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PubMed code 27452283

Compile Data Set for Download or QSAR

Found 241 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(homo sapiens (human))
BDBM50105448
PNG
(2-Amino-N-hydroxy-3-(4-phenoxy-benzenesulfonyl)-2-...)
Show SMILES NC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(C(=O)NO)c1ccccc1
Show InChI InChI=1S/C21H20N2O5S/c22-21(20(24)23-25,16-7-3-1-4-8-16)15-29(26,27)19-13-11-18(12-14-19)28-17-9-5-2-6-10-17/h1-14,25H,15,22H2,(H,23,24)
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n/an/a 0.200n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105456
PNG
(2-Benzylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C23H24N2O5S/c1-23(22(26)25-27,24-16-18-8-4-2-5-9-18)17-31(28,29)21-14-12-20(13-15-21)30-19-10-6-3-7-11-19/h2-15,24,27H,16-17H2,1H3,(H,25,26)
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n/an/a 0.200n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105459
PNG
(CHEMBL94248 | N-Hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCC#C)C(=O)NO
Show InChI InChI=1S/C19H20N2O5S/c1-3-13-20-19(2,18(22)21-23)14-27(24,25)17-11-9-16(10-12-17)26-15-7-5-4-6-8-15/h1,4-12,20,23H,13-14H2,2H3,(H,21,22)
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n/an/a 0.200n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105456
PNG
(2-Benzylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C23H24N2O5S/c1-23(22(26)25-27,24-16-18-8-4-2-5-9-18)17-31(28,29)21-14-12-20(13-15-21)30-19-10-6-3-7-11-19/h2-15,24,27H,16-17H2,1H3,(H,25,26)
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n/an/a 0.200n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187401
PNG
(CHEMBL3827831)
Show SMILES CC(C)(C)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(=O)Nc1ccncc1
Show InChI InChI=1S/C24H32N4O4/c1-24(2,3)21(23(31)26-19-12-14-25-15-13-19)27-22(30)18(16-20(29)28-32)11-7-10-17-8-5-4-6-9-17/h4-6,8-9,12-15,18,21,32H,7,10-11,16H2,1-3H3,(H,27,30)(H,28,29)(H,25,26,31)
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Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105448
PNG
(2-Amino-N-hydroxy-3-(4-phenoxy-benzenesulfonyl)-2-...)
Show SMILES NC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(C(=O)NO)c1ccccc1
Show InChI InChI=1S/C21H20N2O5S/c22-21(20(24)23-25,16-7-3-1-4-8-16)15-29(26,27)19-13-11-18(12-14-19)28-17-9-5-2-6-10-17/h1-14,25H,15,22H2,(H,23,24)
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Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105459
PNG
(CHEMBL94248 | N-Hydroxy-2-methyl-3-(4-phenoxy-benz...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCC#C)C(=O)NO
Show InChI InChI=1S/C19H20N2O5S/c1-3-13-20-19(2,18(22)21-23)14-27(24,25)17-11-9-16(10-12-17)26-15-7-5-4-6-8-15/h1,4-12,20,23H,13-14H2,2H3,(H,21,22)
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n/an/a 0.200n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50148208
PNG
(3-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-8-ox...)
Show SMILES ONC(=O)C1(CC2CCC(C1)O2)NS(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H21FN2O6S/c21-13-1-3-14(4-2-13)28-15-7-9-18(10-8-15)30(26,27)23-20(19(24)22-25)11-16-5-6-17(12-20)29-16/h1-4,7-10,16-17,23,25H,5-6,11-12H2,(H,22,24)
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n/an/a 0.260n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50148208
PNG
(3-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-8-ox...)
