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PubMed code 27475537

Compile data set for download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sphingosine-1-phosphate lyase 1


(Rattus norvegicus)
BDBM50187501
PNG
(CHEMBL3827445)
Show SMILES CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CP(O)(O)=O
Show InChI InChI=1S/C18H40NO4P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
5.00E+3n/an/an/an/an/an/an/an/a



Institute for Advanced Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Competitive inhibition of rat S1PL in presence of D(+)-erythro-sphinganine-1-phosphate measured after 15 mins by Dixon plot analysis


Bioorg Med Chem 24: 4381-4389 (2016)


Article DOI: 10.1016/j.bmc.2016.07.033
BindingDB Entry DOI: 10.7270/Q2862JDX
More data for this
Ligand-Target Pair
Sphingosine-1-phosphate lyase 1


(Homo sapiens)
BDBM50018286
PNG
(CHEMBL3290335)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2ccc(cc12)C#N
Show InChI InChI=1S/C27H23N7/c1-19-18-33(11-12-34(19)26-10-8-22(16-29)17-30-26)27-24-13-21(15-28)7-9-23(24)25(31-32-27)14-20-5-3-2-4-6-20/h2-10,13,17,19H,11-12,14,18H2,1H3/t19-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 94n/an/an/an/an/an/a



Institute for Advanced Chemistry of Catalonia (IQAC-CSIC)

Curated by ChEMBL


Assay Description
Inhibition of human S1PL using RBM13 as substrate measured after 1 hr by fluorogenic assay


Bioorg Med Chem 24: 4381-4389 (2016)


Article DOI: 10.1016/j.bmc.2016.07.033
BindingDB Entry DOI: 10.7270/Q2862JDX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%