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PubMed code 27714957

Compile data set for download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM223126
PNG
(P5i-7)
Show SMILES NC(=S)N\N=C\c1ccc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H10ClN3OS/c13-9-3-1-8(2-4-9)11-6-5-10(17-11)7-15-16-12(14)18/h1-7H,(H3,14,16,18)/b15-7+
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UniChem
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n/an/a 720n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM223131
PNG
(2-((5-(4-methoxyphenyl)furan-2-yl)methylene)hydraz...)
Show SMILES COc1ccc(cc1)-c1ccc(\C=N\NC(N)=O)o1
Show InChI InChI=1S/C13H13N3O3/c1-18-10-4-2-9(3-5-10)12-7-6-11(19-12)8-15-16-13(14)17/h2-8H,1H3,(H3,14,16,17)/b15-8+
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n/an/a 2.10E+3n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM223136
PNG
(2-((6-(4-chlorophenyl)pyridin-2-yl)methylene)hydra...)
Show SMILES NC(=O)N\N=C\c1cccc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C13H11ClN4O/c14-10-6-4-9(5-7-10)12-3-1-2-11(17-12)8-16-18-13(15)19/h1-8H,(H3,15,18,19)/b16-8+
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n/an/a 3.50E+3n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM223134
PNG
(2-((4′-chloro-[1,1′-biphenyl]-3-yl)met...)
Show SMILES NC(=O)N\N=C\c1cccc(c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H12ClN3O/c15-13-6-4-11(5-7-13)12-3-1-2-10(8-12)9-17-18-14(16)19/h1-9H,(H3,16,18,19)/b17-9+
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n/an/a 3.80E+3n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM223135
PNG
(2-((5-(4-chlorophenyl)pyridin-3-yl)methylene)hydra...)
Show SMILES NC(=O)N\N=C\c1cncc(c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C13H11ClN4O/c14-12-3-1-10(2-4-12)11-5-9(6-16-8-11)7-17-18-13(15)19/h1-8H,(H3,15,18,19)/b17-7+
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n/an/a 6.90E+3n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM223129
PNG
(2-((5-(4-fluorophenyl)furan-2-yl)methylene)hydrazi...)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1ccc(F)cc1
Show InChI InChI=1S/C12H10FN3O2/c13-9-3-1-8(2-4-9)11-6-5-10(18-11)7-15-16-12(14)17/h1-7H,(H3,14,16,17)/b15-7+
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n/an/a 1.20E+4n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM223127
PNG
(2-((5-phenylfuran-2-yl)methylene)hydrazinecarboxam...)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1ccccc1
Show InChI InChI=1S/C12H11N3O2/c13-12(16)15-14-8-10-6-7-11(17-10)9-4-2-1-3-5-9/h1-8H,(H3,13,15,16)/b14-8+
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n/an/a 1.20E+4n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM223133
PNG
(2-((5-(2-amino-4-chlorophenyl)furan-2-yl)methylene...)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1ccc(Cl)cc1N
Show InChI InChI=1S/C12H11ClN4O2/c13-7-1-3-9(10(14)5-7)11-4-2-8(19-11)6-16-17-12(15)18/h1-6H,14H2,(H3,15,17,18)/b16-6+
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n/an/a 1.30E+4n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM223128
PNG
(2-((5-(3-fluorophenyl)furan-2-yl)methylene)hydrazi...)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1cccc(F)c1
Show InChI InChI=1S/C12H10FN3O2/c13-9-3-1-2-8(6-9)11-5-4-10(18-11)7-15-16-12(14)17/h1-7H,(H3,14,16,17)/b15-7+
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n/an/a 1.40E+4n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM223130
PNG
(2-((5-(4-nitrophenyl)furan-2-yl)methylene)hydrazin...)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C12H10N4O4/c13-12(17)15-14-7-10-5-6-11(20-10)8-1-3-9(4-2-8)16(18)19/h1-7H,(H3,13,15,17)/b14-7+
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n/an/a 1.80E+4n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM223132
PNG
(2-((5-(4-aminophenyl)furan-2-yl)methylene)hydrazin...)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1ccc(N)cc1
Show InChI InChI=1S/C12H12N4O2/c13-9-3-1-8(2-4-9)11-6-5-10(18-11)7-15-16-12(14)17/h1-7H,13H2,(H3,14,16,17)/b15-7+
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n/an/a 4.00E+4n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM8460
PNG
(5-{[5-(4-chlorophenyl)furan-2-yl]methylidene}-2-su...)
Show SMILES Clc1ccc(cc1)-c1ccc(C=C2C(=O)NC(=S)NC2=O)o1
Show InChI InChI=1S/C15H9ClN2O3S/c16-9-3-1-8(2-4-9)12-6-5-10(21-12)7-11-13(19)17-15(22)18-14(11)20/h1-7H,(H2,17,18,19,20,22)
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Article
PubMed
n/an/a 6.70E+4n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM223137
PNG
(P5i-6)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H10ClN3O2/c13-9-3-1-8(2-4-9)11-6-5-10(18-11)7-15-16-12(14)17/h1-7H,(H3,14,16,17)/b15-7+
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Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 8 (PRMT8)


(Homo sapiens (Human))
BDBM223137
PNG
(P5i-6)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H10ClN3O2/c13-9-3-1-8(2-4-9)11-6-5-10(18-11)7-15-16-12(14)17/h1-7H,(H3,14,16,17)/b15-7+
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Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))
BDBM223137
PNG
(P5i-6)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H10ClN3O2/c13-9-3-1-8(2-4-9)11-6-5-10(18-11)7-15-16-12(14)17/h1-7H,(H3,14,16,17)/b15-7+
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Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein arginine methyltransferase 7 (PRMT7)


(Homo sapiens (Human))
BDBM223137
PNG
(P5i-6)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H10ClN3O2/c13-9-3-1-8(2-4-9)11-6-5-10(18-11)7-15-16-12(14)17/h1-7H,(H3,14,16,17)/b15-7+
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n/an/a>1.00E+5n/an/an/an/an/a25



Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM223137
PNG
(P5i-6)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H10ClN3O2/c13-9-3-1-8(2-4-9)11-6-5-10(18-11)7-15-16-12(14)17/h1-7H,(H3,14,16,17)/b15-7+
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Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens (Human))
BDBM223137
PNG
(P5i-6)
Show SMILES NC(=O)N\N=C\c1ccc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H10ClN3O2/c13-9-3-1-8(2-4-9)11-6-5-10(18-11)7-15-16-12(14)17/h1-7H,(H3,14,16,17)/b15-7+
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Sichuan University



Assay Description
All in vitro enzymatic assays were carried out by Shanghai ChemPartner Co. (998 Halei Road, Pudong New Area, Shanghai, 201203, China). To measure the...


Chem Biol Drug Des 89: 585-598 (2017)


Article DOI: 10.1111/cbdd.12881
BindingDB Entry DOI: 10.7270/Q21V5CTR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%