Show SMILES ONC(=O)C1(CC2CCC(C1)O2)NS(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H21FN2O6S/c21-13-1-3-14(4-2-13)28-15-7-9-18(10-8-15)30(26,27)23-20(19(24)22-25)11-16-5-6-17(12-20)29-16/h1-4,7-10,16-17,23,25H,5-6,11-12H2,(H,22,24)
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n/an/a 0.300n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187423
PNG
(CHEMBL3828455)
Show SMILES CNC(=O)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(C)(C)C
Show InChI InChI=1S/C20H31N3O4/c1-20(2,3)17(19(26)21-4)22-18(25)15(13-16(24)23-27)12-8-11-14-9-6-5-7-10-14/h5-7,9-10,15,17,27H,8,11-13H2,1-4H3,(H,21,26)(H,22,25)(H,23,24)
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n/an/a 0.380n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105451
PNG
(CHEMBL92778 | N-Hydroxy-2-methyl-2-[(naphthalen-2-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2ccccc2c1)C(=O)NO
Show InChI InChI=1S/C27H26N2O5S/c1-27(26(30)29-31,28-18-20-11-12-21-7-5-6-8-22(21)17-20)19-35(32,33)25-15-13-24(14-16-25)34-23-9-3-2-4-10-23/h2-17,28,31H,18-19H2,1H3,(H,29,30)
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n/an/a 0.400n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187405
PNG
(CHEMBL3827377)
Show SMILES CC(NC(=O)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(C)(C)C)c1ccccc1
Show InChI InChI=1S/C27H37N3O4/c1-19(21-15-9-6-10-16-21)28-26(33)24(27(2,3)4)29-25(32)22(18-23(31)30-34)17-11-14-20-12-7-5-8-13-20/h5-10,12-13,15-16,19,22,24,34H,11,14,17-18H2,1-4H3,(H,28,33)(H,29,32)(H,30,31)
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n/an/a 0.400n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187423
PNG
(CHEMBL3828455)
Show SMILES CNC(=O)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(C)(C)C
Show InChI InChI=1S/C20H31N3O4/c1-20(2,3)17(19(26)21-4)22-18(25)15(13-16(24)23-27)12-8-11-14-9-6-5-7-10-14/h5-7,9-10,15,17,27H,8,11-13H2,1-4H3,(H,21,26)(H,22,25)(H,23,24)
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n/an/a 0.400n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105451
PNG
(CHEMBL92778 | N-Hydroxy-2-methyl-2-[(naphthalen-2-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2ccccc2c1)C(=O)NO
Show InChI InChI=1S/C27H26N2O5S/c1-27(26(30)29-31,28-18-20-11-12-21-7-5-6-8-22(21)17-20)19-35(32,33)25-15-13-24(14-16-25)34-23-9-3-2-4-10-23/h2-17,28,31H,18-19H2,1H3,(H,29,30)
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n/an/a 0.400n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187399
PNG
(CHEMBL3827321)
Show SMILES CNC(=O)C(Cc1ccccc1)NC(=O)C(CC(C)C)C(CSc1cccs1)C(=O)NO
Show InChI InChI=1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)
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n/an/a 0.5n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105453
PNG
(2-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-N-hydroxy-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2OCOc2c1)C(=O)NO
Show InChI InChI=1S/C24H24N2O7S/c1-24(23(27)26-28,25-14-17-7-12-21-22(13-17)32-16-31-21)15-34(29,30)20-10-8-19(9-11-20)33-18-5-3-2-4-6-18/h2-13,25,28H,14-16H2,1H3,(H,26,27)
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n/an/a 0.5n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105453
PNG
(2-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-N-hydroxy-...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCc1ccc2OCOc2c1)C(=O)NO
Show InChI InChI=1S/C24H24N2O7S/c1-24(23(27)26-28,25-14-17-7-12-21-22(13-17)32-16-31-21)15-34(29,30)20-10-8-19(9-11-20)33-18-5-3-2-4-6-18/h2-13,25,28H,14-16H2,1H3,(H,26,27)
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n/an/a 0.500n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187399
PNG
(CHEMBL3827321)
Show SMILES CNC(=O)C(Cc1ccccc1)NC(=O)C(CC(C)C)C(CSc1cccs1)C(=O)NO
Show InChI InChI=1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)
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n/an/a 0.500n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105457
PNG
(2-Amino-N-hydroxy-2-methyl-3-(4-phenoxy-benzenesul...)
Show SMILES CC(N)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C16H18N2O5S/c1-16(17,15(19)18-20)11-24(21,22)14-9-7-13(8-10-14)23-12-5-3-2-4-6-12/h2-10,20H,11,17H2,1H3,(H,18,19)
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n/an/a 0.600n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105457
PNG
(2-Amino-N-hydroxy-2-methyl-3-(4-phenoxy-benzenesul...)
