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PubMed code 27987485

Compile data set for download or QSAR
Found 74 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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PubMed
n/an/a 24n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232320
PNG
(CHEMBL4103370)
Show SMILES Clc1ccc(cc1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C16H11ClN4O/c17-11-7-5-10(6-8-11)16-21-20-15(22-16)9-14-18-12-3-1-2-4-13(12)19-14/h1-8H,9H2,(H,18,19)
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n/an/a 81n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232320
PNG
(CHEMBL4103370)
Show SMILES Clc1ccc(cc1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C16H11ClN4O/c17-11-7-5-10(6-8-11)16-21-20-15(22-16)9-14-18-12-3-1-2-4-13(12)19-14/h1-8H,9H2,(H,18,19)
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n/an/a 81n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232327
PNG
(CHEMBL4084249)
Show SMILES COc1ccc(cc1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H14N4O2/c1-22-12-8-6-11(7-9-12)17-21-20-16(23-17)10-15-18-13-4-2-3-5-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)
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n/an/a 98n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232327
PNG
(CHEMBL4084249)
Show SMILES COc1ccc(cc1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H14N4O2/c1-22-12-8-6-11(7-9-12)17-21-20-16(23-17)10-15-18-13-4-2-3-5-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)
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n/an/a 98n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232320
PNG
(CHEMBL4103370)
Show SMILES Clc1ccc(cc1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C16H11ClN4O/c17-11-7-5-10(6-8-11)16-21-20-15(22-16)9-14-18-12-3-1-2-4-13(12)19-14/h1-8H,9H2,(H,18,19)
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n/an/a 610n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232327
PNG
(CHEMBL4084249)
Show SMILES COc1ccc(cc1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H14N4O2/c1-22-12-8-6-11(7-9-12)17-21-20-16(23-17)10-15-18-13-4-2-3-5-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)
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n/an/a 910n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232328
PNG
(CHEMBL4084996)
Show SMILES Clc1ccc(cc1)-c1nnc(Cc2nc3ccc(Cl)cc3[nH]2)o1
Show InChI InChI=1S/C16H10Cl2N4O/c17-10-3-1-9(2-4-10)16-22-21-15(23-16)8-14-19-12-6-5-11(18)7-13(12)20-14/h1-7H,8H2,(H,19,20)
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n/an/a 979n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232328
PNG
(CHEMBL4084996)
Show SMILES Clc1ccc(cc1)-c1nnc(Cc2nc3ccc(Cl)cc3[nH]2)o1
Show InChI InChI=1S/C16H10Cl2N4O/c17-10-3-1-9(2-4-10)16-22-21-15(23-16)8-14-19-12-6-5-11(18)7-13(12)20-14/h1-7H,8H2,(H,19,20)
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PubMed
n/an/a 980n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232328
PNG
(CHEMBL4084996)
Show SMILES Clc1ccc(cc1)-c1nnc(Cc2nc3ccc(Cl)cc3[nH]2)o1
Show InChI InChI=1S/C16H10Cl2N4O/c17-10-3-1-9(2-4-10)16-22-21-15(23-16)8-14-19-12-6-5-11(18)7-13(12)20-14/h1-7H,8H2,(H,19,20)
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PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232321
PNG
(CHEMBL4079125)
Show SMILES Clc1ccc(-c2nnc(Cc3nc4ccccc4[nH]3)o2)c(Cl)c1
Show InChI InChI=1S/C16H10Cl2N4O/c17-9-5-6-10(11(18)7-9)16-22-21-15(23-16)8-14-19-12-3-1-2-4-13(12)20-14/h1-7H,8H2,(H,19,20)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232321
PNG
(CHEMBL4079125)
Show SMILES Clc1ccc(-c2nnc(Cc3nc4ccccc4[nH]3)o2)c(Cl)c1
Show InChI InChI=1S/C16H10Cl2N4O/c17-9-5-6-10(11(18)7-9)16-22-21-15(23-16)8-14-19-12-3-1-2-4-13(12)20-14/h1-7H,8H2,(H,19,20)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232324
