2n1C)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C23H22FN3O2/c1-3-4-22-25-20-10-9-18(13-21(20)26(22)2)27-12-11-19(14-23(27)28)29-15-16-5-7-17(24)8-6-16/h5-14H,3-4,15H2,1-2H3
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n/an/a 34n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163467
PNG
(CHEMBL3792697)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2cc(cs2)C(F)(F)F)cc1=O)C1CC1
Show InChI InChI=1S/C22H18F3N3O2S/c1-27-19-9-15(4-5-18(19)26-21(27)13-2-3-13)28-7-6-16(10-20(28)29)30-11-17-8-14(12-31-17)22(23,24)25/h4-10,12-13H,2-3,11H2,1H3
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n/an/a 34n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163490
PNG
(CHEMBL3793944)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-26-21-12-18(8-9-20(21)25-23(26)16-4-5-16)27-11-10-19(13-22(27)28)29-14-15-2-6-17(24)7-3-15/h2-3,6-13,16H,4-5,14H2,1H3
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n/an/a 35n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50161850
PNG
(CHEMBL3793625)
Show SMILES CCn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C24H22ClN3O2/c1-2-27-22-13-19(9-10-21(22)26-24(27)17-5-6-17)28-12-11-20(14-23(28)29)30-15-16-3-7-18(25)8-4-16/h3-4,7-14,17H,2,5-6,15H2,1H3
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n/an/a 37n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163471
PNG
(CHEMBL3792485)
Show SMILES CCc1nc2ccc(cc2n1C)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C22H20FN3O2/c1-3-21-24-19-9-8-17(12-20(19)25(21)2)26-11-10-18(13-22(26)27)28-14-15-4-6-16(23)7-5-15/h4-13H,3,14H2,1-2H3
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n/an/a 38n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163465
PNG
(CHEMBL3793182)
Show SMILES CCCc1nc2ccc(cc2n1C)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C23H22FN3O2/c1-3-4-22-25-20-10-9-18(13-21(20)26(22)2)27-12-11-19(14-23(27)28)29-15-16-5-7-17(24)8-6-16/h5-14H,3-4,15H2,1-2H3
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n/an/a 39n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163466
PNG
(CHEMBL3793767)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20FN3O2/c1-26-21-12-18(8-9-20(21)25-23(26)16-4-5-16)27-11-10-19(13-22(27)28)29-14-15-2-6-17(24)7-3-15/h2-3,6-13,16H,4-5,14H2,1H3
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n/an/a 40n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163470
PNG
(CHEMBL3794150)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2csc(c2)C(F)(F)F)cc1=O)C1CC1
Show InChI InChI=1S/C22H18F3N3O2S/c1-27-18-9-15(4-5-17(18)26-21(27)14-2-3-14)28-7-6-16(10-20(28)29)30-11-13-8-19(31-12-13)22(23,24)25/h4-10,12,14H,2-3,11H2,1H3
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n/an/a 41n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163437
PNG
(CHEMBL3793953)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccccc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H21N3O2/c1-25-21-13-18(9-10-20(21)24-23(25)17-7-8-17)26-12-11-19(14-22(26)27)28-15-16-5-3-2-4-6-16/h2-6,9-14,17H,7-8,15H2,1H3
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n/an/a 43n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163472
PNG
(CHEMBL3794147)
Show SMILES Cc1c(nc2cnc(cn12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-22(16-4-5-16)25-19-11-24-20(12-27(14)19)26-9-8-18(10-21(26)28)29-13-15-2-6-17(23)7-3-15/h2-3,6-12,16H,4-5,13H2,1H3
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n/an/a 44n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163437
PNG
(CHEMBL3793953)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccccc2)cc1=O)C1CC1
Show InChI InChI=1S/C23H21N3O2/c1-25-21-13-18(9-10-20(21)24-23(25)17-7-8-17)26-12-11-19(14-22(26)27)28-15-16-5-3-2-4-6-16/h2-6,9-14,17H,7-8,15H2,1H3
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n/an/a 45n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163482
PNG
(CHEMBL3793989)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)cn2)cc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-26-20-10-17(6-7-19(20)25-22(26)14-2-3-14)27-9-8-18(11-21(27)28)29-13-16-5-4-15(23)12-24-16/h4-12,14H,2-3,13H2,1H3
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n/an/a 47n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163471
PNG
(CHEMBL3792485)