Show SMILES CC(N)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C16H18N2O5S/c1-16(17,15(19)18-20)11-24(21,22)14-9-7-13(8-10-14)23-12-5-3-2-4-6-12/h2-10,20H,11,17H2,1H3,(H,18,19)
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n/an/a 0.600n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187450
PNG
(CHEMBL3828531)
Show SMILES CNC(=O)C(NC(=O)C(CC(C)C)C(O)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)
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n/an/a 0.700n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187450
PNG
(CHEMBL3828531)
Show SMILES CNC(=O)C(NC(=O)C(CC(C)C)C(O)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)
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n/an/a 0.750n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187414
PNG
(CHEMBL3828007)
Show SMILES CNC(=O)C(NC(=O)C(CCCc1ccc(c(C)c1)-c1ccccc1)CC(=O)NO)C(C)(C)C
Show InChI InChI=1S/C27H37N3O4/c1-18-16-19(14-15-22(18)20-11-7-6-8-12-20)10-9-13-21(17-23(31)30-34)25(32)29-24(26(33)28-5)27(2,3)4/h6-8,11-12,14-16,21,24,34H,9-10,13,17H2,1-5H3,(H,28,33)(H,29,32)(H,30,31)
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n/an/a 1n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187245
PNG
(CHEMBL3827521)
Show SMILES CC(C)(C)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(=O)Nc1ccccc1
Show InChI InChI=1S/C25H33N3O4/c1-25(2,3)22(24(31)26-20-15-8-5-9-16-20)27-23(30)19(17-21(29)28-32)14-10-13-18-11-6-4-7-12-18/h4-9,11-12,15-16,19,22,32H,10,13-14,17H2,1-3H3,(H,26,31)(H,27,30)(H,28,29)
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n/an/a 1n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187414
PNG
(CHEMBL3828007)
Show SMILES CNC(=O)C(NC(=O)C(CCCc1ccc(c(C)c1)-c1ccccc1)CC(=O)NO)C(C)(C)C
Show InChI InChI=1S/C27H37N3O4/c1-18-16-19(14-15-22(18)20-11-7-6-8-12-20)10-9-13-21(17-23(31)30-34)25(32)29-24(26(33)28-5)27(2,3)4/h6-8,11-12,14-16,21,24,34H,9-10,13,17H2,1-5H3,(H,28,33)(H,29,32)(H,30,31)
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Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187245
PNG
(CHEMBL3827521)
Show SMILES CC(C)(C)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(=O)Nc1ccccc1
Show InChI InChI=1S/C25H33N3O4/c1-25(2,3)22(24(31)26-20-15-8-5-9-16-20)27-23(30)19(17-21(29)28-32)14-10-13-18-11-6-4-7-12-18/h4-9,11-12,15-16,19,22,32H,10,13-14,17H2,1-3H3,(H,26,31)(H,27,30)(H,28,29)
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n/an/a 1n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105458
PNG
(CHEMBL433171 | N-Hydroxy-2-methyl-2-phenethylamino...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C24H26N2O5S/c1-24(23(27)26-28,25-17-16-19-8-4-2-5-9-19)18-32(29,30)22-14-12-21(13-15-22)31-20-10-6-3-7-11-20/h2-15,25,28H,16-18H2,1H3,(H,26,27)
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n/an/a 1.30n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187403
PNG
(CHEMBL3828521)
Show SMILES CC(C)(C)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(=O)NC1CCCCC1
Show InChI InChI=1S/C25H39N3O4/c1-25(2,3)22(24(31)26-20-15-8-5-9-16-20)27-23(30)19(17-21(29)28-32)14-10-13-18-11-6-4-7-12-18/h4,6-7,11-12,19-20,22,32H,5,8-10,13-17H2,1-3H3,(H,26,31)(H,27,30)(H,28,29)
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n/an/a 1.30n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105458
PNG
(CHEMBL433171 | N-Hydroxy-2-methyl-2-phenethylamino...)
Show SMILES CC(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)(NCCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C24H26N2O5S/c1-24(23(27)26-28,25-17-16-19-8-4-2-5-9-19)18-32(29,30)22-14-12-21(13-15-22)31-20-10-6-3-7-11-20/h2-15,25,28H,16-18H2,1H3,(H,26,27)
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n/an/a 1.30n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187403
PNG
(CHEMBL3828521)
Show SMILES CC(C)(C)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(=O)NC1CCCCC1
Show InChI InChI=1S/C25H39N3O4/c1-25(2,3)22(24(31)26-20-15-8-5-9-16-20)27-23(30)19(17-21(29)28-32)14-10-13-18-11-6-4-7-12-18/h4,6-7,11-12,19-20,22,32H,5,8-10,13-17H2,1-3H3,(H,26,31)(H,27,30)(H,28,29)
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n/an/a 1.30n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105455
PNG
(2-Ethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benze...)