PNG
(CHEMBL4094471)
Show SMILES Clc1ccccc1-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C16H11ClN4O/c17-11-6-2-1-5-10(11)16-21-20-15(22-16)9-14-18-12-7-3-4-8-13(12)19-14/h1-8H,9H2,(H,18,19)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232324
PNG
(CHEMBL4094471)
Show SMILES Clc1ccccc1-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C16H11ClN4O/c17-11-6-2-1-5-10(11)16-21-20-15(22-16)9-14-18-12-7-3-4-8-13(12)19-14/h1-8H,9H2,(H,18,19)
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PubMed
n/an/a 4.50E+3n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232321
PNG
(CHEMBL4079125)
Show SMILES Clc1ccc(-c2nnc(Cc3nc4ccccc4[nH]3)o2)c(Cl)c1
Show InChI InChI=1S/C16H10Cl2N4O/c17-9-5-6-10(11(18)7-9)16-22-21-15(23-16)8-14-19-12-3-1-2-4-13(12)20-14/h1-7H,8H2,(H,19,20)
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n/an/a 4.70E+3n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232344
PNG
(CHEMBL4066118)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(Cc2cccc3ccccc23)o1
Show InChI InChI=1S/C21H16N4O/c1-2-9-16-14(6-1)7-5-8-15(16)12-20-24-25-21(26-20)13-19-22-17-10-3-4-11-18(17)23-19/h1-11H,12-13H2,(H,22,23)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232344
PNG
(CHEMBL4066118)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(Cc2cccc3ccccc23)o1
Show InChI InChI=1S/C21H16N4O/c1-2-9-16-14(6-1)7-5-8-15(16)12-20-24-25-21(26-20)13-19-22-17-10-3-4-11-18(17)23-19/h1-11H,12-13H2,(H,22,23)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232324
PNG
(CHEMBL4094471)
Show SMILES Clc1ccccc1-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C16H11ClN4O/c17-11-6-2-1-5-10(11)16-21-20-15(22-16)9-14-18-12-7-3-4-8-13(12)19-14/h1-8H,9H2,(H,18,19)
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n/an/a 6.50E+3n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232344
PNG
(CHEMBL4066118)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(Cc2cccc3ccccc23)o1
Show InChI InChI=1S/C21H16N4O/c1-2-9-16-14(6-1)7-5-8-15(16)12-20-24-25-21(26-20)13-19-22-17-10-3-4-11-18(17)23-19/h1-11H,12-13H2,(H,22,23)
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PubMed
n/an/a 8.80E+3n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232322
PNG
(CHEMBL4095623)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(Cc2ccccc2)o1
Show InChI InChI=1S/C17H14N4O/c1-2-6-12(7-3-1)10-16-20-21-17(22-16)11-15-18-13-8-4-5-9-14(13)19-15/h1-9H,10-11H2,(H,18,19)
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PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232322
PNG
(CHEMBL4095623)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(Cc2ccccc2)o1
Show InChI InChI=1S/C17H14N4O/c1-2-6-12(7-3-1)10-16-20-21-17(22-16)11-15-18-13-8-4-5-9-14(13)19-15/h1-9H,10-11H2,(H,18,19)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232330
PNG
(CHEMBL4068254)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C16H12N4O/c1-2-6-11(7-3-1)16-20-19-15(21-16)10-14-17-12-8-4-5-9-13(12)18-14/h1-9H,10H2,(H,17,18)
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n/an/a 3.18E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232330
PNG
(CHEMBL4068254)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C16H12N4O/c1-2-6-11(7-3-1)16-20-19-15(21-16)10-14-17-12-8-4-5-9-13(12)18-14/h1-9H,10H2,(H,17,18)
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n/an/a 3.18E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232319
PNG
(CHEMBL4083493)
Show SMILES Clc1ccc2nc(Cc3nnc(o3)-c3ccccc3Cl)[nH]c2c1
Show InChI InChI=1S/C16H10Cl2N4O/c17-9-5-6-12-13(7-9)20-14(19-12)8-15-21-22-16(23-15)10-3-1-2-4-11(10)18/h1-7H,8H2,(H,19,20)
