Compile Data Set for Download or QSAR
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Found 54 Enz. Inhib. hit(s) with all data for entry = 50049010
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant human FGFR1 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of recombinant human Lyn using peptide substrate poly[Glu:Tyr] (4:1) in presence of [33-P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of recombinant human ABL using peptide substrate EAIYAAPFAKKK in presence of [33-P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human N-terminal GST/His6-tagged c-KIT (544 to 976 residues) expressed in baculovirus infected sf9 cells using biotinylated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant PDGFRbeta (unknown origin) expressed in baculovirus infected insect cells using biotinylated peptide substrate GGLFDDPSYVNV...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using peptidic substrates in presence of ATP by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232830(CHEMBL4092990)
Affinity DataIC50: <1nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant FGFR2 (unknown origin) using peptidic substrates in presence of ATP by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant GST fused FGFR3 (unknown origin) using poly(EY) 4:1 as substrate in presence of [gamma-32P]ATP after 10 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232830(CHEMBL4092990)
Affinity DataIC50:  1nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CSF-1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human N-terminal GST/His6-tagged FLT3 (571 to 993 residues) expressed in baculovirus infected sf9 cells using biotinylated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232829(CHEMBL4065323)
Affinity DataIC50:  1nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of recombinant human VEGFR2 using substrate poly[Glu:Tyr] (4:1) in presence of [33-P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of recombinant human FGFR3 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of recombinant human FGFR1 using substrate KKKSPGEYVNIEFG in presence of [33-P]ATP by kinase hotspot assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of recombinant human FGFR2 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232833(CHEMBL4076610)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232832(CHEMBL4090527)
Affinity DataIC50:  3nMAssay Description:Inhibition of human N-terminal GST-tagged FGFR4 cytoplasmic domain (460 to 802 end residues) expressed in baculovirus expression system using CSKtide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232829(CHEMBL4065323)
Affinity DataIC50:  4nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM6190(3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6...)
Affinity DataIC50:  5nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50399539(CHEMBL2180605)
Affinity DataIC50:  7nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50197683(CHEMBL3907479 | US10689705, Compound 49)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant VEGFR3 (unknown origin) expressed in baculovirus infected insect cells using biotinylated peptide substrate GGGGQDGKDYIVLPI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) expressed in baculovirus infected insect cells using biotinylated peptide substrate GGGGQDGKDYIVLPI ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant FGFR3 (unknown origin) using biotinylated peptide substrate GGGGQDGKDYIVLPI in presence of ATP incubated for 1 to 4 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50197683(CHEMBL3907479 | US10689705, Compound 49)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant VEGFR1 (unknown origin) expressed in baculovirus infected insect cells using biotinylated peptide substrate GGGGQDGKDYIVLPI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50399539(CHEMBL2180605)
Affinity DataIC50:  10nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) expressed in baculovirus infected insect cells using biotinylated peptide substrate GGGGQDGKDYIVLPI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232834(CHEMBL4063676)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50399539(CHEMBL2180605)
Affinity DataIC50:  18nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232830(CHEMBL4092990)
Affinity DataIC50:  22nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50197683(CHEMBL3907479 | US10689705, Compound 49)
Affinity DataIC50:  22nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM6190(3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6...)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant full length human FGFR1 expressed in baculovirus infected insect cells in presence of [gamma-32P]ATP after 10 mins by scint...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50399539(CHEMBL2180605)
Affinity DataIC50:  25nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232829(CHEMBL4065323)
Affinity DataIC50:  32nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232830(CHEMBL4092990)
Affinity DataIC50:  41nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant FGFR4 (unknown origin) using peptidic substrates in presence of ATP by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50399539(CHEMBL2180605)
Affinity DataIC50:  83nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232829(CHEMBL4065323)
Affinity DataIC50:  93nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232832(CHEMBL4090527)
Affinity DataIC50:  150nMAssay Description:Inhibition of human N-terminal GST-tagged FGFR3 cytoplasmic domain (436 to 806 end residues) expressed in baculovirus expression system using CSKtide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50065454(CHEBI:63453 | CHEMBL3348846)
Affinity DataIC50:  165nMAssay Description:Inhibition of recombinant human FGFR4 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50197683(CHEMBL3907479 | US10689705, Compound 49)
Affinity DataIC50:  290nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232832(CHEMBL4090527)
Affinity DataIC50:  493nMAssay Description:Inhibition of human N-terminal GST-tagged FGFR2 cytoplasmic domain (399 to 821 end residues) expressed in baculovirus expression system using CSKtide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232832(CHEMBL4090527)
Affinity DataIC50:  591nMAssay Description:Inhibition of human N-terminal GST-tagged FGFR1 cytoplasmic domain (398 to 822 residues) expressed in baculovirus expression system using CSKtide as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232831(CHEMBL1738735)
Affinity DataIC50:  840nMAssay Description:Inhibition of recombinant His6-tagged FGFR1 (unknown origin) expressed in Escherichia coli BL21(DE3)-RILP using peptidic substrate by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50226193(Acrylamide | CHEBI:28619)
Affinity DataIC50:  938nMAssay Description:Inhibition of human N-terminal GST-tagged FGFR4 cytoplasmic domain (460 to 802 end residues) expressed in baculovirus expression system using CSKtide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232831(CHEMBL1738735)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of recombinant His6-tagged FGFR2 (unknown origin) expressed in Escherichia coli BL21(DE3)-RILP using peptidic substrate by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The First Affiliated Hospital Of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50197683(CHEMBL3907479 | US10689705, Compound 49)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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