Show SMILES CCNC(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-3-19-18(2,17(21)20-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,19,22H,3,13H2,1-2H3,(H,20,21)
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n/an/a 1.30n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105455
PNG
(2-Ethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benze...)
Show SMILES CCNC(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-3-19-18(2,17(21)20-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,19,22H,3,13H2,1-2H3,(H,20,21)
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n/an/a 1.30n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50148216
PNG
(4-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-tetr...)
Show SMILES ONC(=O)C1(CCOCC1)NS(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H19FN2O6S/c19-13-1-3-14(4-2-13)27-15-5-7-16(8-6-15)28(24,25)21-18(17(22)20-23)9-11-26-12-10-18/h1-8,21,23H,9-12H2,(H,20,22)
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n/an/a 1.60n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187402
PNG
(CHEMBL3827566)
Show SMILES CC(C)(C)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(=O)NC1CCCC1
Show InChI InChI=1S/C24H37N3O4/c1-24(2,3)21(23(30)25-19-14-7-8-15-19)26-22(29)18(16-20(28)27-31)13-9-12-17-10-5-4-6-11-17/h4-6,10-11,18-19,21,31H,7-9,12-16H2,1-3H3,(H,25,30)(H,26,29)(H,27,28)
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Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187402
PNG
(CHEMBL3827566)
Show SMILES CC(C)(C)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(=O)NC1CCCC1
Show InChI InChI=1S/C24H37N3O4/c1-24(2,3)21(23(30)25-19-14-7-8-15-19)26-22(29)18(16-20(28)27-31)13-9-12-17-10-5-4-6-11-17/h4-6,10-11,18-19,21,31H,7-9,12-16H2,1-3H3,(H,25,30)(H,26,29)(H,27,28)
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Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50148216
PNG
(4-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-tetr...)
Show SMILES ONC(=O)C1(CCOCC1)NS(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H19FN2O6S/c19-13-1-3-14(4-2-13)27-15-5-7-16(8-6-15)28(24,25)21-18(17(22)20-23)9-11-26-12-10-18/h1-8,21,23H,9-12H2,(H,20,22)
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n/an/a 1.60n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187457
PNG
(CHEMBL3828325)
Show SMILES CNC(=O)C(NC(=O)C(CCc1ccc(Cl)cc1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C32H40ClN2O4P/c1-32(2,3)29(31(37)34-4)35-30(36)27(17-14-23-15-18-28(33)19-16-23)22-40(38,39)21-26-12-10-25(11-13-26)20-24-8-6-5-7-9-24/h5-13,15-16,18-19,27,29H,14,17,20-22H2,1-4H3,(H,34,37)(H,35,36)(H,38,39)
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n/an/a 2.60n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187457
PNG
(CHEMBL3828325)
Show SMILES CNC(=O)C(NC(=O)C(CCc1ccc(Cl)cc1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C32H40ClN2O4P/c1-32(2,3)29(31(37)34-4)35-30(36)27(17-14-23-15-18-28(33)19-16-23)22-40(38,39)21-26-12-10-25(11-13-26)20-24-8-6-5-7-9-24/h5-13,15-16,18-19,27,29H,14,17,20-22H2,1-4H3,(H,34,37)(H,35,36)(H,38,39)
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Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105447
PNG
(2-Amino-N-hydroxy-2-methyl-3-(4-phenylsulfanyl-ben...)
Show SMILES CC(N)(CS(=O)(=O)c1ccc(Sc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C16H18N2O4S2/c1-16(17,15(19)18-20)11-24(21,22)14-9-7-13(8-10-14)23-12-5-3-2-4-6-12/h2-10,20H,11,17H2,1H3,(H,18,19)
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n/an/a 3.20n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105447
PNG
(2-Amino-N-hydroxy-2-methyl-3-(4-phenylsulfanyl-ben...)