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n/an/a 3.32E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232319
PNG
(CHEMBL4083493)
Show SMILES Clc1ccc2nc(Cc3nnc(o3)-c3ccccc3Cl)[nH]c2c1
Show InChI InChI=1S/C16H10Cl2N4O/c17-9-5-6-12-13(7-9)20-14(19-12)8-15-21-22-16(23-15)10-3-1-2-4-11(10)18/h1-7H,8H2,(H,19,20)
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n/an/a 3.32E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232322
PNG
(CHEMBL4095623)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(Cc2ccccc2)o1
Show InChI InChI=1S/C17H14N4O/c1-2-6-12(7-3-1)10-16-20-21-17(22-16)11-15-18-13-8-4-5-9-14(13)19-15/h1-9H,10-11H2,(H,18,19)
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n/an/a 3.69E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232325
PNG
(CHEMBL4074782)
Show SMILES Cc1ccccc1-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H14N4O/c1-11-6-2-3-7-12(11)17-21-20-16(22-17)10-15-18-13-8-4-5-9-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)
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n/an/a 3.97E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232325
PNG
(CHEMBL4074782)
Show SMILES Cc1ccccc1-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H14N4O/c1-11-6-2-3-7-12(11)17-21-20-16(22-17)10-15-18-13-8-4-5-9-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)
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n/an/a 3.97E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232330
PNG
(CHEMBL4068254)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C16H12N4O/c1-2-6-11(7-3-1)16-20-19-15(21-16)10-14-17-12-8-4-5-9-13(12)18-14/h1-9H,10H2,(H,17,18)
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n/an/a 4.00E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232326
PNG
(CHEMBL4102214)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H18N4O/c1-3-9-16(10-4-1)22(17-11-5-2-6-12-17)23-27-26-21(28-23)15-20-24-18-13-7-8-14-19(18)25-20/h1-14,22H,15H2,(H,24,25)
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n/an/a 4.50E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232326
PNG
(CHEMBL4102214)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H18N4O/c1-3-9-16(10-4-1)22(17-11-5-2-6-12-17)23-27-26-21(28-23)15-20-24-18-13-7-8-14-19(18)25-20/h1-14,22H,15H2,(H,24,25)
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n/an/a 4.50E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232329
PNG
(CHEMBL4102942)
Show SMILES Clc1ccc(-c2nnc(Cc3nc4ccc(Cl)cc4[nH]3)o2)c(Cl)c1
Show InChI InChI=1S/C16H9Cl3N4O/c17-8-1-3-10(11(19)5-8)16-23-22-15(24-16)7-14-20-12-4-2-9(18)6-13(12)21-14/h1-6H,7H2,(H,20,21)
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n/an/a 4.51E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232329
PNG
(CHEMBL4102942)
Show SMILES Clc1ccc(-c2nnc(Cc3nc4ccc(Cl)cc4[nH]3)o2)c(Cl)c1
Show InChI InChI=1S/C16H9Cl3N4O/c17-8-1-3-10(11(19)5-8)16-23-22-15(24-16)7-14-20-12-4-2-9(18)6-13(12)21-14/h1-6H,7H2,(H,20,21)
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n/an/a 4.51E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232319
PNG
(CHEMBL4083493)
Show SMILES Clc1ccc2nc(Cc3nnc(o3)-c3ccccc3Cl)[nH]c2c1
Show InChI InChI=1S/C16H10Cl2N4O/c17-9-5-6-12-13(7-9)20-14(19-12)8-15-21-22-16(23-15)10-3-1-2-4-11(10)18/h1-7H,8H2,(H,19,20)
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n/an/a 4.57E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232323
PNG
(CHEMBL4087921)
Show SMILES C(Oc1ccccc1)c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H14N4O2/c1-2-6-12(7-3-1)22-11-17-21-20-16(23-17)10-15-18-13-8-4-5-9-14(13)19-15/h1-9H,10-11H2,(H,18,19)
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n/an/a 4.63E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232323
PNG
(CHEMBL4087921)