Show SMILES CCc1nc2ccc(cc2n1C)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C22H20FN3O2/c1-3-21-24-19-9-8-17(12-20(19)25(21)2)26-11-10-18(13-22(26)27)28-14-15-4-6-16(23)7-5-15/h4-13H,3,14H2,1-2H3
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n/an/a 48n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163486
PNG
(CHEMBL3793118)
Show SMILES Cc1nc2ccc(cc2n1C)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C21H18FN3O2/c1-14-23-19-8-7-17(11-20(19)24(14)2)25-10-9-18(12-21(25)26)27-13-15-3-5-16(22)6-4-15/h3-12H,13H2,1-2H3
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n/an/a 65n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163495
PNG
(CHEMBL3792529)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2cccc(Cl)c2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-26-21-12-18(7-8-20(21)25-23(26)16-5-6-16)27-10-9-19(13-22(27)28)29-14-15-3-2-4-17(24)11-15/h2-4,7-13,16H,5-6,14H2,1H3
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n/an/a 72n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163482
PNG
(CHEMBL3793989)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)cn2)cc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-26-20-10-17(6-7-19(20)25-22(26)14-2-3-14)27-9-8-18(11-21(27)28)29-13-16-5-4-15(23)12-24-16/h4-12,14H,2-3,13H2,1H3
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n/an/a 73n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163488
PNG
(CHEMBL3793343)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2cccs2)cc1=O)C1CC1
Show InChI InChI=1S/C21H19N3O2S/c1-23-19-11-15(6-7-18(19)22-21(23)14-4-5-14)24-9-8-16(12-20(24)25)26-13-17-3-2-10-27-17/h2-3,6-12,14H,4-5,13H2,1H3
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n/an/a 76n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163486
PNG
(CHEMBL3793118)
Show SMILES Cc1nc2ccc(cc2n1C)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C21H18FN3O2/c1-14-23-19-8-7-17(11-20(19)24(14)2)25-10-9-18(12-21(25)26)27-13-15-3-5-16(22)6-4-15/h3-12H,13H2,1-2H3
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n/an/a 77n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163444
PNG
(CHEMBL3794238)
Show SMILES CCCn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C25H24ClN3O2/c1-2-12-29-23-14-20(9-10-22(23)27-25(29)18-5-6-18)28-13-11-21(15-24(28)30)31-16-17-3-7-19(26)8-4-17/h3-4,7-11,13-15,18H,2,5-6,12,16H2,1H3
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n/an/a 85n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50161848
PNG
(CHEMBL3793827)
Show SMILES Cn1c(CC2CC2)nc2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C24H22FN3O2/c1-27-22-13-19(8-9-21(22)26-23(27)12-16-2-3-16)28-11-10-20(14-24(28)29)30-15-17-4-6-18(25)7-5-17/h4-11,13-14,16H,2-3,12,15H2,1H3
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n/an/a 90n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163495
PNG
(CHEMBL3792529)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2cccc(Cl)c2)cc1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-26-21-12-18(7-8-20(21)25-23(26)16-5-6-16)27-10-9-19(13-22(27)28)29-14-15-3-2-4-17(24)11-15/h2-4,7-13,16H,5-6,14H2,1H3
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n/an/a 100n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163444
PNG
(CHEMBL3794238)
Show SMILES CCCn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C25H24ClN3O2/c1-2-12-29-23-14-20(9-10-22(23)27-25(29)18-5-6-18)28-13-11-21(15-24(28)30)31-16-17-3-7-19(26)8-4-17/h3-4,7-11,13-15,18H,2,5-6,12,16H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163488
PNG
(CHEMBL3793343)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2cccs2)cc1=O)C1CC1
Show InChI InChI=1S/C21H19N3O2S/c1-23-19-11-15(6-7-18(19)22-21(23)14-4-5-14)24-9-8-16(12-20(24)25)26-13-17-3-2-10-27-17/h2-3,6-12,14H,4-5,13H2,1H3
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n/an/a 120n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163496
PNG
(CHEMBL3793051)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccccc2Cl)cc1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-26-21-12-17(8-9-20(21)25-23(26)15-6-7-15)27-11-10-18(13-22(27)28)29-14-16-4-2-3-5-19(16)24/h2-5,8-13,15H,6-7,14H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50161848
PNG
(CHEMBL3793827)
