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PubMed code 27262595

Compile data set for download or QSAR
Found 13 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50179250
PNG
(CHEMBL3813826)
Show SMILES OC(=O)C1=NN(C(=O)\C1=C/c1ccc(cc1)N(CCC#N)CCC#N)c1ccc(cc1)S(O)(=O)=O
Show InChI InChI=1S/C23H19N5O6S/c24-11-1-13-27(14-2-12-25)17-5-3-16(4-6-17)15-20-21(23(30)31)26-28(22(20)29)18-7-9-19(10-8-18)35(32,33)34/h3-10,15H,1-2,13-14H2,(H,30,31)(H,32,33,34)/b20-15-
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n/an/a 3.50E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TDP2 using alpha32P-cordycepin-3'-labeled TY19 as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50179184
PNG
(CHEMBL264425)
Show SMILES OC(=O)C(CSSCC(NC(=O)c1ccccc1)C(O)=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C20H20N2O6S2/c23-17(13-7-3-1-4-8-13)21-15(19(25)26)11-29-30-12-16(20(27)28)22-18(24)14-9-5-2-6-10-14/h1-10,15-16H,11-12H2,(H,21,23)(H,22,24)(H,25,26)(H,27,28)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TDP2 using alpha32P-cordycepin-3'-labeled TY19 as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Danio rerio)
BDBM50179250
PNG
(CHEMBL3813826)
Show SMILES OC(=O)C1=NN(C(=O)\C1=C/c1ccc(cc1)N(CCC#N)CCC#N)c1ccc(cc1)S(O)(=O)=O
Show InChI InChI=1S/C23H19N5O6S/c24-11-1-13-27(14-2-12-25)17-5-3-16(4-6-17)15-20-21(23(30)31)26-28(22(20)29)18-7-9-19(10-8-18)35(32,33)34/h3-10,15H,1-2,13-14H2,(H,30,31)(H,32,33,34)/b20-15-
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n/an/a 5.20E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of zebra fish recombinant TDP2 using alpha32P-cordycepin-3'-labeled TY19 as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50179183
PNG
(CHEMBL576840 | NSC-3198)
Show SMILES OC(=O)C(CSSCC(NC(=O)Cc1ccccc1)C(O)=O)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C22H24N2O6S2/c25-19(11-15-7-3-1-4-8-15)23-17(21(27)28)13-31-32-14-18(22(29)30)24-20(26)12-16-9-5-2-6-10-16/h1-10,17-18H,11-14H2,(H,23,25)(H,24,26)(H,27,28)(H,29,30)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TDP2 using alpha32P-cordycepin-3'-labeled TY19 as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Homo sapiens)
BDBM50179251
PNG
(CHEMBL3814209)
Show SMILES COc1ccc(CC2C(=O)N(N=C2C(O)=O)c2ccc(cc2)[N+]([O-])=O)cc1Oc1ccc(F)cc1
Show InChI InChI=1S/C24H18FN3O7/c1-34-20-11-2-14(13-21(20)35-18-9-3-15(25)4-10-18)12-19-22(24(30)31)26-27(23(19)29)16-5-7-17(8-6-16)28(32)33/h2-11,13,19H,12H2,1H3,(H,30,31)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of human TDP2


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Danio rerio)
BDBM50179184
PNG
(CHEMBL264425)
Show SMILES OC(=O)C(CSSCC(NC(=O)c1ccccc1)C(O)=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C20H20N2O6S2/c23-17(13-7-3-1-4-8-13)21-15(19(25)26)11-29-30-12-16(20(27)28)22-18(24)14-9-5-2-6-10-14/h1-10,15-16H,11-12H2,(H,21,23)(H,22,24)(H,25,26)(H,27,28)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of zebra fish recombinant TDP2 using alpha32P-cordycepin-3'-labeled TY19 as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (mTDP2 WT)


(Mus musculus (Mouse))
BDBM50179250
PNG
(CHEMBL3813826)
Show SMILES OC(=O)C1=NN(C(=O)\C1=C/c1ccc(cc1)N(CCC#N)CCC#N)c1ccc(cc1)S(O)(=O)=O
Show InChI InChI=1S/C23H19N5O6S/c24-11-1-13-27(14-2-12-25)17-5-3-16(4-6-17)15-20-21(23(30)31)26-28(22(20)29)18-7-9-19(10-8-18)35(32,33)34/h3-10,15H,1-2,13-14H2,(H,30,31)(H,32,33,34)/b20-15-
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n/an/a 1.50E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant TDP2 using alpha32P-cordycepin-3'-labeled TY19 as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2