Show SMILES C(Oc1ccccc1)c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H14N4O2/c1-2-6-12(7-3-1)22-11-17-21-20-16(23-17)10-15-18-13-8-4-5-9-14(13)19-15/h1-9H,10-11H2,(H,18,19)
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n/an/a 4.63E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232325
PNG
(CHEMBL4074782)
Show SMILES Cc1ccccc1-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H14N4O/c1-11-6-2-3-7-12(11)17-21-20-16(22-17)10-15-18-13-8-4-5-9-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)
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n/an/a 4.68E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232343
PNG
(CHEMBL4095195)
Show SMILES Cc1ccccc1Cc1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C18H16N4O/c1-12-6-2-3-7-13(12)10-17-21-22-18(23-17)11-16-19-14-8-4-5-9-15(14)20-16/h2-9H,10-11H2,1H3,(H,19,20)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232343
PNG
(CHEMBL4095195)
Show SMILES Cc1ccccc1Cc1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C18H16N4O/c1-12-6-2-3-7-13(12)10-17-21-22-18(23-17)11-16-19-14-8-4-5-9-15(14)20-16/h2-9H,10-11H2,1H3,(H,19,20)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232323
PNG
(CHEMBL4087921)
Show SMILES C(Oc1ccccc1)c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H14N4O2/c1-2-6-12(7-3-1)22-11-17-21-20-16(23-17)10-15-18-13-8-4-5-9-14(13)19-15/h1-9H,10-11H2,(H,18,19)
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n/an/a 5.24E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232329
PNG
(CHEMBL4102942)
Show SMILES Clc1ccc(-c2nnc(Cc3nc4ccc(Cl)cc4[nH]3)o2)c(Cl)c1
Show InChI InChI=1S/C16H9Cl3N4O/c17-8-1-3-10(11(19)5-8)16-23-22-15(24-16)7-14-20-12-4-2-9(18)6-13(12)21-14/h1-6H,7H2,(H,20,21)
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n/an/a 5.26E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232326
PNG
(CHEMBL4102214)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H18N4O/c1-3-9-16(10-4-1)22(17-11-5-2-6-12-17)23-27-26-21(28-23)15-20-24-18-13-7-8-14-19(18)25-20/h1-14,22H,15H2,(H,24,25)
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n/an/a 5.76E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232341
PNG
(CHEMBL4065301)
Show SMILES COc1cccc(-c2nnc(Cc3nc4ccccc4[nH]3)o2)c1OC
Show InChI InChI=1S/C18H16N4O3/c1-23-14-9-5-6-11(17(14)24-2)18-22-21-16(25-18)10-15-19-12-7-3-4-8-13(12)20-15/h3-9H,10H2,1-2H3,(H,19,20)
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n/an/a 6.10E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232341
PNG
(CHEMBL4065301)
Show SMILES COc1cccc(-c2nnc(Cc3nc4ccccc4[nH]3)o2)c1OC
Show InChI InChI=1S/C18H16N4O3/c1-23-14-9-5-6-11(17(14)24-2)18-22-21-16(25-18)10-15-19-12-7-3-4-8-13(12)20-15/h3-9H,10H2,1-2H3,(H,19,20)
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n/an/a 6.10E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232336
PNG
(CHEMBL4068814)
Show SMILES CC(=O)c1ccccc1-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C18H14N4O2/c1-11(23)12-6-2-3-7-13(12)18-22-21-17(24-18)10-16-19-14-8-4-5-9-15(14)20-16/h2-9H,10H2,1H3,(H,19,20)
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n/an/a 6.54E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232336
PNG
(CHEMBL4068814)
Show SMILES CC(=O)c1ccccc1-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C18H14N4O2/c1-11(23)12-6-2-3-7-13(12)18-22-21-17(24-18)10-16-19-14-8-4-5-9-15(14)20-16/h2-9H,10H2,1H3,(H,19,20)
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n/an/a 6.55E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232337
PNG
(CHEMBL4094647)
Show SMILES Nc1ccc(O)c(c1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C16H13N5O2/c17-9-5-6-13(22)10(7-9)16-21-20-15(23-16)8-14-18-11-3-1-2-4-12(11)19-14/h1-7,22H,8,17H2,(H,18,19)
