Found 37 Enz. Inhib. hit(s) with all data for entry = 50047854 
Affinity DataKi: 0.0830nMAssay Description:Displacement of [3H]U69,593 from human kappa-opioid receptor expressed in CHO cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Displacement of [3H]DAMGO from human mu-opioid receptor expressed in CHO cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Displacement of [3H]naltrindole from human delta-opioid receptor expressed in CHO cell membranes after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of NH2-terminal His-tagged MET kinase domain (1051 to 1348 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells p...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]LTD4 from LTD4 receptor in guinea pig lung membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 0.830nMAssay Description:Inhibition of TrkC (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 0.840nMAssay Description:Inhibition of the human PDE4B catalytic domain after 30 mins in presence of [3H]cAMP/[3H]cGMP by scintillation countingMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 0.860nMAssay Description:Inhibition of VEGFR2 (unknown origin) preincubated for 60 mins followed by poly (Glu, Tyr) 4:1 substrate addition measured after 2 to 4 hrs by lucife...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 0.870nMAssay Description:Inhibition of NH2-terminal GST-tagged recombinant human Plk1 (1 to 603 residues) expressed in baculovirus expression system using casein as substrate...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of TIE-2 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 2 hrs in presence of [33P]-gamma-ATP by microbeta scintillation cou...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of FLT4 (unknown origin) preincubated for 60 mins followed by biotinylated-poly (Glu, Tyr) 4:1 substrate addition measured after 1 hr by A...More data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of RON (unknown origin) preincubated for 60 mins followed by poly (Glu, Tyr) 4:1 substrate addition for 2 to 4 hrs by luciferase-coupled c...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Displacement of [3H]LTD4 from LTD4 receptor in guinea pig lung membraneMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of PDGFR-alpha (unknown origin) preincubated for 60 mins followed by poly (Glu, Tyr) 4:1 substrate addition for 2 to 4 hrs by luciferase-c...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of FLT3 (unknown origin) preincubated for 60 mins followed by poly (Glu, Tyr) 4:1 substrate addition for 2 to 4 hrs by luciferase-coupled ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 4.10nMAssay Description:Inhibition of HMG-CoA reductase in rat liver microsomes assessed as reduction in [14C]-HMG-CoA conversion to [14C]-mevalonic acid after 15 mins by co...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of KIT (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of TrkB (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of KIT (unknown origin) preincubated for 60 mins followed by biotinylated-poly (Glu, Tyr) 4:1 substrate addition measured after 1 hr by Al...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of FLT1 (unknown origin) preincubated for 60 mins followed by biotinylated-poly (Glu, Tyr) 4:1 substrate addition measured after 1 hr by A...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of TIE-2 (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 9.60nMAssay Description:Inhibition of PDGFR-beta (unknown origin) preincubated for 60 mins followed by poly (Glu, Tyr) 4:1 substrate addition for 2 to 4 hrs by luciferase-co...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of FLT2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of FLT1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of MET autophosphorylation in human MKN45 cells after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of TIE-2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of VEGF induced VEGFR2 phosphorylation in HUVEC preincubated for 1 hr followed by VEGF-stimulation for 5 mins by Western blot analysisMore data for this Ligand-Target Pair
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
St. John'S University
Curated by ChEMBL
St. John'S University
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of HMG-CoA reductase in rat liver microsomes assessed as reduction in [14C]-HMG-CoA conversion to [14C]-mevalonic acid after 15 mins by co...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
Affinity DataIC50: 890nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
