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PubMed code 27765510

Compile data set for download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM50200519
PNG
(CHEMBL3915703)
Show SMILES COc1ccc(cc1)-c1c2ccccc2cc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C24H21NO4/c1-27-18-8-6-16(7-9-18)23-19-5-3-2-4-17(19)14-20-21(26)15-22(29-24(20)23)25-10-12-28-13-11-25/h2-9,14-15H,10-13H2,1H3
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Article
PubMed
n/an/a 5.60E+3n/an/an/an/an/an/a



La Trobe University

Curated by ChEMBL


Assay Description
Inhibition of p110delta (unknown origin) assessed as decrease in ATP consumption after 60 mins by Kinase-Glo assay


Bioorg Med Chem Lett 26: 5534-5538 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.003
BindingDB Entry DOI: 10.7270/Q2FJ2JQZ
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM50200518
PNG
(CHEMBL3945937)
Show SMILES O=c1cc(oc2c(-c3ccccc3)c3ccccc3cc12)N1CCOCC1
Show InChI InChI=1S/C23H19NO3/c25-20-15-21(24-10-12-26-13-11-24)27-23-19(20)14-17-8-4-5-9-18(17)22(23)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2
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Article
PubMed
n/an/a 7.70E+3n/an/an/an/an/an/a



La Trobe University

Curated by ChEMBL


Assay Description
Inhibition of p110delta (unknown origin) assessed as decrease in ATP consumption after 60 mins by Kinase-Glo assay


Bioorg Med Chem Lett 26: 5534-5538 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.003
BindingDB Entry DOI: 10.7270/Q2FJ2JQZ
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (human))
BDBM50200518
PNG
(CHEMBL3945937)
Show SMILES O=c1cc(oc2c(-c3ccccc3)c3ccccc3cc12)N1CCOCC1
Show InChI InChI=1S/C23H19NO3/c25-20-15-21(24-10-12-26-13-11-24)27-23-19(20)14-17-8-4-5-9-18(17)22(23)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2
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PubMed
n/an/a 4.38E+4n/an/an/an/an/an/a



La Trobe University

Curated by ChEMBL


Assay Description
Inhibition of p110alpha (unknown origin) assessed as decrease in ATP consumption after 60 mins by Kinase-Glo assay


Bioorg Med Chem Lett 26: 5534-5538 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.003
BindingDB Entry DOI: 10.7270/Q2FJ2JQZ
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50200519
PNG
(CHEMBL3915703)
Show SMILES COc1ccc(cc1)-c1c2ccccc2cc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C24H21NO4/c1-27-18-8-6-16(7-9-18)23-19-5-3-2-4-17(19)14-20-21(26)15-22(29-24(20)23)25-10-12-28-13-11-25/h2-9,14-15H,10-13H2,1H3
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PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



La Trobe University

Curated by ChEMBL


Assay Description
Inhibition of p110beta (unknown origin) assessed as decrease in ATP consumption after 60 mins by Kinase-Glo assay


Bioorg Med Chem Lett 26: 5534-5538 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.003
BindingDB Entry DOI: 10.7270/Q2FJ2JQZ
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM50200519
PNG
(CHEMBL3915703)
Show SMILES COc1ccc(cc1)-c1c2ccccc2cc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C24H21NO4/c1-27-18-8-6-16(7-9-18)23-19-5-3-2-4-17(19)14-20-21(26)15-22(29-24(20)23)25-10-12-28-13-11-25/h2-9,14-15H,10-13H2,1H3
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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



La Trobe University

Curated by ChEMBL


Assay Description
Inhibition of p110gamma (unknown origin) assessed as decrease in ATP consumption after 60 mins by Kinase-Glo assay


Bioorg Med Chem Lett 26: 5534-5538 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.003
BindingDB Entry DOI: 10.7270/Q2FJ2JQZ
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50200518
PNG
(CHEMBL3945937)
Show SMILES O=c1cc(oc2c(-c3ccccc3)c3ccccc3cc12)N1CCOCC1
Show InChI InChI=1S/C23H19NO3/c25-20-15-21(24-10-12-26-13-11-24)27-23-19(20)14-17-8-4-5-9-18(17)22(23)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2
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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



La Trobe University

Curated by ChEMBL


Assay Description
Inhibition of p110beta (unknown origin) assessed as decrease in ATP consumption after 60 mins by Kinase-Glo assay


Bioorg Med Chem Lett 26: 5534-5538 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.003
BindingDB Entry DOI: 10.7270/Q2FJ2JQZ
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (human))
BDBM50200519
PNG
(CHEMBL3915703)
Show SMILES COc1ccc(cc1)-c1c2ccccc2cc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C24H21NO4/c1-27-18-8-6-16(7-9-18)23-19-5-3-2-4-17(19)14-20-21(26)15-22(29-24(20)23)25-10-12-28-13-11-25/h2-9,14-15H,10-13H2,1H3
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UniChem

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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



La Trobe University

Curated by ChEMBL


Assay Description
Inhibition of p110alpha (unknown origin) assessed as decrease in ATP consumption after 60 mins by Kinase-Glo assay


Bioorg Med Chem Lett 26: 5534-5538 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.003
BindingDB Entry DOI: 10.7270/Q2FJ2JQZ
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM50200518
PNG
(CHEMBL3945937)
Show SMILES O=c1cc(oc2c(-c3ccccc3)c3ccccc3cc12)N1CCOCC1
Show InChI InChI=1S/C23H19NO3/c25-20-15-21(24-10-12-26-13-11-24)27-23-19(20)14-17-8-4-5-9-18(17)22(23)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2
PDB
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UniChem

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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



La Trobe University

Curated by ChEMBL


Assay Description
Inhibition of p110gamma (unknown origin) assessed as decrease in ATP consumption after 60 mins by Kinase-Glo assay


Bioorg Med Chem Lett 26: 5534-5538 (2016)


Article DOI: 10.1016/j.bmcl.2016.10.003
BindingDB Entry DOI: 10.7270/Q2FJ2JQZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%