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n/an/a 7.00E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232337
PNG
(CHEMBL4094647)
Show SMILES Nc1ccc(O)c(c1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C16H13N5O2/c17-9-5-6-13(22)10(7-9)16-21-20-15(23-16)8-14-18-11-3-1-2-4-12(11)19-14/h1-7,22H,8,17H2,(H,18,19)
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n/an/a 7.00E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232345
PNG
(CHEMBL4074726)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)-c1ccccn1
Show InChI InChI=1S/C15H11N5O/c1-2-6-11-10(5-1)17-13(18-11)9-14-19-20-15(21-14)12-7-3-4-8-16-12/h1-8H,9H2,(H,17,18)
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n/an/a 7.35E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232345
PNG
(CHEMBL4074726)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)-c1ccccn1
Show InChI InChI=1S/C15H11N5O/c1-2-6-11-10(5-1)17-13(18-11)9-14-19-20-15(21-14)12-7-3-4-8-16-12/h1-8H,9H2,(H,17,18)
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n/an/a 7.35E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232339
PNG
(CHEMBL4087489)
Show SMILES C(C1=C2C=CC=CC2NC1)c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C19H17N5O/c1-2-6-14-13(5-1)12(11-20-14)9-18-23-24-19(25-18)10-17-21-15-7-3-4-8-16(15)22-17/h1-8,14,20H,9-11H2,(H,21,22)
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n/an/a 8.62E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232339
PNG
(CHEMBL4087489)
Show SMILES C(C1=C2C=CC=CC2NC1)c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C19H17N5O/c1-2-6-14-13(5-1)12(11-20-14)9-18-23-24-19(25-18)10-17-21-15-7-3-4-8-16(15)22-17/h1-8,14,20H,9-11H2,(H,21,22)
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n/an/a 8.63E+4n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232342
PNG
(CHEMBL4090323)
Show SMILES Fc1ccc(cc1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C16H11FN4O/c17-11-7-5-10(6-8-11)16-21-20-15(22-16)9-14-18-12-3-1-2-4-13(12)19-14/h1-8H,9H2,(H,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232334
PNG
(CHEMBL4083305)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)-c1cccnc1
Show InChI InChI=1S/C15H11N5O/c1-2-6-12-11(5-1)17-13(18-12)8-14-19-20-15(21-14)10-4-3-7-16-9-10/h1-7,9H,8H2,(H,17,18)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232342
PNG
(CHEMBL4090323)
Show SMILES Fc1ccc(cc1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C16H11FN4O/c17-11-7-5-10(6-8-11)16-21-20-15(22-16)9-14-18-12-3-1-2-4-13(12)19-14/h1-8H,9H2,(H,18,19)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232338
PNG
(CHEMBL4073285)
Show SMILES OC(=O)c1ccccc1-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H12N4O3/c22-17(23)11-6-2-1-5-10(11)16-21-20-15(24-16)9-14-18-12-7-3-4-8-13(12)19-14/h1-8H,9H2,(H,18,19)(H,22,23)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232317
PNG
(CHEMBL4091284)
Show SMILES Clc1ccc2nc(Cc3nnc(Cc4ccccc4)o3)[nH]c2c1
Show InChI InChI=1S/C17H13ClN4O/c18-12-6-7-13-14(9-12)20-15(19-13)10-17-22-21-16(23-17)8-11-4-2-1-3-5-11/h1-7,9H,8,10H2,(H,19,20)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232332
PNG
(CHEMBL4075892)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)-c1cccs1
Show InChI InChI=1S/C14H10N4OS/c1-2-5-10-9(4-1)15-12(16-10)8-13-17-18-14(19-13)11-6-3-7-20-11/h1-7H,8H2,(H,15,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232340
PNG
(CHEMBL4059610)
Show SMILES Oc1ccc(cc1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C16H12N4O2/c21-11-7-5-10(6-8-11)16-20-19-15(22-16)9-14-17-12-3-1-2-4-13(12)18-14/h1-8,21H,9H2,(H,17,18)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232333
PNG