Show SMILES CC(N)(CS(=O)(=O)c1ccc(Sc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C16H18N2O4S2/c1-16(17,15(19)18-20)11-24(21,22)14-9-7-13(8-10-14)23-12-5-3-2-4-6-12/h2-10,20H,11,17H2,1H3,(H,18,19)
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n/an/a 3.20n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187482
PNG
(CHEMBL3828459)
Show SMILES CCC(NC(=O)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(C)(C)C)c1ccccc1
Show InChI InChI=1S/C28H39N3O4/c1-5-23(21-16-10-7-11-17-21)29-27(34)25(28(2,3)4)30-26(33)22(19-24(32)31-35)18-12-15-20-13-8-6-9-14-20/h6-11,13-14,16-17,22-23,25,35H,5,12,15,18-19H2,1-4H3,(H,29,34)(H,30,33)(H,31,32)
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n/an/a 3.30n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187324
PNG
(CHEMBL3827768)
Show SMILES CC(C)(C)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(=O)NC(C)(C)c1ccccc1
Show InChI InChI=1S/C28H39N3O4/c1-27(2,3)24(26(34)30-28(4,5)22-17-10-7-11-18-22)29-25(33)21(19-23(32)31-35)16-12-15-20-13-8-6-9-14-20/h6-11,13-14,17-18,21,24,35H,12,15-16,19H2,1-5H3,(H,29,33)(H,30,34)(H,31,32)
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n/an/a 3.40n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187324
PNG
(CHEMBL3827768)
Show SMILES CC(C)(C)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(=O)NC(C)(C)c1ccccc1
Show InChI InChI=1S/C28H39N3O4/c1-27(2,3)24(26(34)30-28(4,5)22-17-10-7-11-18-22)29-25(33)21(19-23(32)31-35)16-12-15-20-13-8-6-9-14-20/h6-11,13-14,17-18,21,24,35H,12,15-16,19H2,1-5H3,(H,29,33)(H,30,34)(H,31,32)
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n/an/a 3.40n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187446
PNG
(CHEMBL3827444)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)C(C(C)C)C(=O)NO
Show InChI InChI=1S/C18H23N3O5S/c1-13(2)17(18(22)20-23)21(12-14-5-4-10-19-11-14)27(24,25)16-8-6-15(26-3)7-9-16/h4-11,13,17,23H,12H2,1-3H3,(H,20,22)
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n/an/a 4.60n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187446
PNG
(CHEMBL3827444)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)C(C(C)C)C(=O)NO
Show InChI InChI=1S/C18H23N3O5S/c1-13(2)17(18(22)20-23)21(12-14-5-4-10-19-11-14)27(24,25)16-8-6-15(26-3)7-9-16/h4-11,13,17,23H,12H2,1-3H3,(H,20,22)
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n/an/a 4.60n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105461
PNG
(2-Dimethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-be...)
Show SMILES CN(C)C(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-18(20(2)3,17(21)19-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,22H,13H2,1-3H3,(H,19,21)
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n/an/a 5n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50105461
PNG
(2-Dimethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-be...)
Show SMILES CN(C)C(C)(CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-18(20(2)3,17(21)19-22)13-26(23,24)16-11-9-15(10-12-16)25-14-7-5-4-6-8-14/h4-12,22H,13H2,1-3H3,(H,19,21)
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n/an/a 5n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187244
PNG
(CHEMBL3827627)
Show SMILES CC(C)(C)NC(=O)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(C)(C)C
Show InChI InChI=1S/C23H37N3O4/c1-22(2,3)19(21(29)25-23(4,5)6)24-20(28)17(15-18(27)26-30)14-10-13-16-11-8-7-9-12-16/h7-9,11-12,17,19,30H,10,13-15H2,1-6H3,(H,24,28)(H,25,29)(H,26,27)
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n/an/a 5.80n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187244
PNG
(CHEMBL3827627)
Show SMILES CC(C)(C)NC(=O)C(NC(=O)C(CCCc1ccccc1)CC(=O)NO)C(C)(C)C
Show InChI InChI=1S/C23H37N3O4/c1-22(2,3)19(21(29)25-23(4,5)6)24-20(28)17(15-18(27)26-30)14-10-13-16-11-8-7-9-12-16/h7-9,11-12,17,19,30H,10,13-15H2,1-6H3,(H,24,28)(H,25,29)(H,26,27)
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n/an/a 5.80n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50187465
PNG
(CHEMBL3828219)
Show SMILES CNC(=O)C(Cc1ccc(OC)cc1)NC(=O)C(CC(C)C)CC(=O)NO
Show InChI InChI=1S/C19H29N3O5/c1-12(2)9-14(11-17(23)22-26)18(24)21-16(19(25)20-3)10-13-5-7-15(27-4)8-6-13/h5-8,12,14,16,26H,9-11H2,1-4H3,(H,20,25)(H,21,24)(H,22,23)
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n/an/a 6n/an/an/an/an/an/a



Jadavpur University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 by colorimetric analysis


Bioorg Med Chem 24: 4291-4309 (2016)


Article DOI: 10.1016/j.bmc.2016.07.023
BindingDB Entry DOI: 10.7270/Q2S46TW0
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 241 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%