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PubMed code 28105267

Compile data set for download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase


(Macaca mulatta)
BDBM50204596
PNG
(CHEMBL3977461)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N(C)C)c1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C18H21F3N4O2S/c1-10(2)15(11-5-7-12(8-6-11)28-18(19,20)21)24-16(27)13-9-14(26)23-17(22-13)25(3)4/h5-10,15H,1-4H3,(H,24,27)(H,22,23,26)/t15-/m1/s1
PDB
MMDB

KEGG

B.MOAD
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UniChem

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Article
PubMed
0.190n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rhesus monkey PDE2A3 expressed in AD293 cells using FAM-labeled cAMP as substrate after 60 mins in presence of cGMP by florescence pola...


ACS Med Chem Lett 8: 17-18 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00514
BindingDB Entry DOI: 10.7270/Q24M96HP
More data for this
Ligand-Target Pair
GMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase


(Macaca mulatta)
BDBM50204598
PNG
(CHEMBL3933723)
Show SMILES CC[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N(C)C)c1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C17H19F3N4O2S/c1-4-12(10-5-7-11(8-6-10)27-17(18,19)20)21-15(26)13-9-14(25)23-16(22-13)24(2)3/h5-9,12H,4H2,1-3H3,(H,21,26)(H,22,23,25)/t12-/m1/s1
PDB
MMDB

KEGG

B.MOAD
GoogleScholar
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UniChem

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Article
PubMed
0.510n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rhesus monkey PDE2A3 expressed in AD293 cells using FAM-labeled cAMP as substrate after 60 mins in presence of cGMP by florescence pola...


ACS Med Chem Lett 8: 17-18 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00514
BindingDB Entry DOI: 10.7270/Q24M96HP
More data for this
Ligand-Target Pair
GMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase


(Macaca mulatta)
BDBM50204594
PNG
(CHEMBL3980015)
Show SMILES C[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N(C)C)c1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C16H17F3N4O2S/c1-9(10-4-6-11(7-5-10)26-16(17,18)19)20-14(25)12-8-13(24)22-15(21-12)23(2)3/h4-9H,1-3H3,(H,20,25)(H,21,22,24)/t9-/m1/s1
PDB
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KEGG

B.MOAD
GoogleScholar
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PC sid
UniChem

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Article
PubMed
0.570n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rhesus monkey PDE2A3 expressed in AD293 cells using FAM-labeled cAMP as substrate after 60 mins in presence of cGMP by florescence pola...


ACS Med Chem Lett 8: 17-18 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00514
BindingDB Entry DOI: 10.7270/Q24M96HP
More data for this
Ligand-Target Pair
GMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase


(Macaca mulatta)
BDBM50204595
PNG
(CHEMBL3889667)
Show SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)NC1(CC1)c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C17H16F4N4O2/c1-25(2)15-22-12(8-13(26)23-15)14(27)24-16(5-6-16)9-3-4-10(11(18)7-9)17(19,20)21/h3-4,7-8H,5-6H2,1-2H3,(H,24,27)(H,22,23,26)
PDB
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KEGG

B.MOAD
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PC sid
UniChem

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Article
PubMed
0.800n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rhesus monkey PDE2A3 expressed in AD293 cells using FAM-labeled cAMP as substrate after 60 mins in presence of cGMP by florescence pola...


ACS Med Chem Lett 8: 17-18 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00514
BindingDB Entry DOI: 10.7270/Q24M96HP
More data for this
Ligand-Target Pair
GMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase


(Macaca mulatta)
BDBM50204597
PNG
(CHEMBL3906832)
Show SMILES C[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N(C)C)c1ccc(OC(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C16H16ClF3N4O3/c1-8(9-4-5-12(10(17)6-9)27-16(18,19)20)21-14(26)11-7-13(25)23-15(22-11)24(2)3/h4-8H,1-3H3,(H,21,26)(H,22,23,25)/t8-/m1/s1
PDB
MMDB

KEGG

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.820n/an/an/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rhesus monkey PDE2A3 expressed in AD293 cells using FAM-labeled cAMP as substrate after 60 mins in presence of cGMP by florescence pola...


ACS Med Chem Lett 8: 17-18 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00514
BindingDB Entry DOI: 10.7270/Q24M96HP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%