Show SMILES Cn1c(CC2CC2)nc2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C24H22FN3O2/c1-27-22-13-19(8-9-21(22)26-23(27)12-16-2-3-16)28-11-10-20(14-24(28)29)30-15-17-4-6-18(25)7-5-17/h4-11,13-14,16H,2-3,12,15H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163496
PNG
(CHEMBL3793051)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccccc2Cl)cc1=O)C1CC1
Show InChI InChI=1S/C23H20ClN3O2/c1-26-21-12-17(8-9-20(21)25-23(26)15-6-7-15)27-11-10-18(13-22(27)28)29-14-16-4-2-3-5-19(16)24/h2-5,8-13,15H,6-7,14H2,1H3
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n/an/a 160n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50161846
PNG
(CHEMBL3793700)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C1CCC1
Show InChI InChI=1S/C24H22FN3O2/c1-27-22-13-19(9-10-21(22)26-24(27)17-3-2-4-17)28-12-11-20(14-23(28)29)30-15-16-5-7-18(25)8-6-16/h5-14,17H,2-4,15H2,1H3
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n/an/a 210n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50161846
PNG
(CHEMBL3793700)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C1CCC1
Show InChI InChI=1S/C24H22FN3O2/c1-27-22-13-19(9-10-21(22)26-24(27)17-3-2-4-17)28-12-11-20(14-23(28)29)30-15-16-5-7-18(25)8-6-16/h5-14,17H,2-4,15H2,1H3
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n/an/a 240n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163473
PNG
(CHEMBL3794523)
Show SMILES Cc1c(nc2ccc(nn12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-22(16-4-5-16)24-19-8-9-20(25-27(14)19)26-11-10-18(12-21(26)28)29-13-15-2-6-17(23)7-3-15/h2-3,6-12,16H,4-5,13H2,1H3
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n/an/a 380n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50161847
PNG
(CHEMBL3793395)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C1CCCC1
Show InChI InChI=1S/C25H24FN3O2/c1-28-23-14-20(10-11-22(23)27-25(28)18-4-2-3-5-18)29-13-12-21(15-24(29)30)31-16-17-6-8-19(26)9-7-17/h6-15,18H,2-5,16H2,1H3
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n/an/a 460n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50161847
PNG
(CHEMBL3793395)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O)C1CCCC1
Show InChI InChI=1S/C25H24FN3O2/c1-28-23-14-20(10-11-22(23)27-25(28)18-4-2-3-5-18)29-13-12-21(15-24(29)30)31-16-17-6-8-19(26)9-7-17/h6-15,18H,2-5,16H2,1H3
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n/an/a 600n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50163485
PNG
(CHEMBL3794445)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ncc(Cl)cn2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN5O2/c1-26-18-8-15(4-5-17(18)25-21(26)13-2-3-13)27-7-6-16(9-20(27)28)29-12-19-23-10-14(22)11-24-19/h4-11,13H,2-3,12H2,1H3
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n/an/a 900n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50161849
PNG
(CHEMBL3792417)
Show SMILES Cn1c(CC(C)(C)C)nc2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C25H26FN3O2/c1-25(2,3)15-23-27-21-10-9-19(13-22(21)28(23)4)29-12-11-20(14-24(29)30)31-16-17-5-7-18(26)8-6-17/h5-14H,15-16H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50161849
PNG
(CHEMBL3792417)
Show SMILES Cn1c(CC(C)(C)C)nc2ccc(cc12)-n1ccc(OCc2ccc(F)cc2)cc1=O
Show InChI InChI=1S/C25H26FN3O2/c1-25(2,3)15-23-27-21-10-9-19(13-22(21)28(23)4)29-12-11-20(14-24(29)30)31-16-17-5-7-18(26)8-6-17/h5-14H,15-16H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163485
PNG
(CHEMBL3794445)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ncc(Cl)cn2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN5O2/c1-26-18-8-15(4-5-17(18)25-21(26)13-2-3-13)27-7-6-16(9-20(27)28)29-12-19-23-10-14(22)11-24-19/h4-11,13H,2-3,12H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM50163493
PNG
(CHEMBL3794166)
Show SMILES Cc1c(nc2ncc(cn12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1
Show InChI InChI=1S/C22H19ClN4O2/c1-14-21(16-4-5-16)25-22-24-11-18(12-27(14)22)26-9-8-19(10-20(26)28)29-13-15-2-6-17(23)7-3-15/h2-3,6-12,16H,4-5,13H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50163476
PNG
(CHEMBL3792516)
Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)s2)cc1=O)C1CC1
Show InChI InChI=1S/C21H18ClN3O2S/c1-24-18-10-14(4-6-17(18)23-21(24)13-2-3-13)25-9-8-15(11-20(25)26)27-12-16-5-7-19(22)28-16/h4-11,13H,2-3,12H2,1H3
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp test


Bioorg Med Chem 24: 2486-503 (2016)


Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%