(CHEMBL4061912)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C14H10N4O2/c1-2-5-10-9(4-1)15-12(16-10)8-13-17-18-14(20-13)11-6-3-7-19-11/h1-7H,8H2,(H,15,16)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232335
PNG
(CHEMBL4067556)
Show SMILES N#CCc1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C12H9N5O/c13-6-5-11-16-17-12(18-11)7-10-14-8-3-1-2-4-9(8)15-10/h1-4H,5,7H2,(H,14,15)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232331
PNG
(CHEMBL4086731)
Show SMILES Cc1ccc(cc1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H14N4O/c1-11-6-8-12(9-7-11)17-21-20-16(22-17)10-15-18-13-4-2-3-5-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)
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Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232340
PNG
(CHEMBL4059610)
Show SMILES Oc1ccc(cc1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C16H12N4O2/c21-11-7-5-10(6-8-11)16-20-19-15(22-16)9-14-17-12-3-1-2-4-13(12)18-14/h1-8,21H,9H2,(H,17,18)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232331
PNG
(CHEMBL4086731)
Show SMILES Cc1ccc(cc1)-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H14N4O/c1-11-6-8-12(9-7-11)17-21-20-16(22-17)10-15-18-13-4-2-3-5-14(13)19-15/h2-9H,10H2,1H3,(H,18,19)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232318
PNG
(CHEMBL4063427)
Show SMILES Clc1ccc2nc(Cc3nnc(o3)-c3ccccc3)[nH]c2c1
Show InChI InChI=1S/C16H11ClN4O/c17-11-6-7-12-13(8-11)19-14(18-12)9-15-20-21-16(22-15)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232317
PNG
(CHEMBL4091284)
Show SMILES Clc1ccc2nc(Cc3nnc(Cc4ccccc4)o3)[nH]c2c1
Show InChI InChI=1S/C17H13ClN4O/c18-12-6-7-13-14(9-12)20-15(19-13)10-17-22-21-16(23-17)8-11-4-2-1-3-5-11/h1-7,9H,8,10H2,(H,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232333
PNG
(CHEMBL4061912)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)-c1ccco1
Show InChI InChI=1S/C14H10N4O2/c1-2-5-10-9(4-1)15-12(16-10)8-13-17-18-14(20-13)11-6-3-7-19-11/h1-7H,8H2,(H,15,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232338
PNG
(CHEMBL4073285)
Show SMILES OC(=O)c1ccccc1-c1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C17H12N4O3/c22-17(23)11-6-2-1-5-10(11)16-21-20-15(24-16)9-14-18-12-7-3-4-8-13(12)19-14/h1-8H,9H2,(H,18,19)(H,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50232341
PNG
(CHEMBL4065301)
Show SMILES COc1cccc(-c2nnc(Cc3nc4ccccc4[nH]3)o2)c1OC
Show InChI InChI=1S/C18H16N4O3/c1-23-14-9-5-6-11(17(14)24-2)18-22-21-16(25-18)10-15-19-12-7-3-4-8-13(12)20-15/h3-9H,10H2,1-2H3,(H,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA method


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232332
PNG
(CHEMBL4075892)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)-c1cccs1
Show InChI InChI=1S/C14H10N4OS/c1-2-5-10-9(4-1)15-12(16-10)8-13-17-18-14(19-13)11-6-3-7-20-11/h1-7H,8H2,(H,15,16)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232334
PNG
(CHEMBL4083305)
Show SMILES C(c1nc2ccccc2[nH]1)c1nnc(o1)-c1cccnc1
Show InChI InChI=1S/C15H11N5O/c1-2-6-12-11(5-1)17-13(18-12)8-14-19-20-15(21-14)10-4-3-7-16-9-10/h1-7,9H,8H2,(H,17,18)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232335
PNG
(CHEMBL4067556)
Show SMILES N#CCc1nnc(Cc2nc3ccccc3[nH]2)o1
Show InChI InChI=1S/C12H9N5O/c13-6-5-11-16-17-12(18-11)7-10-14-8-3-1-2-4-9(8)15-10/h1-4H,5,7H2,(H,14,15)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50232318
PNG
(CHEMBL4063427)
Show SMILES Clc1ccc2nc(Cc3nnc(o3)-c3ccccc3)[nH]c2c1
Show InChI InChI=1S/C16H11ClN4O/c17-11-6-7-12-13(8-11)19-14(18-12)9-15-20-21-16(22-15)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)
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Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...


Eur J Med Chem 126: 853-869 (2017)


Article DOI: 10.1016/j.ejmech.2016.12.014
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%