(Danio rerio)
BDBM50179183
PNG
(CHEMBL576840 | NSC-3198)
Show SMILES OC(=O)C(CSSCC(NC(=O)Cc1ccccc1)C(O)=O)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C22H24N2O6S2/c25-19(11-15-7-3-1-4-8-15)23-17(21(27)28)13-31-32-14-18(22(29)30)24-20(26)12-16-9-5-2-6-10-16/h1-10,17-18H,11-14H2,(H,23,25)(H,24,26)(H,27,28)(H,29,30)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of zebra fish recombinant TDP2 using alpha32P-cordycepin-3'-labeled TY19 as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (mTDP2 WT)


(Mus musculus (Mouse))
BDBM50179184
PNG
(CHEMBL264425)
Show SMILES OC(=O)C(CSSCC(NC(=O)c1ccccc1)C(O)=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C20H20N2O6S2/c23-17(13-7-3-1-4-8-13)21-15(19(25)26)11-29-30-12-16(20(27)28)22-18(24)14-9-5-2-6-10-14/h1-10,15-16H,11-12H2,(H,21,23)(H,22,24)(H,25,26)(H,27,28)
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n/an/a>1.11E+5n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant TDP2 using alpha32P-cordycepin-3'-labeled TY19 as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1


(Homo sapiens (Human))
BDBM50179250
PNG
(CHEMBL3813826)
Show SMILES OC(=O)C1=NN(C(=O)\C1=C/c1ccc(cc1)N(CCC#N)CCC#N)c1ccc(cc1)S(O)(=O)=O
Show InChI InChI=1S/C23H19N5O6S/c24-11-1-13-27(14-2-12-25)17-5-3-16(4-6-17)15-20-21(23(30)31)26-28(22(20)29)18-7-9-19(10-8-18)35(32,33)34/h3-10,15H,1-2,13-14H2,(H,30,31)(H,32,33,34)/b20-15-
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n/an/a>1.11E+5n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TDP1 using 5'-[32P]-labeled N14Y as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (mTDP2 WT)


(Mus musculus (Mouse))
BDBM50179183
PNG
(CHEMBL576840 | NSC-3198)
Show SMILES OC(=O)C(CSSCC(NC(=O)Cc1ccccc1)C(O)=O)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C22H24N2O6S2/c25-19(11-15-7-3-1-4-8-15)23-17(21(27)28)13-31-32-14-18(22(29)30)24-20(26)12-16-9-5-2-6-10-16/h1-10,17-18H,11-14H2,(H,23,25)(H,24,26)(H,27,28)(H,29,30)
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n/an/a>1.11E+5n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant TDP2 using alpha32P-cordycepin-3'-labeled TY19 as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1


(Homo sapiens (Human))
BDBM50179183
PNG
(CHEMBL576840 | NSC-3198)
Show SMILES OC(=O)C(CSSCC(NC(=O)Cc1ccccc1)C(O)=O)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C22H24N2O6S2/c25-19(11-15-7-3-1-4-8-15)23-17(21(27)28)13-31-32-14-18(22(29)30)24-20(26)12-16-9-5-2-6-10-16/h1-10,17-18H,11-14H2,(H,23,25)(H,24,26)(H,27,28)(H,29,30)
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n/an/a>1.11E+5n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TDP1 using 5'-[32P]-labeled N14Y as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1


(Homo sapiens (Human))
BDBM50179184
PNG
(CHEMBL264425)
Show SMILES OC(=O)C(CSSCC(NC(=O)c1ccccc1)C(O)=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C20H20N2O6S2/c23-17(13-7-3-1-4-8-13)21-15(19(25)26)11-29-30-12-16(20(27)28)22-18(24)14-9-5-2-6-10-14/h1-10,15-16H,11-12H2,(H,21,23)(H,22,24)(H,25,26)(H,27,28)
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n/an/a>1.11E+5n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TDP1 using 5'-[32P]-labeled N14Y as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%